PubRank

Dan L Longo

Author PubWeight™ 207.03‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. N Engl J Med 2002 24.07
2 Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain. PLoS Genet 2010 8.74
3 Data Sharing. N Engl J Med 2016 5.12
4 Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature 2012 5.00
5 The origins of age-related proinflammatory state. Blood 2004 4.15
6 Intravenous erythropoietin in patients with ST-segment elevation myocardial infarction: REVEAL: a randomized controlled trial. JAMA 2011 4.09
7 Red blood cell distribution width and the risk of death in middle-aged and older adults. Arch Intern Med 2009 3.71
8 Interleukin-6 in aging and chronic disease: a magnificent pathway. J Gerontol A Biol Sci Med Sci 2006 2.85
9 Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice. Science 2005 2.72
10 Precision medicine--personalized, problematic, and promising. N Engl J Med 2015 2.67
11 Tumor heterogeneity and personalized medicine. N Engl J Med 2012 2.63
12 Distinct DNA methylation changes highly correlated with chronological age in the human brain. Hum Mol Genet 2011 2.62
13 Drug-Induced Megaloblastic Anemia. N Engl J Med 2015 2.62
14 Insights into thymic aging and regeneration. Immunol Rev 2005 2.55
15 New therapies for castration-resistant prostate cancer. N Engl J Med 2010 2.37
16 Talking with patients about dying. N Engl J Med 2012 2.34
17 Red cell distribution width and mortality in older adults: a meta-analysis. J Gerontol A Biol Sci Med Sci 2009 2.32
18 Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 2009 2.32
19 Phosphorylation of RelA/p65 on serine 536 defines an I{kappa}B{alpha}-independent NF-{kappa}B pathway. J Biol Chem 2005 2.30
20 Dose-adjusted EPOCH chemotherapy for untreated large B-cell lymphomas: a pharmacodynamic approach with high efficacy. Blood 2002 2.28
21 Linking beta-catenin to androgen-signaling pathway. J Biol Chem 2002 2.27
22 IFN-gamma mediates CD4+ T-cell loss and impairs secondary antitumor responses after successful initial immunotherapy. Nat Med 2007 2.23
23 Proinflammatory state, hepcidin, and anemia in older persons. Blood 2010 2.19
24 Aging predisposes to acute inflammatory induced pathology after tumor immunotherapy. J Exp Med 2013 2.18
25 A controlled trial of reduced meal frequency without caloric restriction in healthy, normal-weight, middle-aged adults. Am J Clin Nutr 2007 2.16
26 Transient improvement in cognitive function and synaptic plasticity in rats following cancer chemotherapy. Clin Cancer Res 2006 1.97
27 Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction. Proc Natl Acad Sci U S A 2008 1.97
28 Transcriptome analysis of mouse stem cells and early embryos. PLoS Biol 2003 1.75
29 Proinflammatory state and circulating erythropoietin in persons with and without anemia. Am J Med 2005 1.72
30 Multiple loci are associated with white blood cell phenotypes. PLoS Genet 2011 1.65
31 Treatment of advanced Hodgkin lymphoma: the more things change, the more they stay the same. J Clin Oncol 2012 1.61
32 Low testosterone levels and the risk of anemia in older men and women. Arch Intern Med 2006 1.61
33 Serum testosterone is associated with aggressive prostate cancer in older men: results from the Baltimore Longitudinal Study of Aging. BJU Int 2009 1.59
34 The frailty syndrome: a critical issue in geriatric oncology. Crit Rev Oncol Hematol 2003 1.58
35 A genome-wide association analysis of serum iron concentrations. Blood 2009 1.55
36 High basal metabolic rate is a risk factor for mortality: the Baltimore Longitudinal Study of Aging. J Gerontol A Biol Sci Med Sci 2008 1.52
37 Late effects from radiation therapy: the hits just keep on coming. J Natl Cancer Inst 2009 1.47
38 Serum erythropoietin and aging: a longitudinal analysis. J Am Geriatr Soc 2005 1.45
39 Identification of nine novel loci associated with white blood cell subtypes in a Japanese population. PLoS Genet 2011 1.45
40 Radiation therapy in the treatment of Hodgkin's disease--do you see what I see? J Natl Cancer Inst 2003 1.42
41 Wnt5A regulates expression of tumor-associated antigens in melanoma via changes in signal transducers and activators of transcription 3 phosphorylation. Cancer Res 2008 1.41
42 Gene expression atlas of the mouse central nervous system: impact and interactions of age, energy intake and gender. Genome Biol 2007 1.35
43 Proteomic analysis of apoptotic pathways reveals prognostic factors in follicular lymphoma. Clin Cancer Res 2005 1.31
44 Changes in weight at the end of life: characterizing weight loss by time to death in a cohort study of older men. Am J Epidemiol 2010 1.29
45 Effect of promoter methylation on the regulation of IFN-gamma gene during in vitro differentiation of human peripheral blood T cells into a Th2 population. J Immunol 2003 1.29
46 Transcriptional regulation of BRCA1 expression by a metabolic switch. Nat Struct Mol Biol 2010 1.25
47 Delineation of antigen-specific and antigen-nonspecific CD8(+) memory T-cell responses after cytokine-based cancer immunotherapy. Blood 2012 1.25
48 A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation. PLoS Genet 2012 1.23
49 Unexplained anaemia in older persons is characterised by low erythropoietin and low levels of pro-inflammatory markers. Br J Haematol 2007 1.22
50 Monoclonal antibody to an endogenous bufadienolide, marinobufagenin, reverses preeclampsia-induced Na/K-ATPase inhibition and lowers blood pressure in NaCl-sensitive hypertension. J Hypertens 2008 1.19
51 Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk. Proc Natl Acad Sci U S A 2007 1.15
52 Haemoglobin concentration and the risk of death in older adults: differences by race/ethnicity in the NHANES III follow-up. Br J Haematol 2009 1.15
53 Pneumococcal vaccination and revaccination of older adults. Clin Microbiol Rev 2003 1.15
54 Rejuvenation of the aging thymus: growth hormone-mediated and ghrelin-mediated signaling pathways. Curr Opin Pharmacol 2010 1.14
55 Transcriptome analysis of age-, gender- and diet-associated changes in murine thymus. Cell Immunol 2007 1.14
56 Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet. Cell Metab 2013 1.14
57 Impact of reduced meal frequency without caloric restriction on glucose regulation in healthy, normal-weight middle-aged men and women. Metabolism 2007 1.13
58 Gender specificity of altered human immune cytokine profiles in aging. FASEB J 2010 1.12
59 Immunity from smallpox vaccine persists for decades: a longitudinal study. Am J Med 2008 1.11
60 Ammonium trichloro(dioxoethylene-o,o')tellurate (AS101) sensitizes tumors to chemotherapy by inhibiting the tumor interleukin 10 autocrine loop. Cancer Res 2004 1.11
61 Generation of mouse ES cell lines engineered for the forced induction of transcription factors. Sci Rep 2011 1.11
62 Systematic repression of transcription factors reveals limited patterns of gene expression changes in ES cells. Sci Rep 2013 1.08
63 Caveolin-induced activation of the phosphatidylinositol 3-kinase/Akt pathway increases arsenite cytotoxicity. Mol Cell Biol 2003 1.07
64 Comparative approaches to facilitate the discovery of prolongevity interventions: effects of tocopherols on lifespan of three invertebrate species. Mech Ageing Dev 2006 1.06
65 Transcriptional autoregulation by BRCA1. Cancer Res 2010 1.05
66 Genetic variation associated with circulating monocyte count in the eMERGE Network. Hum Mol Genet 2013 1.05
67 Mapping proteoglycan-bound water in cartilage: Improved specificity of matrix assessment using multiexponential transverse relaxation analysis. Magn Reson Med 2010 1.04
68 Endogenous sodium pump inhibitors and age-associated increases in salt sensitivity of blood pressure in normotensives. Am J Physiol Regul Integr Comp Physiol 2008 1.04
69 Role of mitofusin 2 (Mfn2) in controlling cellular proliferation. FASEB J 2013 1.03
70 Identification of a common variant in the TFR2 gene implicated in the physiological regulation of serum iron levels. Hum Mol Genet 2010 1.03
71 Nuclear factor-kappaB-dependent reversal of aging-induced alterations in T cell cytokines. FASEB J 2008 1.01
72 Mouse NK cell-mediated rejection of bone marrow allografts exhibits patterns consistent with Ly49 subset licensing. Blood 2011 1.01
73 Design and rationale of the Reduction of Infarct Expansion and Ventricular Remodeling with Erythropoietin after Large Myocardial Infarction (REVEAL) trial. Am Heart J 2010 1.00
74 Increased bone marrow allograft rejection by depletion of NK cells expressing inhibitory Ly49 NK receptors for donor class I antigens. Blood 2002 1.00
75 Effects of aging and calorie restriction on the global gene expression profiles of mouse testis and ovary. BMC Biol 2008 1.00
76 Comparison of the effect of mutant and wild-type p53 on global gene expression. Cancer Res 2004 0.99
77 Definition and management of anemia in patients infected with hepatitis C virus. Liver Int 2006 0.98
78 Activation-induced cell death of aggressive histology lymphomas by CD40 stimulation: induction of bax. Blood 2002 0.97
79 Radiation therapy in Hodgkin disease: why risk a Pyrrhic victory? J Natl Cancer Inst 2005 0.95
80 Traf1 induction and protection from tumor necrosis factor by nuclear factor-kappaB p65 is independent of serine 536 phosphorylation. Cancer Res 2007 0.95
81 Endometriosis: clinical monitoring and treatment procedures in Rhesus Monkeys. J Med Primatol 2007 0.93
82 Interleukin-12-induced interferon-gamma production by human peripheral blood T cells is regulated by mammalian target of rapamycin (mTOR). J Biol Chem 2004 0.93
83 Murine natural killer cell licensing and regulation by T regulatory cells in viral responses. Proc Natl Acad Sci U S A 2013 0.93
84 Neoplastic "Black Ops": cancer's subversive tactics in overcoming host defenses. Semin Cancer Biol 2012 0.92
85 Idiotype vaccination in follicular lymphoma: knocking on the doorway to cure. J Natl Cancer Inst 2006 0.92
86 Dual isotype expressing B cells [kappa(+)/lambda(+)] arise during the ontogeny of B cells in the bone marrow of normal nontransgenic mice. Cell Immunol 2006 0.90
87 Resistance to TGF-beta 1 correlates with aberrant expression of TGF-beta receptor II in human B-cell lymphoma cell lines. Blood 2007 0.90
88 Multifunctional tellurium molecule protects and restores dopaminergic neurons in Parkinson's disease models. FASEB J 2007 0.90
89 DR's orders: human antibody kills tumors by direct signaling. Nat Med 2002 0.87
90 Talking with patients about dying. N Engl J Med 2013 0.87
91 Role of chemotherapy in Hodgkin's lymphoma. Cancer J 2009 0.86
92 More on Data Sharing. N Engl J Med 2016 0.86
93 Controlled meal frequency without caloric restriction alters peripheral blood mononuclear cell cytokine production. J Inflamm (Lond) 2011 0.85
94 Effect of rapamycin on the cyclosporin A-resistant CD28-mediated costimulatory pathway. Blood 2002 0.85
95 Antigen-independent IFN-γ production by human naïve CD4 T cells activated by IL-12 plus IL-18. PLoS One 2011 0.85
96 Recruitment of RelB to the Csf2 promoter enhances RelA-mediated transcription of granulocyte-macrophage colony-stimulating factor. J Biol Chem 2010 0.85
97 Redirecting T cells. N Engl J Med 2011 0.85
98 Preferential enhancement of older human T cell cytokine generation, chemotaxis, proliferation and survival by lenalidomide. Clin Immunol 2010 0.85
99 Telomere dynamics in aging: much ado about nothing? J Gerontol A Biol Sci Med Sci 2009 0.84
100 Release the hounds! Activating the T-cell response to cancer. N Engl J Med 2014 0.83
101 From the guest editor: Hodgkin's lymphoma: an overview. Cancer J 2009 0.83
102 Closing in on a killer: anemia in elderly people. J Gerontol A Biol Sci Med Sci 2005 0.83
103 Activation-induced deaminase-mediated class switch recombination is blocked by anti-IgM signaling in a phosphatidylinositol 3-kinase-dependent fashion. Mol Immunol 2007 0.83
104 Relationship between mean corpuscular volume and cognitive performance in older adults. J Am Geriatr Soc 2013 0.83
105 A link between maze learning and hippocampal expression of neuroleukin and its receptor gp78. J Neurochem 2002 0.83
106 Correlates of D-dimer in older persons. Aging Clin Exp Res 2010 0.83
107 The M603 idiotype is lost in the response to phosphocholine in terminal deoxynucleotidyl transferase-deficient mice. Eur J Immunol 2002 0.82
108 The synthetic tellurium compound, AS101, is a novel inhibitor of IL-1beta converting enzyme. J Interferon Cytokine Res 2007 0.82
109 Personality traits and leptin. Psychosom Med 2013 0.82
110 Human CD4- 8- T cells are a distinctive immunoregulatory subset. FASEB J 2010 0.81
111 Hutchinson-Gilford progeria syndrome. N Engl J Med 2008 0.81
112 Polo-like kinase 1 inactivation following mitotic DNA damaging treatments is independent of ataxia telangiectasia mutated kinase. Mol Cancer Res 2004 0.81
113 Chromatin properties of regulatory DNA probed by manipulation of transcription factors. J Comput Biol 2014 0.80
114 Monoclonal Antibodies in Multiple Myeloma Come of Age. N Engl J Med 2015 0.80
115 Polo-like kinase 1-mediated phosphorylation of the GTP-binding protein Ran is important for bipolar spindle formation. Biochem Biophys Res Commun 2006 0.80
116 Distinctive mechanism for sustained TGF-β signaling and growth inhibition: MEK1 activation-dependent stabilization of type II TGF-β receptors. Mol Cancer Res 2010 0.80
117 Lymphoma and myeloma in older patients. Semin Oncol 2004 0.79
118 Involvement of mTOR in CXCL12 mediated T cell signaling and migration. PLoS One 2011 0.79
119 Transforming growth factor β1 (TGF-β1) suppresses growth of B-cell lymphoma cells by p14(ARF)-dependent regulation of mutant p53. J Biol Chem 2012 0.79
120 T15-idiotype-negative B cells dominate the phosphocholine binding cells in the preimmune repertoire of T15i knockin mice. J Immunol 2002 0.79
121 Patterns of regional cerebral blood flow associated with low hemoglobin in the Baltimore Longitudinal Study of Aging. J Gerontol A Biol Sci Med Sci 2012 0.79
122 Animal models of aging research: implications for human aging and age-related diseases. Annu Rev Anim Biosci 2015 0.79
123 Second Cancers after Treatment for Hodgkin's Lymphoma--Continuing Cause for Concern. N Engl J Med 2015 0.79
124 A report card for geriatric oncology: borderline pass, improvement needed. J Gerontol A Biol Sci Med Sci 2006 0.78
125 Distinctive immunoregulatory effects of adenosine on T cells of older humans. FASEB J 2011 0.77
126 Preserved learning and memory following 5-fluorouracil and cyclophosphamide treatment in rats. Pharmacol Biochem Behav 2011 0.77
127 Association between serum carboxymethyl-lysine, a dominant advanced glycation end product, and anemia in adults: the Baltimore longitudinal study of aging. J Am Geriatr Soc 2008 0.76
128 Drug-Induced Megaloblastic Anemia. N Engl J Med 2016 0.75
129 Cautious Optimism for Offspring of Women with Cancer during Pregnancy. N Engl J Med 2015 0.75
130 Follicular lymphoma: to treat or not to treat is no longer the question. J Natl Cancer Inst 2011 0.75
131 Gender differences in the accuracy of time-dependent blood pressure indices for predicting coronary heart disease: A random-effects modeling approach. Gend Med 2010 0.75
132 Cancer-drug discovery--let's get ready for the next period. N Engl J Med 2014 0.75
133 Reply to P. Borchmann et al. J Clin Oncol 2013 0.75
134 Imatinib Changed Everything. N Engl J Med 2017 0.75
135 PALB2 mutations and breast-cancer risk. N Engl J Med 2014 0.75
136 Personalized cancer care is not new. Oncologist 2013 0.75
137 Blood stem cell transplantation in older patients. Biol Blood Marrow Transplant 2009 0.75
138 2 BCR or NOT 2 BCR - receptor dilution: a unique mechanism for preventing the development of holes in the protective B cell repertoire. Immunobiology 2005 0.75
139 Real Personalized Medicine. J Natl Compr Canc Netw 2016 0.75
140 The Frankenstein monster and recombinant DNA. Hosp Pract 1979 0.75
141 Cancer immunotherapy: are we there yet? Semin Cancer Biol 2012 0.75
142 Licensing delineates helper and effector NK cell subsets during viral infection. JCI Insight 2017 0.75