Published in Neoplasia on February 01, 2011
Glutamine and cancer: cell biology, physiology, and clinical opportunities. J Clin Invest (2013) 3.46
Cellular metabolism and disease: what do metabolic outliers teach us? Cell (2012) 2.90
Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo. Cell Metab (2012) 2.86
Kinetic modeling of hyperpolarized 13C label exchange between pyruvate and lactate in tumor cells. J Biol Chem (2011) 1.76
In situ detection of PHIP at 48 mT: demonstration using a centrally controlled polarizer. J Am Chem Soc (2010) 1.60
Monitoring urea transport in rat kidney in vivo using hyperpolarized ¹³C magnetic resonance imaging. Am J Physiol Renal Physiol (2012) 1.60
Hyperpolarized 13C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging. Proc Natl Acad Sci U S A (2011) 1.52
Hyperpolarized [1-13C]-ascorbic and dehydroascorbic acid: vitamin C as a probe for imaging redox status in vivo. J Am Chem Soc (2011) 1.47
A pulsed injection parahydrogen generator and techniques for quantifying enrichment. J Magn Reson (2011) 1.40
BDPA: an efficient polarizing agent for fast dissolution dynamic nuclear polarization NMR spectroscopy. Chemistry (2011) 1.39
Magnetic resonance imaging of tumor glycolysis using hyperpolarized 13C-labeled glucose. Nat Med (2013) 1.35
Molecular body imaging: MR imaging, CT, and US. part I. principles. Radiology (2012) 1.33
A large volume double channel 1H-X RF probe for hyperpolarized magnetic resonance at 0.0475 T. J Magn Reson (2012) 1.29
Stable isotope-resolved metabolomics and applications for drug development. Pharmacol Ther (2011) 1.29
Molecular imaging for personalized cancer care. Mol Oncol (2012) 1.28
The return of metabolism: biochemistry and physiology of the pentose phosphate pathway. Biol Rev Camb Philos Soc (2014) 1.27
Cancer metabolic reprogramming: importance, main features, and potentials for precise targeted anti-cancer therapies. Cancer Biol Med (2014) 1.27
Non-invasive in vivo assessment of IDH1 mutational status in glioma. Nat Commun (2013) 1.26
Role of glutamine in cancer: therapeutic and imaging implications. J Nucl Med (2011) 1.25
NMR hyperpolarization techniques for biomedicine. Chemistry (2014) 1.21
Hyperpolarized magnetic resonance as a sensitive detector of metabolic function. Biochemistry (2014) 1.20
Metabolic reprogramming and validation of hyperpolarized 13C lactate as a prostate cancer biomarker using a human prostate tissue slice culture bioreactor. Prostate (2013) 1.15
Could 13C MRI assist clinical decision-making for patients with heart disease? NMR Biomed (2011) 1.14
Irreversible catalyst activation enables hyperpolarization and water solubility for NMR signal amplification by reversible exchange. J Phys Chem B (2014) 1.14
PASADENA hyperpolarized 13C phospholactate. J Am Chem Soc (2012) 1.12
Metabolite kinetics in C6 rat glioma model using magnetic resonance spectroscopic imaging of hyperpolarized [1-(13)C]pyruvate. Magn Reson Med (2012) 1.08
Low-field MRI can be more sensitive than high-field MRI. J Magn Reson (2013) 1.08
Impact of Gd3+ on DNP of [1-13C]pyruvate doped with trityl OX063, BDPA, or 4-oxo-TEMPO. J Phys Chem A (2012) 1.07
Clinical implications of cardiac hyperpolarized magnetic resonance imaging. J Cardiovasc Magn Reson (2013) 1.07
Insufficient insulin administration to diabetic rats increases substrate utilization and maintains lactate production in the kidney. Physiol Rep (2014) 1.06
Glycolytic inhibition alters anaplastic thyroid carcinoma tumor metabolism and improves response to conventional chemotherapy and radiation. Mol Cancer Ther (2012) 1.06
High resolution (13)C MRI with hyperpolarized urea: in vivo T(2) mapping and (15)N labeling effects. IEEE Trans Med Imaging (2013) 1.05
The feasibility of formation and kinetics of NMR signal amplification by reversible exchange (SABRE) at high magnetic field (9.4 T). J Am Chem Soc (2014) 1.04
Microtesla SABRE enables 10% nitrogen-15 nuclear spin polarization. J Am Chem Soc (2015) 1.03
Rapid sequential injections of hyperpolarized [1-¹³C]pyruvate in vivo using a sub-kelvin, multi-sample DNP polarizer. Magn Reson Imaging (2012) 1.03
Fast volumetric imaging of ethanol metabolism in rat liver with hyperpolarized [1-(13) C]pyruvate. NMR Biomed (2012) 1.03
New frontiers and developing applications in 19F NMR. Prog Nucl Magn Reson Spectrosc (2012) 1.02
Simultaneous steady-state and dynamic 13C NMR can differentiate alternative routes of pyruvate metabolism in living cancer cells. J Biol Chem (2014) 1.01
Facing and Overcoming Sensitivity Challenges in Biomolecular NMR Spectroscopy. Angew Chem Int Ed Engl (2015) 1.01
Parahydrogen induced polarization of 1-(13)C-phospholactate-d(2) for biomedical imaging with >30,000,000-fold NMR signal enhancement in water. Anal Chem (2014) 1.01
(15)N Hyperpolarization by Reversible Exchange Using SABRE-SHEATH. J Phys Chem C Nanomater Interfaces (2015) 1.01
Treatment with the MEK inhibitor U0126 induces decreased hyperpolarized pyruvate to lactate conversion in breast, but not prostate, cancer cells. NMR Biomed (2012) 1.00
Use of hyperpolarized [1-13C]pyruvate and [2-13C]pyruvate to probe the effects of the anticancer agent dichloroacetate on mitochondrial metabolism in vivo in the normal rat. Magn Reson Imaging (2012) 1.00
Hyperpolarized [1-13C] glutamate: a metabolic imaging biomarker of IDH1 mutational status in glioma. Cancer Res (2014) 0.99
Direct and cost-efficient hyperpolarization of long-lived nuclear spin states on universal (15)N2-diazirine molecular tags. Sci Adv (2016) 0.99
Can NMR solve some significant challenges in metabolomics? J Magn Reson (2015) 0.98
Tumor mechanics and metabolic dysfunction. Free Radic Biol Med (2014) 0.97
Accessing long-lived nuclear singlet states between chemically equivalent spins without breaking symmetry. Nat Phys (2012) 0.97
Electron spin resonance studies of trityl OX063 at a concentration optimal for DNP. Phys Chem Chem Phys (2013) 0.95
Probing lactate dehydrogenase activity in tumors by measuring hydrogen/deuterium exchange in hyperpolarized l-[1-(13)C,U-(2)H]lactate. J Am Chem Soc (2012) 0.95
A catalyzing phantom for reproducible dynamic conversion of hyperpolarized [1-¹³C]-pyruvate. PLoS One (2013) 0.95
Metabolic biomarkers for response to PI3K inhibition in basal-like breast cancer. Breast Cancer Res (2013) 0.95
HR-MAS MR spectroscopy of breast cancer tissue obtained with core needle biopsy: correlation with prognostic factors. PLoS One (2012) 0.95
Combined parallel and partial fourier MR reconstruction for accelerated 8-channel hyperpolarized carbon-13 in vivo magnetic resonance Spectroscopic imaging (MRSI). J Magn Reson Imaging (2013) 0.95
Applications of NMR spectroscopy to systems biochemistry. Prog Nucl Magn Reson Spectrosc (2016) 0.95
A rapid method for direct detection of metabolic conversion and magnetization exchange with application to hyperpolarized substrates. J Magn Reson (2012) 0.95
Hyperpolarized singlet lifetimes of pyruvate in human blood and in the mouse. NMR Biomed (2013) 0.94
Quantitative measurement of cancer metabolism using stimulated echo hyperpolarized carbon-13 MRS. Magn Reson Med (2013) 0.94
High-resolution 3D proton MRI of hyperpolarized gas enabled by parahydrogen and Rh/TiO2 heterogeneous catalyst. Chemistry (2014) 0.94
Nanoscale Catalysts for NMR Signal Enhancement by Reversible Exchange. J Phys Chem C Nanomater Interfaces (2015) 0.93
A method for simultaneous echo planar imaging of hyperpolarized ¹³C pyruvate and ¹³C lactate. J Magn Reson (2012) 0.93
Watching tumours gasp and die with MRI: the promise of hyperpolarised 13C MR spectroscopic imaging. Br J Radiol (2012) 0.93
The efficiency of DPPH as a polarising agent for DNP-NMR spectroscopy. RSC Adv (2012) 0.93
Optimal variable flip angle schemes for dynamic acquisition of exchanging hyperpolarized substrates. J Magn Reson (2013) 0.93
Ratiometric analysis in hyperpolarized NMR (I): test of the two-site exchange model and the quantification of reaction rate constants. NMR Biomed (2013) 0.93
Solvent-free dynamic nuclear polarization of amorphous and crystalline ortho-terphenyl. J Phys Chem B (2013) 0.92
Temperature-ramped (129)Xe spin-exchange optical pumping. Anal Chem (2014) 0.92
Exchange facilitated indirect detection of hyperpolarized 15ND2-amido-glutamine. J Magn Reson (2011) 0.92
The contribution of physics to Nuclear Medicine: physicians' perspective on future directions. EJNMMI Phys (2014) 0.92
Non-invasive in-cell determination of free cytosolic [NAD+]/[NADH] ratios using hyperpolarized glucose show large variations in metabolic phenotypes. J Biol Chem (2013) 0.92
Hyperpolarization of "Neat" Liquids by NMR Signal Amplification by Reversible Exchange. J Phys Chem Lett (2015) 0.91
Hyperpolarized [1-13C]dehydroascorbate MR spectroscopy in a murine model of prostate cancer: comparison with 18F-FDG PET. J Nucl Med (2013) 0.91
In vivo measurement of normal rat intracellular pyruvate and lactate levels after injection of hyperpolarized [1-(13)C]alanine. Magn Reson Imaging (2011) 0.91
Dissolution DNP-NMR spectroscopy using galvinoxyl as a polarizing agent. J Magn Reson (2012) 0.91
Iridium(III) hydrido N-heterocyclic carbene-phosphine complexes as catalysts in magnetization transfer reactions. Inorg Chem (2013) 0.91
Joint spatial-spectral reconstruction and k-t spirals for accelerated 2D spatial/1D spectral imaging of 13C dynamics. Magn Reson Med (2013) 0.90
Dephosphorylation and biodistribution of 1-¹³C-phospholactate in vivo. J Labelled Comp Radiopharm (2014) 0.90
Generating super stimulated-echoes in MRI and their application to hyperpolarized C-13 diffusion metabolic imaging. IEEE Trans Med Imaging (2011) 0.90
IDH1 Mutation Induces Reprogramming of Pyruvate Metabolism. Cancer Res (2015) 0.89
Hyperpolarized NMR probes for biological assays. Sensors (Basel) (2014) 0.89
Imaging cerebral 2-ketoisocaproate metabolism with hyperpolarized (13)C magnetic resonance spectroscopic imaging. J Cereb Blood Flow Metab (2012) 0.89
Lactate and choline metabolites detected in vitro by nuclear magnetic resonance spectroscopy are potential metabolic biomarkers for PI3K inhibition in pediatric glioblastoma. PLoS One (2014) 0.89
Overcoming intratumor heterogeneity of polygenic cancer drug resistance with improved biomarker integration. Neoplasia (2012) 0.89
Over 20% (15)N Hyperpolarization in Under One Minute for Metronidazole, an Antibiotic and Hypoxia Probe. J Am Chem Soc (2016) 0.88
Efficient Synthesis of Nicotinamide-1-(15)N for Ultrafast NMR Hyperpolarization Using Parahydrogen. Bioconjug Chem (2016) 0.88
(15)N Hyperpolarization of Imidazole-(15)N2 for Magnetic Resonance pH Sensing via SABRE-SHEATH. ACS Sens (2016) 0.88
Long-lived spin States for low-field hyperpolarized gas MRI. Chemistry (2014) 0.87
Evaluation of LDH-A and glutaminase inhibition in vivo by hyperpolarized 13C-pyruvate magnetic resonance spectroscopy of tumors. Cancer Res (2013) 0.87
Current and emerging quantitative magnetic resonance imaging methods for assessing and predicting the response of breast cancer to neoadjuvant therapy. Breast Cancer (Dove Med Press) (2012) 0.87
Dynamic metabolic imaging of hyperpolarized [2-(13) C]pyruvate using spiral chemical shift imaging with alternating spectral band excitation. Magn Reson Med (2013) 0.87
Application of hyperpolarized [1-¹³C]lactate for the in vivo investigation of cardiac metabolism. NMR Biomed (2012) 0.87
Visualization, imaging and new preclinical diagnostics in radiation oncology. Radiat Oncol (2014) 0.86
High-resolution low-field molecular magnetic resonance imaging of hyperpolarized liquids. Anal Chem (2014) 0.86
Heterogeneity of glycolysis in cancers and therapeutic opportunities. Biochem Pharmacol (2014) 0.86
(13)C-labeled biochemical probes for the study of cancer metabolism with dynamic nuclear polarization-enhanced magnetic resonance imaging. Cancer Metab (2015) 0.86
Hyperpolarization without persistent radicals for in vivo real-time metabolic imaging. Proc Natl Acad Sci U S A (2013) 0.86
Applications of metabolomics in cancer research. J Carcinog (2013) 0.85
Functional imaging for prostate cancer: therapeutic implications. Semin Nucl Med (2012) 0.85
Sub-second proton imaging of 13C hyperpolarized contrast agents in water. Contrast Media Mol Imaging (2014) 0.84
Influence of deuteration in the glassing matrix on 13C dynamic nuclear polarization. Phys Chem Chem Phys (2013) 0.84
An integrated genomic analysis of human glioblastoma multiforme. Science (2008) 51.36
On the origin of cancer cells. Science (1956) 49.55
Recurring mutations found by sequencing an acute myeloid leukemia genome. N Engl J Med (2009) 33.09
IDH1 and IDH2 mutations in gliomas. N Engl J Med (2009) 32.41
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature (2009) 19.65
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature (2008) 18.20
Increase in signal-to-noise ratio of > 10,000 times in liquid-state NMR. Proc Natl Acad Sci U S A (2003) 15.81
c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature (2009) 13.28
HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab (2006) 13.22
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction. Proc Natl Acad Sci U S A (2008) 11.71
Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell (2006) 9.80
Akt stimulates aerobic glycolysis in cancer cells. Cancer Res (2004) 9.35
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. Cancer Cell (2005) 9.33
p53 regulates mitochondrial respiration. Science (2006) 9.06
Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma. Science (2000) 8.64
Brick by brick: metabolism and tumor cell growth. Curr Opin Genet Dev (2008) 7.87
ATP citrate lyase inhibition can suppress tumor cell growth. Cancer Cell (2005) 7.65
Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. J Clin Invest (2008) 7.52
Molecular imaging with endogenous substances. Proc Natl Acad Sci U S A (2003) 6.90
Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy. Nat Med (2007) 6.84
Real-time metabolic imaging. Proc Natl Acad Sci U S A (2006) 5.89
Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate. Nature (2008) 5.60
c-Myc transactivation of LDH-A: implications for tumor metabolism and growth. Proc Natl Acad Sci U S A (1997) 5.43
Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading. Cancer Res (2008) 4.79
Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma. Am J Hum Genet (2001) 4.71
Mutations in SDHC cause autosomal dominant paraganglioma, type 3. Nat Genet (2000) 4.55
Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors. Nature (2004) 4.45
Hyperpolarized C-13 spectroscopic imaging of the TRAMP mouse at 3T-initial experience. Magn Reson Med (2007) 4.13
Metabolic imaging and other applications of hyperpolarized 13C1. Acad Radiol (2006) 3.97
Biological magnetic resonance imaging using laser-polarized 129Xe. Nature (1994) 3.82
In vivo 13 carbon metabolic imaging at 3T with hyperpolarized 13C-1-pyruvate. Magn Reson Med (2007) 3.58
Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology. Nutrition (2000) 3.58
Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes. Science (1987) 3.44
Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes. Genomics (2004) 3.35
Double spin-echo sequence for rapid spectroscopic imaging of hyperpolarized 13C. J Magn Reson (2007) 3.35
Simultaneous spatial and spectral selective excitation. Magn Reson Med (1990) 3.20
Hyperpolarized 13C allows a direct measure of flux through a single enzyme-catalyzed step by NMR. Proc Natl Acad Sci U S A (2007) 3.15
Increased lipogenesis in cancer cells: new players, novel targets. Curr Opin Clin Nutr Metab Care (2006) 3.09
p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation. Nat Cell Biol (2008) 2.81
Tumour phospholipid metabolism. NMR Biomed (1999) 2.74
Reversible interactions with para-hydrogen enhance NMR sensitivity by polarization transfer. Science (2009) 2.73
Hypoxia inhibits G1/S transition through regulation of p27 expression. J Biol Chem (2000) 2.70
In vivo assessment of pyruvate dehydrogenase flux in the heart using hyperpolarized carbon-13 magnetic resonance. Proc Natl Acad Sci U S A (2008) 2.69
pH imaging. A review of pH measurement methods and applications in cancers. IEEE Eng Med Biol Mag (2004) 2.68
Compressed sensing for resolution enhancement of hyperpolarized 13C flyback 3D-MRSI. J Magn Reson (2008) 2.39
New approaches for imaging tumour responses to treatment. Nat Rev Cancer (2008) 2.38
13C MR spectroscopy measurements of glutaminase activity in human hepatocellular carcinoma cells using hyperpolarized 13C-labeled glutamine. Magn Reson Med (2008) 2.34
PASADENA hyperpolarization of succinic acid for MRI and NMR spectroscopy. J Am Chem Soc (2008) 2.27
A definition of molecular imaging. J Nucl Med (2007) 2.26
Comparison of 68Ga-DOTATOC PET and 111In-DTPAOC (Octreoscan) SPECT in patients with neuroendocrine tumours. Eur J Nucl Med Mol Imaging (2007) 2.25
Kinetic modeling of hyperpolarized 13C1-pyruvate metabolism in normal rats and TRAMP mice. J Magn Reson (2009) 2.05
Real-time assessment of Krebs cycle metabolism using hyperpolarized 13C magnetic resonance spectroscopy. FASEB J (2009) 2.05
Production of hyperpolarized [1,4-13C2]malate from [1,4-13C2]fumarate is a marker of cell necrosis and treatment response in tumors. Proc Natl Acad Sci U S A (2009) 2.04
Q&A: Cancer: clues from cell metabolism. Nature (2010) 1.98
Hyperpolarized 13C magnetic resonance metabolic imaging: application to brain tumors. Neuro Oncol (2010) 1.97
Application of subsecond spiral chemical shift imaging to real-time multislice metabolic imaging of the rat in vivo after injection of hyperpolarized 13C1-pyruvate. Magn Reson Med (2009) 1.93
Kinetics of hyperpolarized 13C1-pyruvate transport and metabolism in living human breast cancer cells. Proc Natl Acad Sci U S A (2009) 1.93
3D compressed sensing for highly accelerated hyperpolarized (13)C MRSI with in vivo applications to transgenic mouse models of cancer. Magn Reson Med (2010) 1.92
Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted. Br J Cancer (2006) 1.91
PET/CT: form and function. Radiology (2007) 1.89
Evaluation of emphysema severity and progression in a rabbit model: comparison of hyperpolarized 3He and 129Xe diffusion MRI with lung morphometry. J Appl Physiol (1985) (2006) 1.87
Cardiac metabolism measured noninvasively by hyperpolarized 13C MRI. Magn Reson Med (2008) 1.86
Minimally invasive pharmacokinetic and pharmacodynamic technologies in hypothesis-testing clinical trials of innovative therapies. J Natl Cancer Inst (2006) 1.83
Noninvasive detection of target modulation following phosphatidylinositol 3-kinase inhibition using hyperpolarized 13C magnetic resonance spectroscopy. Cancer Res (2010) 1.81
Enhancement of chemotherapy by manipulation of tumour pH. Br J Cancer (1999) 1.79
In vivo magnetic resonance spectroscopy in cancer. Annu Rev Biomed Eng (2005) 1.78
Increasing hyperpolarized spin lifetimes through true singlet eigenstates. Science (2009) 1.76
Magnetization transfer measurements of exchange between hyperpolarized [1-13C]pyruvate and [1-13C]lactate in a murine lymphoma. Magn Reson Med (2010) 1.74
Investigation of tumor hyperpolarized [1-13C]-pyruvate dynamics using time-resolved multiband RF excitation echo-planar MRSI. Magn Reson Med (2010) 1.64
Feasibility of using hyperpolarized [1-13C]lactate as a substrate for in vivo metabolic 13C MRSI studies. Magn Reson Imaging (2008) 1.64
Pulse sequence for dynamic volumetric imaging of hyperpolarized metabolic products. J Magn Reson (2008) 1.64
Fast metabolic imaging of systems with sparse spectra: application for hyperpolarized 13C imaging. Magn Reson Med (2006) 1.64
Multiband excitation pulses for hyperpolarized 13C dynamic chemical-shift imaging. J Magn Reson (2008) 1.62
Optimization of fast spiral chemical shift imaging using least squares reconstruction: application for hyperpolarized (13)C metabolic imaging. Magn Reson Med (2007) 1.61
In vivo carbon-13 dynamic MRS and MRSI of normal and fasted rat liver with hyperpolarized 13C-pyruvate. Mol Imaging Biol (2009) 1.61
Therapeutic target metabolism observed using hyperpolarized 15N choline. J Am Chem Soc (2008) 1.60
Hyperpolarization of 13C through order transfer from parahydrogen: a new contrast agent for MRI. Magn Reson Imaging (2005) 1.60
Dynamic Nuclear Polarization of [1-13C]pyruvic acid at 4.6 tesla. J Magn Reson (2008) 1.58
Inhibition of carbohydrate oxidation during the first minute of reperfusion after brief ischemia: NMR detection of hyperpolarized 13CO2 and H13CO3-. Magn Reson Med (2008) 1.52
A comparison between radiolabeled fluorodeoxyglucose uptake and hyperpolarized (13)C-labeled pyruvate utilization as methods for detecting tumor response to treatment. Neoplasia (2009) 1.52
Liver and adipose tissue contributions to newly formed fatty acids in an ascites tumor. Am J Physiol (1984) 1.51
Metabolite quantification and high-field MRS in breast cancer. NMR Biomed (2009) 1.45
Current and potential applications of clinical 13C MR spectroscopy. J Nucl Med (2008) 1.43
A theoretical basis for spontaneous polarization transfer in non-hydrogenative parahydrogen-induced polarization. J Chem Phys (2009) 1.43
Spontaneous transfer of parahydrogen derived spin order to pyridine at low magnetic field. J Am Chem Soc (2009) 1.41
Alphavbeta3-integrin imaging: a new approach to characterise angiogenesis? Eur J Nucl Med Mol Imaging (2006) 1.39
Dynamic contrast-enhanced MRI in normal and abnormal prostate tissues as defined by biopsy, MRI, and 3D MRSI. Magn Reson Med (2005) 1.38
Hyperpolarized [2-13C]-fructose: a hemiketal DNP substrate for in vivo metabolic imaging. J Am Chem Soc (2009) 1.38
Choline phospholipid metabolism in cancer: consequences for molecular pharmaceutical interventions. Mol Pharm (2006) 1.37
A 140 GHz prepolarizer for dissolution dynamic nuclear polarization. J Chem Phys (2008) 1.36
Metabolic imaging in the anesthetized rat brain using hyperpolarized [1-13C] pyruvate and [1-13C] ethyl pyruvate. Magn Reson Med (2010) 1.34
Amino acid, glucose, and lactic acid utilization in vivo by rat tumors. Cancer Res (1982) 1.33
In vivo molecular imaging for planning radiation therapy of gliomas: an application of 1H MRSI. J Magn Reson Imaging (2002) 1.32
Accelerated spectroscopic imaging of hyperpolarized C-13 pyruvate using SENSE parallel imaging. NMR Biomed (2009) 1.31
Hyperpolarized (1)H NMR employing low gamma nucleus for spin polarization storage. J Am Chem Soc (2009) 1.24
Advances in MR spectroscopy of the prostate. Magn Reson Imaging Clin N Am (2008) 1.24
Transketolase-like 1 expression correlates with subtypes of ovarian cancer and the presence of distant metastases. Int J Gynecol Cancer (2007) 1.22
PET/CT in patients with hepatocellular carcinoma using [(18)F]fluorocholine: preliminary comparison with [(18)F]FDG PET/CT. Eur J Nucl Med Mol Imaging (2006) 1.21
Hyperpolarized water as an authentic magnetic resonance imaging contrast agent. Proc Natl Acad Sci U S A (2007) 1.19
Hyperpolarized (89)Y offers the potential of direct imaging of metal ions in biological systems by magnetic resonance. J Am Chem Soc (2007) 1.19
American Cancer Society guidelines for breast screening with MRI as an adjunct to mammography. CA Cancer J Clin (2007) 12.19
Diffusion-weighted magnetic resonance imaging as a cancer biomarker: consensus and recommendations. Neoplasia (2009) 7.44
The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche. Cell Stem Cell (2010) 5.07
Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading. Cancer Res (2008) 4.79
Functional diffusion map: a noninvasive MRI biomarker for early stratification of clinical brain tumor response. Proc Natl Acad Sci U S A (2005) 4.63
Abnormal brain development in newborns with congenital heart disease. N Engl J Med (2007) 4.55
Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase. Nature (2011) 4.32
The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid beta-oxidation. Oncogene (2005) 4.28
Metabolic imaging of patients with prostate cancer using hyperpolarized [1-¹³C]pyruvate. Sci Transl Med (2013) 4.23
Hyperpolarized C-13 spectroscopic imaging of the TRAMP mouse at 3T-initial experience. Magn Reson Med (2007) 4.13
MRI detection of glycogen in vivo by using chemical exchange saturation transfer imaging (glycoCEST). Proc Natl Acad Sci U S A (2007) 3.97
MRI breast screening in high-risk women: cancer detection and survival analysis. Breast Cancer Res Treat (2014) 3.46
Q-ball reconstruction of multimodal fiber orientations using the spherical harmonic basis. Magn Reson Med (2006) 3.35
Double spin-echo sequence for rapid spectroscopic imaging of hyperpolarized 13C. J Magn Reson (2007) 3.35
2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas. Nat Med (2012) 3.30
Evaluation of the functional diffusion map as an early biomarker of time-to-progression and overall survival in high-grade glioma. Proc Natl Acad Sci U S A (2005) 3.15
Hyperpolarized 13C allows a direct measure of flux through a single enzyme-catalyzed step by NMR. Proc Natl Acad Sci U S A (2007) 3.15
Iron oxide nanoparticles as a drug delivery vehicle for MRI monitored magnetic targeting of brain tumors. Biomaterials (2007) 3.12
Role of PFKFB3-driven glycolysis in vessel sprouting. Cell (2013) 3.04
Computed tomography-based biomarker provides unique signature for diagnosis of COPD phenotypes and disease progression. Nat Med (2012) 2.95
Parametric response map as an imaging biomarker to distinguish progression from pseudoprogression in high-grade glioma. J Clin Oncol (2010) 2.90
Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo. Cell Metab (2012) 2.86
Functional diffusion map as an early imaging biomarker for high-grade glioma: correlation with conventional radiologic response and overall survival. J Clin Oncol (2008) 2.84
Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia. Nat Genet (2011) 2.72
Combined magnetic resonance imaging and spectroscopic imaging approach to molecular imaging of prostate cancer. J Magn Reson Imaging (2002) 2.64
Early brain injury in premature newborns detected with magnetic resonance imaging is associated with adverse early neurodevelopmental outcome. J Pediatr (2005) 2.63
It's not just about anatomy: in vivo bioluminescence imaging as an eyepiece into biology. J Magn Reson Imaging (2002) 2.58
Diffusion tensor imaging: serial quantitation of white matter tract maturity in premature newborns. Neuroimage (2004) 2.58
Towards hyperpolarized (13)C-succinate imaging of brain cancer. J Magn Reson (2007) 2.57
MRI thermometry based on PARACEST agents. J Am Chem Soc (2005) 2.47
High-resolution in vivo imaging of blood vessels without labeling. Opt Lett (2007) 2.47
Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver. Cell Metab (2007) 2.47
Vascular targeted nanoparticles for imaging and treatment of brain tumors. Clin Cancer Res (2006) 2.46
Registration-based approach for reconstruction of high-resolution in utero fetal MR brain images. Acad Radiol (2006) 2.43
Compressed sensing for resolution enhancement of hyperpolarized 13C flyback 3D-MRSI. J Magn Reson (2008) 2.39
Diffusion magnetic resonance imaging: a biomarker for treatment response in oncology. J Clin Oncol (2007) 2.39
Design of flyback echo-planar readout gradients for magnetic resonance spectroscopic imaging. Magn Reson Med (2005) 2.33
The parametric response map is an imaging biomarker for early cancer treatment outcome. Nat Med (2009) 2.32
The functional diffusion map: an imaging biomarker for the early prediction of cancer treatment outcome. Neoplasia (2006) 2.30
PASADENA hyperpolarization of succinic acid for MRI and NMR spectroscopy. J Am Chem Soc (2008) 2.27
Using low-E resonators to reduce RF heating in biological samples for static solid-state NMR up to 900 MHz. J Magn Reson (2006) 2.19
Femtosecond phase-coherent two-dimensional spectroscopy. Science (2003) 2.19
Measurement of brain glutamate using TE-averaged PRESS at 3T. Magn Reson Med (2004) 2.16
Phase I trial of a selective c-MET inhibitor ARQ 197 incorporating proof of mechanism pharmacodynamic studies. J Clin Oncol (2011) 2.14
Quantitative diffusion tensor MRI fiber tractography of sensorimotor white matter development in premature infants. Neuroimage (2005) 2.13
A feasibility study of parametric response map analysis of diffusion-weighted magnetic resonance imaging scans of head and neck cancer patients for providing early detection of therapeutic efficacy. Transl Oncol (2009) 2.10
Metabolism of [U-13 C]glucose in human brain tumors in vivo. NMR Biomed (2012) 2.06
Kinetic modeling of hyperpolarized 13C1-pyruvate metabolism in normal rats and TRAMP mice. J Magn Reson (2009) 2.05
13C-pyruvate imaging reveals alterations in glycolysis that precede c-Myc-induced tumor formation and regression. Cell Metab (2011) 2.05
Quantitative analysis of prostate metabolites using 1H HR-MAS spectroscopy. Magn Reson Med (2006) 2.04
Composition of adipose tissue and marrow fat in humans by 1H NMR at 7 Tesla. J Lipid Res (2008) 2.01
Comparing the diagnosis of white matter injury in premature newborns with serial MR imaging and transfontanel ultrasonography findings. AJNR Am J Neuroradiol (2003) 2.01
Hyperpolarized 13C magnetic resonance metabolic imaging: application to brain tumors. Neuro Oncol (2010) 1.97
Two-color, two-photon, and excited-state absorption microscopy. J Biomed Opt (2007) 1.97
Serial quantitative diffusion tensor MRI of the premature brain: development in newborns with and without injury. J Magn Reson Imaging (2002) 1.96
Noninvasive real-time imaging of apoptosis. Proc Natl Acad Sci U S A (2002) 1.93
Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer. Breast Cancer Res (2013) 1.92
3D compressed sensing for highly accelerated hyperpolarized (13)C MRSI with in vivo applications to transgenic mouse models of cancer. Magn Reson Med (2010) 1.92
Proton HR-MAS spectroscopy and quantitative pathologic analysis of MRI/3D-MRSI-targeted postsurgical prostate tissues. Magn Reson Med (2003) 1.89
Development of a robust method for generating 7.0 T multichannel phase images of the brain with application to normal volunteers and patients with neurological diseases. Neuroimage (2007) 1.88
Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase. J Biol Chem (2004) 1.86
Pump-probe imaging differentiates melanoma from melanocytic nevi. Sci Transl Med (2011) 1.86
Multi-compound polarization by DNP allows simultaneous assessment of multiple enzymatic activities in vivo. J Magn Reson (2010) 1.84
Responsive MRI agents for sensing metabolism in vivo. Acc Chem Res (2009) 1.84
Minimally invasive pharmacokinetic and pharmacodynamic technologies in hypothesis-testing clinical trials of innovative therapies. J Natl Cancer Inst (2006) 1.83
Predicting and monitoring cancer treatment response with diffusion-weighted MRI. J Magn Reson Imaging (2010) 1.82
DWI of the spinal cord with reduced FOV single-shot EPI. Magn Reson Med (2008) 1.82
Hyperpolarized (13)C magnetic resonance reveals early- and late-onset changes to in vivo pyruvate metabolism in the failing heart. Eur J Heart Fail (2012) 1.82
Inhibition of cardiac lipoprotein utilization by transgenic overexpression of Angptl4 in the heart. Proc Natl Acad Sci U S A (2005) 1.82
Noninvasive detection of target modulation following phosphatidylinositol 3-kinase inhibition using hyperpolarized 13C magnetic resonance spectroscopy. Cancer Res (2010) 1.81
Diminished hepatic gluconeogenesis via defects in tricarboxylic acid cycle flux in peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha)-deficient mice. J Biol Chem (2006) 1.80
Assessing changes in tumour vascular function using dynamic contrast-enhanced magnetic resonance imaging. NMR Biomed (2002) 1.80
Rapid multislice imaging of hyperpolarized 13C pyruvate and bicarbonate in the heart. Magn Reson Med (2010) 1.80
Survival prediction in high-grade gliomas by MRI perfusion before and during early stage of RT [corrected]. Int J Radiat Oncol Biol Phys (2005) 1.79
The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-gamma2 isoform. Diabetes (2005) 1.76
Sp1 and Sp3 are oxidative stress-inducible, antideath transcription factors in cortical neurons. J Neurosci (2003) 1.72
A pilot study of compositional analysis of the breast and estimation of breast mammographic density using three-dimensional T1-weighted magnetic resonance imaging. Cancer Epidemiol Biomarkers Prev (2008) 1.70
Evaluation of lactate and alanine as metabolic biomarkers of prostate cancer using 1H HR-MAS spectroscopy of biopsy tissues. Magn Reson Med (2008) 1.69
Molecular imaging of Akt kinase activity. Nat Med (2007) 1.68
Fast dynamic 3D MR spectroscopic imaging with compressed sensing and multiband excitation pulses for hyperpolarized 13C studies. Magn Reson Med (2010) 1.67
Brain cancer diagnosis and therapy with nanoplatforms. Adv Drug Deliv Rev (2006) 1.66
Detection of early response to temozolomide treatment in brain tumors using hyperpolarized 13C MR metabolic imaging. J Magn Reson Imaging (2011) 1.65
Investigation of tumor hyperpolarized [1-13C]-pyruvate dynamics using time-resolved multiband RF excitation echo-planar MRSI. Magn Reson Med (2010) 1.64
Feasibility of using hyperpolarized [1-13C]lactate as a substrate for in vivo metabolic 13C MRSI studies. Magn Reson Imaging (2008) 1.64
Pulse sequence for dynamic volumetric imaging of hyperpolarized metabolic products. J Magn Reson (2008) 1.64
Reproducibility of quantitative dynamic MRI of normal human tissues. NMR Biomed (2002) 1.63
A methodology for registration of a histological slide and in vivo MRI volume based on optimizing mutual information. Mol Imaging (2006) 1.63
Multiband excitation pulses for hyperpolarized 13C dynamic chemical-shift imaging. J Magn Reson (2008) 1.62
Near-unity nuclear polarization with an open-source 129Xe hyperpolarizer for NMR and MRI. Proc Natl Acad Sci U S A (2013) 1.61
In vivo carbon-13 dynamic MRS and MRSI of normal and fasted rat liver with hyperpolarized 13C-pyruvate. Mol Imaging Biol (2009) 1.61
Predicting response of colorectal hepatic metastasis: value of pretreatment apparent diffusion coefficients. AJR Am J Roentgenol (2007) 1.60
In situ detection of PHIP at 48 mT: demonstration using a centrally controlled polarizer. J Am Chem Soc (2010) 1.60
Prediction of clinicopathologic response of breast cancer to primary chemotherapy at contrast-enhanced MR imaging: initial clinical results. Radiology (2006) 1.60
Monitoring urea transport in rat kidney in vivo using hyperpolarized ¹³C magnetic resonance imaging. Am J Physiol Renal Physiol (2012) 1.60
Systematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancer. Cell (2013) 1.60