Published in N Engl J Med on June 29, 2011
Screening for Prostate Cancer in Older Patients (PLCO Screening Trial) | NCT00002540
National Lung Screening Trial (NLST) Screening (NLST) | NCT00047385
NK Cell Activity in Smokers Screened for Lung Cancer | NCT02840578
LDCT Screening in Non-smokers in Taiwan | NCT02611570
Robotic ICG Guided Surgery: A Novel Technique for Targeting Small Lung Tumors (RIGGS) | NCT02570958
Metabolism of Deuterated NNN in Smokeless Tobacco Users | NCT02414477
Reducing Lung Cancer Survivors' Anxiety and Dyspnea (RELAX) (RELAX) | NCT02063828
Pre-Post Study for Supporting Appropriate Implementation of Lung Cancer Screening | NCT03077230
Implementation of Smoking Cessation Within NCI NCORP Community Sites | NCT03291587
Korean Lung Cancer Screening Project (K-LUCAS) | NCT03394703
Lung Cancer Screening: A Multilevel Intervention (LungCARE) | NCT03862001
Digital Outreach Intervention for Lung Cancer Screening (mPATH-Lung) | NCT04083859
Comparison of Esophageal Manometry and CT Scan Measurements | NCT04213911
ILAs in CT Lung Cancer Screening Population | NCT04503044
CBCT-Guided Navigational Bronchoscopy For Lung Nodules | NCT04758403
Prolonged Air Leak (PAL) Autologous Blood Patch Intervention Trial | NCT04954625
Liquid Biopsy With PET/CT Versus PET/CT Alone in Diagnosis of Small Lung Nodules | NCT05066776
Early Detection of Four Common Cancers Using the ctDNA Analysing Test (K-DETEK) | NCT05227261
Benefits and harms of CT screening for lung cancer: a systematic review. JAMA (2012) 8.71
Ovarian cancer screening and mortality in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial. Lancet (2015) 7.50
Overdiagnosis in low-dose computed tomography screening for lung cancer. JAMA Intern Med (2014) 7.39
Results of initial low-dose computed tomographic screening for lung cancer. N Engl J Med (2013) 5.92
An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage. Nat Med (2014) 4.98
Screening for lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest (2013) 4.83
Cost-effectiveness of CT screening in the National Lung Screening Trial. N Engl J Med (2014) 4.76
Probability of cancer in pulmonary nodules detected on first screening CT. N Engl J Med (2013) 4.64
Targeting of low-dose CT screening according to the risk of lung-cancer death. N Engl J Med (2013) 4.09
The transcriptional landscape and mutational profile of lung adenocarcinoma. Genome Res (2012) 3.80
Selection criteria for lung-cancer screening. N Engl J Med (2013) 3.69
Predictive accuracy of the Liverpool Lung Project risk model for stratifying patients for computed tomography screening for lung cancer: a case-control and cohort validation study. Ann Intern Med (2012) 3.45
American Cancer Society lung cancer screening guidelines. CA Cancer J Clin (2013) 3.16
Addressing overdiagnosis and overtreatment in cancer: a prescription for change. Lancet Oncol (2014) 3.04
Does the method of radiologic surveillance affect survival after resection of stage I non-small cell lung cancer? J Thorac Cardiovasc Surg (2014) 3.02
Non-small cell lung cancer: identifying prognostic imaging biomarkers by leveraging public gene expression microarray data--methods and preliminary results. Radiology (2012) 2.98
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Meta-analysis of guided bronchoscopy for the evaluation of the pulmonary nodule. Chest (2012) 2.86
Benefits and harms of computed tomography lung cancer screening strategies: a comparative modeling study for the U.S. Preventive Services Task Force. Ann Intern Med (2013) 2.77
Lung cancer: epidemiology, etiology, and prevention. Clin Chest Med (2011) 2.77
Results of the two incidence screenings in the National Lung Screening Trial. N Engl J Med (2013) 2.66
Clinical utility of a plasma-based miRNA signature classifier within computed tomography lung cancer screening: a correlative MILD trial study. J Clin Oncol (2014) 2.57
Phylogenetic ctDNA analysis depicts early stage lung cancer evolution. Nature (2017) 2.54
US lung cancer trends by histologic type. Cancer (2014) 2.46
Impact of micropapillary histologic subtype in selecting limited resection vs lobectomy for lung adenocarcinoma of 2cm or smaller. J Natl Cancer Inst (2013) 2.45
Applying what we know to accelerate cancer prevention. Sci Transl Med (2012) 2.43
Delivering high-quality and affordable care throughout the cancer care continuum. J Clin Oncol (2013) 2.39
The utility of nodule volume in the context of malignancy prediction for small pulmonary nodules. Chest (2014) 2.30
Accuracy of FDG-PET to diagnose lung cancer in areas with infectious lung disease: a meta-analysis. JAMA (2014) 2.20
Gastric adenocarcinoma screening and prevention in the era of new biomarker and endoscopic technologies: a cost-effectiveness analysis. Gut (2015) 2.19
Comparative effectiveness of 5 treatment strategies for early-stage non-small cell lung cancer in the elderly. Int J Radiat Oncol Biol Phys (2012) 2.17
Predicting lung cancer prior to surgical resection in patients with lung nodules. J Thorac Oncol (2014) 2.17
Lung Cancer Risk and Demographic Characteristics of Current 20-29 Pack-year Smokers: Implications for Screening. J Natl Cancer Inst (2015) 2.09
Decision making in patients with pulmonary nodules. Am J Respir Crit Care Med (2011) 2.05
Small cell lung cancer. J Natl Compr Canc Netw (2013) 2.04
Survival of older patients with cancer in the Veterans Health Administration versus fee-for-service Medicare. J Clin Oncol (2012) 2.00
Primary Care Provider-Delivered Smoking Cessation Interventions and Smoking Cessation Among Participants in the National Lung Screening Trial. JAMA Intern Med (2015) 1.92
Doubling times and CT screen–detected lung cancers in the Pittsburgh Lung Screening Study. Am J Respir Crit Care Med (2012) 1.90
Lobectomy, sublobar resection, and stereotactic ablative radiotherapy for early-stage non-small cell lung cancers in the elderly. JAMA Surg (2014) 1.86
Low-dose CT of the lung: potential value of iterative reconstructions. Eur Radiol (2012) 1.85
Defining a gene promoter methylation signature in sputum for lung cancer risk assessment. Clin Cancer Res (2012) 1.80
Impact of lung cancer screening results on participant health-related quality of life and state anxiety in the National Lung Screening Trial. Cancer (2014) 1.80
What do you mean, a spot?: A qualitative analysis of patients' reactions to discussions with their physicians about pulmonary nodules. Chest (2013) 1.79
Quantification of harms in cancer screening trials: literature review. BMJ (2013) 1.77
Epidemiology of lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest (2013) 1.77
The National Lung Screening Trial: results stratified by demographics, smoking history, and lung cancer histology. Cancer (2013) 1.76
Diagnosis of lung cancer in individuals with solitary pulmonary nodules by plasma microRNA biomarkers. BMC Cancer (2011) 1.74
Evaluation of the lung cancer risks at which to screen ever- and never-smokers: screening rules applied to the PLCO and NLST cohorts. PLoS Med (2014) 1.73
Plasma microRNAs as novel biomarkers for early detection of lung cancer. Int J Clin Exp Pathol (2011) 1.73
Noninvasive Computed Tomography-based Risk Stratification of Lung Adenocarcinomas in the National Lung Screening Trial. Am J Respir Crit Care Med (2015) 1.70
Matrix metalloproteinase induction of Rac1b, a key effector of lung cancer progression. Sci Transl Med (2012) 1.67
Recurrence and survival outcomes after anatomic segmentectomy versus lobectomy for clinical stage I non-small-cell lung cancer: a propensity-matched analysis. J Clin Oncol (2014) 1.65
Diacetylspermine Is a Novel Prediagnostic Serum Biomarker for Non-Small-Cell Lung Cancer and Has Additive Performance With Pro-Surfactant Protein B. J Clin Oncol (2015) 1.65
Projected outcomes using different nodule sizes to define a positive CT lung cancer screening examination. J Natl Cancer Inst (2014) 1.64
A multiplexed serum biomarker immunoassay panel discriminates clinical lung cancer patients from high-risk individuals found to be cancer-free by CT screening. J Thorac Oncol (2012) 1.63
Future directions in cancer prevention. Nat Rev Cancer (2012) 1.62
The rising challenge of non-AIDS-defining cancers in HIV-infected patients. Clin Infect Dis (2012) 1.62
Serum uric acid and the risk of respiratory disease: a population-based cohort study. Thorax (2014) 1.62
Circulating inflammation markers and prospective risk for lung cancer. J Natl Cancer Inst (2013) 1.59
Increased risk of additional cancers among patients with gastrointestinal stromal tumors: A population-based study. Cancer (2015) 1.59
Computed tomographic characteristics of interval and post screen carcinomas in lung cancer screening. Eur Radiol (2014) 1.59
Cumulative incidence of cancer after solid organ transplantation. Cancer (2013) 1.58
Development and Validation of Risk Models to Select Ever-Smokers for CT Lung Cancer Screening. JAMA (2016) 1.56
National Lung Screening Trial findings by age: Medicare-eligible versus under-65 population. Ann Intern Med (2014) 1.56
Biomarkers in early-stage non-small-cell lung cancer: current concepts and future directions. J Thorac Oncol (2014) 1.56
Addressing the future burden of cancer and its impact on the oncology workforce: where is cancer prevention and control? J Cancer Educ (2012) 1.54
Randomized, double-blind, placebo-controlled, phase III chemoprevention trial of selenium supplementation in patients with resected stage I non-small-cell lung cancer: ECOG 5597. J Clin Oncol (2013) 1.54
Cancer statistics for Asian Americans, Native Hawaiians, and Pacific Islanders, 2016: Converging incidence in males and females. CA Cancer J Clin (2016) 1.53
Low-Dose CT Lung Cancer Screening Practices and Attitudes among Primary Care Providers at an Academic Medical Center. Cancer Epidemiol Biomarkers Prev (2015) 1.52
EarlyCDT®-Lung test: improved clinical utility through additional autoantibody assays. Tumour Biol (2012) 1.52
Indolent, Potentially Inconsequential Lung Cancers in the Pittsburgh Lung Screening Study. Ann Am Thorac Soc (2015) 1.51
Clinical impact of immune microenvironment in stage I lung adenocarcinoma: tumor interleukin-12 receptor β2 (IL-12Rβ2), IL-7R, and stromal FoxP3/CD3 ratio are independent predictors of recurrence. J Clin Oncol (2012) 1.50
The invisible gorilla strikes again: sustained inattentional blindness in expert observers. Psychol Sci (2013) 1.49
The state of molecular biomarkers for the early detection of lung cancer. Cancer Prev Res (Phila) (2012) 1.49
Airflow Limitation and Histology Shift in the National Lung Screening Trial. The NLST-ACRIN Cohort Substudy. Am J Respir Crit Care Med (2015) 1.48
A cost-utility analysis of lung cancer screening and the additional benefits of incorporating smoking cessation interventions. PLoS One (2013) 1.46
Diagnosis: Early warning system. Nature (2014) 1.45
Cost-effectiveness of follow-up of pulmonary nodules incidentally detected on cardiac computed tomographic angiography in patients with suspected coronary artery disease. Circulation (2014) 1.44
Interpreting secondary cardiac disease variants in an exome cohort. Circ Cardiovasc Genet (2013) 1.43
A method to assess image quality for Low-dose PET: analysis of SNR, CNR, bias and image noise. Cancer Imaging (2016) 1.40
Pros: long-term CT scan follow-up should be the standard of care in patients who are curatively treated for an early-stage non-small cell lung cancer. Transl Lung Cancer Res (2015) 1.40
NELSON lung cancer screening study. Cancer Imaging (2011) 1.37
Single-port video-assisted thoracoscopic surgery for lung cancer. J Thorac Dis (2014) 1.36
CXCR4/CXCL12 axis in non small cell lung cancer (NSCLC) pathologic roles and therapeutic potential. Theranostics (2013) 1.35
Drinking water arsenic in northern chile: high cancer risks 40 years after exposure cessation. Cancer Epidemiol Biomarkers Prev (2013) 1.35
Promise and pitfalls of quantitative imaging in oncology clinical trials. Magn Reson Imaging (2012) 1.34
Lung cancer screening practices of primary care physicians: results from a national survey. Ann Fam Med (2012) 1.33
microRNAs derived from circulating exosomes as noninvasive biomarkers for screening and diagnosing lung cancer. J Thorac Oncol (2013) 1.31
Stigma among patients with lung cancer: a patient-reported measurement model. Psychooncology (2013) 1.30
Lung cancer incidence and mortality in National Lung Screening Trial participants who underwent low-dose CT prevalence screening: a retrospective cohort analysis of a randomised, multicentre, diagnostic screening trial. Lancet Oncol (2016) 1.30
Beliefs and attitudes about lung cancer screening among smokers. Lung Cancer (2012) 1.30
TCIA: An information resource to enable open science. Conf Proc IEEE Eng Med Biol Soc (2013) 1.29
Radiological diagnosis in lung disease: factoring treatment options into the choice of diagnostic modality. Dtsch Arztebl Int (2014) 1.29
Prognostic significance of adenocarcinoma in situ, minimally invasive adenocarcinoma, and nonmucinous lepidic predominant invasive adenocarcinoma of the lung in patients with stage I disease. Am J Surg Pathol (2014) 1.29
Preoperative evaluation for lung cancer resection. J Thorac Dis (2014) 1.27
Translational genomics: the challenge of developing cancer biomarkers. Genome Res (2012) 1.26
Tumor Spread through Air Spaces is an Important Pattern of Invasion and Impacts the Frequency and Location of Recurrences after Limited Resection for Small Stage I Lung Adenocarcinomas. J Thorac Oncol (2015) 1.24
Better evidence about screening for lung cancer. N Engl J Med (2011) 1.24
Use of lung cancer screening tests in the United States: results from the 2010 National Health Interview Survey. Cancer Epidemiol Biomarkers Prev (2012) 1.22
Lung Cancer Screening Using Low Dose CT Scanning in Germany. Dtsch Arztebl Int (2015) 1.19
Mortality results from a randomized prostate-cancer screening trial. N Engl J Med (2009) 30.05
A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nat Genet (2007) 22.96
Diagnostic performance of digital versus film mammography for breast-cancer screening. N Engl J Med (2005) 14.47
The decrease in breast-cancer incidence in 2003 in the United States. N Engl J Med (2007) 12.23
Prostate cancer screening in the randomized Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial: mortality results after 13 years of follow-up. J Natl Cancer Inst (2012) 11.91
Colorectal-cancer incidence and mortality with screening flexible sigmoidoscopy. N Engl J Med (2012) 11.48
Overdiagnosis in cancer. J Natl Cancer Inst (2010) 10.31
MRI evaluation of the contralateral breast in women with recently diagnosed breast cancer. N Engl J Med (2007) 10.28
CT angiography for safe discharge of patients with possible acute coronary syndromes. N Engl J Med (2012) 9.73
Effect of screening on ovarian cancer mortality: the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Randomized Controlled Trial. JAMA (2011) 9.13
A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1). Nat Genet (2009) 8.39
Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. Nat Genet (2009) 7.30
Screening by chest radiograph and lung cancer mortality: the Prostate, Lung, Colorectal, and Ovarian (PLCO) randomized trial. JAMA (2011) 6.45
The National Lung Screening Trial: overview and study design. Radiology (2010) 6.43
Results of initial low-dose computed tomographic screening for lung cancer. N Engl J Med (2013) 5.92
Performance of common genetic variants in breast-cancer risk models. N Engl J Med (2010) 5.79
Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nat Genet (2009) 5.14
A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet (2010) 4.89
Comorbidity and mortality results from a randomized prostate cancer screening trial. J Clin Oncol (2010) 4.84
Systematic reviews of diagnostic test accuracy. Ann Intern Med (2008) 4.84
Cost-effectiveness of CT screening in the National Lung Screening Trial. N Engl J Med (2014) 4.76
Probability of cancer in pulmonary nodules detected on first screening CT. N Engl J Med (2013) 4.64
New models for large prospective studies: is there a better way? Am J Epidemiol (2012) 3.85
Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Nat Genet (2013) 3.81
Cumulative incidence of false-positive test results in lung cancer screening: a randomized trial. Ann Intern Med (2010) 3.79
Detectable clonal mosaicism and its relationship to aging and cancer. Nat Genet (2012) 3.69
Selection criteria for lung-cancer screening. N Engl J Med (2013) 3.69
Prostate cancer screening in the Prostate, Lung, Colorectal and Ovarian cancer screening trial: update on findings from the initial four rounds of screening in a randomized trial. BJU Int (2008) 3.51
Failure of macrolide antibiotic treatment in patients with bacteremia due to erythromycin-resistant Streptococcus pneumoniae. Clin Infect Dis (2002) 3.48
A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer. Nat Genet (2011) 3.37
Postpolypectomy colonoscopy surveillance guidelines: predictive accuracy for advanced adenoma at 4 years. Ann Intern Med (2008) 3.34
Methods for etiologic and early marker investigations in the PLCO trial. Mutat Res (2005) 3.33
Utilization of surveillance colonoscopy in community practice. Gastroenterology (2009) 3.33
Ovarian cancer biomarker performance in prostate, lung, colorectal, and ovarian cancer screening trial specimens. Cancer Prev Res (Phila) (2011) 3.33
Ovarian cancer screening in the Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screening trial: findings from the initial screen of a randomized trial. Am J Obstet Gynecol (2005) 3.25
Lung image database consortium: developing a resource for the medical imaging research community. Radiology (2004) 3.19
Race and colorectal cancer disparities: health-care utilization vs different cancer susceptibilities. J Natl Cancer Inst (2010) 3.16
Positron emission tomography/computed tomography identification of clear cell renal cell carcinoma: results from the REDECT trial. J Clin Oncol (2012) 3.03
A framework for evaluating biomarkers for early detection: validation of biomarker panels for ovarian cancer. Cancer Prev Res (Phila) (2011) 3.03
Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3. Nat Genet (2010) 2.96
Impact of positron emission tomography/computed tomography and positron emission tomography (PET) alone on expected management of patients with cancer: initial results from the National Oncologic PET Registry. J Clin Oncol (2008) 2.96
Prostate Cancer Screening in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial: findings from the initial screening round of a randomized trial. J Natl Cancer Inst (2005) 2.82
Final results of the Lung Screening Study, a randomized feasibility study of spiral CT versus chest X-ray screening for lung cancer. Lung Cancer (2005) 2.79
Benefits and harms of computed tomography lung cancer screening strategies: a comparative modeling study for the U.S. Preventive Services Task Force. Ann Intern Med (2013) 2.77
Description and implementation of a quality control program in an imaging-based clinical trial. Acad Radiol (2006) 2.71
Results of the two incidence screenings in the National Lung Screening Trial. N Engl J Med (2013) 2.66
National Institutes of Health State-of-the-Science Conference statement: Diagnosis and Management of Ductal Carcinoma In Situ September 22-24, 2009. J Natl Cancer Inst (2010) 2.59
Baseline characteristics of participants in the randomized national lung screening trial. J Natl Cancer Inst (2010) 2.50
Are deaths within 1 month of cancer-directed surgery attributed to cancer? J Natl Cancer Inst (2002) 2.48
The Lung Image Database Consortium (LIDC) and Image Database Resource Initiative (IDRI): a completed reference database of lung nodules on CT scans. Med Phys (2011) 2.48
A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11. Hum Mol Genet (2012) 2.45
International Association for the Study of Lung Cancer Computed Tomography Screening Workshop 2011 report. J Thorac Oncol (2012) 2.45
Variation in vector competence for dengue 2 virus among 24 collections of Aedes aegypti from Mexico and the United States. Am J Trop Med Hyg (2002) 2.41
Genomic analysis of detoxification genes in the mosquito Aedes aegypti. Insect Biochem Mol Biol (2007) 2.38
Designing studies to ensure that estimates of test accuracy are transferable. BMJ (2002) 2.36
Lung cancer risk prediction: Prostate, Lung, Colorectal And Ovarian Cancer Screening Trial models and validation. J Natl Cancer Inst (2011) 2.31
Screening women at high risk for breast cancer with mammography and magnetic resonance imaging. Cancer (2005) 2.25
Baseline chest radiograph for lung cancer detection in the randomized Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. J Natl Cancer Inst (2005) 2.24
A simplified high-throughput method for pyrethroid knock-down resistance (kdr) detection in Anopheles gambiae. Malar J (2005) 2.23
Serum prostate-specific antigen hemodilution among obese men undergoing screening in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Cancer Epidemiol Biomarkers Prev (2009) 2.20
The prevalence of atrial fibrillation in incident stroke cases and matched population controls in Rochester, Minnesota: changes over three decades. J Am Coll Cardiol (2003) 2.19
National Institutes of Health Consensus Development Conference Statement: management of hepatitis B. Ann Intern Med (2009) 2.19
Cancer yield of mammography, MR, and US in high-risk women: prospective multi-institution breast cancer screening study. Radiology (2007) 2.18
Proportion of second cancers attributable to radiotherapy treatment in adults: a cohort study in the US SEER cancer registries. Lancet Oncol (2011) 2.16
The Lung Image Database Consortium (LIDC) data collection process for nodule detection and annotation. Acad Radiol (2007) 2.15
Reasons women at elevated risk of breast cancer refuse breast MR imaging screening: ACRIN 6666. Radiology (2010) 2.13
Does kdr genotype predict insecticide-resistance phenotype in mosquitoes? Trends Parasitol (2009) 2.13