Published in Cancer Res on January 25, 2011
Cancer stem cells: the challenges ahead. Nat Cell Biol (2013) 2.78
Spherical cancer models in tumor biology. Neoplasia (2015) 1.75
Arsenic-transformed malignant prostate epithelia can convert noncontiguous normal stem cells into an oncogenic phenotype. Environ Health Perspect (2012) 1.66
The cancer stem cell niche: how essential is the niche in regulating stemness of tumor cells? Cell Stem Cell (2015) 1.66
Aberrant activation, nuclear localization, and phosphorylation of Yes-associated protein-1 in the embryonic kidney and Wilms tumor. Pediatr Blood Cancer (2013) 1.46
The metastatic niche and stromal progression. Cancer Metastasis Rev (2012) 1.30
Short-term single treatment of chemotherapy results in the enrichment of ovarian cancer stem cell-like cells leading to an increased tumor burden. Mol Cancer (2013) 1.27
Pancreatic cancer stem cells: emerging target for designing novel therapy. Cancer Lett (2012) 1.16
The role of breast cancer stem cells in metastasis and therapeutic implications. Am J Pathol (2011) 1.16
Aldehyde dehydrogenase 1 identifies cells with cancer stem cell-like properties in a human renal cell carcinoma cell line. PLoS One (2013) 1.11
Hope and fear for interferon: the receptor-centric outlook on the future of interferon therapy. J Interferon Cytokine Res (2013) 1.07
Regulation of stem cell populations by microRNAs. Adv Exp Med Biol (2013) 1.04
Gastric cancer stem cells: a novel therapeutic target. Cancer Lett (2013) 1.04
β4 Integrin signaling induces expansion of prostate tumor progenitors. J Clin Invest (2013) 1.03
The mesenchymal tumor microenvironment: a drug-resistant niche. Cell Adh Migr (2012) 0.99
Cancer Stem Cells: A Minor Cancer Subpopulation that Redefines Global Cancer Features. Front Oncol (2013) 0.99
Differential effects of drugs targeting cancer stem cell (CSC) and non-CSC populations on lung primary tumors and metastasis. PLoS One (2013) 0.98
cAMP/PKA signaling defects in tumors: genetics and tissue-specific pluripotential cell-derived lesions in human and mouse. Mol Cell Endocrinol (2013) 0.97
Concise Review: Targeting Cancer Stem Cells Using Immunologic Approaches. Stem Cells (2015) 0.97
Head and neck cancer stem cells. J Dent Res (2011) 0.94
ABC transporters B1, C1 and G2 differentially regulate neuroregeneration in mice. PLoS One (2012) 0.94
Identifying new small molecule anti-invasive compounds for glioma treatment. Cell Cycle (2013) 0.94
Cancer stem cell immunology: key to understanding tumorigenesis and tumor immune escape? Front Immunol (2014) 0.93
Cancer cell dormancy in novel mouse models for reversible pancreatic cancer: a lingering challenge in the development of targeted therapies. Cancer Res (2014) 0.93
A 41-gene signature derived from breast cancer stem cells as a predictor of survival. J Exp Clin Cancer Res (2014) 0.93
Desmoplasia and chemoresistance in pancreatic cancer. Cancers (Basel) (2014) 0.93
Mesenchymal stem cell secretome and regenerative therapy after cancer. Biochimie (2013) 0.93
New Findings on Breast Cancer Stem Cells: A Review. J Breast Cancer (2015) 0.92
Cancer stem cells and tumor-associated macrophages: a roadmap for multitargeting strategies. Oncogene (2015) 0.92
Anti-tumorigenic effects of Type 1 interferon are subdued by integrated stress responses. Oncogene (2012) 0.92
Perivascular stem cell niche in head and neck cancer. Cancer Lett (2012) 0.90
Development of hepatocellular carcinoma in a murine model of nonalcoholic steatohepatitis induced by use of a high-fat/fructose diet and sedentary lifestyle. Am J Pathol (2014) 0.89
Proliferation and enrichment of CD133(+) glioblastoma cancer stem cells on 3D chitosan-alginate scaffolds. Biomaterials (2014) 0.89
Cancer stem cells: the 'heartbeat' of gastric cancer. J Gastroenterol (2012) 0.88
Deciphering the Key Features of Malignant Tumor Microenvironment for Anti-cancer Therapy. Cancer Microenviron (2012) 0.88
Excessive hyaluronan production promotes acquisition of cancer stem cell signatures through the coordinated regulation of Twist and the transforming growth factor β (TGF-β)-Snail signaling axis. J Biol Chem (2014) 0.88
CD133, Stem Cells, and Cancer Stem Cells: Myth or Reality? Curr Colorectal Cancer Rep (2011) 0.88
The tumor microenvironment shapes hallmarks of mature B-cell malignancies. Oncogene (2015) 0.87
CD44 variant 6 is correlated with peritoneal dissemination and poor prognosis in patients with advanced epithelial ovarian cancer. Cancer Sci (2015) 0.87
The culture of cancer cell lines as tumorspheres does not systematically result in cancer stem cell enrichment. PLoS One (2014) 0.87
Nanoparticle mediated targeting of VEGFR and cancer stem cells for cancer therapy. Vasc Cell (2011) 0.87
Interrogating open issues in cancer precision medicine with patient-derived xenografts. Nat Rev Cancer (2017) 0.87
Loss of the SxxSS motif in a human T-cell factor-4 isoform confers hypoxia resistance to liver cancer: an oncogenic switch in Wnt signaling. PLoS One (2012) 0.86
Can nanomedicines kill cancer stem cells? Adv Drug Deliv Rev (2013) 0.86
Midbody: from cellular junk to regulator of cell polarity and cell fate. Curr Opin Cell Biol (2015) 0.84
Colorectal adenoma stem-like cell populations: associations with adenoma characteristics and metachronous colorectal neoplasia. Cancer Prev Res (Phila) (2013) 0.84
Cell budding from normal appearing epithelia: a predictor of colorectal cancer metastasis? Int J Biol Sci (2013) 0.83
Notch1-induced T cell leukemia can be potentiated by microenvironmental cues in the spleen. J Hematol Oncol (2014) 0.83
Endothelial cells promote stem-like phenotype of glioma cells through activating the Hedgehog pathway. J Pathol (2014) 0.83
Hypoxia up-regulates SERPINB3 through HIF-2α in human liver cancer cells. Oncotarget (2015) 0.83
Cellular phenotype-dependent and -independent effects of vitamin C on the renewal and gene expression of mouse embryonic fibroblasts. PLoS One (2012) 0.82
The roles of FOXM1 in pancreatic stem cells and carcinogenesis. Mol Cancer (2013) 0.82
Identification of a unique hepatocellular carcinoma line, Li-7, with CD13(+) cancer stem cells hierarchy and population change upon its differentiation during culture and effects of sorafenib. BMC Cancer (2015) 0.81
Niche-dependent gene expression profile of intratumoral heterogeneous ovarian cancer stem cell populations. PLoS One (2013) 0.81
Hypoxia-shaped vascular niche for cancer stem cells. Contemp Oncol (Pozn) (2015) 0.81
DNA damage responses in cancer stem cells: Implications for cancer therapeutic strategies. World J Biol Chem (2015) 0.81
3D tumor tissue analogs and their orthotopic implants for understanding tumor-targeting of microenvironment-responsive nanosized chemotherapy and radiation. Nanomedicine (2015) 0.81
Stem-like plasticity and heterogeneity of circulating tumor cells: current status and prospect challenges in liver cancer. Oncotarget (2016) 0.80
Optimization of biguanide derivatives as selective antitumor agents blocking adaptive stress responses in the tumor microenvironment. Drug Des Devel Ther (2014) 0.79
DEspR roles in tumor vasculo-angiogenesis, invasiveness, CSC-survival and anoikis resistance: a 'common receptor coordinator' paradigm. PLoS One (2014) 0.79
IL-6 Inhibition With MEDI5117 Decreases The Fraction of Head and Neck Cancer Stem Cells and Prevents Tumor Recurrence. Neoplasia (2016) 0.79
A small molecule (pluripotin) as a tool for studying cancer stem cell biology: proof of concept. PLoS One (2013) 0.79
Glioma stem cells enhance endothelial cell migration and proliferation via the Hedgehog pathway. Oncol Lett (2013) 0.79
Acidic extracellular pH of tumors induces octamer-binding transcription factor 4 expression in murine fibroblasts in vitro and in vivo. Sci Rep (2016) 0.79
Imaging of Angiotropism/Vascular Co-Option in a Murine Model of Brain Melanoma: Implications for Melanoma Progression along Extravascular Pathways. Sci Rep (2016) 0.78
Head and Neck Cancer Stem Cells: From Identification to Tumor Immune Network. J Dent Res (2015) 0.78
From tumour heterogeneity to advances in precision treatment of colorectal cancer. Nat Rev Clin Oncol (2016) 0.78
Metabolic activation of mitochondria in glioma stem cells promotes cancer development through a reactive oxygen species-mediated mechanism. Stem Cell Res Ther (2015) 0.78
Interaction between gastric cancer stem cells and the tumor microenvironment. J Gastroenterol (2014) 0.78
Cancer stem cells: Role in tumor growth, recurrence, metastasis, and treatment resistance. Medicine (Baltimore) (2016) 0.78
Activity of cytokine-induced killer cells against bone and soft tissue sarcoma. Oncoimmunology (2014) 0.78
Monitoring the dynamics of Src activity in response to anti-invasive dasatinib treatment at a subcellular level using dual intravital imaging. Cell Adh Migr (2014) 0.78
Characterization and propagation of tumor initiating cells derived from colorectal liver metastases: trials, tribulations and a cautionary note. PLoS One (2015) 0.78
Cancer stem cell niche models and contribution by mesenchymal stroma/stem cells. Mol Cancer (2017) 0.78
Transcriptional regulation of tenascin-W by TGF-beta signaling in the bone metastatic niche of breast cancer cells. Int J Cancer (2015) 0.77
Treatment of agarose-agarose RENCA macrobeads with docetaxel selects for OCT4(+) cells with tumor-initiating capability. Cancer Biol Ther (2013) 0.77
Remnant living cells that escape cell loss in late-stage tumors exhibit cancer stem cell-like characteristics. Cell Death Dis (2012) 0.77
Cancer stem cells as a potential therapeutic target in thyroid carcinoma. Oncol Lett (2016) 0.77
Targeting Lung Cancer Stem Cells: Research and Clinical Impacts. Front Oncol (2017) 0.77
Niche construction game cancer cells play. Eur Phys J Plus (2015) 0.76
Pancreatic cancer stem cell markers and exosomes - the incentive push. World J Gastroenterol (2016) 0.76
Recruitment of normal stem cells to an oncogenic phenotype by noncontiguous carcinogen-transformed epithelia depends on the transforming carcinogen. Environ Health Perspect (2013) 0.76
Mitigation of arsenic-induced acquired cancer phenotype in prostate cancer stem cells by miR-143 restoration. Toxicol Appl Pharmacol (2015) 0.76
SerpinB3 and Yap Interplay Increases Myc Oncogenic Activity. Sci Rep (2015) 0.76
Stem cell technology in breast cancer: current status and potential applications. Stem Cells Cloning (2016) 0.76
Stem Cell Plasticity And Niche Dynamics in Cancer Progression. IEEE Trans Biomed Eng (2016) 0.75
Tumor-Initiating Cells: Emerging Biophysical Methods of Isolation. Curr Stem Cell Rep (2016) 0.75
Autocrine interleukin-23 promotes self-renewal of CD133+ ovarian cancer stem-like cells. Oncotarget (2016) 0.75
Biliary tract cancer stem cells - translational options and challenges. World J Gastroenterol (2017) 0.75
Expression of Cell-Surface Marker ABCB5 Causes Characteristic Modifications of Glucose, Amino Acid and Phospholipid Metabolism in the G3361 Melanoma-Initiating Cell Line. PLoS One (2016) 0.75
A unified model of the hierarchical and stochastic theories of gastric cancer. Br J Cancer (2017) 0.75
Cancer Stem Cells: Plasticity Works against Therapy. Acta Naturae (2016) 0.75
Multi-cycle chemotherapy with the glycolipid-like polymeric micelles evade cancer stem cell enrichment in breast cancer therapy. Oncotarget (2016) 0.75
Challenges in cancer molecular targets and therapeutics. Front Oncol (2011) 0.75
Molecular culprits generating brain tumor stem cells. Brain Tumor Res Treat (2013) 0.75
Modification of Gene Expression, Proliferation, and Function of OP9 Stroma Cells by Bcr-Abl-Expressing Leukemia Cells. PLoS One (2015) 0.75
Pro-inflammatory-Related Loss of CXCL12 Niche Promotes Acute Lymphoblastic Leukemic Progression at the Expense of Normal Lymphopoiesis. Front Immunol (2017) 0.75
Aiming to immune elimination of ovarian cancer stem cells. World J Stem Cells (2013) 0.75
Microenvironmental Niches and Sanctuaries: A Route to Acquired Resistance. Adv Exp Med Biol (2016) 0.75
Chitosan promotes cancer progression and stem cell properties in association with Wnt signaling in colon and hepatocellular carcinoma cells. Sci Rep (2017) 0.75
Wnt activity defines colon cancer stem cells and is regulated by the microenvironment. Nat Cell Biol (2010) 7.73
Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4. Cell Stem Cell (2007) 7.05
Intestinal label-retaining cells are secretory precursors expressing Lgr5. Nature (2013) 4.83
Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions. Nat Med (2013) 4.22
The developing cancer stem-cell model: clinical challenges and opportunities. Lancet Oncol (2012) 2.83
Microenvironmental regulation of stem cells in intestinal homeostasis and cancer. Nature (2011) 2.59
Colon cancer stem cells: promise of targeted therapy. Gastroenterology (2010) 2.58
Apoptosis and non-apoptotic deaths in cancer development and treatment response. Cancer Treat Rev (2008) 2.20
The AC133 epitope, but not the CD133 protein, is lost upon cancer stem cell differentiation. Cancer Res (2010) 2.12
APRIL modulates B and T cell immunity. J Clin Invest (2002) 2.07
Methylation of cancer-stem-cell-associated Wnt target genes predicts poor prognosis in colorectal cancer patients. Cell Stem Cell (2011) 1.80
Lipid droplets: a new player in colorectal cancer stem cells unveiled by spectroscopic imaging. Stem Cells (2015) 1.75
Cancer stem cell tumor model reveals invasive morphology and increased phenotypical heterogeneity. Cancer Res (2010) 1.71
Mutations in the Ras-Raf Axis underlie the prognostic value of CD133 in colorectal cancer. Clin Cancer Res (2012) 1.60
Continuous clonal labeling reveals small numbers of functional stem cells in intestinal crypts and adenomas. Cell Stem Cell (2013) 1.56
Monoclonal antibodies against Lgr5 identify human colorectal cancer stem cells. Stem Cells (2012) 1.55
Activation of the granzyme pathway in children with severe respiratory syncytial virus infection. Pediatr Res (2008) 1.54
The TNF family member APRIL dampens collagen-induced arthritis. Ann Rheum Dis (2012) 1.49
Targeting Wnt signaling in colon cancer stem cells. Clin Cancer Res (2010) 1.46
Cyclooxygenase-2 inhibition inhibits c-Met kinase activity and Wnt activity in colon cancer. Cancer Res (2008) 1.36
APRIL promotes B-1 cell-associated neoplasm. Cancer Cell (2004) 1.34
Macrodissection versus microdissection of rectal carcinoma: minor influence of stroma cells to tumor cell gene expression profiles. BMC Genomics (2005) 1.34
CD40 stimulation leads to effective therapy of CD40(-) tumors through induction of strong systemic cytotoxic T lymphocyte immunity. Proc Natl Acad Sci U S A (2002) 1.34
Molecular identification and targeting of colorectal cancer stem cells. Oncotarget (2010) 1.33
IL-4-mediated drug resistance in colon cancer stem cells. Cell Cycle (2007) 1.29
Modeling evolutionary dynamics of epigenetic mutations in hierarchically organized tumors. PLoS Comput Biol (2011) 1.18
Chemical insights in the concept of hybrid drugs: the antitumor effect of nitric oxide-donating aspirin involves a quinone methide but not nitric oxide nor aspirin. J Med Chem (2007) 1.18
Granzymes at a glance. J Cell Sci (2006) 1.18
Hepatic natural killer cells exclusively kill splenic/blood natural killer-resistant tumor cells by the perforin/granzyme pathway. J Leukoc Biol (2002) 1.17
Betulinic acid, a natural compound with potent anticancer effects. Anticancer Drugs (2010) 1.11
Broad in vitro efficacy of plant-derived betulinic acid against cell lines derived from the most prevalent human cancer types. Cancer Lett (2006) 1.11
Cancer heterogeneity--a multifaceted view. EMBO Rep (2013) 1.11
APRIL but not BLyS serum levels are increased in chronic lymphocytic leukemia: prognostic relevance of APRIL for survival. Haematologica (2007) 1.11
Betulinic acid induces cytochrome c release and apoptosis in a Bax/Bak-independent, permeability transition pore dependent fashion. Apoptosis (2009) 1.09
Tumor microvasculature supports proliferation and expansion of glioma-propagating cells. Int J Cancer (2009) 1.08
Detection and functional analysis of CD8+ T cells specific for PRAME: a target for T-cell therapy. Clin Cancer Res (2006) 1.06
Cancer stem cell dynamics in tumor progression and metastasis: is the microenvironment to blame? Cancer Lett (2012) 1.06
The proteoglycan (heparan sulfate proteoglycan) binding domain of APRIL serves as a platform for ligand multimerization and cross-linking. FASEB J (2009) 1.05
Development and characterization of APRIL antagonistic monoclonal antibodies for treatment of B-cell lymphomas. Blood (2011) 1.05
Disruption of heparan sulfate proteoglycan conformation perturbs B-cell maturation and APRIL-mediated plasma cell survival. Blood (2011) 1.01
Kinome analysis reveals nongenomic glucocorticoid receptor-dependent inhibition of insulin signaling. Endocrinology (2006) 1.00
Regulation of stem cell self-renewal and differentiation by Wnt and Notch are conserved throughout the adenoma-carcinoma sequence in the colon. Mol Cancer (2013) 0.97
Prognostic value of apoptosis in rectal cancer patients of the dutch total mesorectal excision trial: radiotherapy is redundant in intrinsically high-apoptotic tumors. Clin Cancer Res (2006) 0.96
Specific TLR ligands regulate APRIL secretion by dendritic cells in a PKR-dependent manner. Eur J Immunol (2007) 0.94
Assessment of the stromal contribution to Sonic Hedgehog-dependent pancreatic adenocarcinoma. Mol Oncol (2013) 0.92
Expression of the antiapoptotic protein BAG3 is a feature of pancreatic adenocarcinoma and its overexpression is associated with poorer survival. Am J Pathol (2012) 0.92
SPI-CI and SPI-6 cooperate in the protection from effector cell-mediated cytotoxicity. Blood (2004) 0.90
Isolation and propagation of colon cancer stem cells. Methods Mol Biol (2013) 0.89
Exploring cancer stem cell niche directed tumor growth. Cell Cycle (2010) 0.88
Betulin is a potent anti-tumor agent that is enhanced by cholesterol. PLoS One (2009) 0.88
Chronic lymphocytic leukemia disease progression is accelerated by APRIL-TACI interaction in the TCL1 transgenic mouse model. Blood (2013) 0.88
Disease causing mutations in the TNF and TNFR superfamilies: Focus on molecular mechanisms driving disease. Trends Mol Med (2011) 0.88
TWE-PRIL; a fusion protein of TWEAK and APRIL. Biochem Pharmacol (2003) 0.87
Epithelial human leukocyte antigen-DR expression predicts reduced recurrence rates and prolonged survival in rectal cancer patients. Clin Cancer Res (2008) 0.86
The design and characterization of receptor-selective APRIL variants. J Biol Chem (2012) 0.86
Granzyme A- and B-cluster deficiency delays acute lung injury in pneumovirus-infected mice. J Immunol (2009) 0.86
Dissecting cancer heterogeneity--an unsupervised classification approach. Int J Biochem Cell Biol (2013) 0.86
Betulinic acid delivered in liposomes reduces growth of human lung and colon cancers in mice without causing systemic toxicity. Anticancer Drugs (2011) 0.86
The expanding role of APRIL in cancer and immunity. Curr Mol Med (2008) 0.86
Nab2 regulates secondary CD8+ T-cell responses through control of TRAIL expression. Blood (2011) 0.84
Targeting FcαRI on polymorphonuclear cells induces tumor cell killing through autophagy. J Immunol (2011) 0.84
Serpins in T cell immunity. J Leukoc Biol (2008) 0.84
Serpins prevent granzyme-induced death in a species-specific manner. Immunol Cell Biol (2006) 0.84
CD44 expression in intestinal epithelium and colorectal cancer is independent of p53 status. PLoS One (2013) 0.83
Nucleophosmin is cleaved and inactivated by the cytotoxic granule protease granzyme M during natural killer cell-mediated killing. J Biol Chem (2008) 0.83
Effect of 41 degrees C and 43 degrees C on cisplatin radiosensitization in two human carcinoma cell lines with different sensitivities for cisplatin. Oncol Rep (2007) 0.83
Thymus-independent class switch recombination is affected by APRIL. Immunol Cell Biol (2008) 0.82
Fusion of intestinal epithelial cells with bone marrow derived cells is dispensable for tissue homeostasis. Sci Rep (2012) 0.82
"APRIL hath put a spring of youth in everything": Relevance of APRIL for survival. J Cell Physiol (2009) 0.82
NAB2 and EGR-1 exert opposite roles in regulating TRAIL expression in human Natural Killer cells. Immunol Lett (2013) 0.81
Inhibition of homologous recombination by hyperthermia shunts early double strand break repair to non-homologous end-joining. DNA Repair (Amst) (2012) 0.81
G0 cell cycle arrest alone is insufficient for enabling the repair of ionizing radiation-induced potentially lethal damage. Radiat Res (2008) 0.81
Does the serpin PI-9 protect tumor cells? Blood (2006) 0.80
Targeting colorectal cancer stem cells with inducible caspase-9. Apoptosis (2012) 0.80
Mouse tissues express multiple splice variants of prominin-1. PLoS One (2010) 0.80
The transcriptional regulator NAB2 reveals a two-step induction of TRAIL in activated plasmacytoid DCs. Eur J Immunol (2012) 0.79
APRIL in B-cell malignancies and autoimmunity. Results Probl Cell Differ (2009) 0.79
APRIL facilitates viral-induced erythroleukemia but is dispensable for T cell immunity and lymphomagenesis. J Leukoc Biol (2008) 0.78
Gene expression profiling reveals two separate mechanisms regulating apoptosis in rectal carcinomas in vivo. Apoptosis (2007) 0.78
Chromosome fragments have the potential to predict hyperthermia-induced radio-sensitization in two different human tumor cell lines. J Radiat Res (2008) 0.77
APRIL affects antibody responses and early leukocyte infiltration, but not influenza A viral control. Mol Immunol (2008) 0.77
An in vivo functional genetic screen reveals a role for the TRK-T3 oncogene in tumor progression. Oncogene (2004) 0.77
One renegade cancer stem cell? Cell Cycle (2009) 0.77