Published in J Med Chem on May 13, 2011
A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Science (2002) 9.59
Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors. Nature (2011) 5.28
Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE. Am J Hum Genet (2008) 4.66
Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions. Nat Med (2013) 4.22
Subgroup-specific structural variation across 1,000 medulloblastoma genomes. Nature (2012) 4.13
Cancer prevention by tea: animal studies, molecular mechanisms and human relevance. Nat Rev Cancer (2009) 3.90
Epidermal growth factor receptor mutations in plasma DNA samples predict tumor response in Chinese patients with stages IIIB to IV non-small-cell lung cancer. J Clin Oncol (2009) 3.58
Incidence and phenotype of inflammatory bowel disease based on results from the Asia-pacific Crohn's and colitis epidemiology study. Gastroenterology (2013) 3.55
Splicing factor SFRS1 recognizes a functionally diverse landscape of RNA transcripts. Genome Res (2008) 3.33
A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination. Mol Cell (2007) 3.23
The membrane-proximal external region of the human immunodeficiency virus type 1 envelope: dominant site of antibody neutralization and target for vaccine design. Microbiol Mol Biol Rev (2008) 3.16
Dynamic characteristics of blood glucose time series during the course of critical illness: effects of intensive insulin therapy and relative association with mortality. Crit Care Med (2010) 3.16
A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA. Blood (2007) 3.09
Quantum-sized carbon dots for bright and colorful photoluminescence. J Am Chem Soc (2006) 3.08
Tumor stromal architecture can define the intrinsic tumor response to VEGF-targeted therapy. Clin Cancer Res (2013) 3.01
Harnessing a high cargo-capacity transposon for genetic applications in vertebrates. PLoS Genet (2006) 2.99
Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease. Neuron (2006) 2.88
Mechanical strain opens connexin 43 hemichannels in osteocytes: a novel mechanism for the release of prostaglandin. Mol Biol Cell (2005) 2.75
Isolation and characterization of human umbilical cord mesenchymal stem cells with hematopoiesis-supportive function and other potentials. Haematologica (2006) 2.75
Synthesis, insecticidal activity, and QSAR of novel nitromethylene neonicotinoids with tetrahydropyridine fixed cis configuration and exo-ring ether modification. J Agric Food Chem (2007) 2.71
A novel sRNA component of the carbon storage regulatory system of Escherichia coli. Mol Microbiol (2003) 2.63
Ancient pinnate leaf mimesis among lacewings. Proc Natl Acad Sci U S A (2010) 2.56
Protein turnover of the Wallenda/DLK kinase regulates a retrograde response to axonal injury. J Cell Biol (2010) 2.40
PDTD: a web-accessible protein database for drug target identification. BMC Bioinformatics (2008) 2.35
Image-guided optical spectroscopy provides molecular-specific information in vivo: MRI-guided spectroscopy of breast cancer hemoglobin, water, and scatterer size. Opt Lett (2007) 2.34
Activator control of nucleosome occupancy in activation and repression of transcription. PLoS Biol (2008) 2.29
The plasticity of human maternal brain: longitudinal changes in brain anatomy during the early postpartum period. Behav Neurosci (2010) 2.23
Depolymerization of beta-1,6-N-acetyl-D-glucosamine disrupts the integrity of diverse bacterial biofilms. J Bacteriol (2005) 2.16
Acute phase homocysteine related to severity and outcome of atherothrombotic stroke. Eur J Intern Med (2013) 2.13
c-Jun N-terminal kinase activation mediates downregulation of connexin43 in cardiomyocytes. Circ Res (2002) 2.11
Immune-related microRNAs are abundant in breast milk exosomes. Int J Biol Sci (2011) 2.11
Regulatory circuitry of the CsrA/CsrB and BarA/UvrY systems of Escherichia coli. J Bacteriol (2002) 2.10
Hypertension control in community health centers across China: analysis of antihypertensive drug treatment patterns. Am J Hypertens (2013) 2.08
Streptococcus suis sequence type 7 outbreak, Sichuan, China. Emerg Infect Dis (2006) 2.07
Clinical efficacy of oral ganciclovir for prophylaxis and treatment of recurrent herpes simplex keratitis. Chin Med J (Engl) (2015) 2.04
A RSC/nucleosome complex determines chromatin architecture and facilitates activator binding. Cell (2010) 2.00
Functional TRPV4 channels are expressed in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol (2004) 1.92
Sequence diversity of the factor H binding protein vaccine candidate in epidemiologically relevant strains of serogroup B Neisseria meningitidis. J Infect Dis (2009) 1.92
Carbon dots for multiphoton bioimaging. J Am Chem Soc (2007) 1.89
Isolated coronary artery bypass graft combined with bone marrow mononuclear cells delivered through a graft vessel for patients with previous myocardial infarction and chronic heart failure: a single-center, randomized, double-blind, placebo-controlled clinical trial. J Am Coll Cardiol (2011) 1.85
MiR-150 promotes gastric cancer proliferation by negatively regulating the pro-apoptotic gene EGR2. Biochem Biophys Res Commun (2010) 1.80
Musculoskeletal tumors: how to use anatomic, functional, and metabolic MR techniques. Radiology (2012) 1.76
Nucleotide excision repair- and polymerase eta-mediated error-prone removal of mitomycin C interstrand cross-links. Mol Cell Biol (2003) 1.76
Fasudil, a Rho-kinase inhibitor, attenuates glomerulosclerosis in Dahl salt-sensitive rats. J Hypertens (2004) 1.75
Activated beta-catenin induces osteoblast differentiation of C3H10T1/2 cells and participates in BMP2 mediated signal transduction. Biochem Biophys Res Commun (2003) 1.74
Draft genome of the kiwifruit Actinidia chinensis. Nat Commun (2013) 1.72
Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β. Nat Neurosci (2013) 1.72
Disruption of Gja8 (alpha8 connexin) in mice leads to microphthalmia associated with retardation of lens growth and lens fiber maturation. Development (2002) 1.72
mir-17-92 cluster is required for and sufficient to induce cardiomyocyte proliferation in postnatal and adult hearts. Circ Res (2013) 1.72
Growth arrest induced by C75, A fatty acid synthase inhibitor, was partially modulated by p38 MAPK but not by p53 in human hepatocellular carcinoma. Cancer Biol Ther (2006) 1.70
EEG and MEG coherence: measures of functional connectivity at distinct spatial scales of neocortical dynamics. J Neurosci Methods (2007) 1.68
Estimation of subcellular particle size histograms with electron microscopy for prediction of optical scattering in breast tissue. J Biomed Opt (2007) 1.68
CD44+ CD133+ population exhibits cancer stem cell-like characteristics in human gallbladder carcinoma. Cancer Biol Ther (2010) 1.68
Direct differentiation of atrial and ventricular myocytes from human embryonic stem cells by alternating retinoid signals. Cell Res (2010) 1.67
Metagenome-wide analysis of antibiotic resistance genes in a large cohort of human gut microbiota. Nat Commun (2013) 1.65
catena-Poly[[aqua-(dipyrido[3,2-a:2',3'-c]phenazine-κN,N)zinc(II)]-μ-pyrazine-2,3-dicarboxyl-ato-κN,O:O]. Acta Crystallogr Sect E Struct Rep Online (2008) 1.65
High-performance silicon nanohole solar cells. J Am Chem Soc (2010) 1.64
PE, a new sulfated saponin from sea cucumber, exhibits anti-angiogenic and anti-tumor activities in vitro and in vivo. Cancer Biol Ther (2005) 1.64
High basal STAT4 balanced by STAT1 induction to control type 1 interferon effects in natural killer cells. J Exp Med (2007) 1.63
High expression of p300 has an unfavorable impact on survival in resectable esophageal squamous cell carcinoma. Ann Thorac Surg (2011) 1.60
Comparative metagenomics of microbial communities inhabiting deep-sea hydrothermal vent chimneys with contrasting chemistries. ISME J (2010) 1.60
Endoscopic swept-source optical coherence tomography based on a two-axis microelectromechanical system mirror. J Biomed Opt (2013) 1.59
Sequence comparison between the extracellular domain of M2 protein human and avian influenza A virus provides new information for bivalent influenza vaccine design. Microbes Infect (2004) 1.58
Altered resting-state amygdala functional connectivity in men with posttraumatic stress disorder. J Psychiatry Neurosci (2012) 1.58
Carbon dots for optical imaging in vivo. J Am Chem Soc (2009) 1.57
Neural dysregulation in posttraumatic stress disorder: evidence for disrupted equilibrium between salience and default mode brain networks. Psychosom Med (2012) 1.57
Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis. Nat Genet (2013) 1.57
Cytogenetic prognostication within medulloblastoma subgroups. J Clin Oncol (2014) 1.56
Regulation of epithelial cell migration and tumor formation by beta-catenin signaling. Exp Cell Res (2002) 1.55
Tree-structured gatekeeping tests in clinical trials with hierarchically ordered multiple objectives. Stat Med (2007) 1.54
Identification of nuclear and cytoplasmic mRNA targets for the shuttling protein SF2/ASF. PLoS One (2008) 1.51
Estrogen stimulates the expression of mismatch repair gene hMLH1 in colonic epithelial cells. Cancer Prev Res (Phila) (2010) 1.51
The controlled growth of GaN nanowires. Nano Lett (2006) 1.51
PharmMapper server: a web server for potential drug target identification using pharmacophore mapping approach. Nucleic Acids Res (2010) 1.50
Inhibition of TGF-β1-receptor posttranslational core fucosylation attenuates rat renal interstitial fibrosis. Kidney Int (2013) 1.50
A channel connecting the mother cell and forespore during bacterial endospore formation. Proc Natl Acad Sci U S A (2008) 1.49
Treatment of isolated posterior coronal fracture of the lateral tibial plateau through posterolateral approach for direct exposure and buttress plate fixation. Arch Orthop Trauma Surg (2009) 1.49
Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease. Neuron (2008) 1.49
Targeted genomic sequencing identifies PRRT2 mutations as a cause of paroxysmal kinesigenic choreoathetosis. J Med Genet (2011) 1.49
Spatial periodicity of Escherichia coli K-12 biofilm microstructure initiates during a reversible, polar attachment phase of development and requires the polysaccharide adhesin PGA. J Bacteriol (2005) 1.48
Emergence of ciprofloxacin-resistant Neisseria meningitidis in North America. N Engl J Med (2009) 1.48
Structural basis for the regulation of cysteine-protease activity by a new class of protease inhibitors in Plasmodium. Structure (2011) 1.46
Development of the personalized criteria for microscopic review following four different series of hematology analyzer in a Chinese large scale hospital. Chin Med J (Engl) (2010) 1.45
sodC-based real-time PCR for detection of Neisseria meningitidis. PLoS One (2011) 1.45
Targeting of antigen to dendritic cells with poly(gamma-glutamic acid) nanoparticles induces antigen-specific humoral and cellular immunity. J Immunol (2007) 1.45
Genome-wide analysis of aromatase inhibitor-resistant, tamoxifen-resistant, and long-term estrogen-deprived cells reveals a role for estrogen receptor. Cancer Res (2008) 1.44
Genome sequence of the versatile fish pathogen Edwardsiella tarda provides insights into its adaptation to broad host ranges and intracellular niches. PLoS One (2009) 1.44
Contribution of epidermal stem cells to hypertrophic scars pathogenesis. Med Hypotheses (2009) 1.42
A preliminary randomized controlled trial of a nurse-delivered medication adherence intervention among HIV-positive outpatients initiating antiretroviral therapy in Beijing, China. AIDS Behav (2011) 1.41
2-{4-[(2,2-Dimethyl-4,6-dioxo-1,3-dioxan-5-yl-idene)methyl-amino]phen-yl}acetonitrile. Acta Crystallogr Sect E Struct Rep Online (2009) 1.41
Effects of the Factor Xa Inhibitor, Fondaparinux, on the Stability of Atherosclerotic Lesions in Apolipoprotein E-Deficient Mice. Circ J (2015) 1.41
Mechanisms and clinical significance of quality of final kissing balloon inflation in patients with true bifurcation lesions treated by crush stenting technique. Chin Med J (Engl) (2009) 1.40
Fundamental role of the Rip2/caspase-1 pathway in hypoxia and ischemia-induced neuronal cell death. Proc Natl Acad Sci U S A (2003) 1.40
MD/PhD Training in Canada: Results from a national trainee and program director review. Clin Invest Med (2016) 1.39
A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance. Blood (2013) 1.38
Braided thin-walled biodegradable ureteral stent: preliminary evaluation in a canine model. Int J Urol (2013) 1.38
Dose requirements of remifentanil for intubation in nonparalyzed Chinese children. Paediatr Anaesth (2014) 1.38
Imparting functionality to a metal-organic framework material by controlled nanoparticle encapsulation. Nat Chem (2012) 1.36
TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma. Acta Neuropathol (2013) 1.35