CD8⁺ T cells with an intraepithelial phenotype upregulate cytotoxic function upon influenza infection in human lung.

PubWeight™: 1.40‹?› | Rank: Top 5%

🔗 View Article (PMC 3104744)

Published in J Clin Invest on May 02, 2011

Authors

Berber Piet1, Godelieve J de Bree, Barbara S Smids-Dierdorp, Chris M van der Loos, Ester B M Remmerswaal, Jan H von der Thüsen, Jan M W van Haarst, Jan P Eerenberg, Anja ten Brinke, Wim van der Bij, Wim Timens, René A W van Lier, René E Jonkers

Author Affiliations

1: Department of Experimental Immunology, Academic Medical Centre, Amsterdam, Netherlands. b.piet@amc.nl

Articles citing this

Cutting edge: Tissue-retentive lung memory CD4 T cells mediate optimal protection to respiratory virus infection. J Immunol (2011) 3.03

Obesity is associated with impaired immune response to influenza vaccination in humans. Int J Obes (Lond) (2011) 2.54

Human memory T cells: generation, compartmentalization and homeostasis. Nat Rev Immunol (2013) 2.19

CD4+ T cell help guides formation of CD103+ lung-resident memory CD8+ T cells during influenza viral infection. Immunity (2014) 1.98

The emerging role of resident memory T cells in protective immunity and inflammatory disease. Nat Med (2015) 1.69

Programs for the persistence, vigilance and control of human CD8(+) lung-resident memory T cells. Nat Immunol (2016) 1.52

Intravaginal immunization with HPV vectors induces tissue-resident CD8+ T cell responses. J Clin Invest (2012) 1.37

Guarding the perimeter: protection of the mucosa by tissue-resident memory T cells. Mucosal Immunol (2012) 1.35

Local immunity by tissue-resident CD8(+) memory T cells. Front Immunol (2012) 1.30

Resident memory T cells in human health and disease. Sci Transl Med (2015) 1.24

Human CD1c+ dendritic cells drive the differentiation of CD103+ CD8+ mucosal effector T cells via the cytokine TGF-β. Immunity (2013) 1.23

Aerosolized Ebola vaccine protects primates and elicits lung-resident T cell responses. J Clin Invest (2015) 0.99

Every breath you take: the impact of environment on resident memory CD8 T cells in the lung. Front Immunol (2014) 0.90

Antibody-targeted vaccination to lung dendritic cells generates tissue-resident memory CD8 T cells that are highly protective against influenza virus infection. Mucosal Immunol (2015) 0.86

Phenotypic and functional characterization of circulating polyomavirus BK VP1-specific CD8+ T cells in healthy adults. J Virol (2013) 0.86

Asymptomatic memory CD8+ T cells: from development and regulation to consideration for human vaccines and immunotherapeutics. Hum Vaccin Immunother (2014) 0.85

Human CD56+ cytotoxic lung lymphocytes kill autologous lung cells in chronic obstructive pulmonary disease. PLoS One (2014) 0.85

Memory CD4 T cells in influenza. Curr Top Microbiol Immunol (2015) 0.83

The human side of influenza. J Leukoc Biol (2012) 0.83

Functionality of CD4+ and CD8+ T cells from tonsillar tissue. Clin Exp Immunol (2012) 0.81

Cytokine production and antigen recognition by human mucosal homing conjunctival effector memory CD8+ T cells. Invest Ophthalmol Vis Sci (2014) 0.80

Heterosubtypic T-Cell Immunity to Influenza in Humans: Challenges for Universal T-Cell Influenza Vaccines. Front Immunol (2016) 0.79

Anti-CD40-induced inflammatory E-cadherin+ dendritic cells enhance T cell responses and antitumour immunity in murine Lewis lung carcinoma. J Exp Clin Cancer Res (2015) 0.79

The Immune Adaptor ADAP Regulates Reciprocal TGF-β1-Integrin Crosstalk to Protect from Influenza Virus Infection. PLoS Pathog (2015) 0.79

Influenza A Virus Infection in Pigs Attracts Multifunctional and Cross-Reactive T Cells to the Lung. J Virol (2016) 0.79

Primary γδ T cell lymphoma of the lung: report of a case with features suggesting derivation from intraepithelial γδ T lymphocytes. Virchows Arch (2014) 0.78

Bone Marrow T Cells and the Integrated Functions of Recirculating and Tissue-Resident Memory T Cells. Front Immunol (2016) 0.78

Seasonal influenza vaccination is the strongest correlate of cross-reactive antibody responses in migratory bird handlers. MBio (2014) 0.77

Squamous tissue lymphocytes in the esophagus of controls and patients with reflux esophagitis and Barrett's esophagus are characterized by a non-inflammatory phenotype. PLoS One (2014) 0.77

Clonal evolution of CD8+ T cell responses against latent viruses: relationship among phenotype, localization, and function. J Virol (2014) 0.76

CMV-Specific CD8 T Cell Differentiation and Localization: Implications for Adoptive Therapies. Front Immunol (2016) 0.76

Challenges in the development of T-cell-based universal influenza vaccines. Clin Exp Vaccine Res (2017) 0.75

Intranasal Administration of Chitosan Against Influenza A (H7N9) Virus Infection in a Mouse Model. Sci Rep (2016) 0.75

Environmental cues orchestrate regional immune surveillance and protection by pulmonary CTLs. J Leukoc Biol (2016) 0.75

Influenza and Memory T Cells: How to Awake the Force. Vaccines (Basel) (2016) 0.75

Contributions of CD8 T cells to the pathogenesis of mouse adenovirus type 1 respiratory infection. Virology (2017) 0.75

Anti-Adhesion Therapies in Inflammatory Bowel Disease-Molecular and Clinical Aspects. Front Immunol (2017) 0.75

Articles cited by this

The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med (2004) 17.08

Phenotypic and functional separation of memory and effector human CD8+ T cells. J Exp Med (1997) 8.59

HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C. Nature (1998) 7.12

Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the alpha E beta 7 integrin. Nature (1994) 5.73

Lymphocyte-mediated cytotoxicity. Annu Rev Immunol (2001) 4.37

CD8+ T cells clear influenza virus by perforin or Fas-dependent processes. J Immunol (1997) 4.10

Dendritic cell-induced memory T cell activation in nonlymphoid tissues. Science (2008) 3.97

Heterosubtypic immunity to influenza type A virus in mice. Effector mechanisms and their longevity. J Immunol (1994) 3.86

A question of self-preservation: immunopathology in influenza virus infection. Immunol Cell Biol (2007) 3.65

Protection from respiratory virus infections can be mediated by antigen-specific CD4(+) T cells that persist in the lungs. J Exp Med (2001) 3.19

Migration, maintenance and recall of memory T cells in peripheral tissues. Nat Rev Immunol (2009) 3.09

Characterization of an antigen that is recognized on a melanoma showing partial HLA loss by CTL expressing an NK inhibitory receptor. Immunity (1997) 2.71

The role of beta7 integrins in CD8 T cell trafficking during an antiviral immune response. J Exp Med (1999) 2.62

Association of DAP12 with activating CD94/NKG2C NK cell receptors. Immunity (1998) 2.54

Type I interferons regulate cytolytic activity of memory CD8(+) T cells in the lung airways during respiratory virus challenge. Immunity (2010) 2.52

Immunity to respiratory viruses. Annu Rev Immunol (2009) 2.50

Frequency, specificity, and sites of expansion of CD8+ T cells during primary pulmonary influenza virus infection. J Immunol (2005) 2.13

The collagen binding alpha1beta1 integrin VLA-1 regulates CD8 T cell-mediated immune protection against heterologous influenza infection. Immunity (2004) 2.13

TGF-{beta}-dependent CD103 expression by CD8(+) T cells promotes selective destruction of the host intestinal epithelium during graft-versus-host disease. J Exp Med (2005) 2.12

Multiple immunoenzyme staining: methods and visualizations for the observation with spectral imaging. J Histochem Cytochem (2007) 2.09

Selective accumulation of differentiated CD8+ T cells specific for respiratory viruses in the human lung. J Exp Med (2005) 2.04

Naive, effector, and memory CD8 T cells in protection against pulmonary influenza virus infection: homing properties rather than initial frequencies are crucial. J Immunol (1999) 1.99

Generation of gut-homing T cells and their localization to the small intestinal mucosa. Immunol Rev (2007) 1.86

Virus-specific CD8 T cells in peripheral tissues are more resistant to apoptosis than those in lymphoid organs. Immunity (2003) 1.85

Granzymes: exogenous proteinases that induce target cell apoptosis. Immunol Today (1995) 1.76

Identification of a human recent thymic emigrant phenotype. Proc Natl Acad Sci U S A (2000) 1.69

Human bronchial intraepithelial T lymphocytes as a distinct T-cell subset: their long-term survival in SCID-Hu chimeras. Am J Respir Cell Mol Biol (2000) 1.57

Extraction of immune and inflammatory cells from human lung parenchyma: evaluation of an enzymatic digestion procedure. Clin Exp Immunol (1986) 1.57

Alpha E beta 7 integrin interaction with E-cadherin promotes antitumor CTL activity by triggering lytic granule polarization and exocytosis. J Exp Med (2007) 1.42

Cutting edge: effector memory CD8+ T cells in the lung airways retain the potential to mediate recall responses. J Immunol (2003) 1.34

Selective expansion of intraepithelial lymphocytes expressing the HLA-E-specific natural killer receptor CD94 in celiac disease. Gastroenterology (2000) 1.33

CD103 is a marker for alloantigen-induced regulatory CD8+ T cells. J Immunol (2006) 1.33

The human intraepithelial lymphocyte marker HML-1 is an integrin consisting of a beta 7 subunit associated with a distinctive alpha chain. Eur J Immunol (1992) 1.29

Spontaneous cytotoxicity of human intraepithelial lymphocytes against epithelial cell tumors. Gastroenterology (1992) 1.26

Cytotoxic potential of lung CD8(+) T cells increases with chronic obstructive pulmonary disease severity and with in vitro stimulation by IL-18 or IL-15. J Immunol (2010) 1.18

Cutting edge: engagement of NKG2A on CD8+ effector T cells limits immunopathology in influenza pneumonia. J Immunol (2008) 1.15

Collagen distribution and expression of collagen-binding alpha1beta1 (VLA-1) and alpha2beta1 (VLA-2) integrins on CD4 and CD8 T cells during influenza infection. J Immunol (2007) 1.10

Dysregulated NK receptor expression in patients with lymphoproliferative disease of granular lymphocytes. Blood (2004) 1.09

In vivo expression of natural killer cell inhibitory receptors by human melanoma-specific cytolytic T lymphocytes. J Exp Med (1999) 1.08

Identification of a unique population of tissue-memory CD4+ T cells in the airways after influenza infection that is dependent on the integrin VLA-1. J Immunol (2010) 1.07

CTL granules: evolution of vesicles essential for combating virus infections. Immunol Today (1999) 1.07

Up-regulation of inhibitory natural killer receptors CD94/NKG2A with suppressed intracellular perforin expression of tumor-infiltrating CD8+ T lymphocytes in human cervical carcinoma. Cancer Res (2005) 1.06

CXCR6 identifies a putative population of retained human lung T cells characterised by co-expression of activation markers. Immunobiology (2008) 1.03

Proapoptotic functions of cytotoxic lymphocyte granule constituents in vitro and in vivo. Curr Opin Immunol (2000) 1.02

The alpha1beta1 integrin and TNF receptor II protect airway CD8+ effector T cells from apoptosis during influenza infection. J Immunol (2007) 1.00

Intratumoral induction of CD103 triggers tumor-specific CTL function and CCR5-dependent T-cell retention. Cancer Res (2009) 0.99

Generation of alloreactive cytolytic T lymphocytes by immobilized anti-CD3 monoclonal antibodies. Analysis of requirements for human cytolytic T-lymphocyte differentiation. Immunology (1990) 0.96

CD103+ CTL accumulate within the graft epithelium during clinical renal allograft rejection. Transplantation (2001) 0.92

Expression of HLA class I-specific inhibitory receptors in human cytolytic T lymphocytes: a regulated mechanism that controls T-cell activation and function. Hum Immunol (2000) 0.90

Permanent silencing of NKG2A expression for cell-based therapeutics. J Mol Med (Berl) (2008) 0.88

Role of the mucosal integrin alpha(E)(CD103)beta(7) in tissue-restricted cytotoxicity. Clin Exp Immunol (2007) 0.86

T cell adhesion and cytolysis of pancreatic cancer cells: a role for E-cadherin in immunotherapy? Br J Cancer (2002) 0.81

CD8 and CD103 are highly expressed in asthmatic bronchial intraepithelial lymphocytes. Int Arch Allergy Immunol (2010) 0.80

Human bronchial intraepithelial T cells produce interferon-gamma and stimulate epithelial cells. Clin Exp Immunol (2008) 0.77

Tumor viral escape from inhibited T cells. Nat Immunol (2002) 0.76

Articles by these authors

Management of lung nodules detected by volume CT scanning. N Engl J Med (2009) 6.79

Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer. Sci Transl Med (2010) 6.39

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. Nat Genet (2012) 5.28

Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer. Cancer Discov (2011) 4.80

Primary immune responses to human CMV: a critical role for IFN-gamma-producing CD4+ T cells in protection against CMV disease. Blood (2002) 2.83

Neutrophil infiltration of culprit lesions in acute coronary syndromes. Circulation (2002) 2.67

The pathology of chronic obstructive pulmonary disease. Annu Rev Pathol (2009) 2.23

Mucosal immune cell numbers and visceral sensitivity in patients with irritable bowel syndrome: is there any relationship? Am J Gastroenterol (2012) 2.16

Clinical control of asthma associates with measures of airway inflammation. Thorax (2012) 2.15

CD20 deficiency in humans results in impaired T cell-independent antibody responses. J Clin Invest (2009) 2.15

Lung eQTLs to help reveal the molecular underpinnings of asthma. PLoS Genet (2012) 2.09

Cigarette smoke-induced emphysema: A role for the B cell? Am J Respir Crit Care Med (2006) 2.05

Selective accumulation of differentiated CD8+ T cells specific for respiratory viruses in the human lung. J Exp Med (2005) 2.04

Apoptosis threshold set by Noxa and Mcl-1 after T cell activation regulates competitive selection of high-affinity clones. Immunity (2010) 1.98

Lethal T cell immunodeficiency induced by chronic costimulation via CD27-CD70 interactions. Nat Immunol (2002) 1.97

IL-7 receptor alpha chain expression distinguishes functional subsets of virus-specific human CD8+ T cells. Blood (2005) 1.95

Decreased cardiac output, venous congestion and the association with renal impairment in patients with cardiac dysfunction. Eur J Heart Fail (2007) 1.91

Timing and tuning of CD27-CD70 interactions: the impact of signal strength in setting the balance between adaptive responses and immunopathology. Immunol Rev (2009) 1.90

Emergence of a CD4+CD28- granzyme B+, cytomegalovirus-specific T cell subset after recovery of primary cytomegalovirus infection. J Immunol (2004) 1.89

The Noxa/Mcl-1 axis regulates susceptibility to apoptosis under glucose limitation in dividing T cells. Immunity (2006) 1.86

Methylation of cancer-stem-cell-associated Wnt target genes predicts poor prognosis in colorectal cancer patients. Cell Stem Cell (2011) 1.80

Distribution of macrophage polarization markers in human atherosclerosis. Atherosclerosis (2012) 1.79

A dynamic bronchial airway gene expression signature of chronic obstructive pulmonary disease and lung function impairment. Am J Respir Crit Care Med (2013) 1.73

Overrepresentation of IL-17A and IL-22 producing CD8 T cells in lesional skin suggests their involvement in the pathogenesis of psoriasis. PLoS One (2010) 1.73

Clinical and inflammatory determinants of bronchial hyperresponsiveness in COPD. Eur Respir J (2012) 1.71

Effect of fluticasone with and without salmeterol on pulmonary outcomes in chronic obstructive pulmonary disease: a randomized trial. Ann Intern Med (2009) 1.70

Expression of the murine CD27 ligand CD70 in vitro and in vivo. J Immunol (2003) 1.66

Enhanced formation and survival of CD4+ CD25hi Foxp3+ T-cells in chronic lymphocytic leukemia. Leuk Lymphoma (2009) 1.65

Human T-cell memory consists mainly of unexpanded clones. Immunol Lett (2010) 1.60

Uptake of blood coagulation factor VIII by dendritic cells is mediated via its C1 domain. J Allergy Clin Immunol (2011) 1.60

Differential usage of cellular niches by cytomegalovirus versus EBV- and influenza virus-specific CD8+ T cells. J Immunol (2006) 1.55

Low numbers of FOXP3 positive regulatory T cells are present in all developmental stages of human atherosclerotic lesions. PLoS One (2007) 1.51

Remodeling in asthma and chronic obstructive pulmonary disease. Proc Am Thorac Soc (2006) 1.51

Molecular profiling of cytomegalovirus-induced human CD8+ T cell differentiation. J Clin Invest (2010) 1.50

Molecular signature of smoking in human lung tissues. Cancer Res (2012) 1.50

CMV-specific CD8+ T-cell function is not impaired in chronic lymphocytic leukemia. Blood (2013) 1.49

Preferential HLA-DRB1*11-dependent presentation of CUB2-derived peptides by ADAMTS13-pulsed dendritic cells. Blood (2013) 1.49

Respiratory syncytial virus-specific CD8+ memory T cell responses in elderly persons. J Infect Dis (2005) 1.48

Early reperfusion during acute myocardial infarction affects ventricular tachycardia characteristics and the chronic electroanatomic and histological substrate. Circulation (2010) 1.47

Tumor rejection induced by CD70-mediated quantitative and qualitative effects on effector CD8+ T cell formation. J Exp Med (2004) 1.46

CD27 defines phenotypically and functionally different human NK cell subsets. J Immunol (2008) 1.44

Collagen degradation in the abdominal aneurysm: a conspiracy of matrix metalloproteinase and cysteine collagenases. Am J Pathol (2007) 1.43

Cytomegalovirus infection reduces telomere length of the circulating T cell pool. J Immunol (2010) 1.42

Association between complex coronary artery stenosis and unstable angina and the extent of plaque inflammation. Am J Med (2003) 1.41

The size and phenotype of virus-specific T cell populations is determined by repetitive antigenic stimulation and environmental cytokines. J Immunol (2004) 1.41

Transfusion of 35-Day Stored RBCs in the Presence of Endotoxemia Does Not Result in Lung Injury in Humans. Crit Care Med (2016) 1.40

Strong selection of virus-specific cytotoxic CD4+ T-cell clones during primary human cytomegalovirus infection. Blood (2006) 1.40

Differential expression of interleukin-17 family cytokines in intact and complicated human atherosclerotic plaques. J Pathol (2010) 1.39

ATP-binding cassette (ABC) transporters in normal and pathological lung. Respir Res (2005) 1.37

Identification of PCDH1 as a novel susceptibility gene for bronchial hyperresponsiveness. Am J Respir Crit Care Med (2009) 1.35

Thymic epithelial tumours: a population-based study of the incidence, diagnostic procedures and therapy. Eur J Cancer (2008) 1.33

CD103 is a marker for alloantigen-induced regulatory CD8+ T cells. J Immunol (2006) 1.33

Clinical and immunologic aspects of cytomegalovirus infection in solid organ transplant recipients. Transplantation (2005) 1.33

Expression of TRAIL and TRAIL death receptors in stage III non-small cell lung cancer tumors. Clin Cancer Res (2003) 1.29

More alternative activation of macrophages in lungs of asthmatic patients. J Allergy Clin Immunol (2010) 1.28

IL-15 induces antigen-independent expansion and differentiation of human naive CD8+ T cells in vitro. Blood (2003) 1.26

Acute effects of cigarette smoking on inflammation in healthy intermittent smokers. Respir Res (2005) 1.25

Expression of ADAMs ("a disintegrin and metalloprotease") in the human lung. Virchows Arch (2009) 1.24

Human virus-specific CD8+ T cells: diversity specialists. Immunol Rev (2006) 1.24

Guideline on the requirements of external quality assessment programs in molecular pathology. Virchows Arch (2012) 1.24

B cells are crucial for both development and maintenance of the splenic marginal zone. J Immunol (2004) 1.23

IL-10-generated tolerogenic dendritic cells are optimal for functional regulatory T cell induction--a comparative study of human clinical-applicable DC. Clin Immunol (2011) 1.23

Differential regulation of human IL-7 receptor alpha expression by IL-7 and TCR signaling. J Immunol (2008) 1.21

Are there reasons why adult asthma is more common in females? Curr Allergy Asthma Rep (2007) 1.21

IL-21 sustains CD28 expression on IL-15-activated human naive CD8+ T cells. J Immunol (2005) 1.19

Properties of murine (CD8+)CD27- T cells. Eur J Immunol (2005) 1.19

Properties of CD4(+) T cells in human cytomegalovirus infection. Hum Immunol (2004) 1.17

Neutrophils, neutrophil extracellular traps and interleukin-17 associate with the organisation of thrombi in acute myocardial infarction. Thromb Haemost (2012) 1.16

Activation of WNT/β-catenin signaling in pulmonary fibroblasts by TGF-β₁ is increased in chronic obstructive pulmonary disease. PLoS One (2011) 1.16

Rapamycin does not induce anergy but inhibits expansion and differentiation of alloreactive human T cells. Transplantation (2006) 1.16

The costimulatory molecule CD27 maintains clonally diverse CD8(+) T cell responses of low antigen affinity to protect against viral variants. Immunity (2011) 1.15

The epidermal growth factor-seven transmembrane (EGF-TM7) receptor CD97 is required for neutrophil migration and host defense. J Immunol (2004) 1.14

CD27-CD70 interactions sensitise naive CD4+ T cells for IL-12-induced Th1 cell development. Int Immunol (2007) 1.14

Smoking cessation and bronchial epithelial remodelling in COPD: a cross-sectional study. Respir Res (2007) 1.13

Short-term smoke exposure attenuates ovalbumin-induced airway inflammation in allergic mice. Am J Respir Cell Mol Biol (2004) 1.12

Increased expression of T cell activation markers (CD25, CD26, CD40L and CD69) in atherectomy specimens of patients with unstable angina and acute myocardial infarction. Atherosclerosis (2003) 1.12

The neuropeptide substance P mediates adventitial mast cell activation and induces intraplaque hemorrhage in advanced atherosclerosis. Circ Res (2009) 1.12

Small cell carcinoma of the lung and large cell neuroendocrine carcinoma interobserver variability. Histopathology (2010) 1.11

Immune activation modulates hematopoiesis through interactions between CD27 and CD70. Nat Immunol (2005) 1.11

Immunohistochemical analysis of regulatory T cell markers FOXP3 and GITR on CD4+CD25+ T cells in normal skin and inflammatory dermatoses. J Histochem Cytochem (2007) 1.10

Absence of circulating natural killer and primed CD8+ cells in life-threatening varicella. J Infect Dis (2004) 1.09

Common gamma chain cytokines: dissidence in the details. Immunol Lett (2006) 1.08

A fingerprint left by cytomegalovirus infection in the human T cell compartment. J Clin Virol (2007) 1.08

Genomic aberrations in squamous cell lung carcinoma related to lymph node or distant metastasis. Lung Cancer (2009) 1.07

Airway epithelial changes in smokers but not in ex-smokers with asthma. Am J Respir Crit Care Med (2009) 1.07

Microvascular proliferation in congenital vascular malformations of skin and soft tissue. J Clin Pathol (2006) 1.05

Association of current smoking with airway inflammation in chronic obstructive pulmonary disease and asymptomatic smokers. Respir Res (2005) 1.04

Signaling through CD70 regulates B cell activation and IgG production. J Immunol (2004) 1.04

The human EGF-TM7 family member EMR2 is a heterodimeric receptor expressed on myeloid cells. J Leukoc Biol (2002) 1.04

Smoking status and anti-inflammatory macrophages in bronchoalveolar lavage and induced sputum in COPD. Respir Res (2011) 1.04