Published in Biochem J on October 15, 1978
Role of adenylate cyclase in immunologic release of mediators from rat mast cells: agonist and antagonist effects of purine- and ribose-modified adenosine analogs. Proc Natl Acad Sci U S A (1980) 1.82
Capturing adenylyl cyclases as potential drug targets. Nat Rev Drug Discov (2009) 1.66
YC-1 inhibited human platelet aggregation through NO-independent activation of soluble guanylate cyclase. Br J Pharmacol (1995) 1.39
Thromboxane-induced phosphatidate formation in human platelets. Relationship to receptor occupancy and to changes in cytosolic free calcium. Biochem J (1984) 1.39
Nitric oxide inhibits angiotensin II-induced migration of rat aortic smooth muscle cell. Role of cyclic-nucleotides and angiotensin1 receptors. J Clin Invest (1995) 1.34
Impaired activation of murine platelets lacking G alpha(i2). J Clin Invest (2001) 1.31
Prostacyclin modulates cholesteryl ester hydrolytic activity by its effect on cyclic adenosine monophosphate in rabbit aortic smooth muscle cells. J Clin Invest (1982) 1.26
Effects of collagen, ionophore A23187 and prostaglandin E1 on the phosphorylation of specific proteins in blood platelets. Biochem J (1979) 1.26
Inhibitors of membranous adenylyl cyclases. Trends Pharmacol Sci (2011) 1.12
5'-N-ethylcarboxamidoadenosine: a potent inhibitor of human platelet aggregation. Br J Pharmacol (1981) 1.12
Platelet-activating factor stimulates phosphatidylinositol turnover in human platelets. Biochem J (1983) 1.10
Activity-dependent regulation of tyrosine hydroxylase expression in the enteric nervous system. J Physiol (2008) 1.08
Adenosine A(3) receptor suppresses prostate cancer metastasis by inhibiting NADPH oxidase activity. Neoplasia (2009) 1.07
Effects of analogues of adenine nucleotides on increases in intracellular calcium mediated by P2T-purinoceptors on human blood platelets. Br J Pharmacol (1993) 1.03
Alpha 2-adrenergic agonists stimulate DNA synthesis in Chinese hamster lung fibroblasts transfected with a human alpha 2-adrenergic receptor gene. Cell Regul (1990) 1.02
Activation of cGMP-stimulated phosphodiesterase by nitroprusside limits cAMP accumulation in human platelets: effects on platelet aggregation. Biochem J (1997) 1.02
CB1- and CB2-cannabinoid receptor-independent lipolysis induced by WIN 55,212-2 in male rat adipocytes. Naunyn Schmiedebergs Arch Pharmacol (2003) 0.94
Studies on the mechanism of 5-HT1 receptor-induced smooth muscle contraction in dog saphenous vein. Br J Pharmacol (1992) 0.93
Effects of activation of protein kinase C on the agonist-induced stimulation and inhibition of cyclic AMP formation in intact human platelets. Biochem J (1987) 0.90
Platelet beta-adrenoceptors. Br J Pharmacol (1983) 0.90
Release of adenosine from human neutrophils stimulated by platelet activating factor, leukotriene B(4) and opsonized zymosan. Mediators Inflamm (1992) 0.90
Cyclic AMP mimics, but does not mediate, interleukin-1- and tumour-necrosis-factor-stimulated phospholipase A2 secretion from rat renal mesangial cells. Biochem J (1991) 0.90
Desensitization and antagonism of vasopressin-induced phosphoinositide metabolism and elevation of cytosolic free calcium concentration in human platelets. Biochem J (1986) 0.89
Effects of the adenylyl cyclase inhibitor SQ22536 on iloprost-induced vasorelaxation and cyclic AMP elevation in isolated guinea-pig aorta. Br J Pharmacol (1999) 0.88
Identification of a receptor for ADP on blood platelets by photoaffinity labelling. Biochem J (1993) 0.88
A new site and mechanism of action for the widely used adenylate cyclase inhibitor SQ22,536. Mol Pharmacol (2012) 0.87
Induction of intracellular cAMP by a synthetic retroviral envelope peptide: a possible mechanism of immunopathogenesis in retroviral infections. Proc Natl Acad Sci U S A (1995) 0.85
Identification of two distinct vasodilator pathways activated by ATP in the mesenteric bed of the rat. Br J Pharmacol (2001) 0.85
Effects of alpha 2-adrenoceptor agonists and of related compounds on aggregation of, and on adenylate cyclase activity in, human platelets. Br J Pharmacol (1984) 0.83
Platelet aggregation induced by alpha 2-adrenoceptor and protein kinase C activation. A novel synergism. Biochem J (1989) 0.82
Cordycepin-Enriched WIB801C from Cordyceps militaris Inhibits Collagen-Induced [Ca(2+)]i Mobilization via cAMP-Dependent Phosphorylation of Inositol 1, 4, 5-Trisphosphate Receptor in Human Platelets. Biomol Ther (Seoul) (2014) 0.81
Differential inhibition by adenosine or by prostaglandin E1 of human platelet aggregation induced by adenosine 5'-O-(1-thiodiphosphate) and adenosine 5'-O-(2-thiodiphosphate). Br J Pharmacol (1982) 0.79
High concentrations of exogenous arachidonate inhibit calcium mobilization in platelets by stimulation of adenylate cyclase. Biochem J (1988) 0.79
Prostaglandin E2 stimulates cyclic AMP-mediated hyaluronan synthesis in rabbit pericardial mesothelial cells. Biochem J (1993) 0.78
Further investigation into the signal transduction mechanism of the 5-HT4-like receptor in the circular smooth muscle of human colon. Br J Pharmacol (1996) 0.78
Possible mechanisms of the potentiation of blood-platelet activation by adrenaline. Biochem J (1987) 0.77
Involvement of phosphoinositide metabolism in potentiation by adrenaline of ADP-induced aggregation of rabbit platelets. Biochem J (1987) 0.77
Effect of trilinolein on cyclic nucleotide formation in human platelets: relationship with its antiplatelet effect and nitric oxide synthesis. Br J Pharmacol (1995) 0.76
Inhibition of prostaglandin E1-responsive platelet adenylate cyclase by heparin: a study of the mechanism of inhibition and its relevance to platelet aggregation. Br J Pharmacol (1981) 0.75
Proceedings of the British Pharmacological Society. London, 17th-19th December, 1984. Abstracts. Br J Pharmacol (1985) 0.75
Protein measurement with the Folin phenol reagent. J Biol Chem (1951) 1743.91
A simple, sensitive method for the assay of adenyl cyclase. J Pharmacol Exp Ther (1968) 8.05
Two distinct adenosine-sensitive sites on adenylate cyclase. Proc Natl Acad Sci U S A (1977) 3.89
Effects of adenosine on levels of adenosine cyclic 3',5'-monophosphate in human blood platelets in relation to adenosine incorporation and platelet aggregation. Mol Pharmacol (1975) 1.84
Platelet 5-HT uptake and release stopped rapidly by formaldehyde. Nature (1975) 1.84
Effects of adenosine nucleosides on adenylate cyclase, phosphodiesterase, cyclic adenosine monophosphate accumulation, and lipolysis in fat cells. J Biol Chem (1972) 1.82
Interactions of the pharmacological receptors of blood platelets with adenylate cyclase. Ser Haematol (1973) 1.67
Regulation of blood platelet function by cyclic nucleotides. Adv Cyclic Nucleotide Res (1978) 1.65
COMPARATIVE EFFECTIVENESS OF ADENOSINE ANALOGUES AS INHIBITORS OF BLOOD-PLATELET AGGREGATION AND AS VASODILATORS IN MAN. Nature (1965) 1.43
Cyclic AMP and platelet function. N Engl J Med (1972) 1.42
Effects of photolysable 2-azido analogues of adenosine, AMP and ADP on human platelets. Proc R Soc Lond B Biol Sci (1977) 1.29
Stimulation of human platelet adenylate cyclase by prostaglandin D2. Thromb Res (1974) 1.26
Cyclic 3',5'-adenosine monophosphate in human blood platelets. II. Effect of N6-2'-o-dibutyryl cyclic 3',5'-adenosine monophosphate on platelet function. J Clin Invest (1971) 1.26
Platelet aggregation inhibitors. 4. N 6 -substituted adenosines. J Med Chem (1973) 1.20
Aggregation of human blood platelets by vasopressin. Am J Physiol (1972) 1.19
Roles of cyclic nucleotides in platelet function. Ciba Found Symp (1975) 1.18
Activation and inhibition of blood platelet adenylate cyclase by adenosine or by 2-chloroadenosine. Life Sci II (1972) 1.17
On the mechanism of adenyl cyclase inhibition by adenosine. Can J Physiol Pharmacol (1973) 1.10
Adenosine, cyclic AMP metabolism, and glycogenolysis in rat liver cells. J Biol Chem (1977) 1.10
Regulation by glucagon and divalent cations of inhibition of hepatic adenylate cyclase by adenosine. J Biol Chem (1977) 1.06
Accumulation of cyclic adenosine monophosphate in incubated slices of brain tissue. 2. Effects of depolarizing agents, membrane stabilizers, phosphodiesterase inhibitors, and adenosine analogs. J Med Chem (1972) 1.05
Cytochalasin B, the blood platelet release reaction and cyclic GMP. Nature (1975) 1.00
Inhibition of cholera toxin-stimulated intestinal epithelial cell adenylate cyclase by adenosine analogs. Proc Soc Exp Biol Med (1976) 0.99
Inhibition of rat liver adenyl cyclase by adenosine and adenine nucleotides. Experientia (1970) 0.99
Effect of adenosine on cyclic AMP accumulation in ventricular myocardium. Biochem Pharmacol (1976) 0.98
Platelet aggregation inhibitors. 6. 2-Thioadenosine derivatives. J Med Chem (1973) 0.97
Interrelation of prostaglandin endoperoxide (prostaglandin G2) and cyclic 3',5'-adenosine monophosphate in human blood platelets. Biochim Biophys Acta (1977) 0.92
Transport and metabolism of adenosine in human blood platelets. Biochim Biophys Acta (1976) 0.92
Conformational basis for the activation of adenylate cyclase by adenosine. Proc Natl Acad Sci U S A (1977) 0.90
Isolation of a unique peptide inhibitor of hormone-responsive adenylate cyclase. J Biol Chem (1975) 0.88
Formation of prostagland in D2 during endoperoxide-induced platelet aggregation. Thromb Res (1976) 0.85
2'-Deoxyadenosine-3'-monophosphate: a naturally occurring inhibitor of adenylate cyclase in amphibian and mammalian cells. Life Sci (1976) 0.82
Factors affecting platelet cyclic GMP levels during aggregation induced by collagen and by arachidonic acid. Thromb Res (1976) 0.81
Adenosine analogs and human platelets. Effects on nucleotide pools and the aggregation phenomenon. Biochem Pharmacol (1975) 0.81
The effect of adenylate cyclase inhibitor (ACI) on guanylate cyclase, phosphodiesterase and other enzymes in heart. J Cyclic Nucleotide Res (1977) 0.79
Inhibition of glutamate-elicited accumulation of adenosine cyclic 3',5'-monophosphate in brain slices by alpha, omega-diaminocarboxylic acids. Mol Pharmacol (1975) 0.79
Inhibition of fat cell membrane adenylate cyclase by 2'-deoxyadenosine-3'-monophosphate,. Life Sci (1976) 0.79
Pleckstrin domain homology. Nature (1993) 3.03
Fatal infantile cardioencephalomyopathy with COX deficiency and mutations in SCO2, a COX assembly gene. Nat Genet (1999) 2.59
Molecular cloning and expression of the major protein kinase C substrate of platelets. Nature (1988) 2.00
Molecular basis of the synergistic inhibition of platelet function by nitrovasodilators and activators of adenylate cyclase: inhibition of cyclic AMP breakdown by cyclic GMP. Mol Pharmacol (1990) 1.88
Effects of adenosine on levels of adenosine cyclic 3',5'-monophosphate in human blood platelets in relation to adenosine incorporation and platelet aggregation. Mol Pharmacol (1975) 1.84
Guanine nucleotides decrease the free [Ca2+] required for secretion of serotonin from permeabilized blood platelets. Evidence of a role for a GTP-binding protein in platelet activation. FEBS Lett (1984) 1.76
Interactions of the pharmacological receptors of blood platelets with adenylate cyclase. Ser Haematol (1973) 1.67
Regulation of blood platelet function by cyclic nucleotides. Adv Cyclic Nucleotide Res (1978) 1.65
Evidence for a humoral mechanism for enhanced osteogenesis after head injury. J Bone Joint Surg Am (1990) 1.64
Borrelia burgdorferi-associated cutaneous marginal zone lymphoma: a clinicopathological study of two cases illustrating the temporal progression of B. burgdorferi-associated B-cell proliferation in the skin. Histopathology (2000) 1.55
Receptor-induced diacylglycerol formation in permeabilized platelets; possible role for a GTP-binding protein. J Recept Res (1984) 1.51
Purification and characterization of the 47,000-dalton protein phosphorylated during degranulation of human platelets. J Biol Chem (1983) 1.49
Role of small round viruses and small round structured viruses. Lancet (1994) 1.38
Apparent mtDNA heteroplasmy in Alzheimer's disease patients and in normals due to PCR amplification of nucleus-embedded mtDNA pseudogenes. Proc Natl Acad Sci U S A (1997) 1.36
Potentiation by thrombin of the secretion of serotonin from permeabilized platelets equilibrated with Ca2+ buffers. Relationship to protein phosphorylation and diacylglycerol formation. Biochem J (1984) 1.27
Effects of collagen, ionophore A23187 and prostaglandin E1 on the phosphorylation of specific proteins in blood platelets. Biochem J (1979) 1.26
Relationship between phosphorylation of blood platelet proteins and secretion of platelet granule constituents. I. Effects of different aggregating agents. Biochem Biophys Res Commun (1977) 1.26
Detection of 23-27 kDa GTP-binding proteins in platelets and other cells. Biochem J (1987) 1.20
Aggregation of human blood platelets by vasopressin. Am J Physiol (1972) 1.19
Roles of cyclic nucleotides in platelet function. Ciba Found Symp (1975) 1.18
Activation and inhibition of blood platelet adenylate cyclase by adenosine or by 2-chloroadenosine. Life Sci II (1972) 1.17
Primary cutaneous B-cell lymphoma and Borrelia burgdorferi infection in patients from the Highlands of Scotland. Am J Surg Pathol (2000) 1.14
Measurement of circulating prostacyclin. Nature (1981) 1.09
The adenylate kinase of human plasma, erythrocytes and platelets in relation to the degradation of adenosine diphosphate in plasma. Biochem J (1967) 1.09
Dephosphorylation of cofilin in stimulated platelets: roles for a GTP-binding protein and Ca2+. Biochem J (1994) 1.08
Improved diagnosis of reactivated toxoplasmosis. Mol Pathol (1998) 1.07
Factors affecting dense and alpha-granule secretion from electropermeabilized human platelets: Ca(2+)-independent actions of phorbol ester and GTP gamma S. Cell Regul (1990) 1.02
Activation of cGMP-stimulated phosphodiesterase by nitroprusside limits cAMP accumulation in human platelets: effects on platelet aggregation. Biochem J (1997) 1.02
Mitochondrial DNA background modifies the bioenergetics of NARP/MILS ATP6 mutant cells. Hum Mol Genet (2009) 1.02
Cytochalasin B, the blood platelet release reaction and cyclic GMP. Nature (1975) 1.00
GTP gamma S and phorbol ester act synergistically to stimulate both Ca(2+)-independent secretion and phospholipase D activity in permeabilized human platelets. Inhibition by BAPTA and analogues. FEBS Lett (1993) 0.99
Effects of collagen and of aspirin on the concentration of guanosine 3':5'-cyclic monophosphate in human blood platelets: measurement by a prelabelling technique. Biochem J (1974) 0.99
Cyclic nucleotides in platelet function. Thromb Haemost (1978) 0.99
Nitroprusside enhances isoprenaline-induced increases in cAMP in rat aortic smooth muscle. Eur J Pharmacol (1990) 0.97
Vasopressin inhibits the adenylate cyclase activity of human platelet particulate fraction through V1-receptors. FEBS Lett (1983) 0.96
Effects of catecholamines on the formation of adenosine 3':5'-cyclic monophosphate in human blood platelets. Biochem J (1971) 0.96
Testing by Sysmex UF-100 flow cytometer and with bacterial culture in a diagnostic laboratory: a comparison. J Clin Pathol (2006) 0.96
Adenosine 3': 5'-cyclic monophosphate in young and senescent human fibroblasts during growth and stationary phase in vitro. Effects of prostaglandine E1 and of adrenaline. Biochem J (1974) 0.94
Molecular analysis of pleckstrin: the major protein kinase C substrate of platelets. J Cell Biochem (1989) 0.94
Synergistic actions of nitrovasodilators and isoprenaline on rat aortic smooth muscle. Eur J Pharmacol (1991) 0.93
Inhibition of platelet adenylate cyclase by 1-O-alkyl-2-O-acetyl-sn-glyceryl-3-phosphorylcholine (platelet-activating factor). J Biol Chem (1982) 0.91
Effects of activation of protein kinase C on the agonist-induced stimulation and inhibition of cyclic AMP formation in intact human platelets. Biochem J (1987) 0.90
Effects of nitrovasodilators on platelet cyclic nucleotide levels in rabbit blood; role for cyclic AMP in synergistic inhibition of platelet function by SIN-1 and prostaglandin E1. J Cardiovasc Pharmacol (1991) 0.90
Identification of multiple ral gene products in human platelets that account for some but not all of the platelet Gn-proteins. FEBS Lett (1990) 0.88
Activation of phospholipase C associated with isolated rabbit platelet membranes by guanosine 5'-[gamma-thio]triphosphate and by thrombin in the presence of GTP. Biochem J (1987) 0.87
Comparison of IgG antibody profiles by immunoblotting in patients with acute and previous Toxoplasma gondii infection. J Clin Pathol (1991) 0.87
Gn-proteins are distinct from ras p21 and other known low molecular mass GTP-binding proteins in the platelet. FEBS Lett (1988) 0.87
Long-term analysis of differentiation in human myoblasts repopulated with mitochondria harboring mtDNA mutations. Biochem Biophys Res Commun (1999) 0.87
Effects of guanosine 5'-[gamma-thio]triphosphate and thrombin on the phosphoinositide metabolism of electropermeabilized human platelets. Eur J Biochem (1988) 0.86
Relationship between phosphorylation of blood platelet proteins and secretion of platelet granule constituents II. Effects of different inhibitors. Thromb Res (1978) 0.85
GTP not cyclic GMP enhances secretion from permeabilized platelets. Nature (1985) 0.85
Characterization of the protein kinase activities of human platelet supernatant and particulate fractions. Biochem J (1984) 0.85
Photoaffinity labelling of cyclic GMP-inhibited phosphodiesterase (PDE III) in human and rat platelets and rat tissues: effects of phosphodiesterase inhibitors. Eur J Pharmacol (1994) 0.84
Synergistic inhibitory effects of atriopeptin II and isoproterenol on contraction of rat aortic smooth muscle: roles of cGMP and cAMP. Eur J Pharmacol (1993) 0.84
Recurrent myoglobinuria due to a nonsense mutation in the COX I gene of mitochondrial DNA. Neurology (2000) 0.83
Why have Pneumocystis carinii trophozoites been ignored? J Clin Pathol (1990) 0.83
Cloning, functional expression and role in cell growth regulation of a hamster 5-HT2 receptor subtype. Mol Endocrinol (1991) 0.82
Structure of the carboxy-terminal PH domain of pleckstrin at 2.1 Angstroms. Acta Crystallogr D Biol Crystallogr (2006) 0.81
Lyme disease--what is the cost for Scotland? Public Health (2003) 0.81
Increased phosphorylation of specific blood platelet proteins in association with the release reaction. Biochem Soc Trans (1976) 0.81
Identification of different Borrelia burgdorferi genomic groups from Scottish ticks. Mol Pathol (2000) 0.81
Factors affecting platelet cyclic GMP levels during aggregation induced by collagen and by arachidonic acid. Thromb Res (1976) 0.81
Photoaffinity labelling of cyclic GMP-binding proteins in human platelets. Biochem J (1993) 0.80
Chemical cross-linking of pleckstrin in human platelets: evidence for oligomerization of the protein and its dissociation by protein kinase C. Biochem J (1996) 0.80
Factors affecting the activity of guanylate cyclase in lysates of human blood platelets. Biochem J (1978) 0.80
Subcellular distribution of cyclic AMP-dependent protein kinase activity and of cyclic AMP-binding proteins in human platelets. Modification by Ca2+-dependent proteolysis. FEBS Lett (1981) 0.80
Appendix-Calculation of rate of exchange transamination. Biochem J (1965) 0.80
A cost-effective protocol for screening patients for methicillin-resistant Staphylococcus aureus. Br J Biomed Sci (2011) 0.79
Morphoea and Borrelia burgdorferi: results from the Scottish Highlands in the context of the world literature. Mol Pathol (2002) 0.79
Measurement of both cyclic [3H]AMP and cyclic [3H]GMP in cultured vascular smooth muscle cells labeled with [3H]hypoxanthine: use in studies of cardiovascular drugs. Anal Biochem (1993) 0.79
Chinese hamster serotonin (5-HT) type 2 receptor cDNA sequence. Nucleic Acids Res (1990) 0.79
Induction of the 47 kDa platelet substrate of protein kinase C during differentiation of HL-60 cells. Biochem J (1987) 0.78
Receptor-effector coupling in platelets: roles of guanine nucleotides. Adv Exp Med Biol (1985) 0.78
Measurement of changes in platelet cyclic AMP in vitro and in vivo by prelabeling techniques: application to the detection and assay of circulating PGI2. Methods Enzymol (1989) 0.78
Inhibition and subsequent enhancement of platelet responsiveness by prostacyclin in the rabbit. Relationship to platelet adenosine 3',5'-cyclic monophosphate. J Clin Invest (1985) 0.78
Loss of sulfated proteoglycan from the surface of rabbit platelets during adenosine 5'-diphosphate-induced aggregation. Lab Invest (1976) 0.78
Stimulation of phospholipase D in rabbit platelet membranes by nucleoside triphosphates and by phosphocreatine: roles of membrane-bound GDP, nucleoside diphosphate kinase and creatine kinase. Biochem J (1994) 0.76
Effects of NaCl and GTP on the inhibition of platelet adenylate cyclase by 1-O-octadecyl-2-O-acetyl-sn-glyceryl-3-phosphorylcholine (synthetic platelet-activating factor). Biochim Biophys Acta (1984) 0.76
Expression and mutagenesis of the catalytic domain of cGMP-inhibited phosphodiesterase (PDE3) cloned from human platelets. Biochem J (1997) 0.76
Inhibition of blood platelet function by cytochalasins: effects on thrombosthenin and on glucose metabolism. Biochem J (1972) 0.75
Protein kinase C-dependent and Ca2+-dependent mechanisms of secretion from streptolysin O-permeabilized platelets: effects of leakage of cytosolic proteins. Biochem J (1997) 0.75
Evaluation of transgenic approaches for controlling tuber moth in potatoes. Commun Agric Appl Biol Sci (2005) 0.75
A case of polydactylism in sika deer in New Zealand. J Wildl Dis (1971) 0.75
Same-day detection of meticillin-resistant Staphylococcus aureus from screening swabs by real-time polymerase chain reaction. J Hosp Infect (2006) 0.75
Community nursing care study: decubitus ulcer. Nurs Times (1981) 0.75
Comparison of mitochondrial components from human and hamster cell lines. Exp Cell Res (1974) 0.75