Published in Blood on May 11, 2011
A clinically relevant population of leukemic CD34(+)CD38(-) cells in acute myeloid leukemia. Blood (2012) 2.65
Spleens of myelofibrosis patients contain malignant hematopoietic stem cells. J Clin Invest (2012) 1.09
In vivo expansion of co-transplanted T cells impacts on tumor re-initiating activity of human acute myeloid leukemia in NSG mice. PLoS One (2013) 0.93
Myeloid leukemia with transdifferentiation plasticity developing from T-cell progenitors. EMBO J (2016) 0.93
Dysregulated signaling pathways in the development of CNTRL-FGFR1-induced myeloid and lymphoid malignancies associated with FGFR1 in human and mouse models. Blood (2013) 0.92
Diverging fates of cells of origin in acute and chronic leukaemia. EMBO Mol Med (2012) 0.86
Targeting myelogenous leukemia stem cells: role of the circulation. Front Oncol (2012) 0.84
Stem Cell Hierarchy and Clonal Evolution in Acute Lymphoblastic Leukemia. Stem Cells Int (2015) 0.82
MLN0128, a novel mTOR kinase inhibitor, disrupts survival signaling and triggers apoptosis in AML and AML stem/ progenitor cells. Oncotarget (2016) 0.77
Translating leukemia stem cells into the clinical setting: Harmonizing the heterogeneity. Exp Hematol (2016) 0.75
Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax. Cell (2008) 5.75
Direct conversion of human fibroblasts to multilineage blood progenitors. Nature (2010) 5.35
Identification of drugs including a dopamine receptor antagonist that selectively target cancer stem cells. Cell (2012) 4.13
Cytokines and BMP-4 promote hematopoietic differentiation of human embryonic stem cells. Blood (2003) 3.98
IGF and FGF cooperatively establish the regulatory stem cell niche of pluripotent human cells in vitro. Nature (2007) 3.74
Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis. EMBO J (2005) 3.11
Bone marrow-derived stem cells initiate pancreatic regeneration. Nat Biotechnol (2003) 3.02
Endothelial and hematopoietic cell fate of human embryonic stem cells originates from primitive endothelium with hemangioblastic properties. Immunity (2004) 2.89
Characterization of human embryonic stem cells with features of neoplastic progression. Nat Biotechnol (2009) 2.66
Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulation. Nat Med (2005) 2.60
Isolation of human iPS cells using EOS lentiviral vectors to select for pluripotency. Nat Methods (2009) 2.51
Generation of hematopoietic repopulating cells from human embryonic stem cells independent of ectopic HOXB4 expression. J Exp Med (2005) 2.42
Bcl-XL inhibits membrane permeabilization by competing with Bax. PLoS Biol (2008) 2.36
Clonal isolation of hESCs reveals heterogeneity within the pluripotent stem cell compartment. Nat Methods (2006) 2.31
Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin. Blood (2009) 2.31
Interaction with a membrane surface triggers a reversible conformational change in Bax normally associated with induction of apoptosis. J Biol Chem (2003) 2.12
Identification of growth factor conditions that reduce ex vivo cord blood progenitor expansion but do not alter human repopulating cell function in vivo. Haematologica (2005) 2.11
Transfusion of fresh but not old stored blood reduces infarct size and improves cardiac function after acute myocardial infarction in anemic rats*. Crit Care Med (2012) 2.07
Erythropoietin protects cardiomyocytes from apoptosis via up-regulation of endothelial nitric oxide synthase. Cardiovasc Res (2006) 2.02
Bcl-2 changes conformation to inhibit Bax oligomerization. EMBO J (2006) 1.97
Prevention of amino acid conversion in SILAC experiments with embryonic stem cells. Mol Cell Proteomics (2008) 1.83
Human embryonic stem cells possess immune-privileged properties. Stem Cells (2004) 1.82
A randomized phase I clinical and biologic study of two schedules of sorafenib in patients with myelodysplastic syndrome or acute myeloid leukemia: a NCIC (National Cancer Institute of Canada) Clinical Trials Group Study. Leuk Lymphoma (2010) 1.79
Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5. Cancer Cell (2009) 1.78
BH3-only proteins: Orchestrators of apoptosis. Biochim Biophys Acta (2010) 1.76
Mechanisms of action of Bcl-2 family proteins. Cold Spring Harb Perspect Biol (2013) 1.73
Wnt-5A augments repopulating capacity and primitive hematopoietic development of human blood stem cells in vivo. Proc Natl Acad Sci U S A (2003) 1.72
During apoptosis bcl-2 changes membrane topology at both the endoplasmic reticulum and mitochondria. Mol Cell (2004) 1.71
Hedgehog modulates cell cycle regulators in stem cells to control hematopoietic regeneration. Proc Natl Acad Sci U S A (2006) 1.71
The histone demethylase KDM5b/JARID1b plays a role in cell fate decisions by blocking terminal differentiation. Mol Cell Biol (2008) 1.67
Five new pedigrees with inherited RUNX1 mutations causing familial platelet disorder with propensity to myeloid malignancy. Blood (2008) 1.65
Human embryonic stem cells maintained in the absence of mouse embryonic fibroblasts or conditioned media are capable of hematopoietic development. Blood (2005) 1.49
VEGF-A165 augments erythropoietic development from human embryonic stem cells. Blood (2003) 1.43
Revascularization of ischemic limbs after transplantation of human bone marrow cells with high aldehyde dehydrogenase activity. Blood (2009) 1.40
Bcl-XL is qualitatively different from and ten times more effective than Bcl-2 when expressed in a breast cancer cell line. BMC Cancer (2006) 1.33
Cell fate potential of human pluripotent stem cells is encoded by histone modifications. Cell Stem Cell (2011) 1.30
Regional localization within the bone marrow influences the functional capacity of human HSCs. Cell Stem Cell (2013) 1.29
OP9 stroma augments survival of hematopoietic precursors and progenitors during hematopoietic differentiation from human embryonic stem cells. Stem Cells (2008) 1.24
Lengthened G1 phase indicates differentiation status in human embryonic stem cells. Stem Cells Dev (2012) 1.23
Noncanonical Wnt signaling orchestrates early developmental events toward hematopoietic cell fate from human embryonic stem cells. Cell Stem Cell (2009) 1.20
Erythropoietin prevents the acute myocardial inflammatory response induced by ischemia/reperfusion via induction of AP-1. Cardiovasc Res (2005) 1.19
Differences in the mechanisms of proapoptotic BH3 proteins binding to Bcl-XL and Bcl-2 quantified in live MCF-7 cells. Mol Cell (2012) 1.13
The role of erythropoietin and erythropoiesis-stimulating agents in tumor progression. Clin Cancer Res (2011) 1.12
Hematopoietic development from human embryonic stem cell lines. Exp Hematol (2005) 1.11
Analysis of the human fetal liver hematopoietic microenvironment. Stem Cells Dev (2005) 1.10
An enhanced mass spectrometry approach reveals human embryonic stem cell growth factors in culture. Mol Cell Proteomics (2008) 1.09
Phase II multicenter study of oblimersen sodium, a Bcl-2 antisense oligonucleotide, in combination with rituximab in patients with recurrent B-cell non-Hodgkin lymphoma. Br J Haematol (2008) 1.09
Distinguishing between mouse and human pluripotent stem cell regulation: the best laid plans of mice and men. Stem Cells (2010) 1.09
Hierarchical and ontogenic positions serve to define the molecular basis of human hematopoietic stem cell behavior. Dev Cell (2005) 1.05
Clonal interrogation of stem cells. Nat Methods (2011) 1.04
tBid undergoes multiple conformational changes at the membrane required for Bax activation. J Biol Chem (2013) 1.04
There is more to life and death than mitochondria: Bcl-2 proteins at the endoplasmic reticulum. Biochim Biophys Acta (2004) 1.03
Iron overload in myelodysplastic syndromes: a Canadian consensus guideline. Leuk Res (2008) 1.03
Smad7 alters cell fate decisions of human hematopoietic repopulating cells. Blood (2004) 1.02
Signal control of hematopoietic stem cell fate: Wnt, Notch, and Hedgehog as the usual suspects. Curr Opin Hematol (2008) 1.02
Deconstructing human embryonic stem cell cultures: niche regulation of self-renewal and pluripotency. J Mol Med (Berl) (2008) 1.01
Retroviral transduction of hematopoietic cells differentiated from human embryonic stem cell-derived CD45(neg)PFV hemogenic precursors. Mol Ther (2004) 1.01
Clonal tracking of hESCs reveals differential contribution to functional assays. Nat Methods (2010) 1.01
The human stem cell hierarchy is defined by a functional dependence on Mcl-1 for self-renewal capacity. Blood (2010) 1.00
Molecular evidence for OCT4-induced plasticity in adult human fibroblasts required for direct cell fate conversion to lineage specific progenitors. Stem Cells (2014) 0.99
O-GlcNAc-glycosylation of beta-catenin regulates its nuclear localization and transcriptional activity. Exp Cell Res (2008) 0.99
ID1 and ID3 represent conserved negative regulators of human embryonic and induced pluripotent stem cell hematopoiesis. J Cell Sci (2011) 0.98
Endothelial nitric oxide synthase promotes bone marrow stromal cell migration to the ischemic myocardium via upregulation of stromal cell-derived factor-1alpha. Stem Cells (2009) 0.98
Genetic manipulation of human embryonic stem cells: a system to study early human development and potential therapeutic applications. Curr Gene Ther (2005) 0.97
Shedding light on apoptosis at subcellular membranes. Cell (2012) 0.97
Inability of human induced pluripotent stem cell-hematopoietic derivatives to downregulate microRNAs in vivo reveals a block in xenograft hematopoietic regeneration. Stem Cells (2012) 0.96
Pluripotent transcription factors possess distinct roles in normal versus transformed human stem cells. PLoS One (2009) 0.96
Pluripotent human stem cell lines: what we can learn about cancer initiation. Trends Mol Med (2008) 0.96
Human embryonic stem cells: potential tool for achieving immunotolerance? Stem Cell Rev (2005) 0.96
An eleven nucleotide section of the 3'-untranslated region is required for perinuclear localization of rat metallothionein-1 mRNA. Biochem J (2005) 0.94
Autologous and allogeneic stem-cell transplantation for transformed follicular lymphoma: a report of the Canadian blood and marrow transplant group. J Clin Oncol (2013) 0.92
Wnt3a activates dormant c-Kit(-) bone marrow-derived cells with short-term multilineage hematopoietic reconstitution capacity. Stem Cells (2010) 0.92
Erythropoietin improves skeletal muscle microcirculation and tissue bioenergetics in a mouse sepsis model. Crit Care (2007) 0.92
Transplanted human bone marrow progenitor subtypes stimulate endogenous islet regeneration and revascularization. Stem Cells Dev (2011) 0.91
Interaction of the full-length Bax protein with biomimetic mitochondrial liposomes: a small-angle neutron scattering and fluorescence study. Biochim Biophys Acta (2011) 0.91
Novel roles for Notch, Wnt and Hedgehog in hematopoesis derived from human pluripotent stem cells. Int J Dev Biol (2010) 0.91
Formation and hematopoietic differentiation of human embryoid bodies by suspension and hanging drop cultures. Curr Protoc Stem Cell Biol (2007) 0.91
Apoptosis: embedded in membranes. Curr Opin Cell Biol (2010) 0.90
Recombinant human erythropoietin improves gut barrier function in a hemorrhagic shock and resuscitation rat model. J Trauma (2011) 0.90
Notch-HES1 signaling axis controls hemato-endothelial fate decisions of human embryonic and induced pluripotent stem cells. Blood (2013) 0.90
Circumvention of fluorophore photobleaching in fluorescence fluctuation experiments: a beam scanning approach. Chemphyschem (2007) 0.89
In vivo generation of neural tumors from neoplastic pluripotent stem cells models early human pediatric brain tumor formation. Stem Cells (2012) 0.88
Generation of in vitro B-CLL specific HLA class I restricted CTL responses using autologous dendritic cells pulsed with necrotic tumor lysate. Leuk Lymphoma (2006) 0.88
Hematopoietic stem cell biology: too much of a Wnt thing. Nat Immunol (2006) 0.88
Complement targeting of nonhuman sialic acid does not mediate cell death of human embryonic stem cells. Nat Med (2006) 0.88