Published in J Immunol on March 25, 2011
The origins, function, and regulation of T follicular helper cells. J Exp Med (2012) 2.59
Belatacept Does Not Inhibit Follicular T Cell-Dependent B-Cell Differentiation in Kidney Transplantation. Front Immunol (2017) 1.39
CVID-associated TACI mutations affect autoreactive B cell selection and activation. J Clin Invest (2013) 1.04
CD80 expression on B cells regulates murine T follicular helper development, germinal center B cell survival, and plasma cell generation. J Immunol (2012) 1.02
The regulation and role of T follicular helper cells in immunity. Immunology (2011) 0.99
CTLA-4 controls follicular helper T-cell differentiation by regulating the strength of CD28 engagement. Proc Natl Acad Sci U S A (2014) 0.98
CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection. Elife (2014) 0.94
CD8 T cells are essential for recovery from a respiratory vaccinia virus infection. J Immunol (2012) 0.93
Toll-like receptor 4-activated B cells out-compete Toll-like receptor 9-activated B cells to establish peripheral immunological tolerance. Proc Natl Acad Sci U S A (2012) 0.89
The specialized proresolving mediator 17-HDHA enhances the antibody-mediated immune response against influenza virus: a new class of adjuvant? J Immunol (2014) 0.88
IL-21 promotes CD4 T cell responses by phosphatidylinositol 3-kinase-dependent upregulation of CD86 on B cells. J Immunol (2014) 0.87
CD4 T cell differentiation in type 1 diabetes. Clin Exp Immunol (2015) 0.86
Effect of TACI signaling on humoral immunity and autoimmune diseases. J Immunol Res (2015) 0.84
Ubiquitin-mediated fluctuations in MHC class II facilitate efficient germinal center B cell responses. J Exp Med (2016) 0.81
T cell receptor signaling can directly enhance the avidity of CD28 ligand binding. PLoS One (2014) 0.81
CD19 as a therapeutic target in a spontaneous autoimmune polyneuropathy. Clin Exp Immunol (2014) 0.80
The importance of co-stimulation in the orchestration of T helper cell differentiation. Immunol Cell Biol (2015) 0.80
Prohibitins and the cytoplasmic domain of CD86 cooperate to mediate CD86 signaling in B lymphocytes. J Immunol (2012) 0.78
Life of T follicular helper cells. Mol Cells (2014) 0.78
Insights into the development and regulation of T follicular helper cells. Cytokine (2016) 0.76
The regulation of T follicular helper responses during infection. Curr Opin Immunol (2015) 0.76
PP4 is essential for germinal center formation and class switch recombination in mice. PLoS One (2014) 0.76
Follicular Helper T Cells in Systemic Lupus Erythematosus: Why Should They Be Considered as Interesting Therapeutic Targets? J Immunol Res (2016) 0.75
Tissue-specific programming of memory CD8 T cell subsets impacts protection against lethal respiratory virus infection. J Exp Med (2016) 0.75
Plasma cell alloantigen ENPP1 is expressed by a subset of human B cells with potential regulatory functions. Immunol Cell Biol (2016) 0.75
Regulators of Tfh Cell Differentiation. Front Immunol (2016) 0.75
OX40 Cooperates with ICOS To Amplify Follicular Th Cell Development and Germinal Center Reactions during Infection. J Immunol (2016) 0.75
STAT3 Signaling in B Cells Is Critical for Germinal Center Maintenance and Contributes to the Pathogenesis of Murine Models of Lupus. J Immunol (2016) 0.75
Co-stimulatory function in primary germinal center responses: CD40 and B7 are required on distinct antigen-presenting cells. J Exp Med (2017) 0.75
Follicular helper CD4 T cells (TFH). Annu Rev Immunol (2011) 12.50
Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science (2009) 9.22
The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. Immunity (2009) 7.69
Germinal centres: role in B-cell physiology and malignancy. Nat Rev Immunol (2008) 6.09
CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. J Exp Med (2000) 6.06
Antigen-specific memory B cell development. Annu Rev Immunol (2005) 5.28
Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation. J Immunol (2007) 5.14
Follicular B helper T cell activity is confined to CXCR5(hi)ICOS(hi) CD4 T cells and is independent of CD57 expression. Eur J Immunol (2006) 3.85
T follicular helper cells differentiate from Th2 cells in response to helminth antigens. J Exp Med (2009) 3.40
B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation. Immunity (1997) 3.22
Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150). J Immunol (2010) 2.85
Cellular and humoral immunity against vaccinia virus infection of mice. J Immunol (2004) 2.84
Recombinant vaccinia virus-induced T-cell immunity: quantitation of the response to the virus vector and the foreign epitope. J Virol (2002) 2.64
In vivo regulation of Bcl6 and T follicular helper cell development. J Immunol (2010) 2.63
Immunity and immunological memory following smallpox vaccination. Immunol Rev (2006) 2.57
Vaccinia virus H3L envelope protein is a major target of neutralizing antibodies in humans and elicits protection against lethal challenge in mice. J Virol (2005) 2.18
CD28 is required for germinal center formation. J Immunol (1996) 1.78
Follicular helper T cells as cognate regulators of B cell immunity. Curr Opin Immunol (2009) 1.77
Vaccinia virus-specific CD4+ T cell responses target a set of antigens largely distinct from those targeted by CD8+ T cell responses. J Immunol (2007) 1.66
Signals that influence T follicular helper cell differentiation and function. Semin Immunopathol (2010) 1.62
B cell migration and interactions in the early phase of antibody responses. Curr Opin Immunol (2006) 1.62
Distinct role of CD80 and CD86 in the regulation of the activation of B cell and B cell lymphoma. J Biol Chem (2001) 1.55
BCL6 controls the expression of the B7-1/CD80 costimulatory receptor in germinal center B cells. J Exp Med (2003) 1.36
OX40 drives protective vaccinia virus-specific CD8 T cells. J Immunol (2008) 1.33
Single-cell dynamics of T-cell priming. Curr Opin Immunol (2007) 1.31
B7 costimulation is critical for antibody class switching and CD8(+) cytotoxic T-lymphocyte generation in the host response to vesicular stomatitis virus. J Virol (2000) 1.30
The adaptor molecule MyD88 directly promotes CD8 T cell responses to vaccinia virus. J Immunol (2009) 1.24
The TNFR family members OX40 and CD27 link viral virulence to protective T cell vaccines in mice. J Clin Invest (2010) 1.24
CD86 (B7-2) on human B cells. A functional role in proliferation and selective differentiation into IgE- and IgG4-producing cells. J Biol Chem (1997) 1.22
Smallpox vaccines: targets of protective immunity. Immunol Rev (2011) 1.21
Co-stimulation and selection for T-cell help for germinal centres: the role of CD28 and OX40. Immunol Today (2000) 1.15
Stimulation of the B cell receptor, CD86 (B7-2), and the beta 2-adrenergic receptor intrinsically modulates the level of IgG1 and IgE produced per B cell. J Immunol (2000) 1.14
Role of CD28/CD80-86 and CD40/CD154 costimulatory interactions in host defense to primary herpes simplex virus infection. J Virol (2001) 1.07
Preferential use of B7.2 and not B7.1 in priming of vaccinia virus-specific CD8 T cells. J Immunol (2009) 1.05
CD86 regulates IgG1 production via a CD19-dependent mechanism. J Immunol (2007) 1.03
Therapeutic targeting of the BCL6 oncogene for diffuse large B-cell lymphomas. Leuk Lymphoma (2008) 1.00
CD86 stimulation on a B cell activates the phosphatidylinositol 3-kinase/Akt and phospholipase C gamma 2/protein kinase C alpha beta signaling pathways. J Immunol (2006) 1.00
The smallpox vaccine induces an early neutralizing IgM response. Vaccine (2009) 0.97
CD28(-/-) mice show defects in cellular and humoral immunity but are able to control infection with murine gammaherpesvirus 68. J Virol (2002) 0.93
B7 costimulation plays an important role in protection from herpes simplex virus type 2-mediated pathology. J Virol (2002) 0.88
Vaccinia virus infection of mature dendritic cells results in activation of virus-specific naïve CD8+ T cells: a potential mechanism for direct presentation. Virology (2006) 0.88
Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science (2009) 9.22
ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6. Immunity (2011) 5.59
Resolution of a chronic viral infection after interleukin-10 receptor blockade. J Exp Med (2006) 4.97
Human circulating PD-1+CXCR3-CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses. Immunity (2013) 3.72
Profiling the humoral immune response to infection by using proteome microarrays: high-throughput vaccine and diagnostic antigen discovery. Proc Natl Acad Sci U S A (2005) 3.59
STAT5 is a potent negative regulator of TFH cell differentiation. J Exp Med (2012) 3.37
A Blueprint for HIV Vaccine Discovery. Cell Host Microbe (2012) 3.27
IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation. PLoS One (2011) 2.92
Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150). J Immunol (2010) 2.85
In vivo regulation of Bcl6 and T follicular helper cell development. J Immunol (2010) 2.63
Immunity and immunological memory following smallpox vaccination. Immunol Rev (2006) 2.57
Sustained survivin expression from OX40 costimulatory signals drives T cell clonal expansion. Immunity (2005) 2.56
Selective CD4+ T cell help for antibody responses to a large viral pathogen: deterministic linkage of specificities. Immunity (2008) 2.43
Bcl6 and Maf cooperate to instruct human follicular helper CD4 T cell differentiation. J Immunol (2012) 2.34
Inadequate T follicular cell help impairs B cell immunity during HIV infection. Nat Med (2013) 2.29
Immune responses to Bacillus anthracis protective antigen in patients with bioterrorism-related cutaneous or inhalation anthrax. J Infect Dis (2004) 2.29
OX40 (CD134) controls memory T helper 2 cells that drive lung inflammation. J Exp Med (2003) 2.26
The receptor Ly108 functions as a SAP adaptor-dependent on-off switch for T cell help to B cells and NKT cell development. Immunity (2012) 2.19
Vaccinia virus H3L envelope protein is a major target of neutralizing antibodies in humans and elicits protection against lethal challenge in mice. J Virol (2005) 2.18
The tumor necrosis factor family member LIGHT is a target for asthmatic airway remodeling. Nat Med (2011) 2.12
Proteome-wide analysis of the serological response to vaccinia and smallpox. Proteomics (2007) 2.10
Autocrine IL-2 is required for secondary population expansion of CD8(+) memory T cells. Nat Immunol (2011) 1.98
Lethal T cell immunodeficiency induced by chronic costimulation via CD27-CD70 interactions. Nat Immunol (2002) 1.97
SAP regulates T cell-mediated help for humoral immunity by a mechanism distinct from cytokine regulation. J Exp Med (2006) 1.92
Cutting edge: OX40 inhibits TGF-beta- and antigen-driven conversion of naive CD4 T cells into CD25+Foxp3+ T cells. J Immunol (2007) 1.82
Redundancy and plasticity of neutralizing antibody responses are cornerstone attributes of the human immune response to the smallpox vaccine. J Virol (2008) 1.77
Lung type 2 innate lymphoid cells express cysteinyl leukotriene receptor 1, which regulates TH2 cytokine production. J Allergy Clin Immunol (2013) 1.73
Bcl6 expressing follicular helper CD4 T cells are fate committed early and have the capacity to form memory. J Immunol (2013) 1.71
Recruitment of antigen-specific CD8+ T cells in response to infection is markedly efficient. Science (2009) 1.70
Heavily isotype-dependent protective activities of human antibodies against vaccinia virus extracellular virion antigen B5. J Virol (2009) 1.69
SAP regulation of follicular helper CD4 T cell development and humoral immunity is independent of SLAM and Fyn kinase. J Immunol (2007) 1.68
Lung-resident tissue macrophages generate Foxp3+ regulatory T cells and promote airway tolerance. J Exp Med (2013) 1.67
Vaccinia virus-specific CD4+ T cell responses target a set of antigens largely distinct from those targeted by CD8+ T cell responses. J Immunol (2007) 1.66
Expression of the murine CD27 ligand CD70 in vitro and in vivo. J Immunol (2003) 1.66
Cytomegalovirus exploits IL-10-mediated immune regulation in the salivary glands. J Exp Med (2007) 1.66
Cutting edge: STAT1 is required for IL-6-mediated Bcl6 induction for early follicular helper cell differentiation. J Immunol (2013) 1.57
The costimulation-regulated duration of PKB activation controls T cell longevity. Nat Immunol (2004) 1.57
Signals from OX40 regulate nuclear factor of activated T cells c1 and T cell helper 2 lineage commitment. Proc Natl Acad Sci U S A (2006) 1.54
Dissecting T cell lineage relationships by cellular barcoding. J Exp Med (2008) 1.53
Vaccinia virus extracellular enveloped virion neutralization in vitro and protection in vivo depend on complement. J Virol (2008) 1.49
The kinases aurora B and mTOR regulate the G1-S cell cycle progression of T lymphocytes. Nat Immunol (2006) 1.49
Quantitative PCR technique for detecting lymphocytic choriomeningitis virus in vivo. J Virol Methods (2007) 1.45
Anti-Siglec-F antibody reduces allergen-induced eosinophilic inflammation and airway remodeling. J Immunol (2009) 1.43
Identification of regulatory functions for 4-1BB and 4-1BBL in myelopoiesis and the development of dendritic cells. Nat Immunol (2008) 1.42
Implantable left ventricular assist devices as initial therapy for refractory postmyocardial infarction cardiogenic shock. Eur J Cardiothorac Surg (2013) 1.41
Inhibition of NK cell activity by IL-17 allows vaccinia virus to induce severe skin lesions in a mouse model of eczema vaccinatum. J Exp Med (2009) 1.41
Local activation of CD8 T cells and systemic tumor eradication without toxicity via slow release and local delivery of agonistic CD40 antibody. Clin Cancer Res (2011) 1.39
Harnessing CD4⁺ T cell responses in HIV vaccine development. Nat Med (2013) 1.39
Peptide-specific CD8 T regulatory cells use IFN-gamma to elaborate TGF-beta-based suppression. J Immunol (2005) 1.38
STAT6 regulates natural helper cell proliferation during lung inflammation initiated by Alternaria. Am J Physiol Lung Cell Mol Physiol (2012) 1.37
Intrahepatic myeloid-cell aggregates enable local proliferation of CD8(+) T cells and successful immunotherapy against chronic viral liver infection. Nat Immunol (2013) 1.37
Ly9 (CD229)-deficient mice exhibit T cell defects yet do not share several phenotypic characteristics associated with SLAM- and SAP-deficient mice. J Immunol (2006) 1.36
NKT cells prevent chronic joint inflammation after infection with Borrelia burgdorferi. Proc Natl Acad Sci U S A (2008) 1.35
OX40 drives protective vaccinia virus-specific CD8 T cells. J Immunol (2008) 1.33
Differential regulation of Th2 and Th1 lung inflammatory responses by protein kinase C theta. J Immunol (2004) 1.32
Alternaria induces STAT6-dependent acute airway eosinophilia and epithelial FIZZ1 expression that promotes airway fibrosis and epithelial thickness. J Immunol (2012) 1.30
Sustained antibody responses depend on CD28 function in bone marrow-resident plasma cells. J Exp Med (2011) 1.30
Regulation of dendritic cell maturation and function by Bruton's tyrosine kinase via IL-10 and Stat3. Proc Natl Acad Sci U S A (2005) 1.28
Antagonism of airway tolerance by endotoxin/lipopolysaccharide through promoting OX40L and suppressing antigen-specific Foxp3+ T regulatory cells. J Immunol (2008) 1.27
SLAT regulates Th1 and Th2 inflammatory responses by controlling Ca2+/NFAT signaling. J Clin Invest (2007) 1.26
OX40 costimulation promotes persistence of cytomegalovirus-specific CD8 T Cells: A CD4-dependent mechanism. J Immunol (2007) 1.26
Activation of NF-kappaB1 by OX40 contributes to antigen-driven T cell expansion and survival. J Immunol (2008) 1.25
The adaptor molecule MyD88 directly promotes CD8 T cell responses to vaccinia virus. J Immunol (2009) 1.24
Costimulation of CD8 T cell responses by OX40. J Immunol (2004) 1.24
The TNFR family members OX40 and CD27 link viral virulence to protective T cell vaccines in mice. J Clin Invest (2010) 1.24
Therapeutic cancer vaccines. J Clin Invest (2015) 1.23
B cells are crucial for both development and maintenance of the splenic marginal zone. J Immunol (2004) 1.23
OX40 and Bcl-xL promote the persistence of CD8 T cells to recall tumor-associated antigen. J Immunol (2005) 1.22
Protein kinase Ctheta controls Th1 cells in experimental autoimmune encephalomyelitis. J Immunol (2005) 1.21
Functional dichotomy between OX40 and 4-1BB in modulating effector CD8 T cell responses. J Immunol (2006) 1.21
Immune regulation and control of regulatory T cells by OX40 and 4-1BB. Cytokine Growth Factor Rev (2008) 1.21
Convergence of Itch-induced ubiquitination with MEKK1-JNK signaling in Th2 tolerance and airway inflammation. J Clin Invest (2006) 1.21
Monkeypox-induced immunity and failure of childhood smallpox vaccination to provide complete protection. Clin Vaccine Immunol (2007) 1.20
Properties of murine (CD8+)CD27- T cells. Eur J Immunol (2005) 1.19
Controlled local delivery of CTLA-4 blocking antibody induces CD8+ T-cell-dependent tumor eradication and decreases risk of toxic side effects. Clin Cancer Res (2013) 1.18
Correlates of protection efficacy induced by vaccinia virus-specific CD8+ T-cell epitopes in the murine intranasal challenge model. Eur J Immunol (2009) 1.18
Dynamic regulation of Bcl6 in follicular helper CD4 T (Tfh) cells. Curr Opin Immunol (2013) 1.16
Inducible CD4+LAP+Foxp3- regulatory T cells suppress allergic inflammation. J Immunol (2011) 1.16
Mucosal memory CD8⁺ T cells are selected in the periphery by an MHC class I molecule. Nat Immunol (2011) 1.15
CD4+ T cell help has an epitope-dependent impact on CD8+ T cell memory inflation during murine cytomegalovirus infection. J Immunol (2009) 1.15
Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood. J Exp Med (2013) 1.14
Costimulation of mast cells by 4-1BB, a member of the tumor necrosis factor receptor superfamily, with the high-affinity IgE receptor. Blood (2005) 1.14
CD27-CD70 interactions sensitise naive CD4+ T cells for IL-12-induced Th1 cell development. Int Immunol (2007) 1.14
Vaccine-induced effector-memory CD8+ T cell responses predict therapeutic efficacy against tumors. J Immunol (2012) 1.14
Regulation of CD4 T cell memory by OX40 (CD134). Vaccine (2005) 1.13
Deficiency of the cyclin kinase inhibitor p21(WAF-1/CIP-1) promotes apoptosis of activated/memory T cells and inhibits spontaneous systemic autoimmunity. J Exp Med (2004) 1.13