PubRank

Aaron Ciechanover

Author PubWeight™ 90.96‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiol Rev 2002 16.10
2 The HECT family of E3 ubiquitin ligases: multiple players in cancer development. Cancer Cell 2008 3.35
3 HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53. Proc Natl Acad Sci U S A 2003 2.73
4 Targeting proteins for destruction by the ubiquitin system: implications for human pathobiology. Annu Rev Pharmacol Toxicol 2009 2.70
5 Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1. Nat Cell Biol 2002 2.42
6 The polycomb protein Ring1B generates self atypical mixed ubiquitin chains required for its in vitro histone H2A ligase activity. Mol Cell 2006 2.26
7 Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks. Mol Cell 2011 2.16
8 Caspase activation inhibits proteasome function during apoptosis. Mol Cell 2004 1.78
9 Non-canonical ubiquitin-based signals for proteasomal degradation. J Cell Sci 2012 1.75
10 The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation. Nat Rev Mol Cell Biol 2011 1.73
11 Degradation of the Id2 developmental regulator: targeting via N-terminal ubiquitination. Biochem Biophys Res Commun 2004 1.66
12 Narrative review: protein degradation and human diseases: the ubiquitin connection. Ann Intern Med 2006 1.57
13 The 26 S proteasome: from basic mechanisms to drug targeting. J Biol Chem 2009 1.55
14 The tumor suppressor protein p16(INK4a) and the human papillomavirus oncoprotein-58 E7 are naturally occurring lysine-less proteins that are degraded by the ubiquitin system. Direct evidence for ubiquitination at the N-terminal residue. J Biol Chem 2004 1.55
15 The ubiquitin-proteasome system in cardiovascular diseases-a hypothesis extended. Cardiovasc Res 2004 1.46
16 A novel mammalian endoplasmic reticulum ubiquitin ligase homologous to the yeast Hrd1. Biochem Biophys Res Commun 2003 1.37
17 Mechanism of processing of the NF-kappa B2 p100 precursor: identification of the specific polyubiquitin chain-anchoring lysine residue and analysis of the role of NEDD8-modification on the SCF(beta-TrCP) ubiquitin ligase. Oncogene 2004 1.33
18 Ubiquitin as a central cellular regulator. Cell 2004 1.30
19 The size of the proteasomal substrate determines whether its degradation will be mediated by mono- or polyubiquitylation. Mol Cell 2012 1.30
20 Hypoxia-mediated degradation of Na,K-ATPase via mitochondrial reactive oxygen species and the ubiquitin-conjugating system. Circ Res 2006 1.27
21 Modification by single ubiquitin moieties rather than polyubiquitination is sufficient for proteasomal processing of the p105 NF-kappaB precursor. Mol Cell 2009 1.23
22 Degradation of ubiquitin: the fate of the cellular reaper. Cell Cycle 2010 1.22
23 The NEDD8 pathway is essential for SCF(beta -TrCP)-mediated ubiquitination and processing of the NF-kappa B precursor p105. J Biol Chem 2002 1.11
24 E12 and E47 modulate cellular localization and proteasome-mediated degradation of MyoD and Id1. Oncogene 2005 1.10
25 Synthetic polyubiquitinated α-Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology. Proc Natl Acad Sci U S A 2013 1.07
26 Regulation of the polycomb protein Ring1B by self-ubiquitination or by E6-AP may have implications to the pathogenesis of Angelman syndrome. Proc Natl Acad Sci U S A 2010 1.07
27 Determinants of nuclear and cytoplasmic ubiquitin-mediated degradation of MyoD. J Biol Chem 2002 1.06
28 Ubiquitin degradation with its substrate, or as a monomer in a ubiquitination-independent mode, provides clues to proteasome regulation. Proc Natl Acad Sci U S A 2009 1.06
29 Ubiquitin-proteasome-mediated degradation of keratin intermediate filaments in mechanically stimulated A549 cells. J Biol Chem 2008 1.05
30 Ubiquitin-proteasome-mediated degradation, intracellular localization, and protein synthesis of MyoD and Id1 during muscle differentiation. J Biol Chem 2005 1.03
31 Regulation of the Polycomb protein RING1B ubiquitination by USP7. Biochem Biophys Res Commun 2010 1.02
32 Hypoxia-mediated Na-K-ATPase degradation requires von Hippel Lindau protein. FASEB J 2007 1.00
33 Switches, excitable responses and oscillations in the Ring1B/Bmi1 ubiquitination system. PLoS Comput Biol 2011 1.00
34 Inverse relationship between Skp2 ubiquitin ligase and the cyclin dependent kinase inhibitor p27Kip1 in prostate cancer. J Urol 2003 0.99
35 Phosphorylation and ubiquitination are necessary for Na,K-ATPase endocytosis during hypoxia. Cell Signal 2007 0.98
36 Physical and functional interaction of the HECT ubiquitin-protein ligases E6AP and HERC2. J Biol Chem 2011 0.98
37 Dual effects of IkappaB kinase beta-mediated phosphorylation on p105 Fate: SCF(beta-TrCP)-dependent degradation and SCF(beta-TrCP)-independent processing. Mol Cell Biol 2004 0.93
38 FAT10 is a proteasomal degradation signal that is itself regulated by ubiquitination. Mol Biol Cell 2011 0.92
39 ABIN-1 negatively regulates NF-kappaB by inhibiting processing of the p105 precursor. Biochem Biophys Res Commun 2009 0.92
40 Nonenzymatic polyubiquitination of expressed proteins. J Am Chem Soc 2014 0.92
41 PRAJA1 is a ubiquitin ligase for the polycomb repressive complex 2 proteins. Biochem Biophys Res Commun 2011 0.91
42 Oxidative stress-related increase in ubiquitination in early coronary atherogenesis. FASEB J 2003 0.90
43 Personalized medicine: the road ahead. Am J Respir Crit Care Med 2012 0.90
44 Ubiquitin-Proteasome-mediated degradation of Id1 is modulated by MyoD. J Biol Chem 2004 0.89
45 Regulation of the proapoptotic ARTS protein by ubiquitin-mediated degradation. J Biol Chem 2005 0.89
46 Ubiquitination participates in the lysosomal degradation of Na,K-ATPase in steady-state conditions. Am J Respir Cell Mol Biol 2009 0.89
47 HUWE1 ubiquitinates MyoD and targets it for proteasomal degradation. Biochem Biophys Res Commun 2012 0.88
48 Increased ubiquitin immunoreactivity in unstable atherosclerotic plaques associated with acute coronary syndromes. J Am Coll Cardiol 2002 0.88
49 Ubiquitin binding by a CUE domain regulates ubiquitin chain formation by ERAD E3 ligases. Mol Cell 2013 0.88
50 The N-terminal domain of MyoD is necessary and sufficient for its nuclear localization-dependent degradation by the ubiquitin system. Proc Natl Acad Sci U S A 2008 0.87
51 Two distinct ubiquitin-dependent mechanisms are involved in NF-kappaB p105 proteolysis. Biochem Biophys Res Commun 2006 0.86
52 The lysine48-based polyubiquitin chain proteasomal signal: not a single child anymore. Angew Chem Int Ed Engl 2012 0.85
53 A heat-stable polypeptide component of an ATP-dependent proteolytic system from reticulocytes. 1978. Biochem Biophys Res Commun 2012 0.83
54 In vivo interactions of MyoD, Id1, and E2A proteins determined by acceptor photobleaching fluorescence resonance energy transfer. FASEB J 2008 0.83
55 Ubiquitin is degraded by the ubiquitin system as a monomer and as part of its conjugated target. Biochem Biophys Res Commun 2007 0.82
56 HOIL-1L functions as the PKCζ ubiquitin ligase to promote lung tumor growth. Am J Respir Crit Care Med 2014 0.81
57 Epstein-Barr virus-encoded EBNA-5 forms trimolecular protein complexes with MDM2 and p53 and inhibits the transactivating function of p53. Int J Cancer 2011 0.81
58 Modification of the inflammatory mediator LRRFIP2 by the ubiquitin-like protein FAT10 inhibits its activity during cellular response to LPS. Biochem Biophys Res Commun 2012 0.81
59 Modification by single ubiquitin moieties rather than polyubiquitination is sufficient for proteasomal processing of the p105 NF-κB precursor. Adv Exp Med Biol 2011 0.80
60 The ubiquitin-proteasome system--micro target for macro intervention? Int J Cardiovasc Intervent 2005 0.78
61 Generation of free ubiquitin chains is up-regulated in stress and facilitated by the HECT domain ubiquitin ligases UFD4 and HUL5. Biochem J 2012 0.78
62 Early work on the ubiquitin proteasome system, an interview with Aaron Ciechanover. Interview by CDD. Cell Death Differ 2005 0.77
63 Modifying the vicinity of the isopeptide bond to reveal differential behavior of ubiquitin chains with interacting proteins: organic chemistry applied to synthetic proteins. Angew Chem Int Ed Engl 2013 0.77
64 Ubiquitination and degradation of proteins. Methods Mol Biol 2011 0.76
65 p62 at the crossroad of the ubiquitin-proteasome system and autophagy. Oncotarget 2016 0.75
66 An interview with Aaron Ciechanover. Trends Biochem Sci 2013 0.75
67 Glioma-derived cancer stem cells are hypersensitive to proteasomal inhibition. EMBO Rep 2017 0.75
68 The 2008 Lindau Nobel Laureate Meeting: Aaron Ciechanover, Chemistry 2004. J Vis Exp 2009 0.75
69 Response to health in the Occupied Palestinian Territory. Lancet 2011 0.75
70 On the wings of imagination. Nature 2011 0.75
71 RING1B ubiquitination and stability are regulated by ARF. Biochem Biophys Res Commun 2012 0.75
72 A conversation with Aaron Ciechanover. Interview by Ushma S. Neill. J Clin Invest 2013 0.75