The discovery of 5-formylcytosine in embryonic stem cell DNA.

PubWeight™: 4.39‹?› | Rank: Top 1%

🔗 View Article (PMID 21721093)

Published in Angew Chem Int Ed Engl on June 30, 2011

Authors

Toni Pfaffeneder1, Benjamin Hackner, Matthias Truss, Martin Münzel, Markus Müller, Christian A Deiml, Christian Hagemeier, Thomas Carell

Author Affiliations

1: CIPSM, Fakultät für Chemie und Pharmazie, Ludwig-Maximilians-Universität München, München, Germany.

Articles citing this

(truncated to the top 100)

Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science (2011) 13.16

Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome. Cell (2012) 7.09

Thymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sites. J Biol Chem (2011) 4.64

Uncovering the role of 5-hydroxymethylcytosine in the epigenome. Nat Rev Genet (2011) 4.25

Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation. Genes Dev (2011) 4.09

TETonic shift: biological roles of TET proteins in DNA demethylation and transcription. Nat Rev Mol Cell Biol (2013) 3.18

Reversing DNA methylation: mechanisms, genomics, and biological functions. Cell (2014) 3.17

Genome-wide profiling of 5-formylcytosine reveals its roles in epigenetic priming. Cell (2013) 3.13

Genome-wide analysis reveals TET- and TDG-dependent 5-methylcytosine oxidation dynamics. Cell (2013) 3.09

Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA. Nat Chem Biol (2012) 2.45

Generation and replication-dependent dilution of 5fC and 5caC during mouse preimplantation development. Cell Res (2011) 2.36

Tet family proteins and 5-hydroxymethylcytosine in development and disease. Development (2012) 2.24

DNA methylation: TET proteins-guardians of CpG islands? EMBO Rep (2011) 2.23

AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation. Nat Chem Biol (2012) 2.04

Genome-wide distribution of 5-formylcytosine in embryonic stem cells is associated with transcription and depends on thymine DNA glycosylase. Genome Biol (2012) 1.94

5-formylcytosine and 5-carboxylcytosine reduce the rate and substrate specificity of RNA polymerase II transcription. Nat Struct Mol Biol (2012) 1.67

Tet-assisted bisulfite sequencing of 5-hydroxymethylcytosine. Nat Protoc (2012) 1.66

DNA methylation in mammals. Cold Spring Harb Perspect Biol (2014) 1.57

Oxidative bisulfite sequencing of 5-methylcytosine and 5-hydroxymethylcytosine. Nat Protoc (2013) 1.54

Mapping recently identified nucleotide variants in the genome and transcriptome. Nat Biotechnol (2012) 1.51

5mC oxidation by Tet2 modulates enhancer activity and timing of transcriptome reprogramming during differentiation. Mol Cell (2014) 1.42

Mechanism and function of oxidative reversal of DNA and RNA methylation. Annu Rev Biochem (2014) 1.36

Quantitative sequencing of 5-formylcytosine in DNA at single-base resolution. Nat Chem (2014) 1.35

Identification of methylated deoxyadenosines in vertebrates reveals diversity in DNA modifications. Nat Struct Mol Biol (2015) 1.29

The curious chemical biology of cytosine: deamination, methylation, and oxidation as modulators of genomic potential. ACS Chem Biol (2011) 1.25

DNA methylation and methylcytosine oxidation in cell fate decisions. Curr Opin Cell Biol (2013) 1.24

Enhanced 5-methylcytosine detection in single-molecule, real-time sequencing via Tet1 oxidation. BMC Biol (2013) 1.24

The anti-CMS technique for genome-wide mapping of 5-hydroxymethylcytosine. Nat Protoc (2012) 1.24

Primordial germ cells in mice. Cold Spring Harb Perspect Biol (2012) 1.23

Potential functional roles of DNA demethylation intermediates. Trends Biochem Sci (2013) 1.21

Nucleic acid modifications with epigenetic significance. Curr Opin Chem Biol (2012) 1.20

Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex. Nature (2015) 1.20

Nanopores discriminate among five C5-cytosine variants in DNA. J Am Chem Soc (2014) 1.17

Tet-mediated formation of 5-hydroxymethylcytosine in RNA. J Am Chem Soc (2014) 1.14

DNA base damage by reactive oxygen species, oxidizing agents, and UV radiation. Cold Spring Harb Perspect Biol (2013) 1.11

FTO-mediated formation of N6-hydroxymethyladenosine and N6-formyladenosine in mammalian RNA. Nat Commun (2013) 1.10

Role of TET enzymes in DNA methylation, development, and cancer. Genes Dev (2016) 1.08

Ontogeny, distribution and potential roles of 5-hydroxymethylcytosine in human liver function. Genome Biol (2013) 1.04

Chemical modification-assisted bisulfite sequencing (CAB-Seq) for 5-carboxylcytosine detection in DNA. J Am Chem Soc (2013) 1.03

Genome-wide alteration of 5-hydroxymethylcytosine in a mouse model of fragile X-associated tremor/ataxia syndrome. Hum Mol Genet (2013) 1.03

5-Hydroxymethylcytosine--the elusive epigenetic mark in mammalian DNA. Chem Soc Rev (2012) 1.02

DNA demethylation by TDG. Epigenomics (2012) 1.01

BZLF1 governs CpG-methylated chromatin of Epstein-Barr Virus reversing epigenetic repression. PLoS Pathog (2012) 1.01

The GLIB technique for genome-wide mapping of 5-hydroxymethylcytosine. Nat Protoc (2012) 1.01

Nucleic acid oxidation in DNA damage repair and epigenetics. Chem Rev (2014) 1.01

Role of base excision repair in maintaining the genetic and epigenetic integrity of CpG sites. DNA Repair (Amst) (2015) 1.01

5-Formylcytosine alters the structure of the DNA double helix. Nat Struct Mol Biol (2014) 1.00

Age-Dependent Levels of 5-Methyl-, 5-Hydroxymethyl-, and 5-Formylcytosine in Human and Mouse Brain Tissues. Angew Chem Int Ed Engl (2015) 0.99

Tet-mediated covalent labelling of 5-methylcytosine for its genome-wide detection and sequencing. Nat Commun (2013) 0.99

CDA directs metabolism of epigenetic nucleosides revealing a therapeutic window in cancer. Nature (2015) 0.99

Epigenetic changes in the progression of Alzheimer's disease. Mech Ageing Dev (2013) 0.97

Biologically relevant oxidants and terminology, classification and nomenclature of oxidatively generated damage to nucleobases and 2-deoxyribose in nucleic acids. Free Radic Res (2012) 0.97

Base-resolution maps of 5-formylcytosine and 5-carboxylcytosine reveal genome-wide DNA demethylation dynamics. Cell Res (2015) 0.96

NSUN3 and ABH1 modify the wobble position of mt-tRNAMet to expand codon recognition in mitochondrial translation. EMBO J (2016) 0.96

DNA methylation, its mediators and genome integrity. Int J Biol Sci (2015) 0.96

TET-mediated oxidation of methylcytosine causes TDG or NEIL glycosylase dependent gene reactivation. Nucleic Acids Res (2014) 0.95

Regulation of DNA methylation dictates Cd4 expression during the development of helper and cytotoxic T cell lineages. Nat Immunol (2015) 0.95

Chemical methods for decoding cytosine modifications in DNA. Chem Rev (2014) 0.95

TET family proteins: oxidation activity, interacting molecules, and functions in diseases. Chem Rev (2015) 0.94

Identification of DNA methylation changes at cis-regulatory elements during early steps of HSC differentiation using tagmentation-based whole genome bisulfite sequencing. Cell Cycle (2014) 0.93

Divergent mechanisms for enzymatic excision of 5-formylcytosine and 5-carboxylcytosine from DNA. J Am Chem Soc (2013) 0.93

Biochemical reconstitution of TET1-TDG-BER-dependent active DNA demethylation reveals a highly coordinated mechanism. Nat Commun (2016) 0.92

5-Hydroxymethylcytosine, the "Sixth Base", during brain development and ageing. J Neural Transm (Vienna) (2014) 0.92

Crystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed light on the search for DNA decarboxylase. Cell Res (2013) 0.91

Phosphorylation of TET proteins is regulated via O-GlcNAcylation by the O-linked N-acetylglucosamine transferase (OGT). J Biol Chem (2015) 0.91

Enzymatic analysis of Tet proteins: key enzymes in the metabolism of DNA methylation. Methods Enzymol (2012) 0.91

Genome-wide comparison of DNA hydroxymethylation in mouse embryonic stem cells and neural progenitor cells by a new comparative hMeDIP-seq method. Nucleic Acids Res (2013) 0.91

A TET homologue protein from Coprinopsis cinerea (CcTET) that biochemically converts 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine. J Am Chem Soc (2014) 0.90

Nucleic Acid Modifications in Regulation of Gene Expression. Cell Chem Biol (2016) 0.90

Unlocking epigenetic codes in neurogenesis. Genes Dev (2014) 0.89

Selective excision of 5-carboxylcytosine by a thymine DNA glycosylase mutant. J Mol Biol (2013) 0.89

Mechanisms for enzymatic cleavage of the N-glycosidic bond in DNA. Org Biomol Chem (2014) 0.88

The genetic and epigenetic journey of embryonic stem cells into mature neural cells. Front Genet (2012) 0.87

A density functional theory study on the kinetics and thermodynamics of N-glycosidic bond cleavage in 5-substituted 2'-deoxycytidines. Biochemistry (2012) 0.86

Detection of oxidation products of 5-methyl-2'-deoxycytidine in Arabidopsis DNA. PLoS One (2013) 0.86

Bisulfite-free, base-resolution analysis of 5-formylcytosine at the genome scale. Nat Methods (2015) 0.86

Alterations of 5-hydroxymethylcytosine in human cancers. Cancers (Basel) (2013) 0.85

Epigenetic mechanisms in commonly occurring cancers. DNA Cell Biol (2012) 0.84

A comprehensive view of the epigenetic landscape part I: DNA methylation, passive and active DNA demethylation pathways and histone variants. Neurotox Res (2014) 0.83

Differential stabilities and sequence-dependent base pair opening dynamics of Watson-Crick base pairs with 5-hydroxymethylcytosine, 5-formylcytosine, or 5-carboxylcytosine. Biochemistry (2015) 0.83

Mutagenic and cytotoxic properties of oxidation products of 5-methylcytosine revealed by next-generation sequencing. PLoS One (2013) 0.83

Effects of Tet-mediated oxidation products of 5-methylcytosine on DNA transcription in vitro and in mammalian cells. Sci Rep (2014) 0.83

The Mechanisms of Generation, Recognition, and Erasure of DNA 5-Methylcytosine and Thymine Oxidations. J Biol Chem (2015) 0.83

Tet2 Catalyzes Stepwise 5-Methylcytosine Oxidation by an Iterative and de novo Mechanism. J Am Chem Soc (2016) 0.83

In vivo genome-wide profiling reveals a tissue-specific role for 5-formylcytosine. Genome Biol (2016) 0.82

Cytosine modifications in neurodevelopment and diseases. Cell Mol Life Sci (2013) 0.81

E2-mediated small ubiquitin-like modifier (SUMO) modification of thymine DNA glycosylase is efficient but not selective for the enzyme-product complex. J Biol Chem (2014) 0.81

Pyrene-based quantitative detection of the 5-formylcytosine loci symmetry in the CpG duplex content during TET-dependent demethylation. Angew Chem Int Ed Engl (2014) 0.81

Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation. Nat Struct Mol Biol (2016) 0.80

Thymine DNA glycosylase exhibits negligible affinity for nucleobases that it removes from DNA. Nucleic Acids Res (2015) 0.80

Potent methyl oxidation of 5-methyl-2'-deoxycytidine by halogenated quinoid carcinogens and hydrogen peroxide via a metal-independent mechanism. Free Radic Biol Med (2013) 0.80

Comprehensive Assessment of Oxidatively Induced Modifications of DNA in a Rat Model of Human Wilson's Disease. Mol Cell Proteomics (2015) 0.80

Tissue-Specific Differences in DNA Modifications (5-Hydroxymethylcytosine, 5-Formylcytosine, 5-Carboxylcytosine and 5-Hydroxymethyluracil) and Their Interrelationships. PLoS One (2015) 0.80

Mutations along a TET2 active site scaffold stall oxidation at 5-hydroxymethylcytosine. Nat Chem Biol (2016) 0.79

Effects of cytosine modifications on DNA flexibility and nucleosome mechanical stability. Nat Commun (2016) 0.79

5-Hydroxymethylcytosine promotes proliferation of human uterine leiomyoma: a biological link to a new epigenetic modification in benign tumors. J Clin Endocrinol Metab (2014) 0.79

Simultaneous sequencing of oxidized methylcytosines produced by TET/JBP dioxygenases in Coprinopsis cinerea. Proc Natl Acad Sci U S A (2014) 0.79

Selective Chemical Labeling of Natural T Modifications in DNA. J Am Chem Soc (2015) 0.78

Mammalian DNA demethylation: multiple faces and upstream regulation. Epigenetics (2013) 0.78

Effects of tet-induced oxidation products of 5-methylcytosine on DNA replication in mammalian cells. Chem Res Toxicol (2014) 0.78

Articles by these authors

pROC: an open-source package for R and S+ to analyze and compare ROC curves. BMC Bioinformatics (2011) 16.75

Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates. PLoS One (2010) 6.38

Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives. Cell (2013) 4.16

SuperHirn - a novel tool for high resolution LC-MS-based peptide/protein profiling. Proteomics (2007) 3.60

Quantification of the sixth DNA base hydroxymethylcytosine in the brain. Angew Chem Int Ed Engl (2010) 3.50

Safety and immunogenicity of a novel multivalent OspA vaccine against Lyme borreliosis in healthy adults: a double-blind, randomised, dose-escalation phase 1/2 trial. Lancet Infect Dis (2013) 3.46

A clinical trial of a whole-virus H5N1 vaccine derived from cell culture. N Engl J Med (2008) 3.28

Error-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymerase. Nature (2004) 2.68

An integrated mass spectrometric and computational framework for the analysis of protein interaction networks. Nat Biotechnol (2007) 2.59

Crystal structure of a photolyase bound to a CPD-like DNA lesion after in situ repair. Science (2004) 2.51

Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals. EMBO J (2009) 2.37

DNMT1 but not its interaction with the replication machinery is required for maintenance of DNA methylation in human cells. J Cell Biol (2007) 2.20

Mechanism of translesion transcription by RNA polymerase II and its role in cellular resistance to DNA damage. Mol Cell (2012) 1.96

Bypass of DNA lesions generated during anticancer treatment with cisplatin by DNA polymerase eta. Science (2007) 1.94

Click chemistry as a reliable method for the high-density postsynthetic functionalization of alkyne-modified DNA. Org Lett (2006) 1.85

CPD damage recognition by transcribing RNA polymerase II. Science (2007) 1.80

Crystal structure and mechanism of a DNA (6-4) photolyase. Angew Chem Int Ed Engl (2008) 1.76

High resolution PTR-TOF: quantification and formula confirmation of VOC in real time. J Am Soc Mass Spectrom (2010) 1.72

Thymine dimerization in DNA is an ultrafast photoreaction. Science (2007) 1.68

Annexin A3 in urine: a highly specific noninvasive marker for prostate cancer early detection. J Urol (2008) 1.68

Expression levels of the EZH2 polycomb transcriptional repressor correlate with aggressiveness and invasive potential of bladder carcinomas. Int J Mol Med (2005) 1.67

In vitro and in vivo evaluation of [18F]ciprofloxacin for the imaging of bacterial infections with PET. Eur J Nucl Med Mol Imaging (2004) 1.67

Mutations and deletions of the TP53 gene predict nonresponse to treatment and poor outcome in first relapse of childhood acute lymphoblastic leukemia. J Clin Oncol (2011) 1.61

Bioinformatics for protein biomarker panel classification: what is needed to bring biomarker panels into in vitro diagnostics? Expert Rev Proteomics (2009) 1.61

5-Hydroxymethylcytosine, the sixth base of the genome. Angew Chem Int Ed Engl (2011) 1.56

A pilot study to assess the efficacy of tariquidar to inhibit P-glycoprotein at the human blood-brain barrier with (R)-11C-verapamil and PET. J Nucl Med (2009) 1.56

Pharmacoresistance in epilepsy: a pilot PET study with the P-glycoprotein substrate R-[(11)C]verapamil. Epilepsia (2007) 1.55

Cost-effectiveness of preoperative SPECT/CT combined with lymphoscintigraphy vs. lymphoscintigraphy for sentinel lymph node excision in patients with cutaneous malignant melanoma. Eur J Nucl Med Mol Imaging (2014) 1.49

The RIG-I ATPase domain structure reveals insights into ATP-dependent antiviral signalling. EMBO Rep (2011) 1.47

An open-system quantum simulator with trapped ions. Nature (2011) 1.46

DNA--metal base pairs. Angew Chem Int Ed Engl (2007) 1.46

In vivo profile of the human leukocyte microRNA response to endotoxemia. Biochem Biophys Res Commun (2009) 1.45

Tariquidar-induced P-glycoprotein inhibition at the rat blood-brain barrier studied with (R)-11C-verapamil and PET. J Nucl Med (2008) 1.44

Processing and classification of protein mass spectra. Mass Spectrom Rev (2006) 1.42

Search strategies-identified reports on "off-label" drug use in MEDLINE. J Clin Epidemiol (2012) 1.41

Stage-adapted treatment of HIV-associated Hodgkin lymphoma: results of a prospective multicenter study. J Clin Oncol (2012) 1.41

Automated protein identification by tandem mass spectrometry: issues and strategies. Mass Spectrom Rev (2006) 1.40

Quantitative proteomic analysis of protein complexes: concurrent identification of interactors and their state of phosphorylation. Mol Cell Proteomics (2007) 1.38

AAPS-FDA workshop white paper: microdialysis principles, application and regulatory perspectives. Pharm Res (2007) 1.35

Mechanism and stem-cell activity of 5-carboxycytosine decarboxylation determined by isotope tracing. Angew Chem Int Ed Engl (2012) 1.34

Blood-brain barrier P-glycoprotein function in Alzheimer's disease. Brain (2011) 1.33

Structural basis for the recognition of the FapydG lesion (2,6-diamino-4-hydroxy-5-formamidopyrimidine) by formamidopyrimidine-DNA glycosylase. J Biol Chem (2004) 1.33

Mechanism of transcriptional stalling at cisplatin-damaged DNA. Nat Struct Mol Biol (2007) 1.32

Copper-free "click" modification of DNA via nitrile oxide-norbornene 1,3-dipolar cycloaddition. Org Lett (2009) 1.31

Postsynthetic DNA modification through the copper-catalyzed azide-alkyne cycloaddition reaction. Angew Chem Int Ed Engl (2008) 1.30

Low values of 5-hydroxymethylcytosine (5hmC), the "sixth base," are associated with anaplasia in human brain tumors. Int J Cancer (2012) 1.30

Dissociable network properties of anesthetic state transitions. Anesthesiology (2011) 1.29

PCNA ubiquitination is important, but not essential for translesion DNA synthesis in mammalian cells. PLoS Genet (2011) 1.27

Directed DNA metallization. J Am Chem Soc (2006) 1.26

A genetically encoded norbornene amino acid for the mild and selective modification of proteins in a copper-free click reaction. Angew Chem Int Ed Engl (2012) 1.25

Peripheral metabolism of (R)-[11C]verapamil in epilepsy patients. Eur J Nucl Med Mol Imaging (2007) 1.25

Quantum Google in a complex network. Sci Rep (2013) 1.24

Recognition and repair of UV lesions in loop structures of duplex DNA by DASH-type cryptochrome. Proc Natl Acad Sci U S A (2008) 1.24

Classical Hodgkin lymphoma is characterized by high constitutive expression of activating transcription factor 3 (ATF3), which promotes viability of Hodgkin/Reed-Sternberg cells. Blood (2005) 1.24

Rational dosing of antibiotics: the use of plasma concentrations versus tissue concentrations. Int J Antimicrob Agents (2002) 1.23

Dose-response assessment of tariquidar and elacridar and regional quantification of P-glycoprotein inhibition at the rat blood-brain barrier using (R)-[(11)C]verapamil PET. Eur J Nucl Med Mol Imaging (2009) 1.23

Inhibition of human cytomegalovirus replication by small interfering RNAs. J Gen Virol (2004) 1.20

A combined CXCL10, CXCL8 and H-FABP panel for the staging of human African trypanosomiasis patients. PLoS Negl Trop Dis (2009) 1.20

Synthesis and in vivo evaluation of [11C]tariquidar, a positron emission tomography radiotracer based on a third-generation P-glycoprotein inhibitor. Bioorg Med Chem (2010) 1.20

EasyProt--an easy-to-use graphical platform for proteomics data analysis. J Proteomics (2012) 1.20

Influence of functional haplotypes in the drug transporter gene ABCB1 on central nervous system drug distribution in humans. Clin Pharmacol Ther (2005) 1.19

Asymmetric dimethylarginine predicts major adverse cardiovascular events in patients with advanced peripheral artery disease. Arterioscler Thromb Vasc Biol (2006) 1.18

Mutation in the Scyl1 gene encoding amino-terminal kinase-like protein causes a recessive form of spinocerebellar neurodegeneration. EMBO Rep (2007) 1.18

DNA damage bypass operates in the S and G2 phases of the cell cycle and exhibits differential mutagenicity. Nucleic Acids Res (2011) 1.17

Human cytomegalovirus prevents replication licensing by inhibiting MCM loading onto chromatin. EMBO Rep (2003) 1.16

Detection of plant volatiles after leaf wounding and darkening by proton transfer reaction "time-of-flight" mass spectrometry (PTR-TOF). PLoS One (2011) 1.15

Parallel isotope-based quantification of modified tRNA nucleosides. Angew Chem Int Ed Engl (2009) 1.14

The RNA-binding protein RBM3 is required for cell proliferation and protects against serum deprivation-induced cell death. Pediatr Res (2010) 1.14

pH dependence of melanoma cell migration: protons extruded by NHE1 dominate protons of the bulk solution. J Physiol (2007) 1.13

TGGE screening of the entire FBN1 coding sequence in 126 individuals with marfan syndrome and related fibrillinopathies. Hum Mutat (2002) 1.13

Characterization of a new thermophilic spore photoproduct lyase from Geobacillus stearothermophilus (SplG) with defined lesion containing DNA substrates. J Biol Chem (2006) 1.13

Treatment of AIDS-related lymphomas: rituximab is beneficial even in severely immunosuppressed patients. AIDS (2012) 1.12

A cell culture (Vero)-derived H5N1 whole-virus vaccine induces cross-reactive memory responses. J Infect Dis (2009) 1.10

Microdialysis: current applications in clinical pharmacokinetic studies and its potential role in the future. Clin Pharmacokinet (2005) 1.10

Penetration of linezolid into soft tissues of healthy volunteers after single and multiple doses. Antimicrob Agents Chemother (2005) 1.10

Synthesis and small-animal positron emission tomography evaluation of [11C]-elacridar as a radiotracer to assess the distribution of P-glycoprotein at the blood-brain barrier. J Med Chem (2009) 1.09

Plasma and tissue pharmacokinetics of cefpirome in patients with sepsis. Crit Care Med (2002) 1.09

Click-click-click: single to triple modification of DNA. Angew Chem Int Ed Engl (2008) 1.09

The latency-associated UL138 gene product of human cytomegalovirus sensitizes cells to tumor necrosis factor alpha (TNF-alpha) signaling by upregulating TNF-alpha receptor 1 cell surface expression. J Virol (2011) 1.08

Efficient synthesis of 5-hydroxymethylcytosine containing DNA. Org Lett (2010) 1.07

Base pairing and replicative processing of the formamidopyrimidine-dG DNA lesion. J Am Chem Soc (2005) 1.07

Reversible bond formation enables the replication and amplification of a crosslinking salen complex as an orthogonal base pair. Nat Chem (2011) 1.07

Synthesis of highly modified DNA by a combination of PCR with alkyne-bearing triphosphates and click chemistry. Chemistry (2007) 1.06

Gastric cancer growth control by BEZ235 in vivo does not correlate with PI3K/mTOR target inhibition but with [18F]FLT uptake. Clin Cancer Res (2011) 1.06