Published in PLoS One on April 13, 2011
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On-lattice agent-based simulation of populations of cells within the open-source Chaste framework. Interface Focus (2013) 0.83
Computational modeling of 3D tumor growth and angiogenesis for chemotherapy evaluation. PLoS One (2014) 0.82
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Stochastic and Deterministic Models of Cellular p53 Regulation. Front Oncol (2013) 0.80
Estimating oxygen distribution from vasculature in three-dimensional tumour tissue. J R Soc Interface (2016) 0.79
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Mathematical Modelling of a Brain Tumour Initiation and Early Development: A Coupled Model of Glioblastoma Growth, Pre-Existing Vessel Co-Option, Angiogenesis and Blood Perfusion. PLoS One (2016) 0.77
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Modelling non-homogeneous stochastic reaction-diffusion systems: the case study of gemcitabine-treated non-small cell lung cancer growth. BMC Bioinformatics (2012) 0.75
Mathematical modelling of spatio-temporal glioma evolution. Theor Biol Med Model (2013) 0.75
A Validated Multiscale In-Silico Model for Mechano-sensitive Tumour Angiogenesis and Growth. PLoS Comput Biol (2017) 0.75
A Mathematical Model Coupling Tumor Growth and Angiogenesis. PLoS One (2016) 0.75
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Modeling Longitudinal Preclinical Tumor Size Data to Identify Transient Dynamics in Tumor Response to Antiangiogenic Drugs. CPT Pharmacometrics Syst Pharmacol (2016) 0.75
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A cellular automaton model for tumour growth in inhomogeneous environment. J Theor Biol (2003) 1.81
3D multi-cell simulation of tumor growth and angiogenesis. PLoS One (2009) 1.72
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Mathematical modeling of tumor-induced angiogenesis. J Math Biol (2004) 1.51
Lattice and non-lattice models of tumour angiogenesis. Bull Math Biol (2004) 1.39
Structural adaptation of microvascular networks: functional roles of adaptive responses. Am J Physiol Heart Circ Physiol (2001) 1.37
A mathematical model of the effects of hypoxia on the cell-cycle of normal and cancer cells. J Theor Biol (2004) 1.26
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Multicellular tumor spheroid in an off-lattice Voronoi-Delaunay cell model. Phys Rev E Stat Nonlin Soft Matter Phys (2005) 1.18
Flow correlated percolation during vascular remodeling in growing tumors. Phys Rev Lett (2006) 1.11
A computer algorithm describing the process of vessel formation and maturation, and its use for predicting the effects of anti-angiogenic and anti-maturation therapy on vascular tumor growth. Angiogenesis (2002) 1.10
A multiphase model describing vascular tumour growth. Bull Math Biol (2003) 1.08
A computational framework for modelling solid tumour growth. Philos Trans A Math Phys Eng Sci (2008) 0.95
Vessel maturation effects on tumour growth: validation of a computer model in implanted human ovarian carcinoma spheroids. Eur J Cancer (2005) 0.95
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DNA synthesis and repair genes RRM1 and ERCC1 in lung cancer. N Engl J Med (2007) 8.28
Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration. Nature (2008) 4.67
A microenvironmental model of carcinogenesis. Nat Rev Cancer (2008) 4.40
Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy. Int J Radiat Biol (2006) 3.98
Acid-mediated tumor invasion: a multidisciplinary study. Cancer Res (2006) 3.90
Causes and consequences of increased glucose metabolism of cancers. J Nucl Med (2008) 3.79
Environment-mediated drug resistance: a major contributor to minimal residual disease. Nat Rev Cancer (2009) 3.49
Bicarbonate increases tumor pH and inhibits spontaneous metastases. Cancer Res (2009) 3.40
Conformational spread as a mechanism for cooperativity in the bacterial flagellar switch. Science (2010) 3.08
Adaptive therapy. Cancer Res (2009) 2.81
Osteopontin identified as lead marker of colon cancer progression, using pooled sample expression profiling. J Natl Cancer Inst (2002) 2.77
Evolutionary dynamics of carcinogenesis and why targeted therapy does not work. Nat Rev Cancer (2012) 2.71
pH imaging. A review of pH measurement methods and applications in cancers. IEEE Eng Med Biol Mag (2004) 2.68
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Acidity generated by the tumor microenvironment drives local invasion. Cancer Res (2013) 2.63
Dynamic modeling of the central carbon metabolism of Escherichia coli. Biotechnol Bioeng (2002) 2.43
Inherent noise can facilitate coherence in collective swarm motion. Proc Natl Acad Sci U S A (2009) 2.19
Changes in water mobility measured by diffusion MRI predict response of metastatic breast cancer to chemotherapy. Neoplasia (2005) 2.17
Tumor pH and its measurement. J Nucl Med (2010) 2.08
Renal and systemic pH imaging by contrast-enhanced MRI. Magn Reson Med (2003) 2.05
Mathematical modeling of cell population dynamics in the colonic crypt and in colorectal cancer. Proc Natl Acad Sci U S A (2007) 1.99
High resolution pH(e) imaging of rat glioma using pH-dependent relaxivity. Magn Reson Med (2006) 1.97
Self-organizing and stochastic behaviors during the regeneration of hair stem cells. Science (2011) 1.96
Glycolysis in cancer: a potential target for therapy. Int J Biochem Cell Biol (2007) 1.94
The potential role of systemic buffers in reducing intratumoral extracellular pH and acid-mediated invasion. Cancer Res (2009) 1.92
Sharper low-power STED nanoscopy by time gating. Nat Methods (2011) 1.87
Hitting multiple targets with multimeric ligands. Expert Opin Ther Targets (2004) 1.86
Responsive MRI agents for sensing metabolism in vivo. Acc Chem Res (2009) 1.84
Adaptive landscapes and emergent phenotypes: why do cancers have high glycolysis? J Bioenerg Biomembr (2007) 1.83
12-Chemokine gene signature identifies lymph node-like structures in melanoma: potential for patient selection for immunotherapy? Sci Rep (2012) 1.81
Adaptation to hypoxia and acidosis in carcinogenesis and tumor progression. Semin Cancer Biol (2008) 1.76
A theoretical quantitative model for evolution of cancer chemotherapy resistance. Biol Direct (2010) 1.69
Hypoxia and adaptive landscapes in the evolution of carcinogenesis. Cancer Metastasis Rev (2007) 1.68
Mathematical oncology: cancer summed up. Nature (2003) 1.67
Imaging pH and metastasis. NMR Biomed (2011) 1.67
Lanthanide-based time-resolved fluorescence of in cyto ligand-receptor interactions. Anal Biochem (2004) 1.66
Molecular orientation affects localization accuracy in superresolution far-field fluorescence microscopy. Nano Lett (2010) 1.64
Contributions of cell metabolism and H+ diffusion to the acidic pH of tumors. Neoplasia (2003) 1.63
Stability of FDG-PET Radiomics features: an integrated analysis of test-retest and inter-observer variability. Acta Oncol (2013) 1.62
rsEGFP2 enables fast RESOLFT nanoscopy of living cells. Elife (2012) 1.61
A PHABULOSA/cytokinin feedback loop controls root growth in Arabidopsis. Curr Biol (2012) 1.61
Beyond mammography: new frontiers in breast cancer screening. Am J Med (2013) 1.61
Metabolic changes during carcinogenesis: potential impact on invasiveness. J Theor Biol (2006) 1.59
Novel targeting strategy based on multimeric ligands for drug delivery and molecular imaging: homooligomers of alpha-MSH. Bioorg Med Chem Lett (2004) 1.58
Tumor acidity, ion trapping and chemotherapeutics. I. Acid pH affects the distribution of chemotherapeutic agents in vitro. Biochem Pharmacol (2003) 1.57
Identification of metabolic fluxes in hepatic cells from transient 13C-labeling experiments: Part II. Flux estimation. Biotechnol Bioeng (2008) 1.56
Angiogenesis and vascular remodelling in normal and cancerous tissues. J Math Biol (2008) 1.55
Quantitative imaging in cancer evolution and ecology. Radiology (2013) 1.55
Docetaxel induces cell death through mitotic catastrophe in human breast cancer cells. Mol Cancer Ther (2005) 1.54
Hypoxia-inducible factor-1alpha and the glycolytic phenotype in tumors. Neoplasia (2005) 1.54
Prediction of drug response in breast cancer using integrative experimental/computational modeling. Cancer Res (2009) 1.53
Lateral phase separation in lipid-coated microbubbles. Langmuir (2006) 1.52
Of cancer and cave fish. Nat Rev Cancer (2011) 1.50
Hyaluronic acid synthase-1 expression regulates bladder cancer growth, invasion, and angiogenesis through CD44. Cancer Res (2008) 1.48
Dynamic contrast-enhanced and diffusion MRI show rapid and dramatic changes in tumor microenvironment in response to inhibition of HIF-1alpha using PX-478. Neoplasia (2005) 1.45
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Sweat but no gain: inhibiting proliferation of multidrug resistant cancer cells with "ersatzdroges". Int J Cancer (2014) 1.44
Metabolic flux analysis in Escherichia coli by integrating isotopic dynamic and isotopic stationary 13C labeling data. Biotechnol Bioeng (2008) 1.44
Drug resistance and cellular adaptation to tumor acidic pH microenvironment. Mol Pharm (2011) 1.42
Imaging the extracellular pH of tumors by MRI after injection of a single cocktail of T1 and T2 contrast agents. NMR Biomed (2011) 1.40
Determining suitable internal standards for mRNA quantification of increasing cancer progression in human breast cells by real-time reverse transcriptase polymerase chain reaction. Anal Biochem (2005) 1.38
Tumor acidity, ion trapping and chemotherapeutics. II. pH-dependent partition coefficients predict importance of ion trapping on pharmacokinetics of weakly basic chemotherapeutic agents. Biochem Pharmacol (2003) 1.38
Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments. Cancer Res (2012) 1.38
Automated Delineation of Lung Tumors from CT Images Using a Single Click Ensemble Segmentation Approach. Pattern Recognit (2013) 1.36
Heterobivalent ligands crosslink multiple cell-surface receptors: the human melanocortin-4 and delta-opioid receptors. Angew Chem Int Ed Engl (2008) 1.36
A physical sciences network characterization of non-tumorigenic and metastatic cells. Sci Rep (2013) 1.33
An analysis of B cell selection mechanisms in germinal centers. Math Med Biol (2006) 1.32
Early response of prostate carcinoma xenografts to docetaxel chemotherapy monitored with diffusion MRI. Neoplasia (2002) 1.32
Synthesis and evaluation of bivalent NDP-alpha-MSH(7) peptide ligands for binding to the human melanocortin receptor 4 (hMC4R). Bioconjug Chem (2007) 1.31
Systemic buffers inhibit carcinogenesis in TRAMP mice. J Urol (2012) 1.28
Development of a lanthanide-based assay for detection of receptor-ligand interactions at the delta-opioid receptor. Anal Biochem (2005) 1.25
The role of acidity in solid tumour growth and invasion. J Theor Biol (2005) 1.23
Regulation of the Warburg effect in early-passage breast cancer cells. Neoplasia (2008) 1.23
Thermostability of firefly luciferases affects efficiency of detection by in vivo bioluminescence. Mol Imaging (2004) 1.23
A stimulus-responsive contrast agent for ultrasound molecular imaging. Biomaterials (2007) 1.22
Root gravitropism is regulated by a transient lateral auxin gradient controlled by a tipping-point mechanism. Proc Natl Acad Sci U S A (2012) 1.22
Exploiting evolution to treat drug resistance: combination therapy and the double bind. Mol Pharm (2012) 1.22
Reduction of metastasis using a non-volatile buffer. Clin Exp Metastasis (2011) 1.21
Interactions between Shh, Sostdc1 and Wnt signaling and a new feedback loop for spatial patterning of the teeth. Development (2011) 1.21