The E2 protein of human papillomavirus type 8 increases the expression of matrix metalloproteinase-9 in human keratinocytes and organotypic skin cultures.

PubWeight™: 0.82‹?›

🔗 View Article (PMID 21274725)

Published in Med Microbiol Immunol on January 28, 2011

Authors

Baki Akgül1, Ramón García-Escudero, Christine Ekechi, Gertrud Steger, Harshad Navsaria, Herbert Pfister, Alan Storey

Author Affiliations

1: Institute of Virology, University of Cologne, Fürst-Pückler-Str. 56, 50935, Cologne, Germany. baki.akguel@web.de

Articles cited by this

The age of cancer. Nature (2000) 4.32

Crystal structure at 1.7 A of the bovine papillomavirus-1 E2 DNA-binding domain bound to its DNA target. Nature (1992) 4.12

Functional polymorphism in the regulatory region of gelatinase B gene in relation to severity of coronary atherosclerosis. Circulation (1999) 2.56

Human papillomavirus infection and incidence of squamous cell and basal cell carcinomas of the skin. J Natl Cancer Inst (2006) 2.40

Chapter 8: Human papillomavirus and skin cancer. J Natl Cancer Inst Monogr (2003) 2.32

Brd4 is required for e2-mediated transcriptional activation but not genome partitioning of all papillomaviruses. J Virol (2006) 1.92

Bromodomain protein 4 mediates the papillomavirus E2 transcriptional activation function. J Virol (2006) 1.81

HPV-associated skin disease. J Pathol (2006) 1.74

The human papillomavirus type 8 E2 protein induces skin tumors in transgenic mice. J Invest Dermatol (2008) 1.71

Amino acids necessary for DNA contact and dimerization imply novel motifs in the papillomavirus E2 trans-activator. Genes Dev (1992) 1.49

Cutaneous ultraviolet exposure and its relationship to the development of skin cancer. J Am Acad Dermatol (2008) 1.49

Amino acid substitutions that specifically impair the transcriptional activity of papillomavirus E2 affect binding to the long isoform of Brd4. Virology (2006) 1.47

Transactivation by the E2 protein of oncogenic human papillomavirus type 31 is not essential for early and late viral functions. J Virol (1998) 1.40

Development of skin tumors in mice transgenic for early genes of human papillomavirus type 8. Cancer Res (2005) 1.34

AMF-1/Gps2 binds p300 and enhances its interaction with papillomavirus E2 proteins. J Virol (2000) 1.30

cAMP response element-binding protein-binding protein binds to human papillomavirus E2 protein and activates E2-dependent transcription. J Biol Chem (2000) 1.28

Malignant transformation of cutaneous lesions in renal allograft patients: a role for human papillomavirus. Cancer Res (1993) 1.16

Amino acids critical for the functions of the bovine papillomavirus type 1 E2 transactivator. J Virol (1996) 1.14

MMP9 modulates tight junction integrity and cell viability in human airway epithelia. Am J Physiol Lung Cell Mol Physiol (2009) 1.11

Cooperative activation of human papillomavirus type 8 gene expression by the E2 protein and the cellular coactivator p300. J Virol (2002) 1.10

UV-induced squamous cell carcinoma--a role for antiapoptotic signalling pathways. Br J Dermatol (2009) 1.08

Interaction between the HPV-16 E2 transcriptional activator and p53. Oncogene (1999) 1.02

The Papillomavirus E2 protein binds to and synergizes with C/EBP factors involved in keratinocyte differentiation. J Virol (2003) 1.01

The E7 protein of cutaneous human papillomavirus type 8 causes invasion of human keratinocytes into the dermis in organotypic cultures of skin. Cancer Res (2005) 1.01

Cutaneous human papillomaviruses down-regulate AKT1, whereas AKT2 up-regulation and activation associates with tumors. Cancer Res (2007) 0.98

Expression of membrane type 1 matrix metalloproteinase in papillomavirus-positive cells: role of the human papillomavirus (HPV) 16 and HPV8 E7 gene products. J Gen Virol (2005) 0.97

Low-affinity E2-binding site mediates downmodulation of E2 transactivation of the human papillomavirus type 8 late promoter. J Virol (1994) 0.93

The hinge region of the human papillomavirus type 8 E2 protein activates the human p21(WAF1/CIP1) promoter via interaction with Sp1. J Gen Virol (2002) 0.92

Expression of matrix metalloproteinase (MMP)-2, MMP-9, MMP-13, and MT1-MMP in skin tumors of human papillomavirus type 8 transgenic mice. Exp Dermatol (2006) 0.90

Papillomavirus E2 protein induces expression of the matrix metalloproteinase-9 via the extracellular signal-regulated kinase/activator protein-1 signaling pathway. Cancer Res (2005) 0.89

The human papillomavirus type 8 E2 protein suppresses beta4-integrin expression in primary human keratinocytes. J Virol (2004) 0.89

Expression of basement membrane antigens and matrix metalloproteinases 2 and 9 in cutaneous basal and squamous cell carcinomas. Anticancer Res (2000) 0.85

Dual role of tumor suppressor p53 in regulation of DNA replication and oncogene E6-promoter activity of epidermodysplasia verruciformis-associated human papillomavirus type 8. Virology (2003) 0.85

Influence of HPV16 E2 and its localisation on the expression of matrix metalloproteinase-9. Int J Oncol (2010) 0.83

AP-1 and ERK1 but not p38 nor JNK is required for CRPV early protein 2-dependent MMP-9 promoter activation in rabbit epithelial cells. Virus Res (2008) 0.81

Cutaneous carcinomas and preinvasive neoplastic lesions. Role of MMP-2 and MMP-9 metalloproteinases in neoplastic invasion and their relationship with proliferative activity and p53 expression. J Cutan Pathol (2001) 0.80

Overexpression of MMP-2 and MMP-9 in squamous cell carcinomas of immunosuppressed patients. Arch Dermatol Res (2002) 0.77

Articles by these authors

Potential of fibroblast cell therapy for recessive dystrophic epidermolysis bullosa. J Invest Dermatol (2008) 3.34

Human papillomavirus-DNA loads in actinic keratoses exceed those in non-melanoma skin cancers. J Invest Dermatol (2005) 1.94

HPV-associated skin disease. J Pathol (2006) 1.74

The human papillomavirus type 8 E2 protein induces skin tumors in transgenic mice. J Invest Dermatol (2008) 1.71

Gene profiling approaches help to define the specific functions of retinoblastoma family in epidermis. Mol Carcinog (2008) 1.68

Relationship between p53 codon 72 polymorphism and susceptibility to sunburn and skin cancer. J Invest Dermatol (2002) 1.66

Deregulated activity of Akt in epithelial basal cells induces spontaneous tumors and heightened sensitivity to skin carcinogenesis. Cancer Res (2007) 1.56

Primary HIV drug resistance and efficacy of first-line antiretroviral therapy guided by resistance testing. J Acquir Immune Defic Syndr (2006) 1.53

The Rho exchange factors Vav2 and Vav3 favor skin tumor initiation and promotion by engaging extracellular signaling loops. PLoS Biol (2013) 1.50

Merkel cell polyomavirus DNA in persons without merkel cell carcinoma. Emerg Infect Dis (2009) 1.45

[Comment. HPV7-induced skin warts in butchers: an occupational disease?]. J Dtsch Dermatol Ges (2003) 1.40

Compensatory mutations at the HIV cleavage sites p7/p1 and p1/p6-gag in therapy-naive and therapy-experienced patients. Antivir Ther (2006) 1.37

Development of skin tumors in mice transgenic for early genes of human papillomavirus type 8. Cancer Res (2005) 1.34

Evolution of raltegravir resistance during therapy. J Antimicrob Chemother (2009) 1.33

Spontaneous squamous cell carcinoma induced by the somatic inactivation of retinoblastoma and Trp53 tumor suppressors. Cancer Res (2008) 1.32

Multicenter study of the association between betapapillomavirus infection and cutaneous squamous cell carcinoma. Cancer Res (2010) 1.30

The rho exchange factors vav2 and vav3 control a lung metastasis-specific transcriptional program in breast cancer cells. Sci Signal (2012) 1.17

Constitutively active Akt induces ectodermal defects and impaired bone morphogenetic protein signaling. Mol Biol Cell (2007) 1.14

Direct interaction between nucleosome assembly protein 1 and the papillomavirus E2 proteins involved in activation of transcription. Mol Cell Biol (2004) 1.14

Spontaneous tumour development in human papillomavirus type 8 E6 transgenic mice and rapid induction by UV-light exposure and wounding. J Gen Virol (2009) 1.13

EMT and induction of miR-21 mediate metastasis development in Trp53-deficient tumours. Sci Rep (2012) 1.10

Cooperative activation of human papillomavirus type 8 gene expression by the E2 protein and the cellular coactivator p300. J Virol (2002) 1.10

Tyrosine dephosphorylation is required for Bak activation in apoptosis. EMBO J (2010) 1.09

Trends of prevalence of primary HIV drug resistance in Germany. J Antimicrob Chemother (2007) 1.06

Role of HPV E6 proteins in preventing UVB-induced release of pro-apoptotic factors from the mitochondria. Apoptosis (2006) 1.05

Imiquimod leads to a decrease of human papillomavirus DNA and to a sustained clearance of anal intraepithelial neoplasia in HIV-infected men. J Invest Dermatol (2008) 1.05

A new cellular factor recognizes E2 binding sites of papillomaviruses which mediate transcriptional repression by E2. Virology (2002) 1.05

Clinical spectrum and virologic characteristics of anal intraepithelial neoplasia in HIV infection. J Am Acad Dermatol (2005) 1.04

Repression of African swine fever virus polyprotein pp220-encoding gene leads to the assembly of icosahedral core-less particles. J Virol (2002) 1.04

High beta-HPV DNA loads and strong seroreactivity are present in epidermodysplasia verruciformis. J Invest Dermatol (2008) 1.02

African swine fever virus structural protein p54 is essential for the recruitment of envelope precursors to assembly sites. J Virol (2004) 1.02

The E7 protein of cutaneous human papillomavirus type 8 causes invasion of human keratinocytes into the dermis in organotypic cultures of skin. Cancer Res (2005) 1.01

Increased invasive behaviour in cutaneous squamous cell carcinoma with loss of basement-membrane type VII collagen. J Cell Sci (2009) 1.01

Positive correlation between Merkel cell polyomavirus viral load and capsid-specific antibody titer. Med Microbiol Immunol (2011) 1.01

Akt activation synergizes with Trp53 loss in oral epithelium to produce a novel mouse model for head and neck squamous cell carcinoma. Cancer Res (2009) 1.00

Molecular Signature of HPV-Induced Carcinogenesis: pRb, p53 and Gene Expression Profiling. Curr Genomics (2009) 1.00

Penile intraepithelial neoplasia is frequent in HIV-positive men with anal dysplasia. J Invest Dermatol (2008) 1.00

Cutaneous human papillomaviruses down-regulate AKT1, whereas AKT2 up-regulation and activation associates with tumors. Cancer Res (2007) 0.98

Patient-related keloid scar assessment and outcome measures. Plast Reconstr Surg (2012) 0.98

HPV8 early genes modulate differentiation and cell cycle of primary human adult keratinocytes. Exp Dermatol (2007) 0.97

Reactivation of an occult hepatitis B virus escape mutant in an anti-HBs positive, anti-HBc negative lymphoma patient. J Clin Virol (2006) 0.97

Detection of adenoviruses and rotaviruses in drinking water sources used in rural areas of Benin, West Africa. Appl Environ Microbiol (2009) 0.97

Human papillomavirus type 8 interferes with a novel C/EBPβ-mediated mechanism of keratinocyte CCL20 chemokine expression and Langerhans cell migration. PLoS Pathog (2012) 0.96

Beta-papillomavirus DNA loads in hair follicles of immunocompetent people and organ transplant recipients. Med Microbiol Immunol (2011) 0.96

Imiquimod treatment of anal intraepithelial neoplasia in HIV-positive men. Arch Dermatol (2006) 0.95

Blockade of the BAK hydrophobic groove by inhibitory phosphorylation regulates commitment to apoptosis. PLoS One (2012) 0.95

The E6 protein of the cutaneous human papillomavirus type 8 can stimulate the viral early and late promoters by distinct mechanisms. J Virol (2006) 0.94

High prevalence of bevirimat resistance mutations in protease inhibitor-resistant HIV isolates. AIDS (2010) 0.94

p107 acts as a tumor suppressor in pRb-deficient epidermis. Mol Carcinog (2008) 0.94

Prevalence of C-terminal gag cleavage site mutations in HIV from therapy-naïve patients. J Infect (2008) 0.94

Epidermal repair results from activation of follicular and epidermal progenitor keratinocytes mediated by a growth factor cascade. Wound Repair Regen (2007) 0.93

Human papillomavirus load in eyebrow hair follicles and risk of cutaneous squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev (2013) 0.93

Expression of proliferative biomarkers in anal intraepithelial neoplasia of HIV-positive men. J Am Acad Dermatol (2009) 0.92

Quantification of beta-human papillomavirus DNA by real-time PCR. Nat Protoc (2010) 0.92

Chemical chaperones protect epidermolysis bullosa simplex keratinocytes from heat stress-induced keratin aggregation: involvement of heat shock proteins and MAP kinases. J Invest Dermatol (2011) 0.92

A human papillomavirus-associated disease with disseminated warts, depressed cell-mediated immunity, primary lymphedema, and anogenital dysplasia: WILD syndrome. Arch Dermatol (2008) 0.91

Merkel cell polyomavirus infection in HIV-positive men. Arch Dermatol (2011) 0.91

Use of interferon-alpha in recurrent respiratory papillomatosis: 20-year follow-up. Ann Otol Rhinol Laryngol (2005) 0.91

Human papillomavirus type 77 E6 protein selectively inhibits p53-dependent transcription of proapoptotic genes following UV-B irradiation. Oncogene (2004) 0.91

Case-control study of genus-beta human papillomaviruses in plucked eyebrow hairs and cutaneous squamous cell carcinoma. Int J Cancer (2013) 0.91

Human polyomaviruses 6, 7, 9, 10 and Trichodysplasia spinulosa-associated polyomavirus in HIV-infected men. J Gen Virol (2014) 0.91

Sensitive detection of viral transcripts in human tumor transcriptomes. PLoS Comput Biol (2013) 0.90

Expression of matrix metalloproteinase (MMP)-2, MMP-9, MMP-13, and MT1-MMP in skin tumors of human papillomavirus type 8 transgenic mice. Exp Dermatol (2006) 0.90

A deafness-associated mutant human connexin 26 improves the epithelial barrier in vitro. J Membr Biol (2007) 0.90

The human papillomavirus type 8 E2 protein suppresses beta4-integrin expression in primary human keratinocytes. J Virol (2004) 0.89

Protein kinase C (PKC)ζ-mediated Gαq stimulation of ERK5 protein pathway in cardiomyocytes and cardiac fibroblasts. J Biol Chem (2012) 0.88

Detection and characterization of enteroviruses and parechoviruses in healthy people living in the South of Côte d'Ivoire. J Clin Virol (2015) 0.88

Prevalence and characteristics of hepatitis B and C virus infections in treatment-naïve HIV-infected patients. Med Microbiol Immunol (2010) 0.88

"Licensed to kill": tyrosine dephosphorylation and Bak activation. Cell Cycle (2011) 0.88

Epidemiology of transmitted drug resistance in chronically HIV-infected patients in Germany: the RESINA study 2001-2009. Intervirology (2012) 0.87

Protein tyrosine phosphatase H1 is a target of the E6 oncoprotein of high-risk genital human papillomaviruses. J Gen Virol (2007) 0.87

Identification of the regions of the HPV 5 E6 protein involved in Bak degradation and inhibition of apoptosis. Int J Cancer (2008) 0.87

Human papilloma virus (HPV)-associated gynecological alteration in mothers of children with recurrent respiratory papillomatosis during long-term observation. Cancer Detect Prev (2007) 0.87

Developmental and tumoral vascularization is regulated by G protein-coupled receptor kinase 2. J Clin Invest (2013) 0.87

The CD3-zeta chimeric antigen receptor overcomes TCR Hypo-responsiveness of human terminal late-stage T cells. PLoS One (2012) 0.87

Cutaneous HPV5 E6 causes increased expression of Osteoprotegerin and Interleukin 6 which contribute to evasion of UV-induced apoptosis. Carcinogenesis (2010) 0.87

Papillomavirus binding factor (PBF)-mediated inhibition of cell growth is regulated by 14-3-3beta. Arch Biochem Biophys (2007) 0.87

Application of autologous derived-platelet rich plasma gel in the treatment of chronic wound ulcer: diabetic foot ulcer. J Extra Corpor Technol (2010) 0.87

Akt signaling leads to stem cell activation and promotes tumor development in epidermis. Stem Cells (2014) 0.87

Age-associated increase of codon 72 Arginine p53 frequency in gastric cardia and non-cardia adenocarcinoma. Clin Cancer Res (2003) 0.86

Ultra-deformable liposomes containing bleomycin: in vitro stability and toxicity on human cutaneous keratinocyte cell lines. Int J Pharm (2005) 0.86

Characterization of beta papillomavirus E4 expression in tumours from Epidermodysplasia Verruciformis patients and in experimental models. Virology (2012) 0.86

Evolution of protease inhibitor resistance in the gag and pol genes of HIV subtype G isolates. J Antimicrob Chemother (2010) 0.85

Mutational patterns in the frameshift-regulating site of HIV-1 selected by protease inhibitors. Med Microbiol Immunol (2011) 0.85

Human papillomavirus oncogene mRNA testing for the detection of anal dysplasia in HIV-positive men who have sex with men. J Clin Virol (2012) 0.85

A novel tumor suppressor network in squamous malignancies. Sci Rep (2012) 0.84

E2 and the co-activator p300 can cooperate in activation of the human papillomavirus type 16 early promoter. Virology (2008) 0.84

Human papillomavirus type 26-associated periungual squamous cell carcinoma in situ in a HIV-infected patient with concomitant penile and anal intraepithelial neoplasia. J Am Acad Dermatol (2005) 0.84

The evolution of protease mutation 76V is associated with protease mutation 46I and gag mutation 431V. AIDS (2010) 0.84

Upregulation of lipocalin-2 in human papillomavirus-positive keratinocytes and cutaneous squamous cell carcinomas. J Gen Virol (2010) 0.84

Papillomavirus binding factor binds to SAP30 and represses transcription via recruitment of the HDAC1 co-repressor complex. Arch Biochem Biophys (2007) 0.84

Prediction of HIV-1 coreceptor usage (tropism) by sequence analysis using a genotypic approach. J Vis Exp (2011) 0.84

Spontaneous tumor formation in Trp53-deficient epidermis mediated by chromosomal instability and inflammation. Anticancer Res (2009) 0.83