Published in Diabetes on January 31, 2011
Exercise prevents weight gain and alters the gut microbiota in a mouse model of high fat diet-induced obesity. PLoS One (2014) 1.41
What causes the insulin resistance underlying obesity? Curr Opin Endocrinol Diabetes Obes (2012) 1.35
Impact of physical activity on inflammation: effects on cardiovascular disease risk and other inflammatory conditions. Arch Med Sci (2012) 1.13
Short-term bed rest increases TLR4 and IL-6 expression in skeletal muscle of older adults. Am J Physiol Regul Integr Comp Physiol (2013) 0.99
Short-term treatment with bisphenol-A leads to metabolic abnormalities in adult male mice. PLoS One (2012) 0.98
Postexercise improvement in insulin-stimulated glucose uptake occurs concomitant with greater AS160 phosphorylation in muscle from normal and insulin-resistant rats. Diabetes (2014) 0.98
Elevated muscle TLR4 expression and metabolic endotoxemia in human aging. J Gerontol A Biol Sci Med Sci (2014) 0.96
Influence of gut microbiota on subclinical inflammation and insulin resistance. Mediators Inflamm (2013) 0.95
Exercise Therapy Downregulates the Overexpression of TLR4, TLR2, MyD88 and NF-κB after Cerebral Ischemia in Rats. Int J Mol Sci (2013) 0.94
Current understanding of metformin effect on the control of hyperglycemia in diabetes. J Endocrinol (2016) 0.92
The serine protease prostasin regulates hepatic insulin sensitivity by modulating TLR4 signalling. Nat Commun (2014) 0.90
Expression and activity of the TLR4/NF-κB signaling pathway in mouse intestine following administration of a short-term high-fat diet. Exp Ther Med (2013) 0.90
Insight into the impact of dietary saturated fat on tissue-specific cellular processes underlying obesity-related diseases. J Nutr Biochem (2014) 0.86
Effects of voluntary wheel running on LPS-induced sickness behavior in aged mice. Brain Behav Immun (2012) 0.86
Mechanisms for greater insulin-stimulated glucose uptake in normal and insulin-resistant skeletal muscle after acute exercise. Am J Physiol Endocrinol Metab (2015) 0.85
Exercise training enhances white adipose tissue metabolism in rats selectively bred for low- or high-endurance running capacity. Am J Physiol Endocrinol Metab (2013) 0.84
Does lipopolysaccharide-mediated inflammation have a role in OA? Nat Rev Rheumatol (2015) 0.83
Gut Microbiota Modification: Another Piece in the Puzzle of the Benefits of Physical Exercise in Health? Front Physiol (2016) 0.82
Influence of Acute and Chronic Exercise on Glucose Uptake. J Diabetes Res (2016) 0.81
Concern Exercise training decreases mitogen-activated protein kinase phosphatase-3 expression and suppresses hepatic gluconeogenesis in obese mice. J Physiol (2014) 0.81
Physical exercise reduces the expression of RANTES and its CCR5 receptor in the adipose tissue of obese humans. Mediators Inflamm (2014) 0.80
Low-volume exercise can prevent sucrose-induced weight gain but has limited impact on metabolic measures in rats. Eur J Nutr (2012) 0.79
Understanding the individual responsiveness to resistance training periodization. Age (Dordr) (2015) 0.79
Voluntary wheel running attenuates lipopolysaccharide-induced liver inflammation in mice. Am J Physiol Regul Integr Comp Physiol (2016) 0.79
Par14 protein associates with insulin receptor substrate 1 (IRS-1), thereby enhancing insulin-induced IRS-1 phosphorylation and metabolic actions. J Biol Chem (2013) 0.79
Acute exercise decreases PTP-1B protein level and improves insulin signaling in the liver of old rats. Immun Ageing (2013) 0.78
Endurance and Resistance Training Affect High Fat Diet-Induced Increase of Ceramides, Inflammasome Expression, and Systemic Inflammation in Mice. J Diabetes Res (2015) 0.78
IGF-I Exerts an Anti-inflammatory Effect on Skeletal Muscle Cells through Down-regulation of TLR4 Signaling. Immune Netw (2011) 0.78
Lipoic acid attenuates innate immune infiltration and activation in the visceral adipose tissue of obese insulin resistant mice. Lipids (2011) 0.78
S100a8/NF-κB signal pathway is involved in the 800-nm diode laser-induced skin collagen remodeling. Lasers Med Sci (2016) 0.77
Effects of different intensities of physical exercise on insulin sensitivity and protein kinase B/Akt activity in skeletal muscle of obese mice. Einstein (Sao Paulo) (2014) 0.77
Voluntary physical activity prevents insulin resistance in a tissue specific manner. Physiol Rep (2015) 0.76
Ipragliflozin, a sodium-glucose cotransporter 2 inhibitor, ameliorates the development of liver fibrosis in diabetic Otsuka Long-Evans Tokushima fatty rats. J Gastroenterol (2016) 0.76
The intestinal microbiome and surgical disease. Curr Probl Surg (2016) 0.75
Regulation of hepatic TRB3/Akt interaction induced by physical exercise and its effect on the hepatic glucose production in an insulin resistance state. Diabetol Metab Syndr (2015) 0.75
Retraction Note: Diacerhein attenuates the inflammatory response and improves survival in a model of severe sepsis. Crit Care (2016) 0.75
Moderate physical activity from childhood contributes to metabolic health and reduces hepatic fat accumulation in adult rats. Lipids Health Dis (2013) 0.75
Expression of concern. Diabetes (2015) 0.75
Microbial translocation and skeletal muscle in young and old vervet monkeys. Age (Dordr) (2016) 0.75
Inverse association of resistin with physical activity in the general population. PLoS One (2017) 0.75
Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest (2003) 41.22
Inflammation and metabolic disorders. Nature (2006) 33.33
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest (2003) 32.01
Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med (2006) 24.38
TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest (2006) 17.49
Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes (2008) 10.74
Obesity, inflammation, and insulin resistance. Gastroenterology (2007) 7.54
Insulin sensitivity: modulation by nutrients and inflammation. J Clin Invest (2008) 6.60
A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways. J Biol Chem (2007) 6.58
Retracted Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes (2007) 5.67
Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes. J Clin Invest (2002) 4.96
Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity. Circ Res (2007) 4.92
Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals. J Biol Chem (2007) 4.58
Role of the Toll-like receptor 4/NF-kappaB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages. Arterioscler Thromb Vasc Biol (2006) 4.07
MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. Cell Metab (2009) 3.64
Increase in plasma endotoxin concentrations and the expression of Toll-like receptors and suppressor of cytokine signaling-3 in mononuclear cells after a high-fat, high-carbohydrate meal: implications for insulin resistance. Diabetes Care (2009) 2.83
Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects. Am J Physiol Endocrinol Metab (2005) 2.77
JNK and tumor necrosis factor-alpha mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes. J Biol Chem (2005) 2.76
IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans. Am J Physiol Endocrinol Metab (2003) 2.59
Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes. Biochem Biophys Res Commun (2006) 2.56
Bacterial lipopolysaccharide and IFN-gamma induce Toll-like receptor 2 and Toll-like receptor 4 expression in human endothelial cells: role of NF-kappa B activation. J Immunol (2001) 2.37
Cellular events mediated by lipopolysaccharide-stimulated toll-like receptor 4. MD-2 is required for activation of mitogen-activated protein kinases and Elk-1. J Biol Chem (2000) 1.91
S-nitrosation of the insulin receptor, insulin receptor substrate 1, and protein kinase B/Akt: a novel mechanism of insulin resistance. Diabetes (2005) 1.91
Resistance exercise decreases skeletal muscle tumor necrosis factor alpha in frail elderly humans. FASEB J (2001) 1.83
Mitochondrial capacity in skeletal muscle is not stimulated by weight loss despite increases in insulin action and decreases in intramyocellular lipid content. Diabetes (2008) 1.82
Effects of exercise and low-fat diet on adipose tissue inflammation and metabolic complications in obese mice. Am J Physiol Endocrinol Metab (2009) 1.67
Reduction of the plasma concentration of C-reactive protein following nine months of endurance training. Int J Sports Med (2000) 1.60
Intestinal blood flow. Gastroenterology (1980) 1.58
Reversal of diet-induced insulin resistance with a single bout of exercise in the rat: the role of PTP1B and IRS-1 serine phosphorylation. J Physiol (2006) 1.56
Altered regional blood flow responses to submaximal exercise in older rats. J Appl Physiol (1985) (2003) 1.53
Endotoxin and cytokine regulation of toll-like receptor (TLR) 2 and TLR4 gene expression in murine liver and hepatocytes. J Interferon Cytokine Res (2000) 1.52
Effects of exercise on mesenteric blood flow in man. Gut (1987) 1.49
Reduced skeletal muscle inhibitor of kappaB beta content is associated with insulin resistance in subjects with type 2 diabetes: reversal by exercise training. Diabetes (2006) 1.41
Stretch-stimulated glucose uptake in skeletal muscle is mediated by reactive oxygen species and p38 MAP-kinase. J Physiol (2009) 1.40
Western diet modulates insulin signaling, c-Jun N-terminal kinase activity, and insulin receptor substrate-1ser307 phosphorylation in a tissue-specific fashion. Endocrinology (2004) 1.39
Effects of exercise training on subcutaneous and visceral adipose tissue in normal- and high-fat diet-fed rats. Am J Physiol Endocrinol Metab (2009) 1.31
Divergent effects of exercise on metabolic and mitogenic signaling pathways in human skeletal muscle. FASEB J (1998) 1.29
Innate immunity and adipocyte function: ligand-specific activation of multiple Toll-like receptors modulates cytokine, adipokine, and chemokine secretion in adipocytes. Obesity (Silver Spring) (2009) 1.24
Effect of contraction on mitogen-activated protein kinase signal transduction in skeletal muscle. Involvement Of the mitogen- and stress-activated protein kinase 1. J Biol Chem (2000) 1.16
Endurance training improves responsiveness to insulin and modulates insulin signal transduction through the phosphatidylinositol 3-kinase/Akt-1 pathway. Eur J Endocrinol (2002) 1.10
Regulation of hormone-sensitive lipase activity and Ser563 and Ser565 phosphorylation in human skeletal muscle during exercise. J Physiol (2004) 1.07
Impaired regulation of the TNF-alpha converting enzyme/tissue inhibitor of metalloproteinase 3 proteolytic system in skeletal muscle of obese type 2 diabetic patients: a new mechanism of insulin resistance in humans. Diabetologia (2009) 1.06
The acute phase response and exercise: court and field sports. Br J Sports Med (2001) 1.02
Polymyxin B reduces cecal flora, TNF production and hepatic steatosis during total parenteral nutrition in the rat. J Surg Res (1991) 0.99
Regulation of Cbl-associated protein/Cbl pathway in muscle and adipose tissues of two animal models of insulin resistance. Endocrinology (2003) 0.94
High- or low-salt diet from weaning to adulthood: effect on insulin sensitivity in Wistar rats. Hypertension (2000) 0.86
Adaptation to oxidative challenge induced by chronic physical exercise prevents Na+,K+-ATPase activity inhibition after traumatic brain injury. Brain Res (2009) 0.81
Moderate exercise training decreases aortic superoxide production in myocardial infarcted rats. Eur J Appl Physiol (2008) 0.78
Effects of training on spleen and peritoneal exudate reactive oxygen species and lymphocyte proliferation by splenocytes at rest and after an acute bout of exercise. J Sports Sci (2006) 0.77
Retracted Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes (2007) 5.67
Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity. J Neurosci (2009) 3.22
Retracted Gut microbiota is a key modulator of insulin resistance in TLR 2 knockout mice. PLoS Biol (2011) 3.02
IL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKbeta and ER stress inhibition. PLoS Biol (2010) 2.21
High- or low-salt diet from weaning to adulthood: effect on body weight, food intake and energy balance in rats. Nutr Metab Cardiovasc Dis (2005) 2.15
Retracted Atorvastatin improves survival in septic rats: effect on tissue inflammatory pathway and on insulin signaling. PLoS One (2010) 2.08
S-nitrosation of the insulin receptor, insulin receptor substrate 1, and protein kinase B/Akt: a novel mechanism of insulin resistance. Diabetes (2005) 1.91
Metformin amplifies chemotherapy-induced AMPK activation and antitumoral growth. Clin Cancer Res (2011) 1.88
High-fat diet induces apoptosis of hypothalamic neurons. PLoS One (2009) 1.73
Retracted A central role for neuronal AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) in high-protein diet-induced weight loss. Diabetes (2007) 1.59
Retracted Exercise improves insulin and leptin sensitivity in hypothalamus of Wistar rats. Diabetes (2006) 1.57
Reversal of diet-induced insulin resistance with a single bout of exercise in the rat: the role of PTP1B and IRS-1 serine phosphorylation. J Physiol (2006) 1.56
Cross-talk between the insulin and leptin signaling systems in rat hypothalamus. Obes Res (2005) 1.48
Unsaturated fatty acids revert diet-induced hypothalamic inflammation in obesity. PLoS One (2012) 1.47
Interleukin-10 is a protective factor against diet-induced insulin resistance in liver. J Hepatol (2008) 1.47
Inhibition of toll-like receptor 2 expression improves insulin sensitivity and signaling in muscle and white adipose tissue of mice fed a high-fat diet. J Endocrinol (2008) 1.41
Acute physical exercise reverses S-nitrosation of the insulin receptor, insulin receptor substrate 1 and protein kinase B/Akt in diet-induced obese Wistar rats. J Physiol (2007) 1.38
Novel signal transduction pathway for luteinizing hormone and its interaction with insulin: activation of Janus kinase/signal transducer and activator of transcription and phosphoinositol 3-kinase/Akt pathways. Endocrinology (2003) 1.18
Inhibition of UCP2 expression reverses diet-induced diabetes mellitus by effects on both insulin secretion and action. FASEB J (2007) 1.17
The multi-faceted cross-talk between the insulin and angiotensin II signaling systems. Diabetes Metab Res Rev (2006) 1.16
Concern Acute exercise reduces hepatic glucose production through inhibition of the Foxo1/HNF-4alpha pathway in insulin resistant mice. J Physiol (2010) 1.15
Obesity-induced increase in tumor necrosis factor-α leads to development of colon cancer in mice. Gastroenterology (2012) 1.14
Targeted disruption of iNOS prevents LPS-induced S-nitrosation of IRbeta/IRS-1 and Akt and insulin resistance in muscle of mice. Am J Physiol Endocrinol Metab (2006) 1.13
Endurance training improves responsiveness to insulin and modulates insulin signal transduction through the phosphatidylinositol 3-kinase/Akt-1 pathway. Eur J Endocrinol (2002) 1.10
Retracted EGFR tyrosine kinase inhibitor (PD153035) improves glucose tolerance and insulin action in high-fat diet-fed mice. Diabetes (2009) 1.08
Hepatocyte growth factor plays a key role in insulin resistance-associated compensatory mechanisms. Endocrinology (2012) 1.06
Retracted Translational research into gut microbiota: new horizons in obesity treatment. Arq Bras Endocrinol Metabol (2009) 1.06
Central exercise action increases the AMPK and mTOR response to leptin. PLoS One (2008) 1.05
Interaction between leptin and insulin signaling pathways differentially affects JAK-STAT and PI 3-kinase-mediated signaling in rat liver. Biol Chem (2003) 1.03
Antineoplastic effect of rapamycin is potentiated by inhibition of IRS-1 signaling in prostate cancer cells xenografts. J Cancer Res Clin Oncol (2008) 1.03
Modulation of double-stranded RNA-activated protein kinase in insulin sensitive tissues of obese humans. Obesity (Silver Spring) (2013) 1.01
Double-stranded RNA-activated protein kinase is a key modulator of insulin sensitivity in physiological conditions and in obesity in mice. Endocrinology (2012) 1.01
Topical insulin accelerates wound healing in diabetes by enhancing the AKT and ERK pathways: a double-blind placebo-controlled clinical trial. PLoS One (2012) 1.01
The role of gut microbiota on insulin resistance. Nutrients (2013) 0.99
Diacerhein improves glucose tolerance and insulin sensitivity in mice on a high-fat diet. Endocrinology (2011) 0.98
Epidemiological and molecular mechanisms aspects linking obesity and cancer. Arq Bras Endocrinol Metabol (2009) 0.98
Cold-induced PGC-1alpha expression modulates muscle glucose uptake through an insulin receptor/Akt-independent, AMPK-dependent pathway. Am J Physiol Endocrinol Metab (2004) 0.96
Targeted disruption of inducible nitric oxide synthase protects against aging, S-nitrosation, and insulin resistance in muscle of male mice. Diabetes (2012) 0.96
Concern Acute exercise modulates the Foxo1/PGC-1alpha pathway in the liver of diet-induced obesity rats. J Physiol (2009) 0.95
Regulation of Cbl-associated protein/Cbl pathway in muscle and adipose tissues of two animal models of insulin resistance. Endocrinology (2003) 0.94
Phlebotomine fauna (Diptera: Psychodidae) and putative vectors of leishmaniases in impacted area by hydroelectric plant, State of Tocantins, Brazil. PLoS One (2011) 0.94
Endurance exercise training ameliorates insulin resistance and reticulum stress in adipose and hepatic tissue in obese rats. Eur J Appl Physiol (2011) 0.94
A central role for neuronal adenosine 5'-monophosphate-activated protein kinase in cancer-induced anorexia. Endocrinology (2007) 0.94
MamMiBase: a mitochondrial genome database for mammalian phylogenetic studies. Bioinformatics (2005) 0.93
The cross-talk between angiotensin and insulin differentially affects phosphatidylinositol 3-kinase- and mitogen-activated protein kinase-mediated signaling in rat heart: implications for insulin resistance. Endocrinology (2003) 0.91
Concern Inhibition of hypothalamic Foxo1 expression reduced food intake in diet-induced obesity rats. J Physiol (2009) 0.91
β-Hydroxy-β-methylbutyrate (HMβ) supplementation stimulates skeletal muscle hypertrophy in rats via the mTOR pathway. Nutr Metab (Lond) (2011) 0.90
Tumor necrosis factor-alpha activates signal transduction in hypothalamus and modulates the expression of pro-inflammatory proteins and orexigenic/anorexigenic neurotransmitters. J Neurochem (2006) 0.90
GQ-16, a novel peroxisome proliferator-activated receptor γ (PPARγ) ligand, promotes insulin sensitization without weight gain. J Biol Chem (2012) 0.90
Acute exercise reduces insulin resistance-induced TRB3 expression and amelioration of the hepatic production of glucose in the liver of diabetic mice. J Cell Physiol (2009) 0.89
Retracted Tub has a key role in insulin and leptin signaling and action in vivo in hypothalamic nuclei. Diabetes (2012) 0.89
Exercise intensity, inflammatory signaling, and insulin resistance in obese rats. Med Sci Sports Exerc (2010) 0.88