Published in J Immunol on May 13, 2011
Innate immune responses to Pseudomonas aeruginosa infection. Microbes Infect (2011) 1.33
Visualization of murine intranasal dosing efficiency using luminescent Francisella tularensis: effect of instillation volume and form of anesthesia. PLoS One (2012) 1.20
Mechanisms of phagocytosis and host clearance of Pseudomonas aeruginosa. Am J Physiol Lung Cell Mol Physiol (2014) 1.09
IL-1α signaling initiates the inflammatory response to virulent Legionella pneumophila in vivo. J Immunol (2013) 1.08
The Toll-like receptor 5 ligand flagellin promotes asthma by priming allergic responses to indoor allergens. Nat Med (2012) 1.06
Bacterial pathogens activate a common inflammatory pathway through IFNλ regulation of PDCD4. PLoS Pathog (2013) 0.94
Lung epithelial cells are essential effectors of inducible resistance to pneumonia. Mucosal Immunol (2013) 0.91
Cheating by type 3 secretion system-negative Pseudomonas aeruginosa during pulmonary infection. Proc Natl Acad Sci U S A (2014) 0.90
Dynamics of lung defense in pneumonia: resistance, resilience, and remodeling. Annu Rev Physiol (2014) 0.89
Compartment-specific and sequential role of MyD88 and CARD9 in chemokine induction and innate defense during respiratory fungal infection. PLoS Pathog (2015) 0.89
Small molecule screen yields inhibitors of Pseudomonas homoserine lactone-induced host responses. Cell Microbiol (2013) 0.86
Host cell polarity proteins participate in innate immunity to Pseudomonas aeruginosa infection. Cell Host Microbe (2014) 0.86
A conservative amino acid mutation in the master regulator FleQ renders Pseudomonas aeruginosa aflagellate. PLoS One (2014) 0.84
Toll-like receptor agonists partially restore the production of pro-inflammatory cytokines and type I interferon in Sézary syndrome. Oncotarget (2016) 0.83
Innate Immune Signaling Activated by MDR Bacteria in the Airway. Physiol Rev (2016) 0.81
Pseudomonas aeruginosa flagellar motility activates the phagocyte PI3K/Akt pathway to induce phagocytic engulfment. Am J Physiol Lung Cell Mol Physiol (2014) 0.80
Chitinase 3-Like 1 (Chil1) Regulates Survival and Macrophage-Mediated Interleukin-1β and Tumor Necrosis Factor Alpha during Pseudomonas aeruginosa Pneumonia. Infect Immun (2016) 0.80
Hematopoietic but not endothelial cell MyD88 contributes to host defense during gram-negative pneumonia derived sepsis. PLoS Pathog (2014) 0.79
Distinct contributions of interleukin-1α (IL-1α) and IL-1β to innate immune recognition of Pseudomonas aeruginosa in the lung. Infect Immun (2014) 0.78
Swimming Motility Mediates the Formation of Neutrophil Extracellular Traps Induced by Flagellated Pseudomonas aeruginosa. PLoS Pathog (2016) 0.78
Differential ASC requirements reveal a key role for neutrophils and a noncanonical IL-1β response to Pseudomonas aeruginosa. Am J Physiol Lung Cell Mol Physiol (2015) 0.77
Pseudomonas aeruginosa proteolytically alters the interleukin 22-dependent lung mucosal defense. Virulence (2016) 0.77
Acidosis potentiates the host proinflammatory interleukin-1β response to Pseudomonas aeruginosa infection. Infect Immun (2014) 0.76
Morphine compromises bronchial epithelial TLR2/IL17R signaling crosstalk, necessary for lung IL17 homeostasis. Sci Rep (2015) 0.76
Interleukin-1 (IL-1) signaling in intestinal stromal cells controls KC/ CXCL1 secretion, which correlates with recruitment of IL-22- secreting neutrophils at early stages of Citrobacter rodentium infection. Infect Immun (2015) 0.76
TRIF mobilizes unique primary defense against Gram-negative bacteria in intestinal interface. Gut Microbes (2012) 0.76
Interactions between Neutrophils and Pseudomonas aeruginosa in Cystic Fibrosis. Pathogens (2017) 0.75
Lung epithelium and myeloid cells cooperate to clear acute pneumococcal infection. Mucosal Immunol (2015) 0.75
HOST IMMUNE RECOGNITION OF THE EPIDEMIC CYSTIC FIBROSIS PATHOGEN BURKHOLDERIA DOLOSA. Infect Immun (2017) 0.75
A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res (2001) 124.61
Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity (1998) 18.12
Toll-like receptors and innate immunity. Nat Rev Immunol (2001) 16.50
Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol (2009) 14.33
Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome. J Exp Med (2007) 4.95
Pyogenic bacterial infections in humans with MyD88 deficiency. Science (2008) 4.92
Growth and differentiation of mouse tracheal epithelial cells: selection of a proliferative population. Am J Physiol Lung Cell Mol Physiol (2002) 4.68
Critical role for Ipaf in Pseudomonas aeruginosa-induced caspase-1 activation. Eur J Immunol (2007) 4.19
Type III protein secretion is associated with death in lower respiratory and systemic Pseudomonas aeruginosa infections. J Infect Dis (2001) 4.06
Nonmotility and phagocytic resistance of Pseudomonas aeruginosa isolates from chronically colonized patients with cystic fibrosis. Infect Immun (1994) 3.83
Type III protein secretion is associated with poor clinical outcomes in patients with ventilator-associated pneumonia caused by Pseudomonas aeruginosa. Crit Care Med (2002) 3.63
The type III secretion system of Pseudomonas aeruginosa: infection by injection. Nat Rev Microbiol (2009) 3.56
Pathogen-host interactions in Pseudomonas aeruginosa pneumonia. Am J Respir Crit Care Med (2005) 3.52
Cutting edge: TNF-alpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation. J Immunol (2009) 3.32
Caspase-1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo. J Immunol (2010) 3.25
Pseudomonas aeruginosa activates caspase 1 through Ipaf. Proc Natl Acad Sci U S A (2008) 2.99
Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria. Proc Natl Acad Sci U S A (2006) 2.75
CXC chemokine receptor CXCR2 is essential for protective innate host response in murine Pseudomonas aeruginosa pneumonia. Infect Immun (2000) 2.66
Cutting edge: myeloid differentiation factor 88 is essential for pulmonary host defense against Pseudomonas aeruginosa but not Staphylococcus aureus. J Immunol (2004) 2.26
Respiratory epithelial cells regulate lung inflammation in response to inhaled endotoxin. Am J Physiol Lung Cell Mol Physiol (2004) 2.19
cis-acting elements that confer lung epithelial cell expression of the CC10 gene. J Biol Chem (1992) 2.18
Caspase 1-independent activation of interleukin-1beta in neutrophil-predominant inflammation. Arthritis Rheum (2009) 2.16
A prominent role for airway epithelial NF-kappa B activation in lipopolysaccharide-induced airway inflammation. J Immunol (2003) 1.99
Redundant Toll-like receptor signaling in the pulmonary host response to Pseudomonas aeruginosa. Am J Physiol Lung Cell Mol Physiol (2006) 1.89
Lung NF-kappaB activation and neutrophil recruitment require IL-1 and TNF receptor signaling during pneumococcal pneumonia. J Immunol (2005) 1.82
NLR-mediated control of inflammasome assembly in the host response against bacterial pathogens. Semin Immunol (2009) 1.77
Targeted immunomodulation of the NF-kappaB pathway in airway epithelium impacts host defense against Pseudomonas aeruginosa. J Immunol (2006) 1.62
The development of early host response to Pseudomonas aeruginosa lung infection is critically dependent on myeloid differentiation factor 88 in mice. J Biol Chem (2004) 1.58
Inescapable need for neutrophils as mediators of cellular innate immunity to acute Pseudomonas aeruginosa pneumonia. Infect Immun (2009) 1.52
Early response cytokines and innate immunity: essential roles for TNF receptor 1 and type I IL-1 receptor during Escherichia coli pneumonia in mice. J Immunol (2001) 1.45
The Pseudomonas aeruginosa Type III secretion system plays a dual role in the regulation of caspase-1 mediated IL-1beta maturation. J Cell Mol Med (2007) 1.44
Pseudomonas aeruginosa induces localized immunosuppression during pneumonia. Infect Immun (2008) 1.40
Pseudomonas aeruginosa LPS or flagellin are sufficient to activate TLR-dependent signaling in murine alveolar macrophages and airway epithelial cells. PLoS One (2009) 1.35
An essential role for non-bone marrow-derived cells in control of Pseudomonas aeruginosa pneumonia. Am J Respir Cell Mol Biol (2005) 1.34
Role of Toll-like receptor 5 in the innate immune response to acute P. aeruginosa pneumonia. Am J Physiol Lung Cell Mol Physiol (2009) 1.07
Pseudomonas aeruginosa activates human mast cells to induce neutrophil transendothelial migration via mast cell-derived IL-1 alpha and beta. J Immunol (2002) 1.05
In vivo discrimination of type 3 secretion system-positive and -negative Pseudomonas aeruginosa via a caspase-1-dependent pathway. Infect Immun (2010) 1.01
Genetic mechanisms involved in the repression of flagellar assembly by Pseudomonas aeruginosa in human mucus. Mol Microbiol (2007) 0.95
Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell (2004) 29.32
Innate immune recognition. Annu Rev Immunol (2001) 26.65
Toll-like receptor control of the adaptive immune responses. Nat Immunol (2004) 19.15
Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science (2003) 14.04
Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity (2006) 10.61
Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell (2008) 9.59
Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat Med (2005) 8.49
Regulation of adaptive immunity by the innate immune system. Science (2010) 8.00
TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat Immunol (2008) 7.87
Gene-specific control of inflammation by TLR-induced chromatin modifications. Nature (2007) 7.34
Type I interferons in host defense. Immunity (2006) 7.32
Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J Exp Med (2003) 7.26
IRAK-M is a negative regulator of Toll-like receptor signaling. Cell (2002) 6.79
Regulation of phagosome maturation by signals from toll-like receptors. Science (2004) 6.79
A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol (2008) 6.78
Control of inducible gene expression by signal-dependent transcriptional elongation. Cell (2009) 6.57
Control of B-cell responses by Toll-like receptors. Nature (2005) 6.44
Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell (2006) 6.01
RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature (2002) 5.95
Toll-like receptor signaling pathways. Science (2003) 5.86
Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science (2007) 5.54
Toll-dependent selection of microbial antigens for presentation by dendritic cells. Nature (2006) 5.54
A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk. Cancer Res (2008) 5.05
Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome. J Exp Med (2007) 4.95
Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA. Nat Immunol (2005) 4.30
Toll-like receptors and cancer. Nat Rev Cancer (2008) 4.29
The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature (2002) 4.15
Role of toll-like receptors in spontaneous commensal-dependent colitis. Immunity (2006) 3.98
Pattern recognition receptors and control of adaptive immunity. Immunol Rev (2009) 3.91
Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response. Nat Immunol (2009) 3.79
MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. Cell Metab (2009) 3.64
Recognition of microbial infection by Toll-like receptors. Curr Opin Immunol (2003) 3.18
Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells. J Immunol (2002) 3.12
On regulation of phagosome maturation and antigen presentation. Nat Immunol (2006) 3.11
Interactions between the host innate immune system and microbes in inflammatory bowel disease. Gastroenterology (2011) 2.90
Toll-dependent control mechanisms of CD4 T cell activation. Immunity (2004) 2.88
Toll-like receptors: linking innate and adaptive immunity. Adv Exp Med Biol (2005) 2.85
A Yersinia effector protein promotes virulence by preventing inflammasome recognition of the type III secretion system. Cell Host Microbe (2010) 2.84
Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice. Nat Med (2002) 2.77
p53-mediated hematopoietic stem and progenitor cell competition. Cell Stem Cell (2010) 2.65
Retroviral delivery of small interfering RNA into primary cells. Proc Natl Acad Sci U S A (2002) 2.43
Toll-like receptors: linking innate and adaptive immunity. Microbes Infect (2004) 2.38
Cutting edge: TLR4 deficiency confers susceptibility to lethal oxidant lung injury. J Immunol (2005) 2.30
Role of tissue protection in lethal respiratory viral-bacterial coinfection. Science (2013) 2.22
The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition. Proc Natl Acad Sci U S A (2014) 2.22
Age-associated defect in human TLR-1/2 function. J Immunol (2007) 2.20
NKG2D signaling is coupled to the interleukin 15 receptor signaling pathway. Nat Immunol (2007) 2.11
Regulation of pulmonary fibrosis by chemokine receptor CXCR3. J Clin Invest (2004) 2.10
Triggering TLR signaling in vaccination. Trends Immunol (2005) 2.09
Allergic host defences. Nature (2012) 1.99
Control of adaptive immune responses by Toll-like receptors. Curr Opin Immunol (2002) 1.92
Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells. Immunity (2013) 1.88
Bee venom phospholipase A2 induces a primary type 2 response that is dependent on the receptor ST2 and confers protective immunity. Immunity (2013) 1.88
Gene-specific control of the TLR-induced inflammatory response. Clin Immunol (2008) 1.80
Toll-like receptors and acquired immunity. Semin Immunol (2004) 1.79
The phytotoxin coronatine contributes to pathogen fitness and is required for suppression of salicylic acid accumulation in tomato inoculated with Pseudomonas syringae pv. tomato DC3000. Mol Plant Microbe Interact (2007) 1.71
Pseudomonas aeruginosa chronic colonization in cystic fibrosis patients. Curr Opin Pediatr (2007) 1.65
Innate control of adaptive immunity via remodeling of lymph node feed arteriole. Proc Natl Acad Sci U S A (2005) 1.62
A novel sensor kinase-response regulator hybrid regulates type III secretion and is required for virulence in Pseudomonas aeruginosa. Mol Microbiol (2004) 1.62
Innate immunity--cross-talk with adaptive immunity through pattern recognition receptors and cytokines. Curr Opin Immunol (2006) 1.62
Bcl-2-related protein A1 is an endogenous and cytokine-stimulated mediator of cytoprotection in hyperoxic acute lung injury. J Clin Invest (2005) 1.61
Host defense pathways: role of redundancy and compensation in infectious disease phenotypes. Immunity (2011) 1.57
Prevaccine determination of the expression of costimulatory B7 molecules in activated monocytes predicts influenza vaccine responses in young and older adults. J Infect Dis (2007) 1.56
Targeting of immune signalling networks by bacterial pathogens. Nat Cell Biol (2009) 1.52
FlhF is required for swimming and swarming in Pseudomonas aeruginosa. J Bacteriol (2006) 1.50
The control of adaptive immune responses by the innate immune system. Adv Immunol (2011) 1.48
Influenza virus-induced glucocorticoids compromise innate host defense against a secondary bacterial infection. Cell Host Microbe (2010) 1.47
TLR4 up-regulation at protein or gene level is pathogenic for lupus-like autoimmune disease. J Immunol (2006) 1.44
MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice. Nat Commun (2012) 1.44
Signals via the adaptor MyD88 in B cells and DCs make distinct and synergistic contributions to immune activation and tissue damage in lupus. Immunity (2013) 1.40
Antiviral defense: interferons and beyond. J Exp Med (2006) 1.38
Inhibition of pulmonary fibrosis in mice by CXCL10 requires glycosaminoglycan binding and syndecan-4. J Clin Invest (2010) 1.38
IL9 leads to airway inflammation by inducing IL13 expression in airway epithelial cells. Int Immunol (2006) 1.36
Integration of cytokine and heterologous receptor signaling pathways. Nat Immunol (2009) 1.36
Control of infection by pyroptosis and autophagy: role of TLR and NLR. Cell Mol Life Sci (2010) 1.35
Toll-like receptors: balancing host resistance with immune tolerance. Curr Opin Immunol (2003) 1.34
Semaphorin 7A is a negative regulator of T cell responses. Immunity (2006) 1.33
Adjuvants of immunity: harnessing innate immunity to promote adaptive immunity. J Exp Med (2002) 1.33
Innate immune responses to Pseudomonas aeruginosa infection. Microbes Infect (2011) 1.33
Abnormal trafficking and degradation of TLR4 underlie the elevated inflammatory response in cystic fibrosis. J Immunol (2011) 1.31
Pseudomonas aeruginosa exhibits sliding motility in the absence of type IV pili and flagella. J Bacteriol (2007) 1.28
Reduced secretion of YopJ by Yersinia limits in vivo cell death but enhances bacterial virulence. PLoS Pathog (2008) 1.27
Evolution of inflammatory diseases. Curr Biol (2012) 1.27
Mutational analysis of RetS, an unusual sensor kinase-response regulator hybrid required for Pseudomonas aeruginosa virulence. Infect Immun (2006) 1.23
Impact of CD1d deficiency on metabolism. PLoS One (2011) 1.21
Learning tolerance while fighting ignorance. Cell (2009) 1.20
Intrinsic sensor of oncogenic transformation induces a signal for innate immunosurveillance. Proc Natl Acad Sci U S A (2008) 1.20
Streptomycin-induced inflammation enhances Escherichia coli gut colonization through nitrate respiration. MBio (2013) 1.20
State of the art. Mechanistic heterogeneity in chronic obstructive pulmonary disease: insights from transgenic mice. Proc Am Thorac Soc (2006) 1.16
Cutting edge: engagement of NKG2A on CD8+ effector T cells limits immunopathology in influenza pneumonia. J Immunol (2008) 1.15
Role of semaphorin 7a signaling in transforming growth factor β1-induced lung fibrosis and scleroderma-related interstitial lung disease. Arthritis Rheum (2011) 1.14
A Yersinia effector with enhanced inhibitory activity on the NF-κB pathway activates the NLRP3/ASC/caspase-1 inflammasome in macrophages. PLoS Pathog (2011) 1.14
Immunostimulatory activity of haptenated proteins. Proc Natl Acad Sci U S A (2009) 1.10
Role of basophils in the initiation of Th2 responses. Curr Opin Immunol (2010) 1.10
Regulation of Toll-like receptor 4 expression in the lung following hemorrhagic shock and lipopolysaccharide. J Immunol (2002) 1.10
Pseudomonas aeruginosa OspR is an oxidative stress sensing regulator that affects pigment production, antibiotic resistance and dissemination during infection. Mol Microbiol (2009) 1.09
Linking Toll-like receptors to IFN-alpha/beta expression. Nat Immunol (2003) 1.05
Innate sensors of microbial infection. J Clin Immunol (2005) 1.05