Published in Toxicol Appl Pharmacol on May 27, 2011
Sulforaphane protects against ethanol-induced oxidative stress and apoptosis in neural crest cells by the induction of Nrf2-mediated antioxidant response. Br J Pharmacol (2013) 1.01
Sulforaphane restores cellular glutathione levels and reduces chronic periodontitis neutrophil hyperactivity in vitro. PLoS One (2013) 0.86
Overexpression of Nrf2 protects against microcystin-induced hepatotoxicity in mice. PLoS One (2014) 0.83
Sulforaphane attenuates gentamicin-induced nephrotoxicity: role of mitochondrial protection. Evid Based Complement Alternat Med (2013) 0.78
Sulforaphane Attenuates Contrast-Induced Nephropathy in Rats via Nrf2/HO-1 Pathway. Oxid Med Cell Longev (2016) 0.76
Sulforaphane-rich broccoli sprout extract improves hepatic abnormalities in male subjects. World J Gastroenterol (2015) 0.76
Sulforaphane reduces lipopolysaccharide-induced proinflammatory markers in hippocampus and liver but does not improve sickness behavior. Nutr Neurosci (2015) 0.75
Microcystin-LR Induced Apoptosis in Rat Sertoli Cells via the Mitochondrial Caspase-Dependent Pathway: Role of Reactive Oxygen Species. Front Physiol (2016) 0.75
Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. Methods Enzymol (1990) 6.05
Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates. Proc Natl Acad Sci U S A (1994) 2.73
Molecular basis for chemoprevention by sulforaphane: a comprehensive review. Cell Mol Life Sci (2007) 2.73
The toxins of cyanobacteria. Sci Am (1994) 2.69
Liver tumor promotion by the cyanobacterial cyclic peptide toxin microcystin-LR. J Cancer Res Clin Oncol (1992) 2.40
Nuclear factor kappa B is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms. J Biol Chem (2001) 2.26
Downregulation of Bcl-2, FLIP or IAPs (XIAP and survivin) by siRNAs sensitizes resistant melanoma cells to Apo2L/TRAIL-induced apoptosis. Cell Death Differ (2004) 2.17
Nrf2 signaling: an adaptive response pathway for protection against environmental toxic insults. Mutat Res (2007) 2.10
Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer. Clin Cancer Res (2009) 2.04
Molecular targets of dietary phenethyl isothiocyanate and sulforaphane for cancer chemoprevention. AAPS J (2009) 1.95
Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast. Carcinogenesis (2007) 1.91
Detection of microcystins, a blue-green algal hepatotoxin, in drinking water sampled in Haimen and Fusui, endemic areas of primary liver cancer in China, by highly sensitive immunoassay. Carcinogenesis (1996) 1.65
CYP2E1-mediated mechanism of anti-genotoxicity of the broccoli constituent sulforaphane. Carcinogenesis (1996) 1.61
The protein phosphatase inhibitor okadaic acid induces morphological changes typical of apoptosis in mammalian cells. Exp Cell Res (1991) 1.55
Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of DR5. Cancer Res (2006) 1.47
Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation. Proc Natl Acad Sci U S A (2007) 1.43
Identification of an enzymatically formed glutathione conjugate of the cyanobacterial hepatotoxin microcystin-LR: the first step of detoxication. Biochim Biophys Acta (1998) 1.35
Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 dependent pathway. Biochem Pharmacol (2008) 1.26
Gene transfer-induced local heme oxygenase-1 overexpression protects rat kidney transplants from ischemia/reperfusion injury. J Am Soc Nephrol (2003) 1.14
Pathological and biochemical characterization of microcystin-induced hepatopancreas and kidney damage in carp (Cyprinus carpio). Toxicol Appl Pharmacol (2000) 1.12
Microcystin-LR and nodularin induce intracellular glutathione alteration, reactive oxygen species production and lipid peroxidation in primary cultured rat hepatocytes. Toxicol Lett (2004) 0.93
Induction of apoptosis in mouse liver by microcystin-LR: a combined transcriptomic, proteomic, and simulation strategy. Mol Cell Proteomics (2005) 0.92
Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis through downregulation of ERK and Akt in lung adenocarcinoma A549 cells. Carcinogenesis (2006) 0.91
CaM-kinaseII-dependent commitment to microcystin-induced apoptosis is coupled to cell budding, but not to shrinkage or chromatin hypercondensation. Cell Death Differ (2005) 0.90
Sulforaphane protects Microcystin-LR-induced toxicity through activation of the Nrf2-mediated defensive response. Toxicol Appl Pharmacol (2010) 0.89
Hepatic oxidative stress following prolonged sublethal microcystin LR exposure. Toxicol Pathol (1999) 0.87
Involvement of reactive oxygen species in Microcystin-LR-induced cytogenotoxicity. Free Radic Res (2007) 0.86
Prevention of toxin-induced cytoskeletal disruption and apoptotic liver cell death by the grapefruit flavonoid, naringin. Cell Death Differ (2000) 0.84
Activation of Nrf2 by microcystin-LR provides advantages for liver cancer cell growth. Chem Res Toxicol (2010) 0.84
Nostocyclopeptide-M1: a potent, nontoxic inhibitor of the hepatocyte drug transporters OATP1B3 and OATP1B1. Mol Pharm (2011) 0.82
Time-dependent protective efficacy of Trolox (vitamin E analog) against microcystin-induced toxicity in tilapia (Oreochromis niloticus). Environ Toxicol (2009) 0.81
Detection of microcystins in environmental samples using surface plasmon resonance biosensor. Talanta (2009) 0.80
An investigation of the role of vitamin E in the protection of mice against microcystin toxicity. Environ Toxicol (2003) 0.80
Microcystin-LR-induced ultrastructural changes in rats. Vet Pathol (1990) 0.79
Hepatic ultrastructural changes induced by the toxin microcystin-LR (MCLR) in mice. J Environ Pathol Toxicol Oncol (1994) 0.78
Antioxidant responses after microcystin exposure in gills of an estuarine crab species pre-treated with vitamin E. Ecotoxicol Environ Saf (2005) 0.77
Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand. Nature (2011) 4.19
Direct-current nanogenerator driven by ultrasonic waves. Science (2007) 2.98
The dragon strikes: lessons from the Wenchuan earthquake. Anesth Analg (2010) 2.78
A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase. Cancer Res (2004) 2.71
Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature (2012) 2.67
Functional investigation of Fas ligand expressions in human non-small cell lung cancer cells and its clinical implications. Ann Thorac Surg (2012) 2.63
A high throughput Nile red method for quantitative measurement of neutral lipids in microalgae. J Microbiol Methods (2009) 2.60
The neuronal channel NALCN contributes resting sodium permeability and is required for normal respiratory rhythm. Cell (2007) 2.54
Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294. Nat Struct Mol Biol (2009) 2.50
ZnO nanobelt/nanowire Schottky diodes formed by dielectrophoresis alignment across au electrodes. Nano Lett (2006) 2.18
Differential integrity of TALE nuclease genes following adenoviral and lentiviral vector gene transfer into human cells. Nucleic Acids Res (2012) 2.14
Reproducibility of plasma and urine biomarkers among premenopausal and postmenopausal women from the Nurses' Health Studies. Cancer Epidemiol Biomarkers Prev (2010) 2.09
Isothiocyanates as cancer chemopreventive agents: their biological activities and metabolism in rodents and humans. Curr Drug Metab (2002) 2.04
Doppler ultrasound-guided percutaneous nephrolithotomy with two-step tract dilation for management of complex renal stones. Urology (2012) 2.04
A novel approach to 3-D gaze tracking using stereo cameras. IEEE Trans Syst Man Cybern B Cybern (2004) 2.02
The feasibility of measuring renal blood flow using transesophageal echocardiography in patients undergoing cardiac surgery. Anesth Analg (2009) 1.97
Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice. Cancer Res (2005) 1.94
Emulsified isoflurane produces cardiac protection after ischemia-reperfusion injury in rabbits. Anesth Analg (2008) 1.75
Covalent binding to tubulin by isothiocyanates. A mechanism of cell growth arrest and apoptosis. J Biol Chem (2008) 1.73
Piezoelectric field effect transistor and nanoforce sensor based on a single ZnO nanowire. Nano Lett (2006) 1.72
Peptide neurotransmitters activate a cation channel complex of NALCN and UNC-80. Nature (2008) 1.71
Phosphoinositide 3-kinase/Akt pathway plays an important role in chemoresistance of gastric cancer cells against etoposide and doxorubicin induced cell death. Int J Cancer (2008) 1.64
Urinary isothiocyanate levels, brassica, and human breast cancer. Cancer Res (2003) 1.60
The role of protein binding in induction of apoptosis by phenethyl isothiocyanate and sulforaphane in human non-small lung cancer cells. Cancer Res (2007) 1.55
A model for the preferential delivery of isoflurane to the spinal cord of the goat. Vet J (2010) 1.48
The major lipid peroxidation product, trans-4-hydroxy-2-nonenal, preferentially forms DNA adducts at codon 249 of human p53 gene, a unique mutational hotspot in hepatocellular carcinoma. Carcinogenesis (2002) 1.43
Hydrogen-rich saline attenuates lung ischemia-reperfusion injury in rabbits. J Surg Res (2011) 1.41
Echo rounds: intraoperative transesophageal echocardiography-guided patent ductus arteriosus ligation in an asymptomatic nonbacterial endocarditis patient. Anesth Analg (2010) 1.38
Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases. J Mol Biol (2010) 1.37
Cancer preventive isothiocyanates induce selective degradation of cellular alpha- and beta-tubulins by proteasomes. J Biol Chem (2009) 1.34
Integrated nanogenerators in biofluid. Nano Lett (2007) 1.34
Formation of cyclic deoxyguanosine adducts from omega-3 and omega-6 polyunsaturated fatty acids under oxidative conditions. Chem Res Toxicol (2002) 1.25
Correlation between serum CA724 and gastric cancer: multiple analyses based on Chinese population. Mol Biol Rep (2012) 1.24
Distribution of phytoplankton in the Three-Gorge Reservoir during rainy and dry seasons. Sci Total Environ (2006) 1.21
Development of a unique small molecule modulator of CXCR4. PLoS One (2012) 1.18
Complexity reduction in the use of evolutionary algorithms to function optimization: a variable reduction strategy. ScientificWorldJournal (2013) 1.18
Patterned growth of vertically aligned ZnO nanowire arrays on inorganic substrates at low temperature without catalyst. J Am Chem Soc (2008) 1.13
Paclitaxel binding to human and murine MD-2. J Biol Chem (2008) 1.13
Analysis of a diverse global Pisum sp. collection and comparison to a Chinese local P. sativum collection with microsatellite markers. Theor Appl Genet (2008) 1.13
Ingestion of an isothiocyanate metabolite from cruciferous vegetables inhibits growth of human prostate cancer cell xenografts by apoptosis and cell cycle arrest. Carcinogenesis (2004) 1.13
Maternal prepregnancy body mass index and gestational weight gain on offspring overweight in early infancy. PLoS One (2013) 1.13
Targeting cell cycle machinery as a molecular mechanism of sulforaphane in prostate cancer prevention. Int J Oncol (2004) 1.12
The efficacy and safety of intravenous emulsified isoflurane in rats. Anesth Analg (2006) 1.11
Distribution and bioaccumulation of microcystins in water columns: a systematic investigation into the environmental fate and the risks associated with microcystins in Meiliang Bay, Lake Taihu. Water Res (2007) 1.10
A novel, single, transmembrane protein CATSPERG is associated with CATSPER1 channel protein. Biol Reprod (2009) 1.10
Integrated multilayer nanogenerator fabricated using paired nanotip-to-nanowire brushes. Nano Lett (2008) 1.08
Unmodified CdSe quantum dots induce elevation of cytoplasmic calcium levels and impairment of functional properties of sodium channels in rat primary cultured hippocampal neurons. Environ Health Perspect (2008) 1.08
Development of proteomic patterns for detecting lung cancer. Dis Markers (2004) 1.07
Ultrasound-guided transversus abdominis plane block in children. Eur J Anaesthesiol (2014) 1.07
Responses of antioxidant systems in the hepatocytes of common carp (Cyprinus carpio L.) to the toxicity of microcystin-LR. Toxicon (2003) 1.07
Effect of carcinogenic acrolein on DNA repair and mutagenic susceptibility. J Biol Chem (2012) 1.07
Sulforaphane activates heat shock response and enhances proteasome activity through up-regulation of Hsp27. J Biol Chem (2010) 1.06
Sound velocities of Fe and Fe-Si alloy in the Earth's core. Proc Natl Acad Sci U S A (2012) 1.06
Nuclear envelope breakdown is coordinated by both Nup358/RanBP2 and Nup153, two nucleoporins with zinc finger modules. Mol Biol Cell (2005) 1.06
The protective effects of emulsified isoflurane on myocardial ischemia and reperfusion injury in rats. Can J Anaesth (2008) 1.05
N-acetylcysteine conjugate of phenethyl isothiocyanate enhances apoptosis in growth-stimulated human lung cells. Cancer Res (2005) 1.04
Enlargement of high density lipoprotein in mice via liver X receptor activation requires apolipoprotein E and is abolished by cholesteryl ester transfer protein expression. J Biol Chem (2003) 1.04
Selective depletion of mutant p53 by cancer chemopreventive isothiocyanates and their structure-activity relationships. J Med Chem (2011) 1.03
Isothiocyanate exposure, glutathione S-transferase polymorphisms, and colorectal cancer risk. Am J Clin Nutr (2009) 1.03
Nectin-like molecule 1 is a protein 4.1N associated protein and recruits protein 4.1N from cytoplasm to the plasma membrane. Biochim Biophys Acta (2005) 1.02
Isothiocyanates inhibit proteasome activity and proliferation of multiple myeloma cells. Carcinogenesis (2010) 1.02
A clinical assessment of the Glidescope videolaryngoscope in nasotracheal intubation with general anesthesia. J Clin Anesth (2006) 1.02
Anti-inflammatory effects of phospholipid transfer protein (PLTP) deficiency in mice. Biochim Biophys Acta (2005) 1.02
ATF4 protects against neuronal death in cellular Parkinson's disease models by maintaining levels of parkin. J Neurosci (2013) 1.02
Sequence-specific single-molecule analysis of 8-oxo-7,8-dihydroguanine lesions in DNA based on unzipping kinetics of complementary probes in ion channel recordings. J Am Chem Soc (2011) 1.01
Tetra-aqua-bis-(1H-benzimidazole-5,6-di-carboxyl-ato-κN)cobalt(II) dimethyl-formamide disolvate dihydrate. Acta Crystallogr Sect E Struct Rep Online (2009) 1.01
Molecular and cellular effects of green tea on oral cells of smokers: a pilot study. Mol Nutr Food Res (2005) 1.01
Proteins as binding targets of isothiocyanates in cancer prevention. Carcinogenesis (2011) 1.01
Dynamic factors controlling carrier anchoring on vascular cells. IUBMB Life (2011) 1.00
Facile lipid flip-flop in a phospholipid bilayer induced by gramicidin A measured by sum-frequency vibrational spectroscopy. Biophys J (2006) 1.00
Solution structure of proinsulin: connecting domain flexibility and prohormone processing. J Biol Chem (2010) 0.99
Melatonin reduces inflammatory injury through inhibiting NF-kappaB activation in rats with colitis. Mediators Inflamm (2005) 0.99
Nuclear factor kappa B signaling initiates early differentiation of neural stem cells. Stem Cells (2012) 0.99
Effect of developmental lead exposure on the expression of specific NMDA receptor subunit mRNAs in the hippocampus of neonatal rats by digoxigenin-labeled in situ hybridization histochemistry. Neurotoxicol Teratol (2002) 0.99
Low-threshold two-photon pumped ZnO nanowire lasers. Opt Express (2009) 0.98
Overexpression of cellular FLICE-inhibitory protein (FLIP) in gastric adenocarcinoma. Clin Sci (Lond) (2004) 0.98
Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol (2011) 0.98
Synergistic induction of tumor cell death by combining cisplatin with an oncolytic adenovirus carrying TRAIL. Mol Cell Biochem (2007) 0.98
The effect of dietary sphingolipids on plasma sphingomyelin metabolism and atherosclerosis. Biochim Biophys Acta (2005) 0.98
Centrosome attachment to the C. elegans male pronucleus is dependent on the surface area of the nuclear envelope. Dev Biol (2009) 0.98
The role of microcystins in maintaining colonies of bloom-forming Microcystis spp. Environ Microbiol (2011) 0.97
Urinary isothiocyanates; glutathione S-transferase M1, T1, and P1 polymorphisms; and risk of colorectal cancer: the Multiethnic Cohort Study. Cancer Epidemiol Biomarkers Prev (2009) 0.97
Urinary isothiocyanate excretion, brassica consumption, and gene polymorphisms among women living in Shanghai, China. Cancer Epidemiol Biomarkers Prev (2003) 0.97
The optimal timing of initiation of therapeutic hypothermia after cardiac arrest. Resuscitation (2012) 0.97
The lysophosphatidic acid (LPA) receptors their expression and significance in epithelial ovarian neoplasms. Gynecol Oncol (2007) 0.97
Principles of allosteric interactions in cell signaling. J Am Chem Soc (2014) 0.97
Detection of the acrolein-derived cyclic DNA adduct by a quantitative 32P-postlabeling/solid-phase extraction/HPLC method: blocking its artifact formation with glutathione. Anal Biochem (2007) 0.96
MiR-23a inhibits myogenic differentiation through down regulation of fast myosin heavy chain isoforms. Exp Cell Res (2012) 0.96
Repair kinetics of trans-4-hydroxynonenal-induced cyclic 1,N2-propanodeoxyguanine DNA adducts by human cell nuclear extracts. Biochemistry (2004) 0.96
A solid-phase extraction/high-performance liquid chromatography-based (32)P-postlabeling method for detection of cyclic 1,N(2)-propanodeoxyguanosine adducts derived from enals. Anal Biochem (2005) 0.96
Ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) protein regulates osteoblast differentiation. J Biol Chem (2011) 0.96
2,5-Hexanedione induces human ovarian granulosa cell apoptosis through BCL-2, BAX, and CASPASE-3 signaling pathways. Arch Toxicol (2011) 0.95
Vertically aligned Zn2SiO4 nanotube/ZnO nanowire heterojunction arrays. Small (2007) 0.95
Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms and gastric cancer risk: a prospective study of men in Shanghai, China. Int J Cancer (2009) 0.95