Published in Genet Epidemiol on May 18, 2011
A powerful and adaptive association test for rare variants. Genetics (2014) 1.40
A geometric framework for evaluating rare variant tests of association. Genet Epidemiol (2013) 1.28
GEE-based SNP set association test for continuous and discrete traits in family-based association studies. Genet Epidemiol (2013) 1.14
A variance component based multi-marker association test using family and unrelated data. BMC Genet (2013) 0.90
Weighted pedigree-based statistics for testing the association of rare variants. BMC Genomics (2012) 0.87
A unified framework for detecting rare variant quantitative trait associations in pedigree and unrelated individuals via sequence data. Hum Hered (2012) 0.86
Evaluation of the power and type I error of recently proposed family-based tests of association for rare variants. BMC Proc (2014) 0.86
De novo mutations discovered in 8 Mexican American families through whole genome sequencing. BMC Proc (2014) 0.84
Blocking approach for identification of rare variants in family-based association studies. PLoS One (2014) 0.83
Whole genome sequencing data from pedigrees suggests linkage disequilibrium among rare variants created by population admixture. BMC Proc (2014) 0.83
Evaluating the impact of genotype errors on rare variant tests of association. Front Genet (2014) 0.82
Two-phase and family-based designs for next-generation sequencing studies. Front Genet (2013) 0.82
Weighted selective collapsing strategy for detecting rare and common variants in genetic association study. BMC Genet (2012) 0.81
Detecting association of rare variants by testing an optimally weighted combination of variants for quantitative traits in general families. Ann Hum Genet (2013) 0.78
A general approach for combining diverse rare variant association tests provides improved robustness across a wider range of genetic architectures. Eur J Hum Genet (2015) 0.77
Two-stage family-based designs for sequencing studies. BMC Proc (2014) 0.77
Association between AVPR1A, DRD2, and ASPM and endophenotypes of communication disorders. Psychiatr Genet (2014) 0.76
A novel test for testing the optimally weighted combination of rare and common variants based on data of parents and affected children. Genet Epidemiol (2013) 0.76
Renin angiotensinogen system gene polymorphisms and essential hypertension among people of West African descent: a systematic review. J Hum Hypertens (2015) 0.76
Rare variants in fox-1 homolog A (RBFOX1) are associated with lower blood pressure. PLoS Genet (2017) 0.75
Cohen's h for detection of disease association with rare genetic variants. BMC Genomics (2014) 0.75
A novel statistical method for rare-variant association studies in general pedigrees. BMC Proc (2016) 0.75
Test of rare variant association based on affected sib-pairs. Eur J Hum Genet (2014) 0.75
Whole exome association of rare deletions in multiplex oral cleft families. Genet Epidemiol (2016) 0.75
Detecting the Common and Individual Effects of Rare Variants on Quantitative Traits by Using Extreme Phenotype Sampling. Genes (Basel) (2016) 0.75
A robust GWSS method to simultaneously detect rare and common variants for complex disease. PLoS One (2015) 0.75
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 144.95
A map of human genome variation from population-scale sequencing. Nature (2010) 121.13
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09
Finding the missing heritability of complex diseases. Nature (2009) 67.95
Methods for detecting associations with rare variants for common diseases: application to analysis of sequence data. Am J Hum Genet (2008) 26.79
The investigation of linkage between a quantitative trait and a marker locus. Behav Genet (1972) 24.92
Rapid and accurate haplotype phasing and missing-data inference for whole-genome association studies by use of localized haplotype clustering. Am J Hum Genet (2007) 24.68
Are rare variants responsible for susceptibility to complex diseases? Am J Hum Genet (2001) 22.46
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
A groupwise association test for rare mutations using a weighted sum statistic. PLoS Genet (2009) 19.64
Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science (2009) 16.35
Pooled association tests for rare variants in exon-resequencing studies. Am J Hum Genet (2010) 13.18
Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9. Nat Genet (2005) 12.12
Rare independent mutations in renal salt handling genes contribute to blood pressure variation. Nat Genet (2008) 11.80
Genome-wide association study of blood pressure and hypertension. Nat Genet (2009) 11.54
An evaluation of statistical approaches to rare variant analysis in genetic association studies. Genet Epidemiol (2010) 10.54
Multiple rare variants in NPC1L1 associated with reduced sterol absorption and plasma low-density lipoprotein levels. Proc Natl Acad Sci U S A (2006) 8.20
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
A strategy to discover genes that carry multi-allelic or mono-allelic risk for common diseases: a cohort allelic sums test (CAST). Mutat Res (2006) 7.89
Statistical analysis strategies for association studies involving rare variants. Nat Rev Genet (2010) 6.79
Powerful SNP-set analysis for case-control genome-wide association studies. Am J Hum Genet (2010) 6.60
Molecular basis of human hypertension: role of angiotensinogen. Cell (1992) 6.07
A data-adaptive sum test for disease association with multiple common or rare variants. Hum Hered (2010) 5.95
Extending rare-variant testing strategies: analysis of noncoding sequence and imputed genotypes. Am J Hum Genet (2010) 3.47
Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease. Nat Genet (2010) 3.22
Hints of hidden heritability in GWAS. Nat Genet (2010) 3.04
Comprehensive approach to analyzing rare genetic variants. PLoS One (2010) 2.93
Detecting rare variants for complex traits using family and unrelated data. Genet Epidemiol (2010) 2.80
To identify associations with rare variants, just WHaIT: Weighted haplotype and imputation-based tests. Am J Hum Genet (2010) 2.63
A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and affects basal transcription in vitro. J Clin Invest (1997) 2.23
Generalized linear modeling with regularization for detecting common disease rare haplotype association. Genet Epidemiol (2009) 1.75
Genome-wide searching of rare genetic variants in WTCCC data. Hum Genet (2010) 1.39
Angiotensinogen gene in human hypertension. Lack of an association of the 235T allele among African Americans. Hypertension (1994) 1.26
Associations between hypertension and genes in the renin-angiotensin system. Hypertension (2003) 1.09
Haplotypes produced from rare variants in the promoter and coding regions of angiotensinogen contribute to variation in angiotensinogen levels. Hum Mol Genet (2005) 1.08
Angiotensinogen and blood pressure among blacks: findings from a community survey in Jamaica. J Hypertens (1996) 0.82
A common genetic variant is associated with adult and childhood obesity. Science (2006) 14.95
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Optimal two-stage genotyping in population-based association studies. Genet Epidemiol (2003) 6.01
Reconstructing genetic ancestry blocks in admixed individuals. Am J Hum Genet (2006) 5.92
Transferability of tag SNPs in genetic association studies in multiple populations. Nat Genet (2006) 4.78
On a semiparametric test to detect associations between quantitative traits and candidate genes using unrelated individuals. Genet Epidemiol (2003) 4.67
Genetic structure, self-identified race/ethnicity, and confounding in case-control association studies. Am J Hum Genet (2004) 4.51
A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence. Am J Hum Genet (2007) 4.46
Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders. Proc Natl Acad Sci U S A (2010) 3.78
Improved power by use of a weighted score test for linkage disequilibrium mapping. Am J Hum Genet (2006) 3.36
Adding further power to the Haseman and Elston method for detecting linkage in larger sibships: weighting sums and differences. Hum Hered (2003) 3.33
Choosing an optimal method to combine P-values. Stat Med (2009) 3.15
The landscape of recombination in African Americans. Nature (2011) 3.06
The genetic basis of complex traits: rare variants or "common gene, common disease"? Methods Mol Biol (2007) 3.01
A unified association analysis approach for family and unrelated samples correcting for stratification. Am J Hum Genet (2008) 3.00
Dissection of genomewide-scan data in extended families reveals a major locus and oligogenic susceptibility for age-related macular degeneration. Am J Hum Genet (2003) 2.92
Genome scan among Nigerians linking blood pressure to chromosomes 2, 3, and 19. Hypertension (2002) 2.89
Detecting rare variants for complex traits using family and unrelated data. Genet Epidemiol (2010) 2.80
Ethnic- and gender-specific association of the nicotinic acetylcholine receptor alpha4 subunit gene (CHRNA4) with nicotine dependence. Hum Mol Genet (2005) 2.80
Fine mapping of the association with obesity at the FTO locus in African-derived populations. Hum Mol Genet (2010) 2.48
Premature myocardial infarction novel susceptibility locus on chromosome 1P34-36 identified by genomewide linkage analysis. Am J Hum Genet (2004) 2.36
The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts. PLoS Genet (2007) 2.35
Linkage analysis of a complex disease through use of admixed populations. Am J Hum Genet (2004) 2.21
Using the optimal receiver operating characteristic curve to design a predictive genetic test, exemplified with type 2 diabetes. Am J Hum Genet (2008) 2.20
Single- and multilocus allelic variants within the GABA(B) receptor subunit 2 (GABAB2) gene are significantly associated with nicotine dependence. Am J Hum Genet (2005) 2.18
A powerful method of combining measures of association and Hardy-Weinberg disequilibrium for fine-mapping in case-control studies. Stat Med (2006) 2.18
Odds ratio based multifactor-dimensionality reduction method for detecting gene-gene interactions. Bioinformatics (2006) 2.08
Whole genome scan for obstructive sleep apnea and obesity in African-American families. Am J Respir Crit Care Med (2004) 2.03
Racial admixture and its impact on BMI and blood pressure in African and Mexican Americans. Hum Genet (2006) 1.98
Enhanced statistical tests for GWAS in admixed populations: assessment using African Americans from CARe and a Breast Cancer Consortium. PLoS Genet (2011) 1.94
Genome-wide association of anthropometric traits in African- and African-derived populations. Hum Mol Genet (2010) 1.90
The Family Investigation of Nephropathy and Diabetes (FIND): design and methods. J Diabetes Complications (2005) 1.87
A combined analysis of genomewide linkage scans for body mass index from the National Heart, Lung, and Blood Institute Family Blood Pressure Program. Am J Hum Genet (2002) 1.87
Self-reported race and genetic admixture. N Engl J Med (2006) 1.85
A subset of familial colorectal neoplasia kindreds linked to chromosome 9q22.2-31.2. Proc Natl Acad Sci U S A (2003) 1.84
Corin gene minor allele defined by 2 missense mutations is common in blacks and associated with high blood pressure and hypertension. Circulation (2005) 1.84
The meaning of interaction. Hum Hered (2010) 1.83
A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nat Genet (2013) 1.82
EPHA2 is associated with age-related cortical cataract in mice and humans. PLoS Genet (2009) 1.82
A whole-genome scan for obstructive sleep apnea and obesity. Am J Hum Genet (2002) 1.81
Genome-wide scans for diabetic nephropathy and albuminuria in multiethnic populations: the family investigation of nephropathy and diabetes (FIND). Diabetes (2007) 1.79
Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study. Hum Mol Genet (2011) 1.77
A candidate gene study of obstructive sleep apnea in European Americans and African Americans. Am J Respir Crit Care Med (2010) 1.74
Genome-wide association studies: implications for multiethnic samples. Hum Mol Genet (2008) 1.69
Genome-wide scan for estimated glomerular filtration rate in multi-ethnic diabetic populations: the Family Investigation of Nephropathy and Diabetes (FIND). Diabetes (2007) 1.61
A combinatorial approach to detecting gene-gene and gene-environment interactions in family studies. Am J Hum Genet (2008) 1.57
Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations. Am J Hum Genet (2013) 1.55
Improving power in contrasting linkage-disequilibrium patterns between cases and controls. Am J Hum Genet (2007) 1.55
A whole-genome screen of a quantitative trait of age-related maculopathy in sibships from the Beaver Dam Eye Study. Am J Hum Genet (2003) 1.53
A genome-wide scan to identify loci for smoking rate in the Framingham Heart Study population. BMC Genet (2003) 1.50
Interrogating local population structure for fine mapping in genome-wide association studies. Bioinformatics (2010) 1.48
Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. PLoS Genet (2011) 1.47
Log-linear model-based multifactor dimensionality reduction method to detect gene gene interactions. Bioinformatics (2007) 1.44
Genetics of the apnea hypopnea index in Caucasians and African Americans: I. Segregation analysis. Genet Epidemiol (2002) 1.44
An association study of angiotensinogen polymorphisms with serum level and hypertension in an African-American population. J Hypertens (2003) 1.44
Adjustment for local ancestry in genetic association analysis of admixed populations. Bioinformatics (2010) 1.44
Sampling correction in linkage analysis. Genet Epidemiol (2004) 1.43
Genome scan of M. tuberculosis infection and disease in Ugandans. PLoS One (2008) 1.41
Plasma aldosterone is independently associated with the metabolic syndrome. Hypertension (2006) 1.40
Genome-wide searching of rare genetic variants in WTCCC data. Hum Genet (2010) 1.39
Are linkage analysis and the collection of family data dead? Prospects for family studies in the age of genome-wide association. Hum Hered (2007) 1.39
Infrequent detection of germline allele-specific expression of TGFBR1 in lymphoblasts and tissues of colon cancer patients. Cancer Res (2009) 1.38
Pleiotropic effects of a chromosome 3 locus on speech-sound disorder and reading. Am J Hum Genet (2004) 1.36
Haplotype analysis indicates an association between the DOPA decarboxylase (DDC) gene and nicotine dependence. Hum Mol Genet (2005) 1.36
Genome-wide comparison of African-ancestry populations from CARe and other cohorts reveals signals of natural selection. Am J Hum Genet (2011) 1.35
Two major QTLs and several others relate to factors of metabolic syndrome in the family blood pressure program. Hypertension (2005) 1.32
A genomewide search finds major susceptibility loci for nicotine dependence on chromosome 10 in African Americans. Am J Hum Genet (2006) 1.31
Heritability of the severity of diabetic retinopathy: the FIND-Eye study. Invest Ophthalmol Vis Sci (2008) 1.29
Statistical interaction in human genetics: how should we model it if we are looking for biological interaction? Nat Rev Genet (2010) 1.28
Two-level Haseman-Elston regression for general pedigree data analysis. Genet Epidemiol (2005) 1.28
Loci influencing blood pressure identified using a cardiovascular gene-centric array. Hum Mol Genet (2013) 1.27
Identification of a major locus for age-related cortical cataract on chromosome 6p12-q12 in the Beaver Dam Eye Study. Proc Natl Acad Sci U S A (2004) 1.27
Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations. Am J Hum Genet (2013) 1.27
Common variants in the ENPP1 gene are not reproducibly associated with diabetes or obesity. Diabetes (2006) 1.26
Pathway-based analysis for genome-wide association studies using supervised principal components. Genet Epidemiol (2010) 1.25
The power of independent types of genetic information to detect association in a case-control study design. Genet Epidemiol (2008) 1.24
Adaptive two-stage analysis of genetic association in case-control designs. Hum Hered (2007) 1.23
CYP3A5 and ABCB1 genes influence blood pressure and response to treatment, and their effect is modified by salt. Hypertension (2007) 1.23
Single-marker and two-marker association tests for unphased case-control genotype data, with a power comparison. Genet Epidemiol (2010) 1.22
Genetic background of patients from a university medical center in Manhattan: implications for personalized medicine. PLoS One (2011) 1.21
The cyanobactin heterocyclase enzyme: a processive adenylase that operates with a defined order of reaction. Angew Chem Int Ed Engl (2013) 1.20
Association studies of BMI and type 2 diabetes in the neuropeptide Y pathway: a possible role for NPY2R as a candidate gene for type 2 diabetes in men. Diabetes (2007) 1.20
Diminished induction of skin fibrosis in mice with MCP-1 deficiency. J Invest Dermatol (2006) 1.18
A partial least-square approach for modeling gene-gene and gene-environment interactions when multiple markers are genotyped. Genet Epidemiol (2009) 1.18
A sarcoidosis genetic linkage consortium: the sarcoidosis genetic analysis (SAGA) study. Sarcoidosis Vasc Diffuse Lung Dis (2005) 1.18
Two-marker association tests yield new disease associations for coronary artery disease and hypertension. Hum Genet (2011) 1.16
Higher offspring survival among Tibetan women with high oxygen saturation genotypes residing at 4,000 m. Proc Natl Acad Sci U S A (2004) 1.16
Heritability analysis of cytokines as intermediate phenotypes of tuberculosis. J Infect Dis (2003) 1.16
Regression models for linkage: issues of traits, covariates, heterogeneity, and interaction. Hum Hered (2003) 1.15
GEE-based SNP set association test for continuous and discrete traits in family-based association studies. Genet Epidemiol (2013) 1.14
Rapid assessment of genetic ancestry in populations of unknown origin by genome-wide genotyping of pooled samples. PLoS Genet (2010) 1.14
Gene-gene interactions among CHRNA4, CHRNB2, BDNF, and NTRK2 in nicotine dependence. Biol Psychiatry (2008) 1.13
Heritability of renal function in hypertensive families of African descent in the Seychelles (Indian Ocean). Kidney Int (2005) 1.13
Detecting genetic interactions for quantitative traits with U-statistics. Genet Epidemiol (2011) 1.13