Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy.

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Published in Clin Epigenetics on November 09, 2010

Authors

Julia M Wagner, Björn Hackanson, Michael Lübbert, Manfred Jung

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Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode. J Med Chem (2008) 1.31

Risk and prognosis of central nervous system leukemia in patients with Philadelphia chromosome-positive acute leukemias treated with imatinib mesylate. Clin Cancer Res (2003) 1.29

Deregulated expression of EVI1 defines a poor prognostic subset of MLL-rearranged acute myeloid leukemias: a study of the German-Austrian Acute Myeloid Leukemia Study Group and the Dutch-Belgian-Swiss HOVON/SAKK Cooperative Group. J Clin Oncol (2012) 1.28

Epigenetic treatment of hematopoietic malignancies: in vivo targets of demethylating agents. Semin Oncol (2005) 1.26

Enhancement of radiation sensitivity of human squamous carcinoma cells by histone deacetylase inhibitors. Radiat Res (2004) 1.26

Subtype selective substrates for histone deacetylases. J Med Chem (2004) 1.25

Secondary genetic lesions in acute myeloid leukemia with inv(16) or t(16;16): a study of the German-Austrian AML Study Group (AMLSG). Blood (2012) 1.25

The DNA demethylating agent 5-aza-2'-deoxycytidine induces expression of NY-ESO-1 and other cancer/testis antigens in myeloid leukemia cells. Leuk Res (2010) 1.25

Parameters detected by geriatric and quality of life assessment in 195 older patients with myelodysplastic syndromes and acute myeloid leukemia are highly predictive for outcome. Haematologica (2012) 1.24

Induction of human gamma globin gene expression by histone deacetylase inhibitors. Blood (2003) 1.23

Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem (2002) 1.23

Structure-activity studies on suramin analogues as inhibitors of NAD+-dependent histone deacetylases (sirtuins). ChemMedChem (2007) 1.19

Impairment of prostate cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitor. Int J Cancer (2012) 1.18

Characterization of novel inhibitors of histone acetyltransferases. Mol Cancer Ther (2007) 1.17

4-Acyl pyrroles: mimicking acetylated lysines in histone code reading. Angew Chem Int Ed Engl (2013) 1.16

Inhibitors of histone deacetylases as potential therapeutic tools for high-risk embryonal tumors of the nervous system of childhood. Int J Cancer (2007) 1.16

Target-based approach to inhibitors of histone arginine methyltransferases. J Med Chem (2007) 1.16

Superiority of prolonged low-dose azanucleoside administration? Results of 5-aza-2'-deoxycytidine retreatment in high-risk myelodysplasia patients. Cancer (2006) 1.14

Cancer treatment of the future: inhibitors of histone methyltransferases. Int J Biochem Cell Biol (2008) 1.14

DNA hypermethylation and epigenetic silencing of the tumor suppressor gene, SLC5A8, in acute myeloid leukemia with the MLL partial tandem duplication. Blood (2008) 1.12

Diminished sensitivity of chronic lymphocytic leukemia cells to ABT-737 and ABT-263 due to albumin binding in blood. Clin Cancer Res (2010) 1.12

Inhibitors of NAD+ dependent histone deacetylases (sirtuins). Curr Pharm Des (2008) 1.11

Destabilization of ERBB2 transcripts by targeting 3' untranslated region messenger RNA associated HuR and histone deacetylase-6. Mol Cancer Res (2008) 1.11

A novel arginine methyltransferase inhibitor with cellular activity. Bioorg Med Chem Lett (2007) 1.09

Granulocytic sarcoma of Core-binding Factor (CBF) acute myeloid leukemia mimicking pancreatic cancer. Leuk Res (2008) 1.08

Histone deacetylase inhibitors induce a very broad, pleiotropic anticancer drug resistance phenotype in acute myeloid leukemia cells by modulation of multiple ABC transporter genes. Clin Cancer Res (2009) 1.08

New lysine methyltransferase drug targets in cancer. Nat Biotechnol (2012) 1.08

Integrative prognostic risk score in acute myeloid leukemia with normal karyotype. Blood (2011) 1.07

CD34- hematopoietic stem cells: current concepts and controversies. Stem Cells (2003) 1.07

Decitabine. Recent Results Cancer Res (2010) 1.07

Clinical development of demethylating agents in hematology. J Clin Invest (2014) 1.07

Identification of selective inhibitors of NAD+-dependent deacetylases using phenotypic screens in yeast. J Biol Chem (2003) 1.06

Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition. J Med Chem (2006) 1.06

A novel murine model of myeloproliferative disorders generated by overexpression of the transcription factor NF-E2. J Exp Med (2012) 1.05

Reversal of p15/INK4b hypermethylation in AML1/ETO-positive and -negative myeloid leukemia cell lines. Leuk Res (2006) 1.03

Arginine methylation of the B cell antigen receptor promotes differentiation. J Exp Med (2010) 1.02

NAD(+) -dependent histone deacetylases (sirtuins) as novel therapeutic targets. Med Res Rev (2010) 1.02

TSC-22 contributes to hematopoietic precursor cell proliferation and repopulation and is epigenetically silenced in large granular lymphocyte leukemia. Blood (2009) 1.01

Decitabine induces very early in vivo DNA methylation changes in blasts from patients with acute myeloid leukemia. Leuk Res (2012) 1.01

Clinical results with the DNA hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in patients with myelodysplastic syndromes: an update. Semin Hematol (2012) 1.00

In vitro assays for the determination of histone deacetylase activity. Methods (2005) 1.00

Intriguing response to azacitidine in a patient with juvenile myelomonocytic leukemia and monosomy 7. Blood (2009) 1.00

Acquired PTPN11 mutations occur rarely in adult patients with myelodysplastic syndromes and chronic myelomonocytic leukemia. Leuk Res (2004) 0.99

Thiobarbiturates as sirtuin inhibitors: virtual screening, free-energy calculations, and biological testing. ChemMedChem (2008) 0.99

Comparative action of cobalt carbonyl complexes on cancer cells using human tumor xenografts. Anticancer Res (2002) 0.99

Hematologic and molecular spontaneous remission following sepsis in acute monoblastic leukemia with translocation (9;11): a case report and review of the literature. Eur J Haematol (2004) 0.98

Hydroxamide derivatives of short-chain fatty acids are potent inducers of human fetal globin gene expression. Exp Hematol (2003) 0.98

DNA methylation disturbances as novel therapeutic target in lung cancer: preclinical and clinical results. Crit Rev Oncol Hematol (2005) 0.98

Small molecule inhibitors of histone acetyltransferases as epigenetic tools and drug candidates. Arch Pharm (Weinheim) (2011) 0.98

Structural basis for the inhibition of histone deacetylase 8 (HDAC8), a key epigenetic player in the blood fluke Schistosoma mansoni. PLoS Pathog (2013) 0.97

Histone deacetylase inhibitors that target tubulin. Cancer Lett (2009) 0.97

Structure-activity relationships on phenylalanine-containing inhibitors of histone deacetylase: in vitro enzyme inhibition, induction of differentiation, and inhibition of proliferation in Friend leukemic cells. J Med Chem (2002) 0.97

The role of NAD+ dependent histone deacetylases (sirtuins) in ageing. Curr Drug Targets (2006) 0.97

Inhibitors of DNA methylation in the treatment of hematological malignancies and MDS. Clin Immunol (2003) 0.97

Prognostic significance of expression levels of stem cell regulators MSI2 and NUMB in acute myeloid leukemia. Ann Hematol (2012) 0.97

Current status of epigenetic treatment in myelodysplastic syndromes. Ann Hematol (2008) 0.96

Sequential combination of gemtuzumab ozogamicin and standard chemotherapy in older patients with newly diagnosed acute myeloid leukemia: results of a randomized phase III trial by the EORTC and GIMEMA consortium (AML-17). J Clin Oncol (2013) 0.96

Quantitative analyses of DAPK1 methylation in AML and MDS. Int J Cancer (2011) 0.96

Determination of drug-serum protein interactions via fluorescence polarization measurements. Anal Bioanal Chem (2007) 0.95

The ergot alkaloid gene cluster: functional analyses and evolutionary aspects. Phytochemistry (2009) 0.95

Structural and synthetic investigations of tanikolide dimer, a SIRT2 selective inhibitor, and tanikolide seco-acid from the Madagascar marine cyanobacterium Lyngbya majuscula. J Org Chem (2009) 0.95

Prognostic importance of histone methyltransferase MLL5 expression in acute myeloid leukemia. J Clin Oncol (2011) 0.95

Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs). Bioorg Med Chem (2007) 0.95

DNA hypermethylation of myeloid cells, a novel therapeutic target in MDS and AML. Curr Pharm Biotechnol (2006) 0.94

In vivo application of histone deacetylase inhibitor trichostatin-a impairs murine male meiosis. J Androl (2007) 0.93