Longitudinal versus cross-sectional evaluations of leukocyte telomere length dynamics: age-dependent telomere shortening is the rule.

PubWeight™: 1.72‹?› | Rank: Top 3%

🔗 View Article (PMC 3041470)

Published in J Gerontol A Biol Sci Med Sci on February 10, 2011


W Chen1, M Kimura, S Kim, X Cao, S R Srinivasan, G S Berenson, J D Kark, A Aviv

Author Affiliations

1: Tulane Center for Cardiovascular Health, Tulane University Health Sciences Center, New Orleans, Louisiana, USA.

Articles citing this

Telomeres shorten at equivalent rates in somatic tissues of adults. Nat Commun (2013) 2.56

Exposure to violence during childhood is associated with telomere erosion from 5 to 10 years of age: a longitudinal study. Mol Psychiatry (2012) 2.37

Telomere length in epidemiology: a biomarker of aging, age-related disease, both, or neither? Epidemiol Rev (2013) 2.05

Gender and telomere length: systematic review and meta-analysis. Exp Gerontol (2013) 1.62

Genetics of leukocyte telomere length and its role in atherosclerosis. Mutat Res (2011) 1.44

Blood cell telomere length is a dynamic feature. PLoS One (2011) 1.41

The telomere lengthening conundrum--artifact or biology? Nucleic Acids Res (2013) 1.38

Do leukocyte telomere length dynamics depend on baseline telomere length? An analysis that corrects for 'regression to the mean'. Eur J Epidemiol (2013) 1.28

Early life stress and telomere length: investigating the connection and possible mechanisms: a critical survey of the evidence base, research methodology and basic biology. Bioessays (2012) 1.23

Energy intake and leukocyte telomere length in young adults. Am J Clin Nutr (2012) 1.18

Tracking and fixed ranking of leukocyte telomere length across the adult life course. Aging Cell (2013) 1.17

Leucocyte telomere length and risk of type 2 diabetes mellitus: new prospective cohort study and literature-based meta-analysis. PLoS One (2014) 1.17

Association between telomere length and experimentally induced upper respiratory viral infection in healthy adults. JAMA (2013) 1.17

Leukocyte telomere length is associated with noninvasively measured age-related disease: The Cardiovascular Health Study. J Gerontol A Biol Sci Med Sci (2011) 1.08

Is socioeconomic status associated with biological aging as measured by telomere length? Epidemiol Rev (2012) 1.05

An intricate dance: Life experience, multisystem resiliency, and rate of telomere decline throughout the lifespan. Soc Personal Psychol Compass (2012) 1.01

Race-related health disparities and biological aging: does rate of telomere shortening differ across blacks and whites? Biol Psychol (2014) 0.98

Age-associated telomere attrition of lymphocytes in vivo is co-ordinated with changes in telomerase activity, composition of lymphocyte subsets and health conditions. Clin Sci (Lond) (2015) 0.95

A model of canine leukocyte telomere dynamics. Aging Cell (2011) 0.94

Longer leukocyte telomere length in Costa Rica's Nicoya Peninsula: a population-based study. Exp Gerontol (2013) 0.93

Leukocyte telomere dynamics in the elderly. Eur J Epidemiol (2013) 0.92

Longitudinal change in telomere length and the chronic stress response in a randomized pilot biobehavioral clinical study: implications for cancer prevention. Cancer Prev Res (Phila) (2012) 0.91

Telomere length and common disease: study design and analytical challenges. Hum Genet (2015) 0.87

Telomeres and human reproduction. Fertil Steril (2013) 0.86

Is telomere length socially patterned? Evidence from the West of Scotland Twenty-07 Study. PLoS One (2012) 0.86

No association between mean telomere length and life stress observed in a 30 year birth cohort. PLoS One (2014) 0.85

Inflammation, telomere length, and grip strength: a 10-year longitudinal study. Calcif Tissue Int (2014) 0.85

Shorter telomere length in peripheral blood leukocytes is associated with childhood autism. Sci Rep (2014) 0.85

Leukocyte telomere length dynamics in women and men: menopause vs age effects. Int J Epidemiol (2015) 0.83

How old do you feel? The role of age discrimination and biological aging in subjective age. PLoS One (2015) 0.83

The telomere lengthening conundrum - it could be biology. Aging Cell (2016) 0.82

Pessimistic orientation in relation to telomere length in older men: the VA normative aging study. Psychoneuroendocrinology (2014) 0.82

The life cycle of a T cell after vaccination - where does immune ageing strike? Clin Exp Immunol (2016) 0.82

Association between informal caregiving and cellular aging in the survey of the health of wisconsin: the role of caregiving characteristics, stress, and strain. Am J Epidemiol (2014) 0.82

Seasonal variation of peripheral blood leukocyte telomere length in Costa Rica: A population-based observational study. Am J Hum Biol (2014) 0.81

Meta-analysis of Telomere Length in Alzheimer's Disease. J Gerontol A Biol Sci Med Sci (2016) 0.81

Decreasing initial telomere length in humans intergenerationally understates age-associated telomere shortening. Aging Cell (2015) 0.80

Nutrition and lifestyle in healthy aging: the telomerase challenge. Aging (Albany NY) (2016) 0.80

Longitudinal decline of leukocyte telomere length in old age and the association with sex and genetic risk. Aging (Albany NY) (2016) 0.78

Defining the toxicology of aging. Trends Mol Med (2014) 0.78

Increased attrition of leukocyte telomere length in young adults is associated with poorer cognitive function in midlife. Eur J Epidemiol (2015) 0.78

Telomere length in blood and skeletal muscle in relation to measures of glycaemia and insulinaemia. Diabet Med (2012) 0.78

Are Anxiety Disorders Associated with Accelerated Aging? A Focus on Neuroprogression. Neural Plast (2015) 0.77

A Randomized Controlled Trial to Increase Navy Bean or Rice Bran Consumption in Colorectal Cancer Survivors. Nutr Cancer (2016) 0.77

Diurnal and stress-reactive dehydroepiandrosterone levels and telomere length in youth. Endocr Connect (2016) 0.77

Epigenomic Indicators of Age in African Americans. Hereditary Genet (2014) 0.77

Telomere length reprogramming in embryos and stem cells. Biomed Res Int (2014) 0.76

Long term effects of radiation exposure on telomere lengths of leukocytes and its associated biomarkers among atomic-bomb survivors. Oncotarget (2016) 0.75

A prospective study of leukocyte telomere length and risk of phobic anxiety among women. Psychiatry Res (2015) 0.75

Detecting telomere elongation in longitudinal datasets: analysis of a proposal by Simons, Stulp and Nakagawa. PeerJ (2017) 0.75

Accelerated telomere shortening: Tracking the lasting impact of early institutional care at the cellular level. Psychiatry Res (2016) 0.75


Telomere Shortening, Inflammatory Cytokines, and Anti-Cytomegalovirus Antibody Follow Distinct Age-Associated Trajectories in Humans. Front Immunol (2017) 0.75

Cigarette smoking and telomere length: A systematic review of 84 studies and meta-analysis. Environ Res (2017) 0.75

Articles cited by this

Telomere measurement by quantitative PCR. Nucleic Acids Res (2002) 18.69

Obesity, cigarette smoking, and telomere length in women. Lancet (2005) 8.59

Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: a nested case-control study. Lancet (2007) 6.57

Leukocyte telomere length and cardiovascular disease in the cardiovascular health study. Am J Epidemiol (2006) 5.28

Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood. J Exp Med (1999) 4.27

The rate of telomere sequence loss in human leukocytes varies with age. Proc Natl Acad Sci U S A (1998) 4.17

Telomere length as an indicator of biological aging: the gender effect and relation with pulse pressure and pulse wave velocity. Hypertension (2001) 4.07

Telomere length is paternally inherited and is associated with parental lifespan. Proc Natl Acad Sci U S A (2007) 3.67

Telomere length and possible link to X chromosome. Lancet (2004) 3.36

Telomere length inversely correlates with pulse pressure and is highly familial. Hypertension (2000) 3.32

Rise in insulin resistance is associated with escalated telomere attrition. Circulation (2005) 3.27

Telomere length in the newborn. Pediatr Res (2002) 3.26

Leukocyte telomeres are longer in African Americans than in whites: the National Heart, Lung, and Blood Institute Family Heart Study and the Bogalusa Heart Study. Aging Cell (2008) 3.24

Telomere length predicts survival independent of genetic influences. Aging Cell (2007) 3.01

Measurement of telomere length by the Southern blot analysis of terminal restriction fragment lengths. Nat Protoc (2010) 2.88

Influences on the reduction of relative telomere length over 10 years in the population-based Bruneck Study: introduction of a well-controlled high-throughput assay. Int J Epidemiol (2009) 2.87

Leukocyte telomere dynamics: longitudinal findings among young adults in the Bogalusa Heart Study. Am J Epidemiol (2008) 2.86

Telomere length and mortality: a study of leukocytes in elderly Danish twins. Am J Epidemiol (2008) 2.85

Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: a population-based study. Aging Cell (2005) 2.83

Short telomere length and breast cancer risk: a study in sister sets. Cancer Res (2007) 2.70

Telomere length and cardiovascular risk factors in a middle-aged population free of overt cardiovascular disease. Aging Cell (2007) 2.62

Telomere length of circulating leukocytes is decreased in patients with chronic heart failure. J Am Coll Cardiol (2007) 2.36

Association of leukocyte telomere length with circulating biomarkers of the renin-angiotensin-aldosterone system: the Framingham Heart Study. Circulation (2008) 2.22

The individual blood cell telomere attrition rate is telomere length dependent. PLoS Genet (2009) 2.17

Human telomere biology: pitfalls of moving from the laboratory to epidemiology. Int J Epidemiol (2006) 2.16

The epidemiology of human telomeres: faults and promises. J Gerontol A Biol Sci Med Sci (2008) 2.11

Telomere length trajectory and its determinants in persons with coronary artery disease: longitudinal findings from the heart and soul study. PLoS One (2010) 2.10

Telomere biology and cardiovascular disease. Circ Res (2006) 1.96

Obesity and weight gain in adulthood and telomere length. Cancer Epidemiol Biomarkers Prev (2009) 1.91

Telomeres and human somatic fitness. J Gerontol A Biol Sci Med Sci (2006) 1.82

Telomere gap between granulocytes and lymphocytes is a determinant for hematopoetic progenitor cell impairment in patients with previous myocardial infarction. Arterioscler Thromb Vasc Biol (2008) 1.78

Association of marine omega-3 fatty acid levels with telomeric aging in patients with coronary heart disease. JAMA (2010) 1.71

Telomere length in small-for-gestational-age babies. BJOG (2006) 1.66

Leukocyte telomere dynamics and human hematopoietic stem cell kinetics during somatic growth. Exp Hematol (2009) 1.66

Leukocyte telomere length and carotid artery intimal medial thickness: the Framingham Heart Study. Arterioscler Thromb Vasc Biol (2008) 1.64

Biological ageing and cardiovascular disease. Heart (2008) 1.64

Multivitamin use and telomere length in women. Am J Clin Nutr (2009) 1.54

Rapid telomere shortening in children. Blood (1999) 1.35

Stress, social rank and leukocyte telomere length. Aging Cell (2006) 0.99

Higher circulating levels of IGF-1 are associated with longer leukocyte telomere length in healthy subjects. Mech Ageing Dev (2009) 0.99

Increased abdominal obesity, adverse psychosocial factors and shorter telomere length in subjects reporting early ageing; the MONICA Northern Sweden Study. Scand J Public Health (2008) 0.94

Serum insulin-like growth factor-I concentration is associated with leukocyte telomere length in a population-based cohort of elderly men. J Clin Endocrinol Metab (2009) 0.84

A life course perspective on telomere length and social inequalities in aging. Aging Cell (2006) 0.82

Articles by these authors

A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. J Mol Evol (1980) 113.75

Evolutionary rate at the molecular level. Nature (1968) 33.15

The number of heterozygous nucleotide sites maintained in a finite population due to steady flux of mutations. Genetics (1969) 22.59

Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. The Bogalusa Heart Study. N Engl J Med (1998) 15.09

A model of mutation appropriate to estimate the number of electrophoretically detectable alleles in a finite population. Genet Res (1973) 13.08

The relation of overweight to cardiovascular risk factors among children and adolescents: the Bogalusa Heart Study. Pediatrics (1999) 11.20

Genome cross-referencing and XREFdb: implications for the identification and analysis of genes mutated in human disease. Nat Genet (1997) 10.14

A stochastic model concerning the maintenance of genetic variability in quantitative characters. Proc Natl Acad Sci U S A (1965) 9.20

Obesity, cigarette smoking, and telomere length in women. Lancet (2005) 8.59

Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med (1995) 8.51

Artemisinins target the SERCA of Plasmodium falciparum. Nature (2003) 7.72

The substitutional load in a finite population. Heredity (Edinb) (1969) 7.56

Genetics of poliovirus. Annu Rev Genet (1993) 7.41

Linkage disequilibrium at steady state determined by random genetic drift and recurrent mutation. Genetics (1969) 7.33

The genome of the natural genetic engineer Agrobacterium tumefaciens C58. Science (2001) 6.90

The effects of social status on biological aging as measured by white-blood-cell telomere length. Aging Cell (2006) 6.80

Protein polymorphism as a phase of molecular evolution. Nature (1971) 6.68

REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons. Cell (1995) 6.43

Theoretical foundation of population genetics at the molecular level. Theor Popul Biol (1971) 6.38

Relationship of childhood obesity to coronary heart disease risk factors in adulthood: the Bogalusa Heart Study. Pediatrics (2001) 6.06

The probability of consanguineous marriages. Genetics (1966) 5.85

Requirement of CHROMOMETHYLASE3 for maintenance of CpXpG methylation. Science (2001) 5.50

Radiation hybrid mapping: a somatic cell genetic method for constructing high-resolution maps of mammalian chromosomes. Science (1990) 5.35

Estimation of evolutionary distances between homologous nucleotide sequences. Proc Natl Acad Sci U S A (1981) 5.34

Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor. Science (1993) 5.22

On the stochastic model for estimation of mutational distance between homologous proteins. J Mol Evol (1972) 5.16

On some principles governing molecular evolution. Proc Natl Acad Sci U S A (1974) 4.97

Multilayer white light-emitting organic electroluminescent device. Science (1995) 4.86

Genetic variability maintained in a finite population due to mutational production of neutral and nearly neutral isoalleles. Genet Res (1968) 4.83

The rate of molecular evolution considered from the standpoint of population genetics. Proc Natl Acad Sci U S A (1969) 4.75

Pattern of neutral polymorphism in a geographically structured population. Genet Res (1971) 4.65

Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3. Science (2000) 4.57

On the constancy of the evolutionary rate of cistrons. J Mol Evol (1971) 4.49

The age of a neutral mutant persisting in a finite population. Genetics (1973) 4.44

Genetic variability and effective population size when local extinction and recolonization of subpopulations are frequent. Proc Natl Acad Sci U S A (1980) 4.37

HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer. Oncogene (2012) 4.30

The basal ganglia and adaptive motor control. Science (1994) 4.27

Relation of serum lipoprotein levels and systolic blood pressure to early atherosclerosis. The Bogalusa Heart Study. N Engl J Med (1986) 4.26

Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size. Nat Nanotechnol (2011) 4.22

A trial of shortened zidovudine regimens to prevent mother-to-child transmission of human immunodeficiency virus type 1. Perinatal HIV Prevention Trial (Thailand) Investigators. N Engl J Med (2000) 4.14

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice. Nat Med (1997) 4.10

Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis. Proc Natl Acad Sci U S A (2000) 4.08

Telomere length as an indicator of biological aging: the gender effect and relation with pulse pressure and pulse wave velocity. Hypertension (2001) 4.07

Specific and nonspecific NK cell activation during virus infection. Nat Immunol (2001) 4.02

Preponderance of synonymous changes as evidence for the neutral theory of molecular evolution. Nature (1977) 4.00

Development of a pertussis component vaccine in Japan. Lancet (1984) 3.94

Repression of E-cadherin by the polycomb group protein EZH2 in cancer. Oncogene (2008) 3.92

Imaging membrane protein helical wheels. J Magn Reson (2000) 3.80

Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc. J Biol Chem (2000) 3.74

Distribution of allelic frequencies in a finite population under stepwise production of neutral alleles. Proc Natl Acad Sci U S A (1975) 3.64

Linkage disequilibrium between two segregating nucleotide sites under the steady flux of mutations in a finite population. Genetics (1971) 3.51

The average number of generations until extinction of an individual mutant gene in a finite population. Genetics (1969) 3.49

Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart Study. Aging Cell (2006) 3.44

"Fluorescent timer": protein that changes color with time. Science (2000) 3.42

Effect of overall phenotypic selection on genetic change at individual loci. Proc Natl Acad Sci U S A (1978) 3.41

Telomere length inversely correlates with pulse pressure and is highly familial. Hypertension (2000) 3.32

Structural basis of the redox switch in the OxyR transcription factor. Cell (2001) 3.32

Inhibition of human immunodeficiency virus gene amplification by heparin. J Clin Microbiol (1991) 3.32

Structure of the transmembrane region of the M2 protein H(+) channel. Protein Sci (2001) 3.31

Stepwise mutation model and distribution of allelic frequencies in a finite population. Proc Natl Acad Sci U S A (1978) 3.29

Longitudinal changes in cardiovascular risk from childhood to young adulthood in offspring of parents with coronary artery disease: the Bogalusa Heart Study. JAMA (1997) 3.24

Identification of sequences in a yeast histone promoter involved in periodic transcription. Cell (1986) 3.22

Obesity and cardiovascular risk in children. Ann N Y Acad Sci (1993) 3.10

Essential hypertension predicted by tracking of elevated blood pressure from childhood to adulthood: the Bogalusa Heart Study. Am J Hypertens (1995) 3.07

Adipose tissue isomeric trans fatty acids and risk of myocardial infarction in nine countries: the EURAMIC study. Lancet (1995) 3.03

Relation of circumferences and skinfold thicknesses to lipid and insulin concentrations in children and adolescents: the Bogalusa Heart Study. Am J Clin Nutr (1999) 2.91

Weighted-ensemble Brownian dynamics simulations for protein association reactions. Biophys J (1996) 2.87

Predicting protein diffusion coefficients. Proc Natl Acad Sci U S A (1993) 2.87

Kinetics of expression of multiply spliced RNA in early human immunodeficiency virus type 1 infection of lymphocytes and monocytes. Proc Natl Acad Sci U S A (1991) 2.81

Mutation and evolution at the molecular level. Genetics (1973) 2.79

Ischemic preconditioning induces selective translocation of protein kinase C isoforms epsilon and eta in the heart of conscious rabbits without subcellular redistribution of total protein kinase C activity. Circ Res (1997) 2.76

Genomic organization of Borna disease virus. Proc Natl Acad Sci U S A (1994) 2.74

Intracellular disposition and metabolism of fluorescently-labeled unmodified and modified oligonucleotides microinjected into mammalian cells. Nucleic Acids Res (1993) 2.72

Monoclonal antibodies to the extracellular domain of prostate-specific membrane antigen also react with tumor vascular endothelium. Cancer Res (1997) 2.72

Programmable matter by folding. Proc Natl Acad Sci U S A (2010) 2.65

Efficient expression of the Saccharomyces cerevisiae PGK gene depends on an upstream activation sequence but does not require TATA sequences. Mol Cell Biol (1986) 2.63

Sex differences in the evolution of the electrocardiographic QT interval with age. Can J Cardiol (1992) 2.63

Identification of c-myc responsive genes using rat cDNA microarray. Cancer Res (2000) 2.62

Adolescent overweight is associated with adult overweight and related multiple cardiovascular risk factors: the Bogalusa Heart Study. Metabolism (1996) 2.60


Ectopic hypermethylation of flower-specific genes in Arabidopsis. Curr Biol (2000) 2.59

C-Reactive protein binds to apoptotic cells, protects the cells from assembly of the terminal complement components, and sustains an antiinflammatory innate immune response: implications for systemic autoimmunity. J Exp Med (2000) 2.57

Akt/PKB promotes cancer cell invasion via increased motility and metalloproteinase production. FASEB J (2001) 2.55

Persistence of multiple cardiovascular risk clustering related to syndrome X from childhood to young adulthood. The Bogalusa Heart Study. Arch Intern Med (1994) 2.55

Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer. Nature (1996) 2.54

Tracking of serum lipids and lipoproteins from childhood to adulthood. The Bogalusa Heart Study. Am J Epidemiol (1991) 2.52

Fixation of a deleterious allele at one of two "duplicate" loci by mutation pressure and random drift. Proc Natl Acad Sci U S A (1979) 2.51