Published in J Phys Condens Matter on April 26, 2010
Hepatic stellate cells require a stiff environment for myofibroblastic differentiation. Am J Physiol Gastrointest Liver Physiol (2011) 1.70
Hepatic stellate cells and portal fibroblasts are the major cellular sources of collagens and lysyl oxidases in normal liver and early after injury. Am J Physiol Gastrointest Liver Physiol (2013) 1.28
From tissue mechanics to transcription factors. Differentiation (2013) 1.16
Biophysical properties of normal and diseased renal glomeruli. Am J Physiol Cell Physiol (2010) 1.07
Augmentation of integrin-mediated mechanotransduction by hyaluronic acid. Biomaterials (2013) 1.05
Measuring the mechanical properties of living cells using atomic force microscopy. J Vis Exp (2013) 1.02
Biomechanics of TGFβ-induced epithelial-mesenchymal transition: implications for fibrosis and cancer. Clin Transl Med (2014) 0.99
Tissue mechanics and fibrosis. Biochim Biophys Acta (2013) 0.97
Smooth muscle tension induces invasive remodeling of the zebrafish intestine. PLoS Biol (2012) 0.96
Compression stiffening of brain and its effect on mechanosensing by glioma cells. New J Phys (2014) 0.92
Role of constitutive behavior and tumor-host mechanical interactions in the state of stress and growth of solid tumors. PLoS One (2014) 0.90
The mechanical environment modulates intracellular calcium oscillation activities of myofibroblasts. PLoS One (2013) 0.90
Multilayer material properties of aorta determined from nanoindentation tests. J Mech Behav Biomed Mater (2012) 0.88
Inelastic behaviour of collagen networks in cell-matrix interactions and mechanosensation. J R Soc Interface (2015) 0.86
Modulation of matrix elasticity with PEG hydrogels to study melanoma drug responsiveness. Biomaterials (2014) 0.86
Lack of collagen XVIII long isoforms affects kidney podocytes, whereas the short form is needed in the proximal tubular basement membrane. J Biol Chem (2010) 0.81
Adipose stroma induces branching morphogenesis of engineered epithelial tubules. Tissue Eng Part A (2010) 0.81
Hypertension-linked mechanical changes of rat gut. Acta Biomater (2016) 0.77
MEMS-based shear characterization of soft hydrated samples. J Micromech Microeng (2013) 0.76
A biomimetic gelatin-based platform elicits a pro-differentiation effect on podocytes through mechanotransduction. Sci Rep (2017) 0.76
Characterization of changes to the mechanical properties of arteries due to cold storage using nanoindentation tests. Ann Biomed Eng (2012) 0.75
Substrate Stiffness Influences Doxorubicin-Induced p53 Activation via ROCK2 Expression. Biomed Res Int (2017) 0.75
Biochemical and Cellular Determinants of Renal Glomerular Elasticity. PLoS One (2016) 0.75
PEG-peptide hydrogels reveal differential effects of matrix microenvironmental cues on melanoma drug sensitivity. Integr Biol (Camb) (2017) 0.75
Tension in Cancer. Int J Mol Sci (2016) 0.75
Two-Layer Elastographic 3-D Traction Force Microscopy. Sci Rep (2017) 0.75
Role played by Prx1-dependent extracellular matrix properties in vascular smooth muscle development in embryonic lungs. Pulm Circ (2015) 0.75
Water jet indentation for local elasticity measurements of soft materials. Eur Phys J E Soft Matter (2016) 0.75
Nerve Root Compression Increases Spinal Astrocytic Vimentin in Parallel with Sustained Pain and Endothelial Vimentin in Association with Spinal Vascular Reestablishment. Spine (Phila Pa 1976) (2017) 0.75
Matrix elasticity directs stem cell lineage specification. Cell (2006) 43.00
Tissue cells feel and respond to the stiffness of their substrate. Science (2005) 23.42
Reversible unfolding of individual titin immunoglobulin domains by AFM. Science (1997) 19.62
Cell locomotion and focal adhesions are regulated by substrate flexibility. Proc Natl Acad Sci U S A (1997) 19.46
Tensional homeostasis and the malignant phenotype. Cancer Cell (2005) 19.30
Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell (2009) 14.40
Breast density and parenchymal patterns as markers of breast cancer risk: a meta-analysis. Cancer Epidemiol Biomarkers Prev (2006) 10.35
Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion. Cell Motil Cytoskeleton (2005) 10.20
Growth factors, matrices, and forces combine and control stem cells. Science (2009) 8.46
Elastic moduli of breast and prostate tissues under compression. Ultrason Imaging (1998) 6.90
Substrate compliance versus ligand density in cell on gel responses. Biophys J (2004) 6.71
Noninvasive assessment of liver fibrosis by measurement of stiffness in patients with chronic hepatitis C. Hepatology (2005) 5.93
Magnetic resonance elastography: non-invasive mapping of tissue elasticity. Med Image Anal (2001) 5.86
Hyperfiltration in remnant nephrons: a potentially adverse response to renal ablation. Am J Physiol (1981) 4.75
Fibroblast adaptation and stiffness matching to soft elastic substrates. Biophys J (2007) 4.59
Cell mechanics: integrating cell responses to mechanical stimuli. Annu Rev Biomed Eng (2007) 3.70
Increased stiffness of the rat liver precedes matrix deposition: implications for fibrosis. Am J Physiol Gastrointest Liver Physiol (2007) 3.68
A mechanosensitive transcriptional mechanism that controls angiogenesis. Nature (2009) 3.44
The role of matrix stiffness in regulating cell behavior. Hepatology (2008) 2.86
Cell type-specific response to growth on soft materials. J Appl Physiol (1985) (2005) 2.78
A mathematical analysis for indentation tests of articular cartilage. J Biomech (1972) 2.67
Connective tissue morphogenesis by fibroblast traction. I. Tissue culture observations. Dev Biol (1982) 2.54
Non-linear elasticity of extracellular matrices enables contractile cells to communicate local position and orientation. PLoS One (2009) 2.06
Biomechanics: cell research and applications for the next decade. Ann Biomed Eng (2009) 1.81
Microtissue elasticity: measurements by atomic force microscopy and its influence on cell differentiation. Methods Cell Biol (2007) 1.74
Cholesterol depletion increases membrane stiffness of aortic endothelial cells. Biophys J (2004) 1.71
Indentation and adhesive probing of a cell membrane with AFM: theoretical model and experiments. Biophys J (2005) 1.56
Hemodynamic basis for glomerular injury in rats with desoxycorticosterone-salt hypertension. J Clin Invest (1984) 1.55
Demystifying the effects of a three-dimensional microenvironment in tissue morphogenesis. Methods Cell Biol (2007) 1.43
Comparative materials differences revealed in engineered bone as a function of cell-specific differentiation. Nat Mater (2009) 1.42
A simple microindentation technique for mapping the microscale compliance of soft hydrated materials and tissues. J Biomed Mater Res A (2006) 1.34
Biomechanical regulation of cell orientation and fate. Oncogene (2008) 1.31
Mammographic density: a heritable risk factor for breast cancer. Methods Mol Biol (2009) 1.24
Nanoindentation of soft hydrated materials for application to vascular tissues. J Biomed Mater Res A (2004) 1.22
A star-PEG-heparin hydrogel platform to aid cell replacement therapies for neurodegenerative diseases. Biomaterials (2009) 1.19
Mechanical properties of hyaline and repair cartilage studied by nanoindentation. Acta Biomater (2007) 1.05
Glomerular damage after uninephrectomy in young rats. I. Hypertrophy and distortion of capillary architecture. Kidney Int (1992) 1.01
Surface detection errors cause overestimation of the modulus in nanoindentation on soft materials. J Mech Behav Biomed Mater (2008) 1.01
Preparation and study of isolated glomeruli. Methods Enzymol (1990) 0.92
Nonmuscle actin-binding proteins. Annu Rev Cell Biol (1985) 5.46
Actin-binding protein requirement for cortical stability and efficient locomotion. Science (1992) 4.66
Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets. Cell (1995) 4.39
Modulation of gelsolin function by phosphatidylinositol 4,5-bisphosphate. Nature (1987) 3.99
MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium-calmodulin. Nature (1992) 3.49
Cofilin is an essential component of the yeast cortical cytoskeleton. J Cell Biol (1993) 3.23
Corequirement of specific phosphoinositides and small GTP-binding protein Cdc42 in inducing actin assembly in Xenopus egg extracts. J Cell Biol (1998) 2.90
Transposon-mediated site-specific recombination: identification of three binding sites for resolvase at the res sites of gamma delta and Tn3. Cell (1982) 2.74
The polyelectrolyte nature of F-actin and the mechanism of actin bundle formation. J Biol Chem (1996) 2.65
Signaling pathways and cell mechanics involved in wound closure by epithelial cell sheets. Curr Biol (2000) 2.52
Interactions of gelsolin and gelsolin-actin complexes with actin. Effects of calcium on actin nucleation, filament severing, and end blocking. Biochemistry (1985) 2.16
Polyphosphoinositide micelles and polyphosphoinositide-containing vesicles dissociate endogenous gelsolin-actin complexes and promote actin assembly from the fast-growing end of actin filaments blocked by gelsolin. J Biol Chem (1987) 2.08
The COOH terminus of the c-Abl tyrosine kinase contains distinct F- and G-actin binding domains with bundling activity. J Cell Biol (1994) 2.07
Release of the antimicrobial peptide LL-37 from DNA/F-actin bundles in cystic fibrosis sputum. Eur Respir J (2007) 2.06
Structure and mobility of actin filaments as measured by quasielastic light scattering, viscometry, and electron microscopy. J Biol Chem (1986) 1.99
Reversible binding of actin to gelsolin and profilin in human platelet extracts. J Cell Biol (1987) 1.97
F-actin, a model polymer for semiflexible chains in dilute, semidilute, and liquid crystalline solutions. Biophys J (1996) 1.96
Identification of a polyphosphoinositide-binding sequence in an actin monomer-binding domain of gelsolin. J Biol Chem (1992) 1.95
Mutations in the GTP-binding site of GS alpha alter stimulation of adenylyl cyclase. J Biol Chem (1989) 1.95
Thymosin beta 15: a novel regulator of tumor cell motility upregulated in metastatic prostate cancer. Nat Med (1996) 1.94
The actin filament-severing domain of plasma gelsolin. J Cell Biol (1986) 1.93
The role of actin-binding protein 280 in integrin-dependent mechanoprotection. J Biol Chem (1998) 1.89
Identification of critical functional and regulatory domains in gelsolin. J Cell Biol (1989) 1.88
Identification of a polyphosphoinositide-modulated domain in gelsolin which binds to the sides of actin filaments. J Cell Biol (1988) 1.76
Renin expression in renal proximal tubule. J Clin Invest (1993) 1.74
RETROPERITONEAL RUPTURE OF THE DUODENUM BY BLUNT FORCE. Ann Surg (1916) 1.74
Right-sided Staphylococcus aureus endocarditis in intravenous drug abusers: two-week combination therapy. Ann Intern Med (1988) 1.67
Identification of receptor contact site involved in receptor-G protein coupling. Nature (1988) 1.65
Biomechanical analysis of experimental diffuse axonal injury. J Neurotrauma (1995) 1.57
Oligomeric structure of type I and type II transforming growth factor beta receptors: homodimers form in the ER and persist at the plasma membrane. J Cell Biol (1998) 1.56
Bidirectional translocation of neurofilaments along microtubules mediated in part by dynein/dynactin. Mol Biol Cell (2000) 1.56
Retroperitoneal laparoscopic radical nephrectomy: the Cleveland clinic experience. J Urol (2000) 1.52
Conformational states of fibronectin. Effects of pH, ionic strength, and collagen binding. J Biol Chem (1982) 1.52
Mechanical properties of actin filament networks depend on preparation, polymerization conditions, and storage of actin monomers. Biophys J (1998) 1.51
Differential regulation of Na/H antiporter by acid in renal epithelial cells and fibroblasts. J Clin Invest (1991) 1.48
Impact of Helicobacter hepaticus infection in B6C3F1 mice from twelve National Toxicology Program two-year carcinogenesis studies. Toxicol Pathol (1998) 1.47
Indications for chest roentgenogram in the febrile young infant. Pediatr Emerg Care (1989) 1.46
Structure of the profilin-poly-L-proline complex involved in morphogenesis and cytoskeletal regulation. Nat Struct Biol (1997) 1.44
Laparoscopic radical nephroureterectomy for upper tract transitional cell carcinoma: the Cleveland Clinic experience. J Urol (2000) 1.42
Transrectal ultrasound guided prostate biopsy--defining a new standard. J Urol (2000) 1.42
Isolation and properties of two actin-binding domains in gelsolin. J Biol Chem (1985) 1.41
Short-course intensity-modulated radiotherapy (70 GY at 2.5 GY per fraction) for localized prostate cancer: preliminary results on late toxicity and quality of life. Int J Radiat Oncol Biol Phys (2001) 1.41
Mechanisms of mitochondria-neurofilament interactions. J Neurosci (2003) 1.41
Cobalamin deficiency associated with methylmalonic acidemia in a cat. J Am Vet Med Assoc (1992) 1.40
Interactions of tensin with actin and identification of its three distinct actin-binding domains. J Cell Biol (1994) 1.40
Can prostate specific antigen derivatives reduce the frequency of unnecessary prostate biopsies? J Urol (1996) 1.40
Reduction in viscosity of cystic fibrosis sputum in vitro by gelsolin. Science (1994) 1.38
Molecular characteristics of Na(+)-coupled glucose transporters in adult and embryonic rat kidney. J Biol Chem (1995) 1.38
Left ventricular diverticulum: MRI demonstration (congenital broad-based left ventricular aneurysm) Pediatr Radiol (1994) 1.38
Cooperativity in F-actin: binding of gelsolin at the barbed end affects structure and dynamics of the whole filament. J Mol Biol (1996) 1.37
Mechanical effects of neurofilament cross-bridges. Modulation by phosphorylation, lipids, and interactions with F-actin. J Biol Chem (1996) 1.37
Cell permeant polyphosphoinositide-binding peptides that block cell motility and actin assembly. J Biol Chem (2001) 1.35
Carboxyl terminal domain of Gs alpha specifies coupling of receptors to stimulation of adenylyl cyclase. Science (1988) 1.35
Analysis of the gamma delta res site. Sites required for site-specific recombination and gene expression. J Mol Biol (1984) 1.35
Factor IX inhibitors and anaphylaxis in hemophilia B. J Pediatr Hematol Oncol (1997) 1.34
The high affinity Na+/glucose cotransporter. Re-evaluation of function and distribution of expression. J Biol Chem (1994) 1.31
LROC analysis of detector-response compensation in SPECT. IEEE Trans Med Imaging (2000) 1.31
Role of plasma gelsolin and the vitamin D-binding protein in clearing actin from the circulation. J Clin Invest (1986) 1.30
Distribution of actin filament lengths measured by fluorescence microscopy. Am J Physiol (1992) 1.28
Hierarchical self-assembly of F-actin and cationic lipid complexes: stacked three-layer tubule networks. Science (2000) 1.28
Polyproline affinity method for purification of platelet profilin and modification with pyrene-maleimide. Methods Enzymol (1991) 1.27
Opposite effects of electrostatics and steric exclusion on bundle formation by F-actin and other filamentous polyelectrolytes. Biochemistry (1997) 1.26
The soluble exoplasmic domain of the type II transforming growth factor (TGF)-beta receptor. A heterogeneously glycosylated protein with high affinity and selectivity for TGF-beta ligands. J Biol Chem (1995) 1.25
Interaction of the calcium-sensing receptor and filamin, a potential scaffolding protein. J Biol Chem (2001) 1.25
Declining rates of extracapsular extension after radical prostatectomy: evidence for continued stage migration. J Clin Oncol (1999) 1.24
Laparoscopic radical cystoprostatectomy with ileal conduit performed completely intracorporeally: the initial 2 cases. Urology (2000) 1.23
Domain analysis of cortexillin I: actin-bundling, PIP(2)-binding and the rescue of cytokinesis. EMBO J (1999) 1.23
Modulation of gelsolin function. Activation at low pH overrides Ca2+ requirement. J Biol Chem (1993) 1.23
Increased ADAMTS-13 proteolytic activity in rat hepatic stellate cells upon activation in vitro and in vivo. J Thromb Haemost (2006) 1.22
Profilin, a weak CAP for actin and RAS. Cell (1991) 1.21
Association between a CYP3A4 genetic variant and clinical presentation in African-American prostate cancer patients. Cancer Epidemiol Biomarkers Prev (1999) 1.20
The C termini of constitutive nitric-oxide synthases control electron flow through the flavin and heme domains and affect modulation by calmodulin. J Biol Chem (2000) 1.20
Cofilin and gelsolin segment-1: molecular dynamics simulation and biochemical analysis predict a similar actin binding mode. J Mol Biol (1998) 1.20
Impact of diagnostic ureteroscopy on long-term survival in patients with upper tract transitional cell carcinoma. J Urol (1999) 1.19
D3 phosphoinositides and outside-in integrin signaling by glycoprotein IIb-IIIa mediate platelet actin assembly and filopodial extension induced by phorbol 12-myristate 13-acetate. J Biol Chem (1996) 1.19
Expression of mRNA (D2) encoding a protein involved in amino acid transport in S3 proximal tubule. Am J Physiol (1992) 1.18
Sequential binding of actin monomers to plasma gelsolin and its inhibition by vitamin D-binding protein. Biochem Biophys Res Commun (1986) 1.17
Viruses in idiopathic inflammatory myopathies: absence of candidate viral genomes in muscle. Lancet (1992) 1.17
Semisynthesis and biological activity of porcine [LeuB24]insulin and [LeuB25]insulin. Proc Natl Acad Sci U S A (1980) 1.16
Purification and characterization of the alpha subunit of G13. J Biol Chem (1994) 1.16
Depression of gelsolin levels and detection of gelsolin-actin complexes in plasma of patients with acute lung injury. Am Rev Respir Dis (1988) 1.15
Biochemical failure does not predict overall survival after radical prostatectomy for localized prostate cancer: 10-year results. Urology (1999) 1.14
Isolation of an olfactory cDNA: similarity to retinol-binding protein suggests a role in olfaction. Science (1987) 1.14
Quantitative measurement of plasma gelsolin and its incorporation into fibrin clots. J Lab Clin Med (1987) 1.14
Distinct biochemical characteristics of the two human profilin isoforms. Eur J Biochem (1995) 1.12
Family history of prostate cancer in patients with localized prostate cancer: an independent predictor of treatment outcome. J Clin Oncol (1997) 1.11
Gelsolin displaces phalloidin from actin filaments. A new fluorescence method shows that both Ca2+ and Mg2+ affect the rate at which gelsolin severs F-actin. J Biol Chem (1994) 1.11
The structure of divalent cation-induced aggregates of PIP2 and their alteration by gelsolin and tau. Biophys J (1997) 1.10
Phalloidin binding and rheological differences among actin isoforms. Biochemistry (1996) 1.10
Evidence that a 27-residue sequence is the actin-binding site of ABP-120. J Biol Chem (1991) 1.09
Kinetics of actin monomer exchange at the slow growing ends of actin filaments and their relation to the elongation of filaments shortened by gelsolin. J Muscle Res Cell Motil (1986) 1.09
Mechanical perturbation elicits a phenotypic difference between Dictyostelium wild-type cells and cytoskeletal mutants. Biophys J (1996) 1.08
The actin side-binding domain of gelsolin also caps actin filaments. Implications for actin filament severing. J Biol Chem (1994) 1.08
The plasma and cytoplasmic forms of human gelsolin differ in disulfide structure. Biochemistry (1996) 1.08
Stage T1-2 prostate cancer: a multivariate analysis of factors affecting biochemical and clinical failures after radical prostatectomy. Int J Radiat Oncol Biol Phys (1997) 1.08
Cloning and chromosomal localization of a human kidney cDNA involved in cystine, dibasic, and neutral amino acid transport. J Clin Invest (1993) 1.07
Renal oncocytoma: clinical and biological correlates. J Urol (1993) 1.07
Identification and fine mapping of a region showing a high frequency of allelic imbalance on chromosome 16q23.2 that corresponds to a prostate cancer susceptibility locus. Cancer Res (2000) 1.06
Actin filaments mediate DNA fiber formation in chronic inflammatory airway disease. Am J Pathol (1996) 1.06
Gelsolin concentration in cerebrospinal fluid from patients with multiple sclerosis and other neurological disorders. Eur J Neurol (2008) 1.06