Extracapsular extension is a poor predictor of disease recurrence in surgically treated oropharyngeal squamous cell carcinoma.

PubWeight™: 0.98‹?› | Rank: Top 15%

🔗 View Article (PMC 3925389)

Published in Mod Pathol on June 24, 2011

Authors

James S Lewis1, Danielle H Carpenter, Wade L Thorstad, Qin Zhang, Bruce H Haughey

Author Affiliations

1: Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA. jlewis@path.wustl.edu

Articles citing this

Long-term prognosis and risk factors among patients with HPV-associated oropharyngeal squamous cell carcinoma. Cancer (2013) 0.94

Tumor cell anaplasia and multinucleation are predictors of disease recurrence in oropharyngeal squamous cell carcinoma, including among just the human papillomavirus-related cancers. Am J Surg Pathol (2012) 0.86

Influence of extracapsular nodal spread extent on prognosis of oral squamous cell carcinoma. Head Neck (2015) 0.86

Prognostic significance of the degree of extranodal extension in patients with penile carcinoma. Asian J Androl (2014) 0.80

Inter- and intra-observer variability in the classification of extracapsular extension in p16 positive oropharyngeal squamous cell carcinoma nodal metastases. Oral Oncol (2015) 0.79

Prognostic biological features in neck dissection specimens. Eur Arch Otorhinolaryngol (2012) 0.79

Is postoperative adjuvant chemoradiotherapy necessary for high-risk oropharyngeal squamous cell carcinoma? Int J Clin Oncol (2013) 0.78

Prognostic Importance of Comorbidity and the Association Between Comorbidity and p16 in Oropharyngeal Squamous Cell Carcinoma. JAMA Otolaryngol Head Neck Surg (2016) 0.77

Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: What Is New in the 2017 WHO Blue Book for Tumors and Tumor-Like Lesions of the Neck and Lymph Nodes. Head Neck Pathol (2017) 0.75

The Role of Adjuvant Chemotherapy in Surgically Managed, p16-Positive Oropharyngeal Squamous Cell Carcinoma. JAMA Otolaryngol Head Neck Surg (2016) 0.75

Lymph Node Central Necrosis on the Computed Tomography as the Predictor of the Extra Capsular Spread in Metastatic Head and Neck Squamous Cell Carcinoma. Indian J Otolaryngol Head Neck Surg (2017) 0.75

Biological Features of Human Papillomavirus-related Head and Neck Cancers Contributing to Improved Response. Clin Oncol (R Coll Radiol) (2016) 0.75

Which is the most suitable lymph node predictor for overall survival after primary surgery of head and neck cancer: pN, the number or the ratio of positive lymph nodes, or log odds? J Cancer Res Clin Oncol (2015) 0.75

Articles cited by this

Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. J Natl Cancer Inst (2008) 12.77

Survival of squamous cell carcinoma of the head and neck in relation to human papillomavirus infection: review and meta-analysis. Int J Cancer (2007) 3.98

p16 positive oropharyngeal squamous cell carcinoma:an entity with a favorable prognosis regardless of tumor HPV status. Am J Surg Pathol (2010) 3.37

Head and neck squamous cell cancer and the human papillomavirus: summary of a National Cancer Institute State of the Science Meeting, November 9-10, 2008, Washington, D.C. Head Neck (2009) 2.59

Expression of p16 protein identifies a distinct entity of tonsillar carcinomas associated with human papillomavirus. Am J Pathol (2003) 2.26

HPV-related nonkeratinizing squamous cell carcinoma of the oropharynx: utility of microscopic features in predicting patient outcome. Head Neck Pathol (2009) 2.08

The extracapsular spread of tumors in cervical node metastasis. Arch Otolaryngol (1981) 1.92

Cervical lymph node metastasis in oral cancer: the importance of even microscopic extracapsular spread. Oral Oncol (2003) 1.81

Prognostic factors of neck node metastasis. Clin Otolaryngol Allied Sci (1982) 1.67

HPV-16 infection predicts treatment outcome in oropharyngeal squamous cell carcinoma. Otolaryngol Head Neck Surg (2009) 1.49

Prognostic significance of p16 protein levels in oropharyngeal squamous cell cancer. Clin Cancer Res (2004) 1.44

Is the improved prognosis of p16 positive oropharyngeal squamous cell carcinoma dependent of the treatment modality? Int J Cancer (2010) 1.41

Extracapsular spread. A significant predictor of treatment failure in patients with squamous cell carcinoma of the tongue. Cancer (2001) 1.40

Prognostic significance of microscopic and macroscopic extracapsular spread from metastatic tumor in the cervical lymph nodes. Oral Oncol (2002) 1.38

Transoral laser microsurgery (TLM) +/- adjuvant therapy for advanced stage oropharyngeal cancer: outcomes and prognostic factors. Laryngoscope (2009) 1.37

Extent of extracapsular spread: a critical prognosticator in oral tongue cancer. Cancer (2003) 1.33

Guidelines for prognosis in head and neck cancer with nodal metastasis. Laryngoscope (1978) 1.30

Cervical lymph node metastases. Incidence and implications of extracapsular carcinoma. Arch Otolaryngol (1985) 1.18

Extracapsular spread in oral squamous cell carcinoma. Head Neck (2010) 1.14

HPV status and regional metastasis in the prognosis of oral and oropharyngeal cancer. Eur Arch Otorhinolaryngol (2007) 1.13

Quantitative analysis of the extent of extracapsular invasion and its prognostic significance: a prospective study of 170 cases of carcinoma of the larynx and hypopharynx. Head Neck (1998) 1.12

Extracapsular spread of carcinoma in cervical lymph nodes. Impact upon survival in patients with carcinoma of the supraglottic larynx. Cancer (1985) 1.05

Prognostic significance of histologic host response in cancer of the larynx or hypopharynx. Cancer (1971) 1.00

Cervical node metastases in squamous cell carcinoma of the upper aerodigestive tract: the significance of extracapsular spread and soft tissue deposits. Head Neck (2003) 0.98

The prognostic impact of metastatic pattern of lymph nodes in patients with oral and oropharyngeal squamous cell carcinomas. Eur Arch Otorhinolaryngol (2003) 0.92

Extracapsular spread of squamous cell carcinoma in neck lymph nodes: prognostic factor of laryngeal cancer. Laryngoscope (1991) 0.91

Squamous cell carcinoma of the upper aerodigestive tract: the prevalence of microscopic extracapsular spread and soft tissue deposits in the clinically N0 neck. Head Neck (2002) 0.91

The topography of cervical lymph node metastases revisited: the histological findings in 526 sides of neck dissection from 439 previously untreated patients. Int J Oral Maxillofac Surg (2007) 0.89

Distribution and impact of lymph node metastases in oropharyngeal cancer. Acta Otolaryngol (2006) 0.87

Outcome of multimodal treatment for oropharyngeal carcinoma: a single institution experience. Oral Oncol (2006) 0.86

Soft tissue deposits in neck dissections of patients with head and neck squamous cell carcinoma: prospective analysis of prevalence, survival, and its implications. Arch Otolaryngol Head Neck Surg (2004) 0.84

Patterns of spread in recurrent head and neck squamous cell carcinoma. Otolaryngol Head Neck Surg (2001) 0.83

Quantitative analysis of extracapsular extension of metastatic lymph nodes and its significance in radiotherapy planning in head and neck squamous cell carcinoma. Int J Radiat Oncol Biol Phys (2009) 0.83

Upper aerodigestive tract squamous cell carcinoma: distribution of extracapsular spread and soft tissue deposits in the neck. Acta Otolaryngol (2004) 0.81

Articles by these authors

Randomized phase III trial of concurrent accelerated radiation plus cisplatin with or without cetuximab for stage III to IV head and neck carcinoma: RTOG 0522. J Clin Oncol (2014) 5.80

Impact of FDG-PET on radiation therapy volume delineation in non-small-cell lung cancer. Int J Radiat Oncol Biol Phys (2004) 4.13

p16 positive oropharyngeal squamous cell carcinoma:an entity with a favorable prognosis regardless of tumor HPV status. Am J Surg Pathol (2010) 3.37

Genome wide association studies for milk production traits in Chinese Holstein population. PLoS One (2010) 2.13

Ethanol-diesel fuel blends -- a review. Bioresour Technol (2005) 2.12

Vanadium exposure-induced neurobehavioral alterations among Chinese workers. Neurotoxicology (2013) 2.08

Best linear unbiased prediction of genomic breeding values using a trait-specific marker-derived relationship matrix. PLoS One (2010) 2.08

HPV-related nonkeratinizing squamous cell carcinoma of the oropharynx: utility of microscopic features in predicting patient outcome. Head Neck Pathol (2009) 2.08

Human papillomavirus-positive basaloid squamous cell carcinomas of the upper aerodigestive tract: a distinct clinicopathologic and molecular subtype of basaloid squamous cell carcinoma. Hum Pathol (2010) 2.01

High-risk human papillomavirus E6/E7 mRNA detection by a novel in situ hybridization assay strongly correlates with p16 expression and patient outcomes in oropharyngeal squamous cell carcinoma. Am J Surg Pathol (2011) 2.00

Microscopic margins and patterns of treatment failure in resected pancreatic adenocarcinoma. Arch Surg (2012) 1.91

Patient care in multidisciplinary cancer clinics: does attention to psychosocial needs predict patient satisfaction? Psychooncology (2003) 1.88

Prognostic significance of FDG-PET in relapsed or refractory classical Hodgkin lymphoma treated with standard salvage chemotherapy and autologous stem cell transplantation. Biol Blood Marrow Transplant (2011) 1.82

Adding pegylated interferon to entecavir for hepatitis B e antigen-positive chronic hepatitis B: A multicenter randomized trial (ARES study). Hepatology (2015) 1.74

The cardiac transcription network modulated by Gata4, Mef2a, Nkx2.5, Srf, histone modifications, and microRNAs. PLoS Genet (2011) 1.69

Surgical resection of the primary tumor is associated with increased long-term survival in patients with stage IV breast cancer after controlling for site of metastasis. Ann Surg Oncol (2007) 1.66

High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome. Nature (2013) 1.66

The stop signal revised: immature cerebellar granule neurons in the external germinal layer arrest pontine mossy fiber growth. J Neurosci (2006) 1.65

Toward clean and crackless transfer of graphene. ACS Nano (2011) 1.64

Intensity-modulated radiation therapy for oropharyngeal carcinoma: impact of tumor volume. Int J Radiat Oncol Biol Phys (2004) 1.64

Head and neck cancers. J Natl Compr Canc Netw (2011) 1.64

Activation of antibiotic biosynthesis by specified mutations in the rpoB gene (encoding the RNA polymerase beta subunit) of Streptomyces lividans. J Bacteriol (2002) 1.55

Hyperoxia stimulates an Nrf2-ARE transcriptional response via ROS-EGFR-PI3K-Akt/ERK MAP kinase signaling in pulmonary epithelial cells. Antioxid Redox Signal (2006) 1.44

Human papillomavirus and oropharynx cancer: biology, detection and clinical implications. Laryngoscope (2010) 1.42

Head and neck cancers, Version 2.2014. Clinical practice guidelines in oncology. J Natl Compr Canc Netw (2014) 1.39

Transoral laser microsurgery (TLM) +/- adjuvant therapy for advanced stage oropharyngeal cancer: outcomes and prognostic factors. Laryngoscope (2009) 1.37

Head and neck cancers, version 2.2013. Featured updates to the NCCN guidelines. J Natl Compr Canc Netw (2013) 1.35

Predicting dose-volume histograms for organs-at-risk in IMRT planning. Med Phys (2012) 1.35

[(18)F]FLT-PET imaging does not always "light up" proliferating tumor cells. Clin Cancer Res (2011) 1.35

Lymphovascular space invasion is an independent risk factor for nodal disease and poor outcomes in endometrioid endometrial cancer. Gynecol Oncol (2011) 1.34

Up-regulation of DLK1 as an imprinted gene could contribute to human hepatocellular carcinoma. Carcinogenesis (2006) 1.33

IMRT treatment planning based on prioritizing prescription goals. Phys Med Biol (2007) 1.32

HBsAg inhibits TLR9-mediated activation and IFN-alpha production in plasmacytoid dendritic cells. Mol Immunol (2009) 1.31

Genetic variants at 1q22 and 10q23 reproducibly associated with gastric cancer susceptibility in a Chinese population. Carcinogenesis (2011) 1.28

Cellular uptake and fate of PEGylated gold nanoparticles is dependent on both cell-penetration peptides and particle size. ACS Nano (2011) 1.26

Transcriptionally-active high-risk human papillomavirus is rare in oral cavity and laryngeal/hypopharyngeal squamous cell carcinomas--a tissue microarray study utilizing E6/E7 mRNA in situ hybridization. Histopathology (2012) 1.25

Purinergic signaling: a fundamental mechanism in neutrophil activation. Sci Signal (2010) 1.24

Mitochondrial damage associated molecular patterns from femoral reamings activate neutrophils through formyl peptide receptors and P44/42 MAP kinase. J Orthop Trauma (2010) 1.24

Expression, circulation, and excretion profile of microRNA-21, -155, and -18a following acute kidney injury. Toxicol Sci (2012) 1.24

Carcinoma of paranasal sinuses: long-term outcomes with radiotherapy. Int J Radiat Oncol Biol Phys (2004) 1.22

Detoxification without intoxication: herbicide safeners activate plant defense gene expression. Plant Physiol (2010) 1.20

2-(2-Chloro-phen-oxy)benzoic acid. Acta Crystallogr Sect E Struct Rep Online (2011) 1.20

A genome-wide detection of copy number variations using SNP genotyping arrays in swine. BMC Genomics (2012) 1.18

Papillary squamous cell carcinoma of the head and neck: clinicopathologic and molecular features with special reference to human papillomavirus. Am J Surg Pathol (2013) 1.18

Mitochondrial peptides are potent immune activators that activate human neutrophils via FPR-1. J Trauma (2010) 1.17

Expression profiles and function of Toll-like receptors 2 and 4 in peripheral blood mononuclear cells of chronic hepatitis B patients. Clin Immunol (2008) 1.14

Saturated fatty acid induction of endoplasmic reticulum stress and apoptosis in human liver cells via the PERK/ATF4/CHOP signaling pathway. Mol Cell Biochem (2012) 1.13

Transoral laser microsurgery for advanced laryngeal cancer. Arch Otolaryngol Head Neck Surg (2007) 1.12

Swallowing function after transoral laser microsurgery (TLM) ± adjuvant therapy for advanced-stage oropharyngeal cancer. Laryngoscope (2011) 1.11

A novel RT-PCR method for quantification of human papillomavirus transcripts in archived tissues and its application in oropharyngeal cancer prognosis. Int J Cancer (2012) 1.11

Biomarker and pharmacologic evaluation of the γ-secretase inhibitor PF-03084014 in breast cancer models. Clin Cancer Res (2012) 1.10

Transcriptional profiling of mammary gland in Holstein cows with extremely different milk protein and fat percentage using RNA sequencing. BMC Genomics (2014) 1.09

Extracapsular spread and adjuvant therapy in human papillomavirus-related, p16-positive oropharyngeal carcinoma. Cancer (2011) 1.09

Reliability of gross visual assessment of specimen adequacy during EUS-guided FNA of pancreatic masses. Gastrointest Endosc (2009) 1.08

Jaundice: an important, poorly recognized risk factor for diminished survival in patients with adenocarcinoma of the head of the pancreas. HPB (Oxford) (2013) 1.08

Human papillomavirus-related squamous cell carcinoma of the oropharynx: a comparative study in whites and African Americans. Arch Otolaryngol Head Neck Surg (2011) 1.07

A Fast Variational Method for the Construction of Resolution Adaptive C-Smooth Molecular Surfaces. Comput Methods Appl Mech Eng (2009) 1.07

Genome-wide detection of copy number variations using high-density SNP genotyping platforms in Holsteins. BMC Genomics (2013) 1.06

B7-H1 expression model for immune evasion in human papillomavirus-related oropharyngeal squamous cell carcinoma. Head Neck Pathol (2012) 1.05

Oxidant species trigger late preconditioning against myocardial stunning in conscious rabbits. Am J Physiol Heart Circ Physiol (2002) 1.05

PF-00477736 mediates checkpoint kinase 1 signaling pathway and potentiates docetaxel-induced efficacy in xenografts. Clin Cancer Res (2009) 1.05

Synergistic effect of the γ-secretase inhibitor PF-03084014 and docetaxel in breast cancer models. Stem Cells Transl Med (2013) 1.04

Structure and function of glucose-6-phosphate dehydrogenase-deficient variants in Chinese population. Hum Genet (2006) 1.04

Correlation between genomic DNA copy number alterations and transcriptional expression in hepatitis B virus-associated hepatocellular carcinoma. FEBS Lett (2006) 1.04

Diet-induced obesity and hepatic gene expression alterations in C57BL/6J and ICAM-1-deficient mice. Am J Physiol Endocrinol Metab (2002) 1.04

Transoral laser microsurgery: a new approach for unknown primaries of the head and neck. Laryngoscope (2011) 1.04

Recognition of nonkeratinizing morphology in oropharyngeal squamous cell carcinoma - a prospective cohort and interobserver variability study. Histopathology (2011) 1.03

A novel PET tumor delineation method based on adaptive region-growing and dual-front active contours. Med Phys (2008) 1.02

Quality assessment of cortex cinnamomi by HPLC chemical fingerprint, principle component analysis and cluster analysis. J Sep Sci (2007) 1.02

Screening for retinopathy of prematurity in China: a neonatal units-based prospective study. Invest Ophthalmol Vis Sci (2013) 1.02

Mitogen regulated induction of FRA-1 proto-oncogene is controlled by the transcription factors binding to both serum and TPA response elements. Oncogene (2005) 1.01

Dendritic cell expression of the signaling molecule TRAF6 is critical for gut microbiota-dependent immune tolerance. Immunity (2013) 1.00

The Excite Trial: relationship of intensity of constraint induced movement therapy to improvement in the wolf motor function test. Restor Neurol Neurosci (2007) 1.00

Stenting for malignant colonic obstruction: a comparison of efficacy and complications in colonic versus extracolonic malignancy. Gastrointest Endosc (2009) 1.00

Genome-wide identification of copy number variations in Chinese Holstein. PLoS One (2012) 1.00

Role of fusion in radiotherapy treatment planning. Semin Nucl Med (2003) 1.00

Posttraumatic stress disorder and depression among new mothers at 8 months later of the 2008 Sichuan earthquake in China. Arch Womens Ment Health (2012) 0.99

Mechanisms of endothelial dysfunction with development of type 1 diabetes mellitus: role of insulin and C-peptide. J Cell Biochem (2005) 0.99

Investigation of surface endothelialization on biomedical nitinol (NiTi) alloy: Effects of surface micropatterning combined with plasma nanocoatings. Acta Biomater (2009) 0.99

Detection and significance of human papillomavirus, CDKN2A(p16) and CDKN1A(p21) expression in squamous cell carcinoma of the larynx. Mod Pathol (2012) 0.98

Nasogastric placement of sump tube through the leak for the treatment of esophagogastric anastomotic leak after esophagectomy for esophageal carcinoma. J Surg Res (2010) 0.98

PF-03732010: a fully human monoclonal antibody against P-cadherin with antitumor and antimetastatic activity. Clin Cancer Res (2010) 0.98

A genome-wide association study identifies two novel promising candidate genes affecting Escherichia coli F4ab/F4ac susceptibility in swine. PLoS One (2012) 0.98

Relaxin and beta-estradiol modulate targeted matrix degradation in specific synovial joint fibrocartilages: progesterone prevents matrix loss. Arthritis Res Ther (2006) 0.97

Do patients return to work after hip arthroplasty surgery. J Arthroplasty (2011) 0.97

The effect of calcium and vitamin D supplementation on obesity in postmenopausal women: secondary analysis for a large-scale, placebo controlled, double-blind, 4-year longitudinal clinical trial. Nutr Metab (Lond) (2010) 0.96

Endoplasmic reticulum stress leads to lipid accumulation through upregulation of SREBP-1c in normal hepatic and hepatoma cells. Mol Cell Biochem (2013) 0.96

Transoral resection of pharyngeal cancer: summary of a National Cancer Institute Head and Neck Cancer Steering Committee Clinical Trials Planning Meeting, November 6-7, 2011, Arlington, Virginia. Head Neck (2012) 0.96

Can the Wolf Motor Function Test be streamlined? Neurorehabil Neural Repair (2009) 0.95

A quantitative histomorphometric classifier (QuHbIC) identifies aggressive versus indolent p16-positive oropharyngeal squamous cell carcinoma. Am J Surg Pathol (2014) 0.95

Radiotherapeutic management of cervical lymph node metastases from an unknown primary site. Arch Otolaryngol Head Neck Surg (2012) 0.94