| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
SKI-606, a Src/Abl inhibitor with in vivo activity in colon tumor xenograft models.
|
Cancer Res
|
2005
|
1.29
|
|
2
|
WAY-163909, a 5-HT2C agonist, enhances the preclinical potency of current antipsychotics.
|
Psychopharmacology (Berl)
|
2008
|
0.90
|
|
3
|
The metabotropic glutamate receptor 7 allosteric modulator AMN082: a monoaminergic agent in disguise?
|
J Pharmacol Exp Ther
|
2011
|
0.87
|
|
4
|
Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic triglyceride synthesis.
|
J Med Chem
|
2008
|
0.86
|
|
5
|
Pharmacokinetic and pharmacodynamic profiles of the novel serotonin and norepinephrine reuptake inhibitor desvenlafaxine succinate in ovariectomized Sprague-Dawley rats.
|
Brain Res
|
2006
|
0.82
|
|
6
|
Discovery of phenyl acetic acid substituted quinolines as novel liver X receptor agonists for the treatment of atherosclerosis.
|
J Med Chem
|
2006
|
0.81
|
|
7
|
Synthesis, potency, and in vivo evaluation of 2-piperazin-1-ylquinoline analogues as dual serotonin reuptake inhibitors and serotonin 5-HT1A receptor antagonists.
|
J Med Chem
|
2009
|
0.80
|
|
8
|
Design, synthesis, and SAR of new pyrrole-oxindole progesterone receptor modulators leading to 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348).
|
J Med Chem
|
2008
|
0.79
|
|
9
|
Discovery of a class of potent gap-junction modifiers as novel antiarrhythmic agents.
|
Bioorg Med Chem Lett
|
2009
|
0.79
|
|
10
|
Further modification on phenyl acetic acid based quinolines as liver X receptor modulators.
|
Bioorg Med Chem
|
2007
|
0.79
|
|
11
|
3-(3-Aryloxyaryl)imidazo[1,2-a]pyridine sulfones as liver X receptor agonists.
|
Bioorg Med Chem Lett
|
2009
|
0.78
|
|
12
|
2-phenyl-4-piperazinylbenzimidazoles: orally active inhibitors of the gonadotropin releasing hormone (GnRH) receptor.
|
Bioorg Med Chem
|
2008
|
0.78
|
|
13
|
The synthesis and biological evaluation of quinolyl-piperazinyl piperidines as potent serotonin 5-HT1A antagonists.
|
J Med Chem
|
2010
|
0.77
|
|
14
|
Selective Kv1.5 blockers: development of (R)-1-(methylsulfonylamino)-3-[2-(4-methoxyphenyl)ethyl]-4-(4-methoxyphenyl)-2-imidazolidinone (KVI-020/WYE-160020) as a potential treatment for atrial arrhythmia.
|
J Med Chem
|
2009
|
0.77
|
|
15
|
Discovery of (2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid hydrochloride (GAP-134)13, an orally active small molecule gap-junction modifier for the treatment of atrial fibrillation.
|
J Med Chem
|
2009
|
0.77
|
|
16
|
1-(3-Aryloxyaryl)benzimidazole sulfones are liver X receptor agonists.
|
Bioorg Med Chem Lett
|
2009
|
0.77
|
|
17
|
Development of an early biomarker for the ovarian liability of selective estrogen receptor modulators in rats.
|
J Steroid Biochem Mol Biol
|
2008
|
0.76
|
|
18
|
Dual acting norepinephrine reuptake inhibitors and 5-HT(2A) receptor antagonists: Identification, synthesis and activity of novel 4-aminoethyl-3-(phenylsulfonyl)-1H-indoles.
|
Bioorg Med Chem
|
2009
|
0.76
|
|
19
|
5-Cyclic amine-3-arylsulfonylindazoles as novel 5-HT6 receptor antagonists.
|
J Med Chem
|
2010
|
0.75
|
|
20
|
Small molecule antagonists of the gonadotropin-releasing hormone (GnRH) receptor: structure-activity relationships of small heterocyclic groups appended to the 2-phenyl-4-piperazinyl-benzimidazole template.
|
Bioorg Med Chem Lett
|
2009
|
0.75
|
|
21
|
Synthesis of 4-(3-biaryl)quinoline sulfones as potent liver X receptor agonists.
|
Bioorg Med Chem Lett
|
2010
|
0.75
|
|
22
|
5-Piperazinyl-3-sulfonylindazoles as potent and selective 5-hydroxytryptamine-6 antagonists.
|
J Med Chem
|
2010
|
0.75
|
|
23
|
Novel progesterone receptor modulators: 4-aryl-phenylsulfonamides.
|
Bioorg Med Chem Lett
|
2012
|
0.75
|