Published in Drug Metab Dispos on March 23, 2011
Bile salt export pump is dysregulated with altered farnesoid X receptor isoform expression in patients with hepatocellular carcinoma. Hepatology (2013) 0.91
Keap1 knockdown increases markers of metabolic syndrome after long-term high fat diet feeding. Free Radic Biol Med (2013) 0.89
Fasting induces nuclear factor E2-related factor 2 and ATP-binding Cassette transporters via protein kinase A and Sirtuin-1 in mouse and human. Antioxid Redox Signal (2013) 0.81
Endocrine and metabolic regulation of renal drug transporters. J Biochem Mol Toxicol (2012) 0.80
Alcohol cirrhosis alters nuclear receptor and drug transporter expression in human liver. Drug Metab Dispos (2013) 0.80
Pregnancy represses induction of efflux transporters in livers of type I diabetic mice. Pharm Res (2013) 0.78
Effect of caloric restriction and AMPK activation on hepatic nuclear receptor, biotransformation enzyme, and transporter expression in lean and obese mice. Pharm Res (2013) 0.77
The altered renal and hepatic expression of solute carrier transporters (SLCs) in type 1 diabetic mice. PLoS One (2015) 0.76
Effect of nonalcoholic steatohepatitis on renal filtration and secretion of adefovir. Biochem Pharmacol (2016) 0.75
Renal efflux transporter expression in pregnant mice with Type I diabetes. Toxicol Lett (2012) 0.75
Altered Hepatic Transport by Fetal Arsenite Exposure in Diet-Induced Fatty Liver Disease. J Biochem Mol Toxicol (2016) 0.75
Ischemia/Reperfusion-inducible protein modulates the function of organic cation transporter 1 and multidrug and toxin extrusion 1. Mol Pharm (2013) 0.75
Differential expression of breast cancer-resistance protein, lung resistance protein, and multidrug resistance protein 1 in retinas of streptozotocin-induced diabetic mice. Int J Ophthalmol (2017) 0.75
Hepatic Transporter Expression in Metabolic Syndrome: Phenotype, Serum Metabolic Hormones, and Transcription Factor Expression. Drug Metab Dispos (2016) 0.75
Protein measurement with the Folin phenol reagent. J Biol Chem (1951) 1743.91
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Adipokines and insulin resistance. Mol Med (2008) 2.97
The MRP family of drug efflux pumps. Oncogene (2003) 2.37
Bile acid transporters. J Lipid Res (2009) 2.31
Obesity trends in Latin America: transiting from under- to overweight. J Nutr (2001) 2.14
Differential expression of mouse hepatic transporter genes in response to acetaminophen and carbon tetrachloride. Toxicol Sci (2004) 1.98
Transporters and drug therapy: implications for drug disposition and disease. Clin Pharmacol Ther (2005) 1.81
Substrates and inhibitors of human multidrug resistance associated proteins and the implications in drug development. Curr Med Chem (2008) 1.78
Multiple transporters affect the disposition of atorvastatin and its two active hydroxy metabolites: application of in vitro and ex situ systems. J Pharmacol Exp Ther (2005) 1.67
Regulation of mouse organic anion-transporting polypeptides (Oatps) in liver by prototypical microsomal enzyme inducers that activate distinct transcription factor pathways. Drug Metab Dispos (2005) 1.55
Impact of obesity on oral contraceptive pharmacokinetics and hypothalamic-pituitary-ovarian activity. Contraception (2009) 1.52
The role of fatty acids in the development and progression of nonalcoholic fatty liver disease. J Nutr Biochem (2008) 1.52
Tissue distribution and ontogeny of mouse organic anion transporting polypeptides (Oatps). Drug Metab Dispos (2005) 1.49
Leptin stimulates fibroblast growth factor 23 expression in bone and suppresses renal 1alpha,25-dihydroxyvitamin D3 synthesis in leptin-deficient mice. J Bone Miner Res (2010) 1.34
Effect of obesity on vancomycin pharmacokinetic parameters as determined by using a Bayesian forecasting technique. Antimicrob Agents Chemother (1993) 1.34
Rat and mouse differences in gender-predominant expression of organic anion transporter (Oat1-3; Slc22a6-8) mRNA levels. Drug Metab Dispos (2004) 1.31
Efflux transporter expression and acetaminophen metabolite excretion are altered in rodent models of nonalcoholic fatty liver disease. Drug Metab Dispos (2007) 1.29
Ursodeoxycholic acid stimulates Nrf2-mediated hepatocellular transport, detoxification, and antioxidative stress systems in mice. Am J Physiol Gastrointest Liver Physiol (2008) 1.27
Drug-metabolizing enzyme and transporter expression in a mouse model of diabetes and obesity. Mol Pharm (2008) 1.21
Nrf2- and PPAR alpha-mediated regulation of hepatic Mrp transporters after exposure to perfluorooctanoic acid and perfluorodecanoic acid. Toxicol Sci (2008) 1.20
Pregnane X receptor and constitutive androstane receptor at the crossroads of drug metabolism and energy metabolism. Drug Metab Dispos (2010) 1.18
Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis. J Biol Chem (2003) 1.17
Regulation of drug transporter expression in human hepatocytes exposed to the proinflammatory cytokines tumor necrosis factor-alpha or interleukin-6. Drug Metab Dispos (2008) 1.14
Early hepatic insulin resistance precedes the onset of diabetes in obese C57BLKS-db/db mice. Diabetes (2010) 1.01
Prevalence of obesity and correlations with lifestyle and dietary factors in Chinese men. Obesity (Silver Spring) (2008) 0.99
The role of the nuclear receptor constitutive androstane receptor in the pathogenesis of non-alcoholic steatohepatitis. Gut (2006) 0.98
Induction of multidrug resistance protein 3 (mrp3) in vivo is independent of constitutive androstane receptor. Drug Metab Dispos (2003) 0.97
Effect of obesity on gentamicin pharmacokinetics. J Clin Pharmacol (1981) 0.97
Leptin attenuates gene expression for renal 25-hydroxyvitamin D3-1alpha-hydroxylase in mice via the long form of the leptin receptor. Arch Biochem Biophys (2007) 0.97
Fat storage and the biology of energy expenditure. Transl Res (2009) 0.96
Reduction of low molecular weight protein-tyrosine phosphatase expression improves hyperglycemia and insulin sensitivity in obese mice. J Biol Chem (2007) 0.95
Central infusion of histamine reduces fat accumulation and upregulates UCP family in leptin-resistant obese mice. Diabetes (2001) 0.95
Differential regulation of hepatic transporters in the absence of tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, and nuclear factor-kappaB in two models of cholestasis. Drug Metab Dispos (2006) 0.91
Changes in physiology with increasing fat mass. Semin Pediatr Surg (2009) 0.90
Life-style factors associated with overweight and obesity among Spanish adults. Nutr Hosp (2009) 0.89
Expression and functional analysis of hepatic cytochromes P450, nuclear receptors, and membrane transporters in 10- and 25-week-old db/db mice. Drug Metab Dispos (2010) 0.85
Pharmacokinetic and pharmacodynamic aspects of antibiotic use in high-risk populations. Infect Dis Clin North Am (2007) 0.85
Obesity effects on nitrazepam disposition. Br J Clin Pharmacol (1986) 0.78
Lipid-lowering drugs and serum liver enzymes: the effects of body weight and baseline enzyme levels. Fundam Clin Pharmacol (2003) 0.78
Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway. Hepatology (2007) 2.11
Induction of the multidrug resistance-associated protein family of transporters by chemical activators of receptor-mediated pathways in mouse liver. Drug Metab Dispos (2005) 1.90
Tissue distribution and hepatic and renal ontogeny of the multidrug resistance-associated protein (Mrp) family in mice. Drug Metab Dispos (2005) 1.61
Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2. Toxicol Appl Pharmacol (2007) 1.60
Early growth response factor-1 is critical for cholestatic liver injury. Toxicol Sci (2006) 1.51
Induction of drug-metabolizing enzymes by garlic and allyl sulfide compounds via activation of constitutive androstane receptor and nuclear factor E2-related factor 2. Drug Metab Dispos (2007) 1.29
Efflux transporter expression and acetaminophen metabolite excretion are altered in rodent models of nonalcoholic fatty liver disease. Drug Metab Dispos (2007) 1.29
Nuclear factor-E2-related factor 2 expression in liver is critical for induction of NAD(P)H:quinone oxidoreductase 1 during cholestasis. Cell Stress Chaperones (2006) 1.23
Enhanced Nrf2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice. Diabetes (2012) 1.23
Tissue distribution and hormonal regulation of the breast cancer resistance protein (Bcrp/Abcg2) in rats and mice. Biochem Biophys Res Commun (2005) 1.22
Drug-metabolizing enzyme and transporter expression in a mouse model of diabetes and obesity. Mol Pharm (2008) 1.21
Enhanced acetaminophen toxicity by activation of the pregnane X receptor. Toxicol Sci (2004) 1.11
The Nrf2 activator oltipraz also activates the constitutive androstane receptor. Drug Metab Dispos (2008) 1.08
Lipopolysaccharide-mediated regulation of hepatic transporter mRNA levels in rats. Drug Metab Dispos (2004) 1.08
Bromobenzene-induced hepatotoxicity at the transcriptome level. Toxicol Sci (2004) 1.07
Altered UDP-glucuronosyltransferase and sulfotransferase expression and function during progressive stages of human nonalcoholic fatty liver disease. Drug Metab Dispos (2012) 1.05
Role of NAD(P)H:quinone oxidoreductase 1 in clofibrate-mediated hepatoprotection from acetaminophen. Toxicology (2006) 1.01
Induction of multidrug resistance protein 3 (mrp3) in vivo is independent of constitutive androstane receptor. Drug Metab Dispos (2003) 0.97
Severe diabetes and leptin resistance cause differential hepatic and renal transporter expression in mice. Comp Hepatol (2012) 0.93
UDP-glucuronosyltransferase expression in mouse liver is increased in obesity- and fasting-induced steatosis. Drug Metab Dispos (2011) 0.92
Up-regulation of Mrp4 expression in kidney of Mrp2-deficient TR- rats. Biochem Pharmacol (2005) 0.92
Keap1-knockdown decreases fasting-induced fatty liver via altered lipid metabolism and decreased fatty acid mobilization from adipose tissue. PLoS One (2013) 0.91
Differential regulation of hepatic transporters in the absence of tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, and nuclear factor-kappaB in two models of cholestasis. Drug Metab Dispos (2006) 0.91
Keap1 knockdown increases markers of metabolic syndrome after long-term high fat diet feeding. Free Radic Biol Med (2013) 0.89
Retinoid X receptor alpha Regulates the expression of glutathione s-transferase genes and modulates acetaminophen-glutathione conjugation in mouse liver. Mol Pharmacol (2005) 0.88
The traditional ayurvedic medicine, Eugenia jambolana (Jamun fruit), decreases liver inflammation, injury and fibrosis during cholestasis. Liver Int (2011) 0.88
Minimal role of hepatic transporters in the hepatoprotection against LCA-induced intrahepatic cholestasis. Toxicol Sci (2007) 0.84
Downregulation of sulfotransferase expression and activity in diseased human livers. Drug Metab Dispos (2013) 0.82
Induction of drug metabolism enzymes and transporters by oltipraz in rats. J Biochem Mol Toxicol (2008) 0.82
Fasting induces nuclear factor E2-related factor 2 and ATP-binding Cassette transporters via protein kinase A and Sirtuin-1 in mouse and human. Antioxid Redox Signal (2013) 0.81
Regulation of hepatic phase II metabolism in pregnant mice. J Pharmacol Exp Ther (2012) 0.81
Deficiency in Nrf2 transcription factor decreases adipose tissue mass and hepatic lipid accumulation in leptin-deficient mice. Obesity (Silver Spring) (2014) 0.81
Alcohol cirrhosis alters nuclear receptor and drug transporter expression in human liver. Drug Metab Dispos (2013) 0.80
Gender divergent expression of Nqo1 in Sprague Dawley and August Copenhagen x Irish rats. J Biochem Mol Toxicol (2008) 0.80
Pregnancy represses induction of efflux transporters in livers of type I diabetic mice. Pharm Res (2013) 0.78
Constitutive activation of nuclear factor-E2-related factor 2 induces biotransformation enzyme and transporter expression in livers of mice with hepatocyte-specific deletion of Kelch-like ECH-associated protein 1. J Biochem Mol Toxicol (2011) 0.78
Caloric restriction-mediated induction of lipid metabolism gene expression in liver is enhanced by Keap1-knockdown. Pharm Res (2013) 0.78
Effect of caloric restriction and AMPK activation on hepatic nuclear receptor, biotransformation enzyme, and transporter expression in lean and obese mice. Pharm Res (2013) 0.77
Effects of developmental deltamethrin exposure on white adipose tissue gene expression. J Biochem Mol Toxicol (2013) 0.76