All-natural nitrite and nitrate containing dietary supplement promotes nitric oxide production and reduces triglycerides in humans.

PubWeight™: 0.94‹?›

🔗 View Article (PMID 21530799)

Published in Nutr Res on April 01, 2011

Authors

Janet Zand1, Frank Lanza, Harsha K Garg, Nathan S Bryan

Author Affiliations

1: Neogenis Laboratories, Inc, Austin, TX 78746, USA.

Associated clinical trials:

Acute Nitrate Supplementation in Cyclists | NCT01384968

Articles citing this

Vascular effects of dietary nitrate (as found in green leafy vegetables and beetroot) via the nitrate-nitrite-nitric oxide pathway. Br J Clin Pharmacol (2013) 1.26

Sun Exposure and Its Effects on Human Health: Mechanisms through Which Sun Exposure Could Reduce the Risk of Developing Obesity and Cardiometabolic Dysfunction. Int J Environ Res Public Health (2016) 1.06

You're only as old as your arteries: translational strategies for preserving vascular endothelial function with aging. Physiology (Bethesda) (2014) 1.04

Arginase inhibition alleviates hypertension in the metabolic syndrome. Br J Pharmacol (2013) 0.96

Dietary nitrate improves vascular function in patients with hypercholesterolemia: a randomized, double-blind, placebo-controlled study. Am J Clin Nutr (2015) 0.83

Nitric oxide and geriatrics: Implications in diagnostics and treatment of the elderly. J Geriatr Cardiol (2011) 0.82

Beneficial effects of inorganic nitrate/nitrite in type 2 diabetes and its complications. Nutr Metab (Lond) (2015) 0.82

Dietary intake and bio-activation of nitrite and nitrate in newborn infants. Pediatr Res (2014) 0.78

Effect of hawthorn standardized extract on flow mediated dilation in prehypertensive and mildly hypertensive adults: a randomized, controlled cross-over trial. BMC Complement Altern Med (2012) 0.78

It is rocket science - why dietary nitrate is hard to 'beet'! Part II: further mechanisms and therapeutic potential of the nitrate-nitrite-NO pathway. Br J Clin Pharmacol (2016) 0.78

Natural product nitric oxide chemistry: new activity of old medicines. Evid Based Complement Alternat Med (2012) 0.77

Platelet inhibitory effects of juices from Pachyrhizus erosus L. root and Psidium guajava L. fruit: a randomized controlled trial in healthy volunteers. BMC Complement Altern Med (2016) 0.76

My Continuing Evolution as a Surgeon-Scientist: A Decade after the Jacobson Promising Investigator Award. J Am Coll Surg (2016) 0.75

Short-term treatment with nitrate is not sufficient to induce in vivo antithrombotic effects in rats and mice. Naunyn Schmiedebergs Arch Pharmacol (2016) 0.75

Nitric oxide enhancement strategies. Future Sci OA (2015) 0.75

Evaluation of a crataegus-based multiherb formula for dyslipidemia: a randomized, double-blind, placebo-controlled clinical trial. Evid Based Complement Alternat Med (2014) 0.75

Articles by these authors

Food sources of nitrates and nitrites: the physiologic context for potential health benefits. Am J Clin Nutr (2009) 3.11

Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals. Free Radic Biol Med (2003) 2.83

Concomitant S-, N-, and heme-nitros(yl)ation in biological tissues and fluids: implications for the fate of NO in vivo. FASEB J (2002) 2.46

Nitrate and nitrite in biology, nutrition and therapeutics. Nat Chem Biol (2009) 2.29

Dietary nitrite prevents hypercholesterolemic microvascular inflammation and reverses endothelial dysfunction. Am J Physiol Heart Circ Physiol (2009) 1.89

Cardioprotective effects of thioredoxin in myocardial ischemia and reperfusion: role of S-nitrosation [corrected]. Proc Natl Acad Sci U S A (2004) 1.76

Nutritional epidemiology in the context of nitric oxide biology: a risk-benefit evaluation for dietary nitrite and nitrate. Nitric Oxide (2009) 1.71

Concomitant presence of N-nitroso and S-nitroso proteins in human plasma. Free Radic Biol Med (2002) 1.71

Coronary microvascular pericytes are the cellular target of sunitinib malate-induced cardiotoxicity. Sci Transl Med (2013) 1.69

Tissue processing of nitrite in hypoxia: an intricate interplay of nitric oxide-generating and -scavenging systems. J Biol Chem (2008) 1.61

Requirement of argininosuccinate lyase for systemic nitric oxide production. Nat Med (2011) 1.54

Cardiomyocyte-specific overexpression of NO synthase-3 protects against myocardial ischemia-reperfusion injury. Arterioscler Thromb Vasc Biol (2006) 1.49

Chemical nature of nitric oxide storage forms in rat vascular tissue. Proc Natl Acad Sci U S A (2002) 1.49

Measurement of nitric oxide levels in the red cell: validation of tri-iodide-based chemiluminescence with acid-sulfanilamide pretreatment. J Biol Chem (2006) 1.36

Genetic overexpression of eNOS attenuates hepatic ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol (2006) 1.33

Nitric oxide promotes distant organ protection: evidence for an endocrine role of nitric oxide. Proc Natl Acad Sci U S A (2008) 1.31

NO adducts in mammalian red blood cells: too much or too little? Nat Med (2003) 1.30

An assessment of the management of acute bleeding varices: a multicenter prospective member-based study. Am J Gastroenterol (2003) 1.22

Kinetic and cellular characterization of novel inhibitors of S-nitrosoglutathione reductase. J Biol Chem (2009) 1.04

Role of nitric oxide signaling components in differentiation of embryonic stem cells into myocardial cells. Proc Natl Acad Sci U S A (2008) 1.04

Mechanistic insights into nitrite-induced cardioprotection using an integrated metabolomic/proteomic approach. Circ Res (2009) 1.03

Differential nitros(yl)ation of blood and tissue constituents during glyceryl trinitrate biotransformation in vivo. Proc Natl Acad Sci U S A (2004) 1.02

Nitric-oxide supplementation for treatment of long-term complications in argininosuccinic aciduria. Am J Hum Genet (2012) 0.98

Nitrite and nitrate: cardiovascular risk-benefit and metabolic effect. Curr Opin Lipidol (2011) 0.95

Nitroso-redox status and vascular function in marginal and severe ascorbate deficiency. Antioxid Redox Signal (2012) 0.88

Sodium nitrite: the "cure" for nitric oxide insufficiency. Meat Sci (2012) 0.87

An integrated approach to assessing nitroso-redox balance in systemic inflammation. Free Radic Biol Med (2011) 0.86

Nitric oxide bioactivity of traditional Chinese medicines used for cardiovascular indications. Free Radic Biol Med (2009) 0.85

Nitric oxide and geriatrics: Implications in diagnostics and treatment of the elderly. J Geriatr Cardiol (2011) 0.82

Curcumin induces differentiation of embryonic stem cells through possible modulation of nitric oxide-cyclic GMP pathway. Protein Cell (2012) 0.82

Nitrate and nitrite content of human, formula, bovine, and soy milks: implications for dietary nitrite and nitrate recommendations. Breastfeed Med (2010) 0.81

Nitrosative stress in an animal model of necrotizing enterocolitis. Free Radic Biol Med (2005) 0.81

Glutathione peroxidase deficiency exacerbates ischemia-reperfusion injury in male but not female myocardium: insights into antioxidant compensatory mechanisms. Am J Physiol Heart Circ Physiol (2009) 0.80

Nitric oxide and its metabolites in the critical phase of illness: rapid biomarkers in the making. Open Biochem J (2013) 0.80

Dietary sources of nitrite as a modulator of ischemia/reperfusion injury. Kidney Int (2009) 0.79

On the dynamics of nitrite, nitrate and other biomarkers of nitric oxide production in inflammatory bowel disease. Nitric Oxide (2009) 0.79

A randomized, placebo-controlled, 6-month study of once-weekly alendronate oral solution for postmenopausal osteoporosis. Am J Geriatr Pharmacother (2005) 0.78

Urinary nitrate might be an early biomarker for pediatric acute kidney injury in the emergency department. Pediatr Res (2011) 0.78

Redox-sensitivity and site-specificity of S- and N- denitrosation in proteins. PLoS One (2010) 0.77

Concentration- and stage-specific effects of nitrite on colon cancer cell lines. Nitric Oxide (2012) 0.77

Natural product nitric oxide chemistry: new activity of old medicines. Evid Based Complement Alternat Med (2012) 0.77

Analytical techniques for assaying nitric oxide bioactivity. J Vis Exp (2012) 0.76

N-Nitroso products from the reaction of indoles with Angeli's salt. Chem Res Toxicol (2006) 0.76

Towards nitric oxide based diagnostics: call to action. Trends Mol Med (2011) 0.76

Nitric oxide availability as a marker of oxidative stress. Methods Mol Biol (2015) 0.75

Letter by Bryan regarding article, "red and processed meat consumption and risk of incident coronary heart disease, stroke, and diabetes mellitus: a systematic review and meta-analysis". Circulation (2011) 0.75

Survey of residual nitrite and nitrate in conventional and organic/natural/uncured/indirectly cured meats available at retail in the United States. J Agric Food Chem (2012) 0.75

Translational research in the developing world: molecular medicine goes global. Trends Mol Med (2012) 0.75

A multicenter, randomized, double-blind, active-comparator, placebo-controlled, parallel-group comparison of the incidence of endoscopic gastric and duodenal ulcer rates with valdecoxib or naproxen in healthy subjects aged 65 to 75 years. Clin Ther (2006) 0.75