Published in PLoS One on January 24, 2011
Fitness costs and diversity of the cytotoxic T lymphocyte (CTL) response determine the rate of CTL escape during acute and chronic phases of HIV infection. J Virol (2011) 1.57
Quantifying T lymphocyte turnover. J Theor Biol (2013) 1.35
A general functional response of cytotoxic T lymphocyte-mediated killing of target cells. Biophys J (2014) 0.99
Why don't CD8+ T cells reduce the lifespan of SIV-infected cells in vivo? PLoS Comput Biol (2011) 0.95
Rates of CTL killing in persistent viral infection in vivo. PLoS Comput Biol (2014) 0.87
Virus replication strategies and the critical CTL numbers required for the control of infection. PLoS Comput Biol (2011) 0.81
Spatial heterogeneity and peptide availability determine CTL killing efficiency in vivo. PLoS Comput Biol (2014) 0.80
Estimating the In Vivo Killing Efficacy of Cytotoxic T Lymphocytes across Different Peptide-MHC Complex Densities. PLoS Comput Biol (2015) 0.80
Evaluation of non-reciprocal heterologous immunity between unrelated viruses. Virology (2015) 0.78
Mathematical modeling provides kinetic details of the human immune response to vaccination. Front Cell Infect Microbiol (2015) 0.77
Investigating the Consequences of Interference between Multiple CD8+ T Cell Escape Mutations in Early HIV Infection. PLoS Comput Biol (2016) 0.76
How is the effectiveness of immune surveillance impacted by the spatial distribution of spreading infections? Philos Trans R Soc Lond B Biol Sci (2015) 0.76
A Sigmoid Functional Response Emerges When Cytotoxic T Lymphocytes Start Killing Fresh Target Cells. Biophys J (2017) 0.75
Understanding Experimental LCMV Infection of Mice: The Role of Mathematical Models. J Immunol Res (2015) 0.75
Modelling and Simulation of the Dynamics of the Antigen-Specific T Cell Response Using Variable Structure Control Theory. PLoS One (2016) 0.75
A biased competition theory of cytotoxic T lymphocyte interaction with tumor nodules. PLoS One (2015) 0.75
Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity (1998) 17.27
Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major. Nat Med (2007) 11.80
Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells. Nat Immunol (2001) 9.23
Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge. Nat Med (2009) 7.33
Immune control of an SIV challenge by a T-cell-based vaccine in rhesus monkeys. Nature (2008) 6.17
Differential regulation of antiviral T-cell immunity results in stable CD8+ but declining CD4+ T-cell memory. Nat Med (2001) 5.74
Vaccines: correlates of vaccine-induced immunity. Clin Infect Dis (2008) 5.69
Correlates of immune protection in HIV-1 infection: what we know, what we don't know, what we should know. Nat Med (2004) 5.49
Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8(+) T cell responses. J Exp Med (2007) 5.22
Cutting edge: rapid in vivo killing by memory CD8 T cells. J Immunol (2003) 4.25
The failed HIV Merck vaccine study: a step back or a launching point for future vaccine development? J Exp Med (2008) 4.15
Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation. Immunity (2006) 3.92
Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cells. PLoS Med (2008) 3.48
Signal 3 determines tolerance versus full activation of naive CD8 T cells: dissociating proliferation and development of effector function. J Exp Med (2003) 3.21
Differentiation of naive CTL to effector and memory CTL: correlation of effector function with phenotype and cell division. J Immunol (1998) 2.73
Memory CD8 T cell responses exceeding a large but definable threshold provide long-term immunity to malaria. Proc Natl Acad Sci U S A (2008) 2.62
Memory CD8 T-cell compartment grows in size with immunological experience. Nature (2008) 2.49
Progression of armed CTL from draining lymph node to spleen shortly after localized infection with herpes simplex virus 1. J Immunol (2002) 2.29
Rapid cytotoxic T lymphocyte activation occurs in the draining lymph nodes after cutaneous herpes simplex virus infection as a result of early antigen presentation and not the presence of virus. J Exp Med (2002) 2.14
The VITAL assay: a versatile fluorometric technique for assessing CTL- and NKT-mediated cytotoxicity against multiple targets in vitro and in vivo. J Immunol Methods (2004) 2.13
Distinct kinetics of cytokine production and cytolysis in effector and memory T cells after viral infection. Eur J Immunol (1999) 2.11
Different dynamics of CD4+ and CD8+ T cell responses during and after acute lymphocytic choriomeningitis virus infection. J Immunol (2003) 2.03
Emergence of polyfunctional CD8+ T cells after prolonged suppression of human immunodeficiency virus replication by antiretroviral therapy. J Virol (2008) 1.79
Recruitment times, proliferation, and apoptosis rates during the CD8(+) T-cell response to lymphocytic choriomeningitis virus. J Virol (2001) 1.72
Direct quantitation of rapid elimination of viral antigen-positive lymphocytes by antiviral CD8(+) T cells in vivo. Eur J Immunol (2000) 1.61
Extending the quasi-steady state approximation by changing variables. Bull Math Biol (1996) 1.61
Cutting edge: rapid in vivo CTL activity by polyoma virus-specific effector and memory CD8+ T cells. J Immunol (2003) 1.55
A functional and kinetic comparison of antiviral effector and memory cytotoxic T lymphocyte populations in vivo and in vitro. Eur J Immunol (1997) 1.52
CD8+ T cell concentration determines their efficiency in killing cognate antigen-expressing syngeneic mammalian cells in vitro and in mouse tissues. J Exp Med (2010) 1.48
The law of mass action governs antigen-stimulated cytolytic activity of CD8+ cytotoxic T lymphocytes. Proc Natl Acad Sci U S A (1995) 1.43
Peptide antigen treatment of naive and virus-immune mice: antigen-specific tolerance versus immunopathology. Immunity (1997) 1.39
Estimation of the rate of killing by cytotoxic T lymphocytes in vivo. Proc Natl Acad Sci U S A (2007) 1.33
Defining parameters for successful immunocytotherapy of persistent viral infection. Virology (2000) 1.25
Rulers over randomness: stroma cells guide lymphocyte migration in lymph nodes. Immunity (2006) 1.23
Comprehensive early and lasting loss of memory CD8 T cells and functional memory during acute and persistent viral infections. J Immunol (2004) 1.17
Tracing tolerance and immunity in vivo by CFSE-labeling of administered cells. Methods Mol Biol (2007) 1.17
Investigating CTL mediated killing with a 3D cellular automaton. PLoS Comput Biol (2009) 1.15
Underwhelming the immune response: effect of slow virus growth on CD8+-T-lymphocyte responses. J Virol (2004) 1.14
Estimating in vivo death rates of targets due to CD8 T-cell-mediated killing. J Virol (2008) 1.13
Understanding the failure of CD8+ T-cell vaccination against simian/human immunodeficiency virus. J Virol (2007) 1.11
Revisiting estimates of CTL killing rates in vivo. PLoS One (2007) 1.09
Dynamics of CD8+ T cell responses during acute and chronic lymphocytic choriomeningitis virus infection. J Immunol (2007) 1.03
Cutting edge: rapid and efficient in vivo cytotoxicity by cytotoxic T cells is independent of granzymes A and B. J Immunol (2009) 0.98
Mechanism of cell-mediated cytotoxicity at the single cell level. VIII. Kinetics of lysis of target cells bound by more than one cytotoxic T lymphocyte. J Immunol (1984) 0.96
Visualizing CTL activity for different CD8+ effector T cells supports the idea that lower TCR/epitope avidity may be advantageous for target cell killing. Cell Death Differ (2009) 0.92
The infiltration kinetics of simian immunodeficiency virus-specific T cells drawn to sites of high antigenic stimulation determines local in vivo viral escape. Proc Natl Acad Sci U S A (2001) 0.83
Discriminating between different pathways of memory CD8+ T cell differentiation. J Immunol (2007) 0.83
Molecular signature of CD8+ T cell exhaustion during chronic viral infection. Immunity (2007) 10.83
Antigen-independent memory CD8 T cells do not develop during chronic viral infection. Proc Natl Acad Sci U S A (2004) 4.56
Dynamic T cell migration program provides resident memory within intestinal epithelium. J Exp Med (2010) 4.09
Cutting edge: gut microenvironment promotes differentiation of a unique memory CD8 T cell population. J Immunol (2006) 3.35
Caspase-1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo. J Immunol (2010) 3.25
Enhancing therapeutic vaccination by blocking PD-1-mediated inhibitory signals during chronic infection. J Exp Med (2008) 2.81
Visualizing antigen-specific and infected cells in situ predicts outcomes in early viral infection. Science (2009) 2.64
Continuous recruitment of naive T cells contributes to heterogeneity of antiviral CD8 T cells during persistent infection. J Exp Med (2006) 2.55
Do most lymphocytes in humans really reside in the gut? Trends Immunol (2007) 2.49
Innate and adaptive interferons suppress IL-1α and IL-1β production by distinct pulmonary myeloid subsets during Mycobacterium tuberculosis infection. Immunity (2011) 2.19
Elevated frequencies of highly activated CD4+ T cells in HIV+ patients developing immune reconstitution inflammatory syndrome. Blood (2010) 1.66
Antigen-specific CD4 T-cell help rescues exhausted CD8 T cells during chronic viral infection. Proc Natl Acad Sci U S A (2011) 1.62
MHC polymorphism under host-pathogen coevolution. Immunogenetics (2004) 1.61
Dynamics of immune escape during HIV/SIV infection. PLoS Comput Biol (2008) 1.54
Redundant and pathogenic roles for IL-22 in mycobacterial, protozoan, and helminth infections. J Immunol (2010) 1.53
Procedures for reliable estimation of viral fitness from time-series data. Proc Biol Sci (2002) 1.46
Estimating Costs and Benefits of CTL Escape Mutations in SIV/HIV Infection. PLoS Comput Biol (2006) 1.36
Estimation of the rate of killing by cytotoxic T lymphocytes in vivo. Proc Natl Acad Sci U S A (2007) 1.33
Adaptive tolerance and clonal anergy are distinct biochemical states. J Immunol (2006) 1.32
Cutting edge: control of Mycobacterium tuberculosis infection by a subset of lung parenchyma-homing CD4 T cells. J Immunol (2014) 1.21
4-1BB signaling synergizes with programmed death ligand 1 blockade to augment CD8 T cell responses during chronic viral infection. J Immunol (2011) 1.20
Cord factor and peptidoglycan recapitulate the Th17-promoting adjuvant activity of mycobacteria through mincle/CARD9 signaling and the inflammasome. J Immunol (2013) 1.15
Estimating in vivo death rates of targets due to CD8 T-cell-mediated killing. J Virol (2008) 1.13
In mice, tuberculosis progression is associated with intensive inflammatory response and the accumulation of Gr-1 cells in the lungs. PLoS One (2010) 1.13
Revisiting estimates of CTL killing rates in vivo. PLoS One (2007) 1.09
De novo T-cell generation in patients at different ages and stages of HIV-1 disease. Blood (2004) 1.07
Plasma heme oxygenase-1 levels distinguish latent or successfully treated human tuberculosis from active disease. PLoS One (2013) 1.07
Thymic selection does not limit the individual MHC diversity. Eur J Immunol (2003) 1.05
IL-2 regulates expansion of CD4+ T cell populations by affecting cell death: insights from modeling CFSE data. J Immunol (2007) 1.04
Dynamics of CD8+ T cell responses during acute and chronic lymphocytic choriomeningitis virus infection. J Immunol (2007) 1.03
Implications of CTL-mediated killing of HIV-infected cells during the non-productive stage of infection. PLoS One (2011) 1.01
A spatial model of germinal center reactions: cellular adhesion based sorting of B cells results in efficient affinity maturation. J Theor Biol (2003) 0.98
Identifying viral parameters from in vitro cell cultures. Front Microbiol (2012) 0.95
A mechanistic model for bromodeoxyuridine dilution naturally explains labelling data of self-renewing T cell populations. J R Soc Interface (2012) 0.92
Explicit kinetic heterogeneity: mathematical models for interpretation of deuterium labeling of heterogeneous cell populations. PLoS Comput Biol (2010) 0.91
Intracellular transactivation of HIV can account for the decelerating decay of virus load during drug therapy. Mol Syst Biol (2010) 0.89
The integration hypothesis: an evolutionary pathway to benign SIV infection. PLoS Pathog (2006) 0.84
CD4 T Cell-Derived IFN-γ Plays a Minimal Role in Control of Pulmonary Mycobacterium tuberculosis Infection and Must Be Actively Repressed by PD-1 to Prevent Lethal Disease. PLoS Pathog (2016) 0.83
Cutting edge: Expression of FcγRIIB tempers memory CD8 T cell function in vivo. J Immunol (2013) 0.81
Broad CTL Response in Early HIV Infection Drives Multiple Concurrent CTL Escapes. PLoS Comput Biol (2015) 0.81
Impaired immune evasion in HIV through intracellular delays and multiple infection of cells. Proc Biol Sci (2012) 0.80
Memorizing innate instructions requires a sufficiently specific adaptive immune system. Int Immunol (2002) 0.80
Clonal exhaustion as a result of immune deviation. Bull Math Biol (2003) 0.79
Complementarity of Binding Motifs is a General Property of HLA-A and HLA-B Molecules and Does Not Seem to Effect HLA Haplotype Composition. Front Immunol (2013) 0.78
A new model to simulate and analyze proliferating cell populations in BrdU labeling experiments. BMC Syst Biol (2013) 0.77