PubRank

Emmanuel J H J Wiertz

Author PubWeight™ 52.30‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Ubiquitination of serine, threonine, or lysine residues on the cytoplasmic tail can induce ERAD of MHC-I by viral E3 ligase mK3. J Cell Biol 2007 2.53
2 Host shutoff during productive Epstein-Barr virus infection is mediated by BGLF5 and may contribute to immune evasion. Proc Natl Acad Sci U S A 2007 1.82
3 A CD8+ T cell immune evasion protein specific to Epstein-Barr virus and its close relatives in Old World primates. J Exp Med 2007 1.70
4 Viral immune evasion: a masterpiece of evolution. Immunogenetics 2002 1.49
5 Endogenous HLA class II epitopes that are immunogenic in vivo show distinct behavior toward HLA-DM and its natural inhibitor HLA-DO. Blood 2012 1.49
6 The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER. J Cell Biol 2009 1.48
7 Two mechanistically distinct immune evasion proteins of cowpox virus combine to avoid antiviral CD8 T cells. Cell Host Microbe 2009 1.48
8 Epstein-Barr virus gp42 is posttranslationally modified to produce soluble gp42 that mediates HLA class II immune evasion. J Virol 2005 1.36
9 Varicelloviruses avoid T cell recognition by UL49.5-mediated inactivation of the transporter associated with antigen processing. Proc Natl Acad Sci U S A 2005 1.36
10 The Epstein-Barr virus G-protein-coupled receptor contributes to immune evasion by targeting MHC class I molecules for degradation. PLoS Pathog 2009 1.31
11 The DNase of gammaherpesviruses impairs recognition by virus-specific CD8+ T cells through an additional host shutoff function. J Virol 2007 1.29
12 Viral evasion of T cell immunity: ancient mechanisms offering new applications. Curr Opin Immunol 2010 1.24
13 Impaired transporter associated with antigen processing-dependent peptide transport during productive EBV infection. J Immunol 2005 1.23
14 Interference with T cell receptor-HLA-DR interactions by Epstein-Barr virus gp42 results in reduced T helper cell recognition. Proc Natl Acad Sci U S A 2003 1.20
15 Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products. Semin Cancer Biol 2008 1.20
16 Specific targeting of the EBV lytic phase protein BNLF2a to the transporter associated with antigen processing results in impairment of HLA class I-restricted antigen presentation. J Immunol 2009 1.17
17 Stage-specific inhibition of MHC class I presentation by the Epstein-Barr virus BNLF2a protein during virus lytic cycle. PLoS Pathog 2009 1.11
18 In cis inhibition of antigen processing by the latency-associated nuclear antigen I of Kaposi sarcoma herpes virus. Mol Immunol 2006 1.10
19 Herpesviruses and immunity: the art of evasion. Vet Microbiol 2010 1.08
20 Varicellovirus UL 49.5 proteins differentially affect the function of the transporter associated with antigen processing, TAP. PLoS Pathog 2008 1.08
21 Ube2j2 ubiquitinates hydroxylated amino acids on ER-associated degradation substrates. J Cell Biol 2009 1.07
22 The comparative genomics of human respiratory syncytial virus subgroups A and B: genetic variability and molecular evolutionary dynamics. J Virol 2013 1.01
23 Human cytomegalovirus-encoded US2 differentially affects surface expression of MHC class I locus products and targets membrane-bound, but not soluble HLA-G1 for degradation. J Immunol 2003 0.99
24 Bovine herpesvirus 1 UL49.5 protein inhibits the transporter associated with antigen processing despite complex formation with glycoprotein M. J Virol 2006 0.94
25 The varicellovirus-encoded TAP inhibitor UL49.5 regulates the presentation of CTL epitopes by Qa-1b1. J Immunol 2007 0.92
26 EBV protein BNLF2a exploits host tail-anchored protein integration machinery to inhibit TAP. J Immunol 2011 0.91
27 Subtle sequence variation among MHC class I locus products greatly influences sensitivity to HCMV US2- and US11-mediated degradation. Int Immunol 2005 0.90
28 Signaling of a varicelloviral factor across the endoplasmic reticulum membrane induces destruction of the peptide-loading complex and immune evasion. J Biol Chem 2008 0.89
29 Inhibition of mouse TAP by immune evasion molecules encoded by non-murine herpesviruses. Mol Immunol 2011 0.89
30 Exploitation of herpesvirus immune evasion strategies to modify the immunogenicity of human mesenchymal stem cell transplants. PLoS One 2011 0.88
31 Human cytomegalovirus-encoded US2 and US11 target unassembled MHC class I heavy chains for degradation. Mol Immunol 2005 0.88
32 Amino acid composition of alpha1/alpha2 domains and cytoplasmic tail of MHC class I molecules determine their susceptibility to human cytomegalovirus US11-mediated down-regulation. Eur J Immunol 2003 0.88
33 The varicellovirus UL49.5 protein blocks the transporter associated with antigen processing (TAP) by inhibiting essential conformational transitions in the 6+6 transmembrane TAP core complex. J Immunol 2008 0.88
34 CD8+ T cell responses against TAP-inhibited cells are readily detected in the human population. J Immunol 2010 0.86
35 The "Bridge" in the Epstein-Barr virus alkaline exonuclease protein BGLF5 contributes to shutoff activity during productive infection. J Virol 2012 0.86
36 The capacity of UL49.5 proteins to inhibit TAP is widely distributed among members of the genus Varicellovirus. J Virol 2010 0.85
37 Exploiting human herpesvirus immune evasion for therapeutic gain: potential and pitfalls. Immunol Cell Biol 2011 0.84
38 Noncytotoxic inhibition of cytomegalovirus replication through NK cell protease granzyme M-mediated cleavage of viral phosphoprotein 71. J Immunol 2010 0.82
39 The nested open reading frame in the Epstein-Barr virus nuclear antigen-1 mRNA encodes a protein capable of inhibiting antigen presentation in cis. Mol Immunol 2007 0.81
40 Structural and functional analysis of the TAP-inhibiting UL49.5 proteins of varicelloviruses. Mol Immunol 2011 0.81
41 TAP-inhibiting proteins US6, ICP47 and UL49.5 differentially affect minor and major histocompatibility antigen-specific recognition by cytotoxic T lymphocytes. Int Immunol 2007 0.81
42 Synthesis and biological evaluation of a chitobiose-based peptide N-glycanase inhibitor library. J Org Chem 2009 0.80
43 Adenoviral vectors stimulate glucagon transcription in human mesenchymal stem cells expressing pancreatic transcription factors. PLoS One 2012 0.79
44 Rat cytomegalovirus induces a temporal downregulation of major histocompatibility complex class I cell surface expression. Viral Immunol 2005 0.78
45 Induction of protective CTL immunity against peptide transporter TAP-deficient tumors through dendritic cell vaccination. Cancer Res 2007 0.77
46 Epstein-Barr virus isolates retain their capacity to evade T cell immunity through BNLF2a despite extensive sequence variation. J Virol 2011 0.77
47 Manipulation of the immune response by Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus: consequences for tumor development. Semin Cancer Biol 2008 0.76
48 TAP mediates import of Mycobacterium tuberculosis-derived peptides into phagosomes and facilitates loading onto HLA-I. PLoS One 2013 0.76
49 Erratum: Exploiting the exploiter: a viral inhibitor stabilizes TAP for cryo-EM. Nat Struct Mol Biol 2016 0.75
50 Evaluation of viral interference with MHC class I-restricted antigen processing and presentation using a flow cytometry-based approach. Methods Mol Biol 2013 0.75