PubRank

Martijn Verdoes

Author PubWeight™ 23.86‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib. Nat Methods 2005 1.78
2 Selective inhibitor of proteasome's caspase-like sites sensitizes cells to specific inhibition of chymotrypsin-like sites. Chem Biol 2009 1.47
3 Functional imaging of proteases: recent advances in the design and application of substrate-based and activity-based probes. Curr Opin Chem Biol 2011 1.31
4 Specific cell-permeable inhibitor of proteasome trypsin-like sites selectively sensitizes myeloma cells to bortezomib and carfilzomib. Chem Biol 2011 1.13
5 New approaches for dissecting protease functions to improve probe development and drug discovery. Nat Struct Mol Biol 2012 1.11
6 Validation of the proteasome as a therapeutic target in Plasmodium using an epoxyketone inhibitor with parasite-specific toxicity. Chem Biol 2012 1.09
7 Functional imaging of legumain in cancer using a new quenched activity-based probe. J Am Chem Soc 2012 1.05
8 Activity-based profiling reveals reactivity of the murine thymoproteasome-specific subunit beta5t. Chem Biol 2010 1.01
9 Proteasome activity profiling: a simple, robust and versatile method revealing subunit-selective inhibitors and cytoplasmic, defense-induced proteasome activities. Plant J 2009 1.01
10 Subclassification and biochemical analysis of plant papain-like cysteine proteases displays subfamily-specific characteristics. Plant Physiol 2012 0.99
11 Non-invasive imaging of cysteine cathepsin activity in solid tumors using a 64Cu-labeled activity-based probe. PLoS One 2011 0.97
12 An optimized activity-based probe for the study of caspase-6 activation. Chem Biol 2012 0.97
13 Relative quantification of proteasome activity by activity-based protein profiling and LC-MS/MS. Nat Protoc 2013 0.96
14 Nature of pharmacophore influences active site specificity of proteasome inhibitors. J Biol Chem 2010 0.94
15 Minitags for small molecules: detecting targets of reactive small molecules in living plant tissues using 'click chemistry'. Plant J 2008 0.91
16 Assessing subunit dependency of the Plasmodium proteasome using small molecule inhibitors and active site probes. ACS Chem Biol 2014 0.90
17 Identification of a serine protease inhibitor which causes inclusion vacuole reduction and is lethal to Chlamydia trachomatis. Mol Microbiol 2013 0.90
18 Proteasome activity imaging and profiling characterizes bacterial effector syringolin A. Plant Physiol 2010 0.90
19 Two-step bioorthogonal activity-based proteasome profiling using copper-free click reagents: a comparative study. Bioorg Med Chem 2011 0.83
20 Two-step labeling of endogenous enzymatic activities by Diels-Alder ligation. Chembiochem 2010 0.81
21 Receptor-mediated targeting of cathepsins in professional antigen presenting cells. Angew Chem Int Ed Engl 2009 0.80
22 Design of Protease Activated Optical Contrast Agents That Exploit a Latent Lysosomotropic Effect for Use in Fluorescence-Guided Surgery. ACS Chem Biol 2015 0.79
23 O-GlcNAc peptide epoxyketones are recognized by mammalian proteasomes. J Am Chem Soc 2009 0.79
24 An unusual reverse turn structure adopted by a furanoid sugar amino acid incorporated in gramicidin S. J Am Chem Soc 2004 0.78
25 The use of a mannitol-derived fused oxacycle as a combinatorial scaffold. J Org Chem 2003 0.75
26 A practical synthesis of gramicidin s and sugar amino Acid containing analogues. J Org Chem 2004 0.75
27 Exploring dual electrophiles in peptide-based proteasome inhibitors: carbonyls and epoxides. Org Biomol Chem 2014 0.75