Armed and targeted measles virus for chemovirotherapy of pancreatic cancer.

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Published in Cancer Gene Ther on June 24, 2011

Authors

S Bossow1, C Grossardt, A Temme, M F Leber, S Sawall, E P Rieber, R Cattaneo, C von Kalle, G Ungerechts

Author Affiliations

1: Department of Translational Oncology, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Heidelberg, Germany.

Associated clinical trials:

A Phase I Gene Therapy Study of FP253/Fludarabine for Prostate Cancer (FP253-GDEPT) | NCT00625430

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A procedure for selective full length cDNA cloning of specific RNA species. Nucleic Acids Res (1987) 1.15

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The anti-beta2-glycoprotein I activity in human anti-phospholipid syndrome sera is due to monoreactive low-affinity autoantibodies directed to epitopes located on native beta2-glycoprotein I and preserved during species' evolution. J Immunol (1996) 1.12

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Expression of interleukin-6 and interleukin-6 receptor in Hodgkin's disease. Blood (1991) 0.99

Lengthening of the forearm by the Ilizarov technique. Clin Orthop Relat Res (1990) 0.99

Systemic lupus erythematosus in Europe at the change of the millennium: lessons from the "Euro-Lupus Project". Autoimmun Rev (2005) 0.97