Structure-activity relationships of N2-substituted guanines as inhibitors of HSV1 and HSV2 thymidine kinases.

PubWeight™: 1.19‹?› | Rank: Top 10%

🔗 View Article (PMID 2153203)

Published in J Med Chem on January 01, 1990

Authors

C Hildebrand1, D Sandoli, F Focher, J Gambino, G Ciarrocchi, S Spadari, G Wright

Author Affiliations

1: Department of Pharmacology, University of Massachusetts Medical School, Worcester 01655.

Articles by these authors

Stromal gene signatures in large-B-cell lymphomas. N Engl J Med (2008) 11.34

Synchronization of HeLa cell cultures by inhibition of DNA polymerase alpha with aphidicolin. Nucleic Acids Res (1980) 3.34

Biomedical informatics: we are what we publish. Methods Inf Med (2013) 2.79

THE ELECTROCARDIOGRAM IN FRIEDREICH DISEASE. Br Heart J (1942) 2.39

GeneMANIA Cytoscape plugin: fast gene function predictions on the desktop. Bioinformatics (2010) 2.39

The accuracy of EUS-FNA in assessing mediastinal lymphadenopathy and staging patients with NSCLC. Eur Respir J (2005) 2.37

Submillimetre galaxies reside in dark matter haloes with masses greater than 3 × 10(11) solar masses. Nature (2011) 2.21

Hazards for elderly people admitted for respite ("holiday admissions") and social care ("social admissions"). Br Med J (Clin Res Ed) (1986) 2.19

DNA ligase I is recruited to sites of DNA replication by an interaction with proliferating cell nuclear antigen: identification of a common targeting mechanism for the assembly of replication factories. EMBO J (1998) 2.10

Replicational fidelity: mechanisms of mutation avoidance and mutation fixation. Cold Spring Harb Symp Quant Biol (1979) 2.10

Distinctive patterns of BCL6 molecular alterations and their functional consequences in different subgroups of diffuse large B-cell lymphoma. Leukemia (2007) 2.03

The interrelation between DNA synthesis and various DNA polymerase activities in synchronized HeLa cells. J Mol Biol (1974) 1.87

Musculoskeletal ultrasound training in rheumatology: the Belfast experience. Rheumatology (Oxford) (2005) 1.86

Insulin-like growth factor binding protein 1 stimulates cell migration and binds to the alpha 5 beta 1 integrin by means of its Arg-Gly-Asp sequence. Proc Natl Acad Sci U S A (1993) 1.85

Determination of pyrimidine dimer unwinding angle by measurement of DNA electrophoretic mobility. J Mol Biol (1982) 1.84

Identification and functional analysis of beta-tubulin genes by site specific integrative transformation in Aspergillus nidulans. J Cell Biol (1985) 1.83

Urban exposure to carbon monoxide. Arch Environ Health (1972) 1.79

Clustered genes for ribosomal ribonucleic acids in Escherichia coli. J Mol Biol (1970) 1.77

Revised nomenclature for eukaryotic DNA polymerases. Eur J Biochem (1990) 1.73

Mechanism of inhibition of herpes simplex virus and vaccinia virus DNA polymerases by aphidicolin, a highly specific inhibitor of DNA replication in eucaryotes. J Virol (1980) 1.67

Variations of DNA polymerase-alpha and -beta during prolonged stimulation of human lymphocytes. Proc Natl Acad Sci U S A (1976) 1.67

Treatment-related chromosome abnormalities in human embryos. Hum Reprod (1997) 1.65

Videocinematography of fresh and cryopreserved embryos: a retrospective analysis of embryonic morphology and implantation. Fertil Steril (1989) 1.63

Okazaki fragment processing: modulation of the strand displacement activity of DNA polymerase delta by the concerted action of replication protein A, proliferating cell nuclear antigen, and flap endonuclease-1. Proc Natl Acad Sci U S A (2001) 1.61

Effect of aphidicolin on viral and human DNA polymerases. Biochem Biophys Res Commun (1979) 1.60

An evaluation of nebulized prostacyclin in patients with primary and secondary pulmonary hypertension. Eur Heart J (1997) 1.59

The N-terminal domain of human DNA ligase I contains the nuclear localization signal and directs the enzyme to sites of DNA replication. EMBO J (1995) 1.59

Functional roles of DNA polymerases beta and gamma. Proc Natl Acad Sci U S A (1979) 1.59

Role of ammonia and inflammation in minimal hepatic encephalopathy. Metab Brain Dis (2007) 1.57

Analysis of multidisciplinary lung cancer practice. Intern Med J (2007) 1.55

HeLa cell R-deoxyribonucleic acid polymerases. Separation and characterization of two enzymatic activities. J Biol Chem (1974) 1.50

Effects of mitotic and tubulin mutations on microtubule architecture in actively growing protoplasts of Aspergillus nidulans. J Cell Biol (1984) 1.45

Focal neuronal migration disorders and intractable partial epilepsy: a study of 30 patients. Ann Neurol (1991) 1.45

The miRNA-17∼92 cluster mediates chemoresistance and enhances tumor growth in mantle cell lymphoma via PI3K/AKT pathway activation. Leukemia (2011) 1.43

A comparison of two systems for assessing cerebral venous oxyhaemoglobin saturation during cardiopulmonary bypass in humans. Anaesthesia (1993) 1.42

Multiple pregnancy rate and embryo number transferred during in vitro fertilization. Am J Obstet Gynecol (1997) 1.42

Variation of DNA polymerases-alpha, -beta. and -gamma during perinatal tissue growth and differentiation. Nucleic Acids Res (1977) 1.42

L-thymidine is phosphorylated by herpes simplex virus type 1 thymidine kinase and inhibits viral growth. J Med Chem (1992) 1.41

N2-phenyldeoxyguanosine: a novel selective inhibitor of herpes simplex thymidine kinase. J Med Chem (1988) 1.40

FMD control strategies. Vet Rec (2001) 1.39

RNA-primed DNA synthesis: specific catalysis by HeLa cell DNA polymerase alpha. Proc Natl Acad Sci U S A (1975) 1.35

Materials and techniques for electrochemical biosensor design and construction. Biosens Bioelectron (2000) 1.34

Human menopausal gonadotropin/human chorionic gonadotropin follicular maturation for oocyte aspiration: phase II, 1981. Fertil Steril (1983) 1.33

A blind randomised cross-over trial comparing metipranolol 0.3% with timolol 0.25% in open-angle glaucoma: a pilot study. Br J Ophthalmol (1986) 1.30

Purification and properties of a polynucleotide ligase from human cell cultures. Eur J Biochem (1971) 1.27

A decade of diabetes: keeping children out of hospital. BMJ (1993) 1.27

What are the implications of variation in root hair length on tolerance to phosphorus deficiency in combination with water stress in barley (Hordeum vulgare)? Ann Bot (2012) 1.26

Uracil in OriS of herpes simplex 1 alters its specific recognition by origin binding protein (OBP): does virus induced uracil-DNA glycosylase play a key role in viral reactivation and replication? Chromosoma (1992) 1.25

Identity of DNA polymerase gamma from synaptosomal mitochondria and rat-brain nuclei. Eur J Biochem (1977) 1.24

Critical role for transcriptional repressor Snail2 in transformation by oncogenic RAS in colorectal carcinoma cells. Oncogene (2010) 1.24

Activity profiles of enzymes that control the uracil incorporation into DNA during neuronal development. Mutat Res (1990) 1.23

DNA unwinding and inhibition of T4 DNA ligase by anthracyclines. Nucleic Acids Res (1988) 1.22

Specific and reversible inhibition by aphidicolin in the alpha-like DNA polymerase of plant cells. FEBS Lett (1980) 1.22

The program for in vitro fertilization at Norfolk. Fertil Steril (1982) 1.21

Functional characterization of the T4 DNA ligase: a new insight into the mechanism of action. Nucleic Acids Res (1997) 1.20

Calf thymus DNA polymerase delta: purification, biochemical and functional properties of the enzyme after its separation from DNA polymerase alpha, a DNA dependent ATPase and proliferating cell nuclear antigen. Nucleic Acids Res (1988) 1.20

Functions of DNA polymerases alpha, beta, and gamma in neurons during development. Cold Spring Harb Symp Quant Biol (1979) 1.20

Assisted hatching with or without bovine oviductal epithelial cell co-culture for poor prognosis in-vitro fertilization patients. Hum Reprod (1994) 1.19

Reproductive and other factors and risk of epithelial ovarian cancer: an Australian case-control study. Survey of Women's Health Study Group. Int J Cancer (1995) 1.18

Brain damage in dogs immediately following pulsatile and non-pulsatile blood flows in extracorporeal circulation. Thorax (1972) 1.18

Inhibition of Micrococcus luteus DNA topoisomerase I by UV photoproducts. Proc Natl Acad Sci U S A (1983) 1.17

The specific binding of nuclear protein(s) to the cAMP responsive element (CRE) sequence (TGACGTCA) is reduced by the misincorporation of U and increased by the deamination of C. Nucleic Acids Res (1990) 1.16

Birth after cryopreservation of immature oocytes with subsequent in vitro maturation. Fertil Steril (1998) 1.15

The replication factory targeting sequence/PCNA-binding site is required in G(1) to control the phosphorylation status of DNA ligase I. EMBO J (1999) 1.14

Selective interaction of the human immunodeficiency virus type 1 reverse transcriptase nonnucleoside inhibitor efavirenz and its thio-substituted analog with different enzyme-substrate complexes. Antimicrob Agents Chemother (2000) 1.14

Use of ATP, dATP and their alpha-thio derivatives to study DNA ligase adenylation. Biochem J (1990) 1.13

A gamma-like DNA polymerase in spinach chloroplasts. Eur J Biochem (1980) 1.13

On the identity of dnaP and dnaF genes of Bacillus subtilis. Mol Gen Genet (1976) 1.12

Inhibitors of Bacillus subtilis DNA polymerase III. 6-(arylalkylamino)uracils and 6-anilinouracils. J Med Chem (1977) 1.12

AMP-dependent DNA relaxation catalyzed by DNA ligase occurs by a nicking-closing mechanism. Nucleic Acids Res (1988) 1.12

Further characterization of a cell-free system for measuring replicative and repair DNA synthesis with cultured human fibroblasts and evidence for the involvement of DNA polymerase alpha in DNA repair. Nucleic Acids Res (1979) 1.11

Positive regulatory domain I binding factor 1 silences class II transactivator expression in multiple myeloma cells. J Biol Chem (2001) 1.11

An autoradiographic demonstration of nuclear DNA replication by DNA polymerase alpha and of mitochondrial DNA synthesis by DNA polymerase gamma. Nucleic Acids Res (1981) 1.10

Quinolone binding to DNA is mediated by magnesium ions. Proc Natl Acad Sci U S A (1992) 1.10

Involvement of a particular species of beta-tubulin (beta 3) in conidial development in Aspergillus nidulans. J Cell Biol (1985) 1.09

Reinsemination by intracytoplasmic sperm injection of 1-day-old oocytes after complete conventional fertilization failure. Fertil Steril (1997) 1.08

Induction of polynucleotide ligase in human lymphocytes stimulated by phytohemoagglutinin. Biochem Biophys Res Commun (1972) 1.08

Specific inhibition of human DNA ligase adenylation by a distamycin derivative possessing antitumor activity. Nucleic Acids Res (1991) 1.08

Multiple roles of DNA ligase at the replication fork. Biochim Biophys Acta (1988) 1.08

Rat liver DNA ligases. Catalytic properties of a novel form of DNA ligase. Eur J Biochem (1992) 1.07

DNA polymerase switching: I. Replication factor C displaces DNA polymerase alpha prior to PCNA loading. J Mol Biol (2000) 1.07

Resistance to nevirapine of HIV-1 reverse transcriptase mutants: loss of stabilizing interactions and thermodynamic or steric barriers are induced by different single amino acid substitutions. J Mol Biol (1997) 1.07

DNA polymerase beta from brain neurons is a repair enzyme. Eur J Biochem (1979) 1.06

Lack of enantiospecificity of human 2'-deoxycytidine kinase: relevance for the activation of beta-L-deoxycytidine analogs as antineoplastic and antiviral agents. Mol Pharmacol (1997) 1.05

A cell-free assay measuring repair DNA synthesis in human fibroblasts. Proc Natl Acad Sci U S A (1978) 1.05

The importance of the follicular phase to success and failure in in vitro fertilization. Fertil Steril (1983) 1.05

Surgery for early stage non-small cell lung cancer. Cochrane Database Syst Rev (2005) 1.05

Partial dissection of the zona pellucida of frozen-thawed human embryos may enhance blastocyst hatching, implantation, and pregnancy rates. Am J Obstet Gynecol (1991) 1.04

Cloning and sequence analysis of a cDNA coding for the murine DNA ligase I enzyme. Gene (1994) 1.04