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SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials. BMJ (2013) 9.01

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A pragmatic view on pragmatic trials. Dialogues Clin Neurosci (2011) 2.19

Threats to validity in the design and conduct of preclinical efficacy studies: a systematic review of guidelines for in vivo animal experiments. PLoS Med (2013) 1.92

Doctors record higher blood pressures than nurses: systematic review and meta-analysis. Br J Gen Pract (2014) 1.91

Are treatments more effective than placebos? A systematic review and meta-analysis. PLoS One (2013) 1.56

The need for randomization in animal trials: an overview of systematic reviews. PLoS One (2014) 1.22

Guidelines for randomized clinical trial protocol content: a systematic review. Syst Rev (2012) 1.15

Single-incision laparoscopic colectomy versus conventional multiport laparoscopic colectomy: a meta-analysis of comparative studies. Int J Colorectal Dis (2012) 1.03

Meeting the challenges of recruitment to multicentre, community-based, lifestyle-change trials: a case study of the BeWEL trial. Trials (2013) 0.94

Moxibustion in the management of irritable bowel syndrome: systematic review and meta-analysis. BMC Complement Altern Med (2013) 0.89

Comment on "Limitations of observational evidence: implications for evidence-based dietary recommendations". Adv Nutr (2014) 0.89

Risk of selection bias in randomised trials. Trials (2015) 0.86

Antiviral therapy for prevention of hepatocellular carcinoma and mortality in chronic hepatitis B: systematic review and meta-analysis. BMJ Open (2013) 0.84

Quality improvement needed in quality improvement randomised trials: systematic review of interventions to improve care in diabetes. BMJ Open (2013) 0.83

Catheter Ablation for Atrial Fibrillation in Heart Failure Patients: A Meta-Analysis of Randomized Controlled Trials. JACC Clin Electrophysiol (2015) 0.82

Evaluating causal relationships between urban built environment characteristics and obesity: a methodological review of observational studies. Int J Behav Nutr Phys Act (2014) 0.81

Accuracy of the Berger-Exner test for detecting third-order selection bias in randomised controlled trials: a simulation-based investigation. BMC Med Res Methodol (2014) 0.81

Using multiple types of studies in systematic reviews of health care interventions--a systematic review. PLoS One (2013) 0.81

Mirroring everyday clinical practice in clinical trial design: a new concept to improve the external validity of randomized double-blind placebo-controlled trials in the pharmacological treatment of major depression. BMC Med (2012) 0.80

A systematic review of the cost-effectiveness of nurse practitioners and clinical nurse specialists: what is the quality of the evidence? Nurs Res Pract (2014) 0.80

Lower versus higher oxygen concentration for delivery room stabilisation of preterm neonates: systematic review. PLoS One (2012) 0.79

Research gaps identified during systematic reviews of clinical trials: glass-ionomer cements. BMC Oral Health (2012) 0.79

Single-incision versus standard multi-incision laparoscopic colectomy in patients with malignant or benign colonic disease: a systematic review, meta-analysis and assessment of the evidence. BMC Surg (2016) 0.79

Withdrawal of biologic agents in rheumatoid arthritis: a systematic review and meta-analysis. Clin Rheumatol (2016) 0.78

Clinical trial design for endovascular ischemic stroke intervention. Neurology (2012) 0.78

Cancer concepts and principles: primer for the interventional oncologist-part I. J Vasc Interv Radiol (2013) 0.77

Failure of a numerical quality assessment scale to identify potential risk of bias in a systematic review: a comparison study. BMC Res Notes (2015) 0.75

Effect of Telehealth Interventions on Hospitalization Indicators: A Systematic Review. Perspect Health Inf Manag (2016) 0.75

Time to publication for publicly funded clinical trials in Australia: an observational study. BMJ Open (2017) 0.75

Acupoint Herbal Patching for Asthma: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Medicine (Baltimore) (2016) 0.75

In search of justification for the unpredictability paradox. Trials (2014) 0.75

Methodological Quality of Studies of Endstage Renal Disease in Lupus Nephritis, 1970 to 2015. J Rheumatol (2017) 0.75

A protocol for a systematic review of non-randomised evaluations of strategies to improve participant recruitment to randomised controlled trials. Syst Rev (2016) 0.75

Mechanisms and direction of allocation bias in randomised clinical trials. BMC Med Res Methodol (2016) 0.75

Surgical stabilization for open tibial fractures in children: External fixation or elastic stable intramedullary nail - which method is optimal? Indian J Orthop (2016) 0.75

Development of an algorithm to provide awareness in choosing study designs for inclusion in systematic reviews of healthcare interventions: a method study. BMJ Open (2015) 0.75

Experiences of recruiting to a pilot trial of Cardiac Rehabilitation In patients with Bowel cancer (CRIB) with an embedded process evaluation: lessons learned to improve recruitment. Pilot Feasibility Stud (2015) 0.75

Design Characteristics Influence Performance of Clinical Prediction Rules in Validation: A Meta-Epidemiological Study. PLoS One (2016) 0.75

Guidelines for reporting meta-epidemiological methodology research. Evid Based Med (2017) 0.75

Progesterone in women with arrested premature labor, a report of a randomised clinical trial and updated meta-analysis. BMC Pregnancy Childbirth (2017) 0.75

GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ (2008) 33.10

The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ (2011) 29.14

Grading quality of evidence and strength of recommendations. BMJ (2004) 26.08

GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables. J Clin Epidemiol (2010) 11.77

Antithrombotic therapy for VTE disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest (2012) 10.75

Audit and feedback: effects on professional practice and healthcare outcomes. Cochrane Database Syst Rev (2012) 10.32

GRADE guidelines: 3. Rating the quality of evidence. J Clin Epidemiol (2011) 10.02

Improving the reporting of pragmatic trials: an extension of the CONSORT statement. BMJ (2008) 9.98

Randomized trials stopped early for benefit: a systematic review. JAMA (2005) 8.43

A pragmatic-explanatory continuum indicator summary (PRECIS): a tool to help trial designers. J Clin Epidemiol (2009) 7.86

Going from evidence to recommendations. BMJ (2008) 7.30

Systems for grading the quality of evidence and the strength of recommendations I: critical appraisal of existing approaches The GRADE Working Group. BMC Health Serv Res (2004) 7.20

Continuing education meetings and workshops: effects on professional practice and health care outcomes. Cochrane Database Syst Rev (2009) 7.07

What is "quality of evidence" and why is it important to clinicians? BMJ (2008) 6.99

Outcomes associated with drug-eluting and bare-metal stents: a collaborative network meta-analysis. Lancet (2007) 6.77

Diagnosis and management of stable chronic obstructive pulmonary disease: a clinical practice guideline update from the American College of Physicians, American College of Chest Physicians, American Thoracic Society, and European Respiratory Society. Ann Intern Med (2011) 6.56

Driving pressure and survival in the acute respiratory distress syndrome. N Engl J Med (2015) 6.06

Stopping randomized trials early for benefit and estimation of treatment effects: systematic review and meta-regression analysis. JAMA (2010) 5.90

Executive summary: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest (2012) 5.88

GRADE guidelines: a new series of articles in the Journal of Clinical Epidemiology. J Clin Epidemiol (2010) 5.78

Use of qualitative methods alongside randomised controlled trials of complex healthcare interventions: methodological study. BMJ (2009) 5.68

Publication bias in clinical trials due to statistical significance or direction of trial results. Cochrane Database Syst Rev (2009) 5.57

An official ATS statement: grading the quality of evidence and strength of recommendations in ATS guidelines and recommendations. Am J Respir Crit Care Med (2006) 5.29

Perioperative management of antithrombotic therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest (2012) 5.29

Grading quality of evidence and strength of recommendations for diagnostic tests and strategies. BMJ (2008) 5.16

GRADE guidelines: 4. Rating the quality of evidence--study limitations (risk of bias). J Clin Epidemiol (2011) 5.10

Bariatric surgery versus non-surgical treatment for obesity: a systematic review and meta-analysis of randomised controlled trials. BMJ (2013) 5.08

Prevention of VTE in nonsurgical patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest (2012) 5.02

Grading strength of recommendations and quality of evidence in clinical guidelines: report from an american college of chest physicians task force. Chest (2006) 4.77

Association between industry funding and statistically significant pro-industry findings in medical and surgical randomized trials. CMAJ (2004) 4.53

Mortality in randomized controlled trials comparing drug-eluting vs. bare metal stents in coronary artery disease: a meta-analysis. Eur Heart J (2006) 4.38

Short-term vs conventional glucocorticoid therapy in acute exacerbations of chronic obstructive pulmonary disease: the REDUCE randomized clinical trial. JAMA (2013) 4.33

Effects of low-carbohydrate vs low-fat diets on weight loss and cardiovascular risk factors: a meta-analysis of randomized controlled trials. Arch Intern Med (2006) 4.19

SUPPORT Tools for evidence-informed health Policymaking (STP). Health Res Policy Syst (2009) 3.93

Letters, numbers, symbols and words: how to communicate grades of evidence and recommendations. CMAJ (2003) 3.92

A new 'mechanistic-practical" framework for designing and interpreting randomized trials. J Clin Epidemiol (2008) 3.75

A pragmatic-explanatory continuum indicator summary (PRECIS): a tool to help trial designers. CMAJ (2009) 3.65

GRADE guidelines: 2. Framing the question and deciding on important outcomes. J Clin Epidemiol (2010) 3.60

GRADE guidelines: 14. Going from evidence to recommendations: the significance and presentation of recommendations. J Clin Epidemiol (2013) 3.58

GRADE guidelines 6. Rating the quality of evidence--imprecision. J Clin Epidemiol (2011) 3.54

Is a subgroup effect believable? Updating criteria to evaluate the credibility of subgroup analyses. BMJ (2010) 3.54

The vexing problem of guidelines and conflict of interest: a potential solution. Ann Intern Med (2010) 3.47

SUPPORT Tools for evidence-informed health Policymaking (STP) 14: Organising and using policy dialogues to support evidence-informed policymaking. Health Res Policy Syst (2009) 3.45

GRADE guidelines: 5. Rating the quality of evidence--publication bias. J Clin Epidemiol (2011) 3.44

Association between change in high density lipoprotein cholesterol and cardiovascular disease morbidity and mortality: systematic review and meta-regression analysis. BMJ (2009) 3.39

SUPPORT Tools for evidence-informed health Policymaking (STP) 13: Preparing and using policy briefs to support evidence-informed policymaking. Health Res Policy Syst (2009) 3.34

Patients at the center: in our practice, and in our use of language. ACP J Club (2004) 3.32

GRADE guidelines: 9. Rating up the quality of evidence. J Clin Epidemiol (2011) 3.30

Supporting the delivery of cost-effective interventions in primary health-care systems in low-income and middle-income countries: an overview of systematic reviews. Lancet (2008) 3.28

Validity of composite end points in clinical trials. BMJ (2005) 3.26

Quality of care in for-profit and not-for-profit nursing homes: systematic review and meta-analysis. BMJ (2009) 3.22

Methodology for the development of antithrombotic therapy and prevention of thrombosis guidelines: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest (2012) 3.14

Problems with use of composite end points in cardiovascular trials: systematic review of randomised controlled trials. BMJ (2007) 3.06

Antivirals for treatment of influenza: a systematic review and meta-analysis of observational studies. Ann Intern Med (2012) 3.05

GRADE guidelines: 7. Rating the quality of evidence--inconsistency. J Clin Epidemiol (2011) 3.02

A checklist for identifying determinants of practice: a systematic review and synthesis of frameworks and taxonomies of factors that prevent or enable improvements in healthcare professional practice. Implement Sci (2013) 3.00

Procalcitonin algorithms for antibiotic therapy decisions: a systematic review of randomized controlled trials and recommendations for clinical algorithms. Arch Intern Med (2011) 2.97

Corticosteroid Therapy for Patients Hospitalized With Community-Acquired Pneumonia: A Systematic Review and Meta-analysis. Ann Intern Med (2015) 2.95

Improving the use of research evidence in guideline development: 10. Integrating values and consumer involvement. Health Res Policy Syst (2006) 2.93

Systems for grading the quality of evidence and the strength of recommendations II: pilot study of a new system. BMC Health Serv Res (2005) 2.91

Oral direct Factor Xa inhibitors versus low-molecular-weight heparin to prevent venous thromboembolism in patients undergoing total hip or knee replacement: a systematic review and meta-analysis. Ann Intern Med (2012) 2.91

GRADE guidelines: 8. Rating the quality of evidence--indirectness. J Clin Epidemiol (2011) 2.83