Published in Invest Ophthalmol Vis Sci on July 11, 2011
Dengue virus infection mediates HMGB1 release from monocytes involving PCAF acetylase complex and induces vascular leakage in endothelial cells. PLoS One (2012) 0.93
Antidiabetic drug metformin suppresses endotoxin-induced uveitis in rats. Invest Ophthalmol Vis Sci (2012) 0.88
Green tea extract treatment alleviates ocular inflammation in a rat model of endotoxin-induced uveitis. PLoS One (2014) 0.84
HMGB1 is an early and critical mediator in an animal model of uveitis induced by IRBP-specific T cells. J Leukoc Biol (2013) 0.83
Retracted Piceatannol suppresses endotoxin-induced ocular inflammation in rats. Int Immunopharmacol (2013) 0.83
Ethyl pyruvate ameliorates endotoxin-induced corneal inflammation. Invest Ophthalmol Vis Sci (2012) 0.82
Treatment with melatonin after onset of experimental uveitis attenuates ocular inflammation. Br J Pharmacol (2014) 0.79
Protective effects of the galectin-1 protein on in vivo and in vitro models of ocular inflammation. Mol Vis (2015) 0.76
An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice. Nat Med (2003) 6.61
A central role for inflammation in the pathogenesis of diabetic retinopathy. FASEB J (2004) 5.33
Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation. Mutat Res (2001) 3.94
Nitric oxide activates cyclooxygenase enzymes. Proc Natl Acad Sci U S A (1993) 3.93
Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation. Proc Natl Acad Sci U S A (2002) 3.68
The natural history of uveitis. Int Ophthalmol (1990) 3.28
Ringer's ethyl pyruvate solution ameliorates ischemia/reperfusion-induced intestinal mucosal injury in rats. Crit Care Med (2001) 2.12
Aqueous humor and serum tumor necrosis factor-alpha in clinical uveitis. Ophthalmic Res (2001) 2.06
Ethyl pyruvate modulates inflammatory gene expression in mice subjected to hemorrhagic shock. Am J Physiol Gastrointest Liver Physiol (2002) 1.70
Contribution of TNF-alpha to leukocyte adhesion, vascular leakage, and apoptotic cell death in endotoxin-induced uveitis in vivo. Invest Ophthalmol Vis Sci (2003) 1.66
Aldose reductase inhibition prevents endotoxin-induced uveitis in rats. Invest Ophthalmol Vis Sci (2007) 1.61
Suppression of diabetes-induced retinal inflammation by blocking the angiotensin II type 1 receptor or its downstream nuclear factor-kappaB pathway. Invest Ophthalmol Vis Sci (2007) 1.59
Ethyl pyruvate inhibits nuclear factor-kappaB-dependent signaling by directly targeting p65. J Pharmacol Exp Ther (2004) 1.51
Anti-inflammatory adjuvant in resuscitation fluids improves survival in hemorrhage. Crit Care Med (2009) 1.51
Ethyl pyruvate decreases HMGB1 release and ameliorates murine colitis. J Leukoc Biol (2009) 1.45
Cytokines in human intraocular inflammation. Curr Eye Res (1992) 1.44
The biochemical basis for the anti-inflammatory and cytoprotective actions of ethyl pyruvate and related compounds. Biochem Pharmacol (2010) 1.43
Epidemiology and course of disease in childhood uveitis. Ophthalmology (2009) 1.35
The role of high mobility group box1 in pulmonary fibrosis. Am J Respir Cell Mol Biol (2008) 1.34
Efficacy of infliximab in the treatment of uveitis that is resistant to treatment with the combination of azathioprine, cyclosporine, and corticosteroids in Behçet's disease: an open-label trial. Arthritis Rheum (2005) 1.32
Neuroprotective effects of angiotensin II type 1 receptor (AT1R) blocker, telmisartan, via modulating AT1R and AT2R signaling in retinal inflammation. Invest Ophthalmol Vis Sci (2006) 1.24
Interleukin-6 receptor-mediated activation of signal transducer and activator of transcription-3 (STAT3) promotes choroidal neovascularization. Am J Pathol (2007) 1.23
Suppression of ocular inflammation in endotoxin-induced uveitis by blocking the angiotensin II type 1 receptor. Invest Ophthalmol Vis Sci (2005) 1.18
Evidence that glutathione depletion is a mechanism responsible for the anti-inflammatory effects of ethyl pyruvate in cultured lipopolysaccharide-stimulated RAW 264.7 cells. J Pharmacol Exp Ther (2003) 1.10
Inhibition of leukocyte sticking and infiltration, but not rolling, by antibodies to ICAM-1 and LFA-1 in murine endotoxin-induced uveitis. Invest Ophthalmol Vis Sci (2001) 1.07
H(2)O(2)-mediated oxidative stress activates NF-kappa B in lens epithelial cells. Free Radic Biol Med (2001) 1.05
The role of nitric oxide synthase in endotoxin-induced uveitis: effects of NG-nitro L-arginine. Invest Ophthalmol Vis Sci (1994) 1.02
Uveitis: advances in understanding of pathogenesis and treatment. Curr Rheumatol Rep (2006) 1.02
Role and regulation of IL-8 and MCP-1 in LPS-induced uveitis in rabbits. Exp Eye Res (1999) 1.01
The effect of high-mobility group box 1 protein on activity of regulatory T cells after thermal injury in rats. Shock (2009) 1.00
Prevention of intracellular oxidative stress to lens by pyruvate and its ester. Free Radic Res (1998) 0.99
Delayed ethyl pyruvate therapy attenuates experimental severe acute pancreatitis via reduced serum high mobility group box 1 levels in rats. World J Gastroenterol (2008) 0.98
Ethyl pyruvate modulates acute inflammatory reactions in human endothelial cells in relation to the NF-kappaB pathway. Br J Pharmacol (2008) 0.97
Inhibition of endotoxin-induced uveitis and potentiation of cyclooxygenase-2 protein expression by alpha-melanocyte-stimulating hormone. Invest Ophthalmol Vis Sci (2004) 0.97
Prevention of endotoxin-induced uveitis in rats by benfotiamine, a lipophilic analogue of vitamin B1. Invest Ophthalmol Vis Sci (2009) 0.96
Additive effect of nitric oxide and prostaglandin-E2 synthesis inhibitors in endotoxin-induced uveitis in the rabbit. Inflamm Res (1996) 0.95
Strong in vivo activation of NF-kappaB in mouse lenses by classic stressors. Invest Ophthalmol Vis Sci (2003) 0.94
Differential gene expression in the human ciliary epithelium. Prog Retin Eye Res (1999) 0.93
Oxidative damage to lens in culture: reversibility by pyruvate and ethyl pyruvate. Ophthalmologica (2006) 0.89
Responses of cultured human keratocytes and myofibroblasts to ethyl pyruvate: a microarray analysis of gene expression. Invest Ophthalmol Vis Sci (2010) 0.88
Beneficial effects of ethyl pyruvate in a mouse model of spinal cord injury. Shock (2009) 0.86
Attenuation of sugar cataract by ethyl pyruvate. Mol Cell Biochem (1999) 0.85
Ethyl pyruvate prevents inflammatory responses and organ damage during resuscitation in porcine hemorrhage. Shock (2010) 0.85
Emerging role of antioxidants in the protection of uveitis complications. Curr Med Chem (2011) 0.84
Prevention of endotoxin-induced uveitis in rats by plant sterol guggulsterone. Invest Ophthalmol Vis Sci (2010) 0.84
Synovial nitric oxide concentrations are increased and correlated with serum levels in patients with active Behçet's disease: a pilot study. Clin Rheumatol (2005) 0.84
Lens thiol depletion by peroxynitrite. Protective effect of pyruvate. Mol Cell Biochem (2006) 0.82
Intraocular penetration of pyruvate following its topical administration in mice. Mol Cell Biochem (2009) 0.81
Attenuation of galactose-induced cataract by pyruvate. Free Radic Res (1999) 0.77
Role of aldose reductase and oxidative damage in diabetes and the consequent potential for therapeutic options. Endocr Rev (2005) 2.42
Aldose reductase inhibition prevents endotoxin-induced uveitis in rats. Invest Ophthalmol Vis Sci (2007) 1.61
Aldose reductase mediates the lipopolysaccharide-induced release of inflammatory mediators in RAW264.7 murine macrophages. J Biol Chem (2006) 1.46
Aldose reductase regulates growth factor-induced cyclooxygenase-2 expression and prostaglandin E2 production in human colon cancer cells. Cancer Res (2006) 1.27
Identification of novel mutations causing familial primary congenital glaucoma in Indian pedigrees. Invest Ophthalmol Vis Sci (2002) 1.18
Contribution of aldose reductase to diabetic hyperproliferation of vascular smooth muscle cells. Diabetes (2006) 1.13
Inhibition of aldose reductase prevents experimental allergic airway inflammation in mice. PLoS One (2009) 1.11
Aldose reductase deficiency in mice prevents azoxymethane-induced colonic preneoplastic aberrant crypt foci formation. Carcinogenesis (2008) 1.10
Aldose reductase inhibition suppresses oxidative stress-induced inflammatory disorders. Chem Biol Interact (2011) 1.09
Correlations of genotype with phenotype in Indian patients with primary congenital glaucoma. Invest Ophthalmol Vis Sci (2004) 1.09
Regulation of CD95 (Fas) expression and Fas-mediated apoptotic signaling in HLE B-3 cells by 4-hydroxynonenal. Biochemistry (2006) 1.09
Focus on molecules: nuclear factor-kappaB. Exp Eye Res (2008) 1.08
Prevention of posterior capsular opacification through aldose reductase inhibition. Invest Ophthalmol Vis Sci (2008) 1.07
Nitric oxide prevents aldose reductase activation and sorbitol accumulation during diabetes. Diabetes (2002) 1.06
Role of aldehyde dehydrogenase isozymes in the defense of rat lens and human lens epithelial cells against oxidative stress. Invest Ophthalmol Vis Sci (2005) 1.05
Carotenoid derived aldehydes-induced oxidative stress causes apoptotic cell death in human retinal pigment epithelial cells. Exp Eye Res (2007) 1.03
Aldose reductase regulates high glucose-induced ectodomain shedding of tumor necrosis factor (TNF)-alpha via protein kinase C-delta and TNF-alpha converting enzyme in vascular smooth muscle cells. Endocrinology (2008) 1.01
Inhibition of aldose reductase prevents lipopolysaccharide-induced inflammatory response in human lens epithelial cells. Invest Ophthalmol Vis Sci (2006) 1.01
Regulation of NF-κB-induced inflammatory signaling by lipid peroxidation-derived aldehydes. Oxid Med Cell Longev (2013) 1.00
Aldose reductase mediates endotoxin-induced production of nitric oxide and cytotoxicity in murine macrophages. Free Radic Biol Med (2007) 1.00
Aldose reductase regulates TNF-alpha-induced PGE2 production in human colon cancer cells. Cancer Lett (2007) 0.98
Prevention of endotoxin-induced uveitis in rats by benfotiamine, a lipophilic analogue of vitamin B1. Invest Ophthalmol Vis Sci (2009) 0.96
Aldose reductase-regulated tumor necrosis factor-alpha production is essential for high glucose-induced vascular smooth muscle cell growth. Endocrinology (2007) 0.96
Aldose reductase inhibition suppresses the expression of Th2 cytokines and airway inflammation in ovalbumin-induced asthma in mice. J Immunol (2009) 0.95
Inhibition of aldose reductase prevents angiogenesis in vitro and in vivo. Angiogenesis (2011) 0.95
Disease-causing mutations in proteins: structural analysis of the CYP1B1 mutations causing primary congenital glaucoma in humans. Biophys J (2006) 0.95
Measurement and identification of S-glutathiolated proteins. Methods Enzymol (2010) 0.94
Aldose reductase deficiency protects sugar-induced lens opacification in rats. Chem Biol Interact (2011) 0.93
Anti-inflammatory effect of aldose reductase inhibition in murine polymicrobial sepsis. Cytokine (2009) 0.93
Glutathione level regulates HNE-induced genotoxicity in human erythroleukemia cells. Toxicol Appl Pharmacol (2007) 0.92
Inhibition of aldose reductase prevents endotoxin-induced inflammation by regulating the arachidonic acid pathway in murine macrophages. Free Radic Biol Med (2011) 0.92
Post-translational protein modification by carotenoid cleavage products. Biofactors (2011) 0.91
Metabolism of lipid derived aldehyde, 4-hydroxynonenal in human lens epithelial cells and rat lens. Invest Ophthalmol Vis Sci (2003) 0.90
Aldose reductase inhibition prevents metaplasia of airway epithelial cells. PLoS One (2010) 0.89
Structure of a glutathione conjugate bound to the active site of aldose reductase. Proteins (2006) 0.89
Topical metal chelation therapy ameliorates oxidation-induced toxicity in diabetic cataract. J Toxicol Environ Health A (2011) 0.89
Protection of HLE B-3 cells against hydrogen peroxide- and naphthalene-induced lipid peroxidation and apoptosis by transfection with hGSTA1 and hGSTA2. Invest Ophthalmol Vis Sci (2002) 0.89
Antidiabetic drug metformin suppresses endotoxin-induced uveitis in rats. Invest Ophthalmol Vis Sci (2012) 0.88
Inhibition of aldose reductase prevents colon cancer metastasis. Carcinogenesis (2011) 0.88
Molecular cloning and oxidative modification of human lens ALDH1A1: implication in impaired detoxification of lipid aldehydes. J Toxicol Environ Health A (2009) 0.88
Novel mutation in FOXC1 wing region causing Axenfeld-Rieger anomaly. Invest Ophthalmol Vis Sci (2002) 0.87
Aldose reductase inhibition prevents allergic airway remodeling through PI3K/AKT/GSK3β pathway in mice. PLoS One (2013) 0.87
Cadmium-induced apoptotic death of human retinal pigment epithelial cells is mediated by MAPK pathway. Exp Eye Res (2009) 0.87
4-Hydroxynonenal in the pathogenesis and progression of human diseases. Curr Med Chem (2014) 0.87
L-Arginine prevents metabolic effects of high glucose in diabetic mice. FEBS Lett (2008) 0.87
Aldose reductase regulates vascular smooth muscle cell proliferation by modulating G1/S phase transition of cell cycle. Endocrinology (2010) 0.86
Synthesis, quantification, characterization, and signaling properties of glutathionyl conjugates of enals. Methods Enzymol (2010) 0.85
Prevention of endotoxin-induced uveitis in rats by plant sterol guggulsterone. Invest Ophthalmol Vis Sci (2010) 0.84
Endotoxin-induced uveitis in rodents. Methods Mol Biol (2013) 0.83
Aldose reductase inhibition prevents colon cancer growth by restoring phosphatase and tensin homolog through modulation of miR-21 and FOXO3a. Antioxid Redox Signal (2012) 0.83
Inhibition of fiber cell globulization and hyperglycemia-induced lens opacification by aminopeptidase inhibitor bestatin. Invest Ophthalmol Vis Sci (2002) 0.83
Anti-inflammatory effects of benfotiamine are mediated through the regulation of the arachidonic acid pathway in macrophages. Free Radic Biol Med (2011) 0.83
A potential therapeutic role for aldose reductase inhibitors in the treatment of endotoxin-related inflammatory diseases. Expert Opin Investig Drugs (2012) 0.83
Retracted Piceatannol suppresses endotoxin-induced ocular inflammation in rats. Int Immunopharmacol (2013) 0.83
Aldose reductase inhibition: emerging drug target for the treatment of cardiovascular complications. Recent Pat Cardiovasc Drug Discov (2010) 0.82
Role of aldose reductase in TNF-alpha-induced apoptosis of vascular endothelial cells. Chem Biol Interact (2003) 0.82
Aldose reductase deficiency protects from autoimmune- and endotoxin-induced uveitis in mice. Invest Ophthalmol Vis Sci (2011) 0.82
Assessment of methylsulfonylmethane as a permeability enhancer for regional EDTA chelation therapy. Drug Deliv (2009) 0.82
Protective role of benfotiamine, a fat-soluble vitamin B1 analogue, in lipopolysaccharide-induced cytotoxic signals in murine macrophages. Free Radic Biol Med (2010) 0.82
Targeting aldose reductase for the treatment of cancer. Curr Cancer Drug Targets (2011) 0.81
Genotoxic effects of carotenoid breakdown products in human retinal pigment epithelial cells. Curr Eye Res (2009) 0.80
Aldose reductase inhibition prevents lipopolysaccharide-induced glucose uptake and glucose transporter 3 expression in RAW264.7 macrophages. Int J Biochem Cell Biol (2010) 0.80
Amelioration of experimental autoimmune uveoretinitis by aldose reductase inhibition in Lewis rats. Invest Ophthalmol Vis Sci (2011) 0.80
Aldose reductase inhibition suppresses colon cancer cell viability by modulating microRNA-21 mediated programmed cell death 4 (PDCD4) expression. Eur J Cancer (2013) 0.79
Inhibition of aldose reductase attenuates endotoxin signals in human non-pigmented ciliary epithelial cells. Exp Eye Res (2010) 0.79
Aldose reductase prevents aldehyde toxicity in cultured human lens epithelial cells. Exp Eye Res (2006) 0.78
Focus on molecules: lutein. Exp Eye Res (2011) 0.78
Aldose reductase inhibition enhances TRAIL-induced human colon cancer cell apoptosis through AKT/FOXO3a-dependent upregulation of death receptors. Free Radic Biol Med (2013) 0.78
Aldose reductase inhibition suppresses airway inflammation. Chem Biol Interact (2011) 0.77
Aldose reductase inhibition for the treatment of asthma. Expert Rev Clin Immunol (2010) 0.77
Regulation of lens aldose reductase activity by nitric oxide. Exp Eye Res (2005) 0.77
Aldose reductase deficiency in mice protects from ragweed pollen extract (RWE)-induced allergic asthma. Respir Res (2011) 0.77
Prevention of VEGF-induced growth and tube formation in human retinal endothelial cells by aldose reductase inhibition. J Diabetes Complications (2012) 0.76
Prevention of allergic rhinitis by aldose reductase inhibition in a murine model. Inflamm Allergy Drug Targets (2013) 0.75
Congenital glaucoma associated with 22p+ variant in a dysmorphic child. Indian J Ophthalmol (2003) 0.75
[Metabolism and detoxification of the lipid derived aldehyde, 4-Hydroxynonenal in diabetic cataractogenesis in rat]. Zhonghua Yan Ke Za Zhi (2009) 0.75
Regulation of aldose reductase and the polyol pathway activity by nitric oxide. Chem Biol Interact (2003) 0.75