Published in Med Oncol on February 08, 2011
Mortality after incident cancer in people with and without type 2 diabetes: impact of metformin on survival. Diabetes Care (2012) 2.32
Metformin therapy and risk of cancer in patients with type 2 diabetes: systematic review. PLoS One (2013) 2.10
Obesity, inflammation, and liver cancer. J Hepatol (2011) 2.09
Metformin prevents liver tumorigenesis by inhibiting pathways driving hepatic lipogenesis. Cancer Prev Res (Phila) (2012) 1.90
Metformin inhibits melanoma development through autophagy and apoptosis mechanisms. Cell Death Dis (2011) 1.76
Metformin kills and radiosensitizes cancer cells and preferentially kills cancer stem cells. Sci Rep (2012) 1.66
A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells. Am J Physiol Cell Physiol (2012) 1.62
Salinomycin as a drug for targeting human cancer stem cells. J Biomed Biotechnol (2012) 1.50
Blocking lactate export by inhibiting the Myc target MCT1 Disables glycolysis and glutathione synthesis. Cancer Res (2013) 1.46
The use of metformin and the incidence of lung cancer in patients with type 2 diabetes. Diabetes Care (2012) 1.42
Metformin: an emerging new therapeutic option for targeting cancer stem cells and metastasis. J Oncol (2012) 1.24
Metformin in cancer prevention and therapy. Ann Transl Med (2014) 1.18
Diabetes and cancer: two diseases with obesity as a common risk factor. Diabetes Obes Metab (2013) 1.11
Metformin suppresses growth of human head and neck squamous cell carcinoma via global inhibition of protein translation. Cell Cycle (2012) 1.11
Metabolism and brain cancer. Clinics (Sao Paulo) (2011) 1.10
New molecules and old drugs as emerging approaches to selectively target human glioblastoma cancer stem cells. Biomed Res Int (2014) 1.08
Bioavailable copper modulates oxidative phosphorylation and growth of tumors. Proc Natl Acad Sci U S A (2013) 1.06
Metformin repositioning as antitumoral agent: selective antiproliferative effects in human glioblastoma stem cells, via inhibition of CLIC1-mediated ion current. Oncotarget (2014) 1.05
Glucose promotes breast cancer aggression and reduces metformin efficacy. Cell Cycle (2013) 0.99
Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs oxphos and prostate cancer metastatic spread. Oncotarget (2015) 0.97
Metformin, at concentrations corresponding to the treatment of diabetes, potentiates the cytotoxic effects of carboplatin in cultures of ovarian cancer cells. Reprod Sci (2013) 0.94
Metformin reduces thyroid cancer risk in Taiwanese patients with type 2 diabetes. PLoS One (2014) 0.94
Metformin induces apoptosis through AMPK-dependent inhibition of UPR signaling in ALL lymphoblasts. PLoS One (2013) 0.92
Metformin for cancer and aging prevention: is it a time to make the long story short? Oncotarget (2015) 0.92
Response of breast cancer cells and cancer stem cells to metformin and hyperthermia alone or combined. PLoS One (2014) 0.91
Effect of metformin on cancer risk and treatment outcome of prostate cancer: a meta-analysis of epidemiological observational studies. PLoS One (2014) 0.91
Metformin may reduce oral cancer risk in patients with type 2 diabetes. Oncotarget (2016) 0.90
Metformin: On Ongoing Journey across Diabetes, Cancer Therapy and Prevention. Metabolites (2013) 0.89
Lovastatin induces multiple stress pathways including LKB1/AMPK activation that regulate its cytotoxic effects in squamous cell carcinoma cells. PLoS One (2012) 0.87
Role of the ROS/AMPK signaling pathway in tetramethylpyrazine-induced apoptosis in gastric cancer cells. Oncol Lett (2013) 0.86
Preventive effect of Metformin against N-nitrosodiethylamine-initiated hepatocellular carcinoma in rats. Saudi Pharm J (2012) 0.83
Metformin inhibits leptin-induced growth and migration of glioblastoma cells. Oncol Lett (2012) 0.83
Metformin Synergistically Enhances Cisplatin-Induced Cytotoxicity in Esophageal Squamous Cancer Cells under Glucose-Deprivation Conditions. Biomed Res Int (2016) 0.82
Effect of Metformin on Viability, Morphology, and Ultrastructure of Mouse Bone Marrow-Derived Multipotent Mesenchymal Stromal Cells and Balb/3T3 Embryonic Fibroblast Cell Line. Biomed Res Int (2015) 0.82
Metformin and lung cancer risk of patients with type 2 diabetes mellitus: A meta-analysis. Biomed Rep (2015) 0.81
Metformin use among type 2 diabetics and risk of pancreatic cancer in a clinic-based case-control study. Int J Cancer (2014) 0.80
Novel strategies of protecting non-cancer cells during chemotherapy: are they ready for clinical testing? Oncotarget (2011) 0.80
Enhanced anti-tumor activity and cytotoxic effect on cancer stem cell population of metformin-butyrate compared with metformin HCl in breast cancer. Oncotarget (2016) 0.80
Optimization of biguanide derivatives as selective antitumor agents blocking adaptive stress responses in the tumor microenvironment. Drug Des Devel Ther (2014) 0.79
In vitro and in vivo antiproliferative activity of metformin on stem-like cells isolated from spontaneous canine mammary carcinomas: translational implications for human tumors. BMC Cancer (2015) 0.79
Cancer stem cells: a systems biology view of their role in prognosis and therapy. Anticancer Drugs (2014) 0.79
Metformin and prostate cancer stem cells: a novel therapeutic target. Prostate Cancer Prostatic Dis (2015) 0.79
Metformin sensitizes the response of oral squamous cell carcinoma to cisplatin treatment through inhibition of NF-κB/HIF-1α signal axis. Sci Rep (2016) 0.78
AMP-activated protein kinase fortifies epithelial tight junctions during energetic stress via its effector GIV/Girdin. Elife (2016) 0.78
Activation of the cellular unfolded protein response by recombinant adeno-associated virus vectors. PLoS One (2013) 0.78
Investigational cancer drugs targeting cell metabolism in clinical development. Expert Opin Investig Drugs (2014) 0.78
Metformin suppressed the proliferation of LoVo cells and induced a time-dependent metabolic and transcriptional alteration. Sci Rep (2015) 0.78
Association between metformin use and mortality in patients with type 2 diabetes mellitus and localized resectable pancreatic cancer: a nationwide population-based study in korea. Oncotarget (2017) 0.78
Metformin may protect nondiabetic breast cancer women from metastasis. Clin Exp Metastasis (2016) 0.77
Growth inhibition of colon cancer cells by compounds affecting AMPK activity. World J Gastrointest Oncol (2014) 0.77
Dynamic scenario of metabolic pathway adaptation in tumors and therapeutic approach. Oncoscience (2015) 0.77
Metformin Decreases Reactive Oxygen Species, Enhances Osteogenic Properties of Adipose-Derived Multipotent Mesenchymal Stem Cells In Vitro, and Increases Bone Density In Vivo. Oxid Med Cell Longev (2016) 0.76
Metformin upregulates E-cadherin and inhibits B16F10 cell motility, invasion and migration. Oncol Lett (2015) 0.76
Adenosine Monophosphate-activated Protein Kinase (AMPK) Activators For the Prevention, Treatment and Potential Reversal of Pathological Pain. Curr Drug Targets (2016) 0.76
Metformin and cancer: Technical and clinical implications for FDG-PET imaging. World J Radiol (2015) 0.76
The stress polarity pathway: AMPK 'GIV'-es protection against metabolic insults. Aging (Albany NY) (2017) 0.76
Metformin prevents hormonal and metabolic disturbances and 1,2-dimethylhydrazine-induced colon carcinogenesis in non-diabetic rats. Cancer Biol Med (2017) 0.75
The Effect of Metformin and GANT61 Combinations on the Radiosensitivity of Prostate Cancer Cells. Int J Mol Sci (2017) 0.75
Metformin is synthetically lethal with glucose withdrawal in cancer cells. Cell Cycle (2012) 0.75
Tristetraprolin mediates the anti-proliferative effects of metformin in breast cancer cells. Breast Cancer Res Treat (2016) 0.75
Metformin inhibits early stage diethylnitrosamine‑induced hepatocarcinogenesis in rats. Mol Med Rep (2015) 0.75
The cell-autonomous mechanisms underlying the activity of metformin as an anticancer drug. Br J Cancer (2016) 0.75
The impact of metformin and salinomycin on transforming growth factor β-induced epithelial-to-mesenchymal transition in non-small cell lung cancer cell lines. Oncol Lett (2016) 0.75
Construction of In Vivo Fluorescent Imaging of Echinococcus granulosus in a Mouse Model. Korean J Parasitol (2016) 0.75
Diabetes, use of metformin, and the risk of meningioma. PLoS One (2017) 0.75
Combined transcriptome and metabolome analyses of metformin effects reveal novel links between metabolic networks in steroidogenic systems. Sci Rep (2017) 0.75
Metformin and endometrial cancer survival: a quantitative synthesis of observational studies. Oncotarget (2017) 0.75
Safety of early discharge for low-risk patients with febrile neutropenia: a multicenter randomized controlled trial. J Clin Oncol (2011) 1.26
Effects of a brief multimedia psychoeducational intervention on the attitudes and interest of patients with cancer regarding clinical trial participation: a multicenter randomized controlled trial. J Clin Oncol (2012) 0.97
Trisomy 8 as the sole cytogenetic abnormality in an adult patient with acute lymphoblastic leukemia. Cancer Genet (2012) 0.75
Trials and Tribulations for Adolescents and Young Adults with Cancer: Measuring the Impact of a Community-Based Program. J Natl Compr Canc Netw (2017) 0.75
Tumor lysis syndrome in a nonsmall cell lung cancer. Conn Med (2014) 0.75
Zollinger-ellison syndrome with subsequent association of insulinoma. JOP (2010) 0.75