Sequential therapy with JX-594, a targeted oncolytic poxvirus, followed by sorafenib in hepatocellular carcinoma: preclinical and clinical demonstration of combination efficacy.

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Published in Mol Ther on March 22, 2011

Authors

Jeong Heo1, Caroline J Breitbach, Anne Moon, Chang Won Kim, Rick Patt, Mi Kyung Kim, Yu Kyung Lee, Sung Yong Oh, Hyun Young Woo, Kelley Parato, Julia Rintoul, Theresa Falls, Theresa Hickman, Byung-Geon Rhee, John C Bell, David H Kirn, Tae-Ho Hwang

Author Affiliations

1: Pusan National University, Busan, South Korea.

Associated clinical trials:

A Study of Recombinant Vaccinia Virus to Treat Unresectable Primary Hepatocellular Carcinoma | NCT00554372

A Study of Recombinant Vaccinia Virus to Evaluate the Safety and Efficacy of a Transdermal Injection Within the Tumor of Patients With Primary or Metastatic Hepatic Carcinoma | NCT00629759

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