Functional analysis of epigenetic regulation of tandem RhopH1/clag genes reveals a role in Plasmodium falciparum growth.

PubWeight™: 0.99‹?› | Rank: Top 15%

🔗 View Article (PMC 3622951)

Published in Mol Microbiol on March 07, 2011

Authors

Christy A Comeaux1, Bradley I Coleman, Amy K Bei, Nicole Whitehurst, Manoj T Duraisingh

Author Affiliations

1: Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA.

Articles citing this

Transcriptional variation in the malaria parasite Plasmodium falciparum. Genome Res (2012) 2.15

Population genomic scan for candidate signatures of balancing selection to guide antigen characterization in malaria parasites. PLoS Genet (2012) 1.55

Solute restriction reveals an essential role for clag3-associated channels in malaria parasite nutrient acquisition. Mol Pharmacol (2012) 1.14

An epigenetic antimalarial resistance mechanism involving parasite genes linked to nutrient uptake. J Biol Chem (2013) 1.05

Epigenetic switches in clag3 genes mediate blasticidin S resistance in malaria parasites. Cell Microbiol (2013) 1.01

A view on the role of epigenetics in the biology of malaria parasites. PLoS Pathog (2012) 0.92

Recruitment of PfSET2 by RNA polymerase II to variant antigen encoding loci contributes to antigenic variation in P. falciparum. PLoS Pathog (2014) 0.90

Nuclear repositioning precedes promoter accessibility and is linked to the switching frequency of a Plasmodium falciparum invasion gene. Cell Host Microbe (2012) 0.89

Why do malaria parasites increase host erythrocyte permeability? Trends Parasitol (2014) 0.88

Strand-specific RNA sequencing in Plasmodium falciparum malaria identifies developmentally regulated long non-coding RNA and circular RNA. BMC Genomics (2015) 0.87

Deciphering the principles that govern mutually exclusive expression of Plasmodium falciparum clag3 genes. Nucleic Acids Res (2015) 0.84

The conserved clag multigene family of malaria parasites: essential roles in host-pathogen interaction. Drug Resist Updat (2014) 0.81

Variation in Plasmodium falciparum erythrocyte invasion phenotypes and merozoite ligand gene expression across different populations in areas of malaria endemicity. Infect Immun (2015) 0.78

An essential dual-function complex mediates erythrocyte invasion and channel-mediated nutrient uptake in malaria parasites. Elife (2017) 0.77

The Plasmodium falciparum rhoptry protein RhopH3 plays essential roles in host cell invasion and nutrient uptake. Elife (2017) 0.76

Malaria Parasite CLAG3, a Protein Linked to Nutrient Channels, Participates in High Molecular Weight Membrane-Associated Complexes in the Infected Erythrocyte. PLoS One (2016) 0.76

Plasmodium falciparum parasites deploy RhopH2 into the host erythrocyte to obtain nutrients, grow and replicate. Elife (2017) 0.75

Expression of the Plasmodium falciparum Clonally Variant clag3 Genes in Human Infections. J Infect Dis (2017) 0.75

Articles cited by this

Human malaria parasites in continuous culture. Science (1976) 59.70

Invasion of red blood cells by malaria parasites. Cell (2006) 5.94

Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil. Proc Natl Acad Sci U S A (1997) 5.75

A genome-wide map of diversity in Plasmodium falciparum. Nat Genet (2006) 4.50

Molecular mechanism for switching of P. falciparum invasion pathways into human erythrocytes. Science (2005) 2.81

Targeted disruption of an erythrocyte binding antigen in Plasmodium falciparum is associated with a switch toward a sialic acid-independent pathway of invasion. Proc Natl Acad Sci U S A (2000) 2.76

5' flanking region of var genes nucleate histone modification patterns linked to phenotypic inheritance of virulence traits in malaria parasites. Mol Microbiol (2007) 2.72

Negative selection of Plasmodium falciparum reveals targeted gene deletion by double crossover recombination. Int J Parasitol (2002) 2.70

Phenotypic variation of Plasmodium falciparum merozoite proteins directs receptor targeting for invasion of human erythrocytes. EMBO J (2003) 2.56

Mutually exclusive expression of virulence genes by malaria parasites is regulated independently of antigen production. PLoS Pathog (2006) 2.18

Epigenetic memory at malaria virulence genes. Proc Natl Acad Sci U S A (2007) 2.11

Distinct external signals trigger sequential release of apical organelles during erythrocyte invasion by malaria parasites. PLoS Pathog (2010) 2.01

Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum. PLoS Biol (2009) 1.72

Epigenetic silencing of Plasmodium falciparum genes linked to erythrocyte invasion. PLoS Pathog (2007) 1.63

Rhoptry neck protein RON2 forms a complex with microneme protein AMA1 in Plasmodium falciparum merozoites. Parasitol Int (2008) 1.52

Isolation of a Plasmodium falciparum rhoptry protein. Mol Biochem Parasitol (1985) 1.45

Variable switching rates of malaria virulence genes are associated with chromosomal position. Mol Microbiol (2007) 1.45

The high molecular mass rhoptry protein, RhopH1, is encoded by members of the clag multigene family in Plasmodium falciparum and Plasmodium yoelii. Mol Biochem Parasitol (2001) 1.33

Apical expression of three RhopH1/Clag proteins as components of the Plasmodium falciparum RhopH complex. Mol Biochem Parasitol (2005) 1.26

The Plasmodium falciparum clag9 gene encodes a rhoptry protein that is transferred to the host erythrocyte upon invasion. Mol Microbiol (2004) 1.17

Epigenetic control of the variable expression of a Plasmodium falciparum receptor protein for erythrocyte invasion. Proc Natl Acad Sci U S A (2010) 1.17

Primary structure of a Plasmodium falciparum rhoptry antigen. Mol Biochem Parasitol (1991) 1.15

Diversity and evolution of the rhoph1/clag multigene family of Plasmodium falciparum. Mol Biochem Parasitol (2007) 1.14

Mutually exclusive var gene expression in the malaria parasite: multiple layers of regulation. Trends Parasitol (2008) 1.00

Analysis of the high molecular weight rhoptry complex of Plasmodium falciparum using monoclonal antibodies. Parasitology (1994) 0.96

Interaction of the 140/130/110 kDa rhoptry protein complex of Plasmodium falciparum with the erythrocyte membrane and liposomes. Exp Parasitol (1991) 0.92

Localisation and timing of expression of putative Plasmodium berghei rhoptry proteins in merozoites and sporozoites. Mol Biochem Parasitol (2009) 0.91

Conserved regions of the Plasmodium yoelii rhoptry protein RhopH3 revealed by comparison with the P. falciparum homologue. Mol Biochem Parasitol (2001) 0.87

The CLAG/RhopH1 locus on chromosome 3 of Plasmodium falciparum: two genes or two alleles of the same gene? Mol Biochem Parasitol (2006) 0.85

Genetic analysis of the cytoplasmic domain of the PfRh2b merozoite invasion protein of Plasmodium falciparum. Int J Parasitol (2008) 0.84

Erythrocyte invasion by Plasmodium falciparum: multiple ligand-receptor interactions and phenotypic switching. Subcell Biochem (2008) 0.83

Rhop-3 protein conservation among Plasmodium species and induced protection against lethal P. yoelii and P. berghei challenge. Parasitol Res (2006) 0.80

Articles by these authors

A genome-wide map of diversity in Plasmodium falciparum. Nat Genet (2006) 4.50

An intermediate grade of finished genomic sequence suitable for comparative analyses. Genome Res (2004) 4.38

Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum. Nature (2011) 3.83

Plasmodium falciparum erythrocyte invasion through glycophorin C and selection for Gerbich negativity in human populations. Nat Med (2002) 3.29

A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes. Science (2010) 3.27

Molecular mechanism for switching of P. falciparum invasion pathways into human erythrocytes. Science (2005) 2.81

A novel erythrocyte binding antigen-175 paralogue from Plasmodium falciparum defines a new trypsin-resistant receptor on human erythrocytes. J Biol Chem (2003) 2.08

Reticulocyte-binding protein homologue 1 is required for sialic acid-dependent invasion into human erythrocytes by Plasmodium falciparum. Mol Microbiol (2005) 1.98

Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum. PLoS Biol (2009) 1.72

Evidence-based annotation of the malaria parasite's genome using comparative expression profiling. PLoS One (2008) 1.61

A flow cytometry-based assay for measuring invasion of red blood cells by Plasmodium falciparum. Am J Hematol (2010) 1.57

Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum. J Med Chem (2009) 1.42

Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J Biol Chem (2008) 1.34

Laboratory malaria diagnostic capacity in health facilities in five administrative zones of Oromia Regional State, Ethiopia. Trop Med Int Health (2010) 1.31

A DOC2 protein identified by mutational profiling is essential for apicomplexan parasite exocytosis. Science (2012) 1.24

Plasmodium falciparum Sir2: an unusual sirtuin with dual histone deacetylase and ADP-ribosyltransferase activity. Eukaryot Cell (2007) 1.21

Variant merozoite protein expression is associated with erythrocyte invasion phenotypes in Plasmodium falciparum isolates from Tanzania. Mol Biochem Parasitol (2007) 1.20

Suggestive evidence for Darwinian Selection against asparagine-linked glycans of Plasmodium falciparum and Toxoplasma gondii. Eukaryot Cell (2009) 1.20

Heterochromatin-mediated control of virulence gene expression. Mol Microbiol (2006) 1.12

Identification by functional proteomics of a deubiquitinating/deNeddylating enzyme in Plasmodium falciparum. Mol Microbiol (2006) 1.11

Molecular analysis of erythrocyte invasion in Plasmodium falciparum isolates from Senegal. Infect Immun (2007) 1.11

Transcriptional control and gene silencing in Plasmodium falciparum. Cell Microbiol (2008) 1.04

Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors. Chem Biol (2011) 1.04

In vitro genetic analysis of an erythrocyte determinant of malaria infection. J Infect Dis (2010) 1.04

A mitogen-activated protein kinase regulates male gametogenesis and transmission of the malaria parasite Plasmodium berghei. EMBO Rep (2005) 1.03

Antisense RNA and RNAi in protozoan parasites: working hard or hardly working? Mol Biochem Parasitol (2007) 1.02

Plasmodium falciparum merozoite surface antigen, PfRH5, elicits detectable levels of invasion-inhibiting antibodies in humans. J Infect Dis (2013) 1.01

Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors. Bioorg Med Chem Lett (2008) 1.00

Changes in drug sensitivity and anti-malarial drug resistance mutations over time among Plasmodium falciparum parasites in Senegal. Malar J (2013) 0.98

Analysis of pfhrp2 genetic diversity in Senegal and implications for use of rapid diagnostic tests. Malar J (2014) 0.97

Improving malaria control in West Africa: interruption of transmission as a paradigm shift. Acta Trop (2011) 0.96

Epigenetics in Plasmodium: what do we really know? Eukaryot Cell (2010) 0.96

Functional diversification between two related Plasmodium falciparum merozoite invasion ligands is determined by changes in the cytoplasmic domain. Mol Microbiol (2010) 0.96

Cooperativity between Plasmodium falciparum adhesive proteins for invasion into erythrocytes. Mol Microbiol (2009) 0.95

SNP genotyping identifies new signatures of selection in a deep sample of West African Plasmodium falciparum malaria parasites. Mol Biol Evol (2012) 0.95

Epigenetic dysregulation of virulence gene expression in severe Plasmodium falciparum malaria. J Infect Dis (2012) 0.94

Evolution of the pfcrt T76 and pfmdr1 Y86 markers and chloroquine susceptibility 8 years after cessation of chloroquine use in Pikine, Senegal. Parasitol Res (2012) 0.92

Malaria evolution in South Asia: knowledge for control and elimination. Acta Trop (2012) 0.91

Characterization and structural studies of the Plasmodium falciparum ubiquitin and Nedd8 hydrolase UCHL3. J Biol Chem (2009) 0.91

Human red blood cell-adapted Plasmodium knowlesi parasites: a new model system for malaria research. Cell Microbiol (2014) 0.91

Evolution of apicomplexan secretory organelles. Int J Parasitol (2012) 0.90

Functional analysis of erythrocyte determinants of Plasmodium infection. Int J Parasitol (2012) 0.90

Nuclear repositioning precedes promoter accessibility and is linked to the switching frequency of a Plasmodium falciparum invasion gene. Cell Host Microbe (2012) 0.89

Whole genome profiling of spontaneous and chemically induced mutations in Toxoplasma gondii. BMC Genomics (2014) 0.89

Population genetic analysis of large sequence polymorphisms in Plasmodium falciparum blood-stage antigens. Infect Genet Evol (2009) 0.89

Inhibitory humoral responses to the Plasmodium falciparum vaccine candidate EBA-175 are independent of the erythrocyte invasion pathway. Clin Vaccine Immunol (2013) 0.88

Trypanosoma cruzi triggers an early type I IFN response in vivo at the site of intradermal infection. J Immunol (2009) 0.88

Antiparasitic chemotherapy: from genomes to mechanisms. Annu Rev Pharmacol Toxicol (2013) 0.88

Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum. Antimicrob Agents Chemother (2011) 0.86

The effect of Plasmodium falciparum Sir2a histone deacetylase on clonal and longitudinal variation in expression of the var family of virulence genes. Int J Parasitol (2009) 0.84

Genetic analysis of the cytoplasmic domain of the PfRh2b merozoite invasion protein of Plasmodium falciparum. Int J Parasitol (2008) 0.84

Specific phosphorylation of the PfRh2b invasion ligand of Plasmodium falciparum. Biochem J (2013) 0.83

Host-parasite interactions that guide red blood cell invasion by malaria parasites. Curr Opin Hematol (2015) 0.82

Identification and disruption of the gene encoding the third member of the low-molecular-mass rhoptry complex in Plasmodium falciparum. Infect Immun (2002) 0.82

Enrichment of reticulocytes from whole blood using aqueous multiphase systems of polymers. Am J Hematol (2014) 0.81

Unravelling a histone code for malaria virulence. Mol Microbiol (2007) 0.75

Distribution of erythrocyte binding antigen 175 (EBA-175) alleles and ABO blood groups in a hypoendemic area in Senegal. J Infect Dev Ctries (2012) 0.75

Optimization of flow cytometric detection and cell sorting of transgenic Plasmodium parasites using interchangeable optical filters. Malar J (2012) 0.75

Erratum: Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony. Nat Microbiol (2017) 0.75