Autophagy as a therapeutic target in cardiovascular disease.

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Molecular mechanisms of diabetic cardiomyopathy. Diabetologia (2014) 1.53

Therapeutic targeting of autophagy in disease: biology and pharmacology. Pharmacol Rev (2013) 1.25

Akt2 knockout preserves cardiac function in high-fat diet-induced obesity by rescuing cardiac autophagosome maturation. J Mol Cell Biol (2012) 1.20

Adiponectin knockout accentuates high fat diet-induced obesity and cardiac dysfunction: role of autophagy. Biochim Biophys Acta (2013) 1.18

Relationship between the proteasomal system and autophagy. Int J Biochem Mol Biol (2013) 1.16

Translational evidence that impaired autophagy contributes to arterial ageing. J Physiol (2012) 1.12

Molecular mechanisms of autophagy in the cardiovascular system. Circ Res (2015) 1.10

Transition from obesity to metabolic syndrome is associated with altered myocardial autophagy and apoptosis. Arterioscler Thromb Vasc Biol (2012) 1.07

Suppression of autophagy is protective in high glucose-induced cardiomyocyte injury. Autophagy (2012) 1.05

Berberine alleviates ox-LDL induced inflammatory factors by up-regulation of autophagy via AMPK/mTOR signaling pathway. J Transl Med (2015) 0.99

Regulation of the autophagic bcl-2/beclin 1 interaction. Cells (2012) 0.98

Deficiency in AMPK attenuates ethanol-induced cardiac contractile dysfunction through inhibition of autophagosome formation. Cardiovasc Res (2012) 0.97

Cardiac alpha1-adrenergic receptors: novel aspects of expression, signaling mechanisms, physiologic function, and clinical importance. Pharmacol Rev (2013) 0.96

Mechanical unloading activates FoxO3 to trigger Bnip3-dependent cardiomyocyte atrophy. J Am Heart Assoc (2013) 0.94

Proteotoxicity: an underappreciated pathology in cardiac disease. J Mol Cell Cardiol (2013) 0.91

Neddylation and deneddylation in cardiac biology. Am J Cardiovasc Dis (2014) 0.90

Implications of autophagy for vascular smooth muscle cell function and plasticity. Free Radic Biol Med (2013) 0.88

Obesity and weight loss result in increased adipose tissue ABCG1 expression in db/db mice. Biochim Biophys Acta (2011) 0.88

Oxidative stress and autophagy in cardiovascular homeostasis. Antioxid Redox Signal (2013) 0.86

Autophagic regulation of smooth muscle cell biology. Redox Biol (2014) 0.85

RalGDS-dependent cardiomyocyte autophagy is required for load-induced ventricular hypertrophy. J Mol Cell Cardiol (2013) 0.84

Extracellular nucleotides inhibit insulin receptor signaling, stimulate autophagy and control lipoprotein secretion. PLoS One (2012) 0.84

MAFbx/Atrogin-1 is required for atrophic remodeling of the unloaded heart. J Mol Cell Cardiol (2014) 0.83

Heavy metal scavenger metallothionein attenuates ER stress-induced myocardial contractile anomalies: role of autophagy. Toxicol Lett (2014) 0.83

Cardiac autophagy: good with the bad. J Cardiovasc Pharmacol (2012) 0.83

Carboxyl terminus of Hsp70-interacting protein (CHIP) is required to modulate cardiac hypertrophy and attenuate autophagy during exercise. Cell Biochem Funct (2013) 0.83

Cardiovascular autophagy: crossroads of pathology, pharmacology and toxicology. Cardiovasc Toxicol (2013) 0.82

Aliskiren ameliorates pressure overload-induced heart hypertrophy and fibrosis in mice. Acta Pharmacol Sin (2014) 0.82

Cardiac-specific catalase overexpression rescues anthrax lethal toxin-induced cardiac contractile dysfunction: role of oxidative stress and autophagy. BMC Med (2012) 0.81

Cardiomyocyte autophagy: metabolic profit and loss. Heart Fail Rev (2013) 0.81

Sodium Butyrate Induces Endoplasmic Reticulum Stress and Autophagy in Colorectal Cells: Implications for Apoptosis. PLoS One (2016) 0.81

Targets, trafficking, and timing of cardiac autophagy. Pharmacol Res (2012) 0.80

Heavy metal scavenger metallothionein mitigates deep hypothermia-induced myocardial contractile anomalies: role of autophagy. Am J Physiol Endocrinol Metab (2012) 0.80

Pharmacologic preconditioning with berberine attenuating ischemia-induced apoptosis and promoting autophagy in neuron. Am J Transl Res (2016) 0.79

Therapeutic targeting of autophagy in cardiovascular disease. J Mol Cell Cardiol (2015) 0.79

mTOR-Independent autophagy inducer trehalose rescues against insulin resistance-induced myocardial contractile anomalies: Role of p38 MAPK and Foxo1. Pharmacol Res (2016) 0.78

Danon disease - dysregulation of autophagy in a multisystem disorder with cardiomyopathy. J Cell Sci (2016) 0.78

Eicosapentaenoic acid attenuated oxidative stress-induced cardiomyoblast apoptosis by activating adaptive autophagy. Eur J Nutr (2013) 0.78

AMP-activated protein kinase deficiency rescues paraquat-induced cardiac contractile dysfunction through an autophagy-dependent mechanism. Toxicol Sci (2014) 0.78

BRG1 and BRM SWI/SNF ATPases redundantly maintain cardiomyocyte homeostasis by regulating cardiomyocyte mitophagy and mitochondrial dynamics in vivo. Cardiovasc Pathol (2016) 0.78

MiR-129-5p-mediated Beclin-1 suppression inhibits endothelial cell autophagy in atherosclerosis. Am J Transl Res (2016) 0.78

The role of autophagy in cardiac hypertrophy. Acta Biochim Biophys Sin (Shanghai) (2016) 0.78

Akt2 knockout alleviates prolonged caloric restriction-induced change in cardiac contractile function through regulation of autophagy. J Mol Cell Cardiol (2013) 0.77

MicroRNA regulation of autophagy in cardiovascular disease. Front Biosci (Landmark Ed) (2017) 0.76

Nuclear factor erythroid-2 related factor 2 (Nrf2)-mediated protein quality control in cardiomyocytes. Front Biosci (Landmark Ed) (2016) 0.76

The potential role of lysosome-associated membrane protein 3 (LAMP3) on cardiac remodelling. Am J Transl Res (2016) 0.76

Echinochrome A regulates phosphorylation of phospholamban Ser16 and Thr17 suppressing cardiac SERCA2A Ca²⁺ reuptake. Pflugers Arch (2014) 0.75

Ginsenoside Rg1 protects starving H9c2 cells by dissociation of Bcl-2-Beclin1 complex. BMC Complement Altern Med (2016) 0.75

Mitochondrial functional impairment in response to environmental toxins in the cardiorenal metabolic syndrome. Arch Toxicol (2015) 0.75

Sestrin 1 ameliorates cardiac hypertrophy via autophagy activation. J Cell Mol Med (2017) 0.75

Altered mTOR and Beclin-1 mediated autophagic activation during right ventricular remodeling in monocrotaline-induced pulmonary hypertension. Respir Res (2017) 0.75

Diet-induced obesity impairs spermatogenesis: a potential role for autophagy. Sci Rep (2017) 0.75

Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue. Biochem J (1955) 38.61

Autophagy in the pathogenesis of disease. Cell (2008) 34.68

Autophagy fights disease through cellular self-digestion. Nature (2008) 33.83

Heart disease and stroke statistics--2011 update: a report from the American Heart Association. Circulation (2010) 30.07

The role of autophagy during the early neonatal starvation period. Nature (2004) 22.40

Methods in mammalian autophagy research. Cell (2010) 20.08

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature (2009) 19.56

Autophagy as a regulated pathway of cellular degradation. Science (2000) 17.27

Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol (2007) 15.47

Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet (2009) 14.06

Autophagosome formation: core machinery and adaptations. Nat Cell Biol (2007) 13.59

An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J Biol Chem (2009) 12.73

Autophagy: from phenomenology to molecular understanding in less than a decade. Nat Rev Mol Cell Biol (2007) 10.79

The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat Rev Genet (2009) 9.68

Dynamics and diversity in autophagy mechanisms: lessons from yeast. Nat Rev Mol Cell Biol (2009) 9.32

Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol Biol Cell (2009) 9.14

Eaten alive: a history of macroautophagy. Nat Cell Biol (2010) 8.83

The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat Med (2007) 8.82

Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. J Biol Chem (2000) 8.68

Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy. Circ Res (2007) 8.44

Autophagy and metabolism. Science (2010) 8.10

Recent progress in the biology and physiology of sirtuins. Nature (2009) 7.73

The coordinate regulation of the p53 and mTOR pathways in cells. Proc Natl Acad Sci U S A (2005) 7.38

Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy. Autophagy (2005) 7.33

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells. J Cell Biol (2008) 7.16

Autophagic cell death: the story of a misnomer. Nat Rev Mol Cell Biol (2008) 6.78

AMPK in Health and Disease. Physiol Rev (2009) 6.38

Regulation of mammalian autophagy in physiology and pathophysiology. Physiol Rev (2010) 6.35

Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice. Nature (2000) 6.34

Cardiac plasticity. N Engl J Med (2008) 6.29

Termination of autophagy and reformation of lysosomes regulated by mTOR. Nature (2010) 6.26

Regulation of autophagy by cytoplasmic p53. Nat Cell Biol (2008) 5.97

The role of the Atg1/ULK1 complex in autophagy regulation. Curr Opin Cell Biol (2010) 5.95

Atg32 is a mitochondrial protein that confers selectivity during mitophagy. Dev Cell (2009) 5.77

Lithium induces autophagy by inhibiting inositol monophosphatase. J Cell Biol (2005) 5.21

Cardiac autophagy is a maladaptive response to hemodynamic stress. J Clin Invest (2007) 5.17

Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains. Mol Cell Biol (2009) 4.95

Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria. Cell (2010) 4.62

Histone deacetylase inhibitors in cancer therapy. J Clin Oncol (2009) 4.58

Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes. J Biol Chem (2006) 4.57

siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy. J Biol Chem (2007) 4.33

The role of autophagy in mammalian development: cell makeover rather than cell death. Dev Cell (2008) 4.25

Apoptotic and autophagic cell death induced by histone deacetylase inhibitors. Proc Natl Acad Sci U S A (2004) 4.20

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nat Chem Biol (2008) 4.19

The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway. J Biol Chem (2001) 4.14

Regulation of autophagy by the inositol trisphosphate receptor. Cell Death Differ (2007) 4.12

Histone deacetylase inhibitors: Potential in cancer therapy. J Cell Biochem (2009) 3.88

Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription coupling. J Clin Invest (2006) 3.72

Autophagy in chronically ischemic myocardium. Proc Natl Acad Sci U S A (2005) 3.55

Autophagy: basic principles and relevance to disease. Annu Rev Pathol (2008) 3.52

Small molecule regulators of autophagy identified by an image-based high-throughput screen. Proc Natl Acad Sci U S A (2007) 3.37

An overview of the molecular mechanism of autophagy. Curr Top Microbiol Immunol (2009) 3.29

Autophagy in the cellular energetic balance. Cell Metab (2011) 3.06

An Atg9-containing compartment that functions in the early steps of autophagosome biogenesis. J Cell Biol (2010) 2.98

LKB1 and AMP-activated protein kinase control of mTOR signalling and growth. Acta Physiol (Oxf) (2009) 2.94

The autophagy effector Beclin 1: a novel BH3-only protein. Oncogene (2008) 2.94

Insulin-like growth factor-1 and TNF-alpha regulate autophagy through c-jun N-terminal kinase and Akt pathways in human atherosclerotic vascular smooth cells. Immunol Cell Biol (2006) 2.80

Histone deacetylase (HDAC) inhibitors attenuate cardiac hypertrophy by suppressing autophagy. Proc Natl Acad Sci U S A (2011) 2.80

Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity. Nat Cell Biol (2010) 2.78

Suppression of class I and II histone deacetylases blunts pressure-overload cardiac hypertrophy. Circulation (2006) 2.70

FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging. Cell (2010) 2.66

Autophagy regulation by p53. Curr Opin Cell Biol (2010) 2.56

FoxO transcription factors promote autophagy in cardiomyocytes. J Biol Chem (2009) 2.40

Arsenic trioxide induces autophagic cell death in malignant glioma cells by upregulation of mitochondrial cell death protein BNIP3. Oncogene (2005) 2.34

The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1. Cell Death Differ (2009) 2.29

Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PLoS One (2009) 2.20

TOR-dependent control of autophagy: biting the hand that feeds. Curr Opin Cell Biol (2009) 2.17

Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein. Blood (2010) 2.15

Autophagy is an adaptive response in desmin-related cardiomyopathy. Proc Natl Acad Sci U S A (2008) 2.07

Profound cardioprotection with chloramphenicol succinate in the swine model of myocardial ischemia-reperfusion injury. Circulation (2010) 2.06

Rapamycin inhibits mTORC1, but not completely. Autophagy (2009) 1.99

Metformin prevents progression of heart failure in dogs: role of AMP-activated protein kinase. Circulation (2009) 1.95

Regulation of SIRT1 in cellular functions: role of polyphenols. Arch Biochem Biophys (2010) 1.91

Autophagy in load-induced heart disease. Circ Res (2008) 1.89

Urocortin inhibits Beclin1-mediated autophagic cell death in cardiac myocytes exposed to ischaemia/reperfusion injury. J Mol Cell Cardiol (2006) 1.83

The clinical development of histone deacetylase inhibitors as targeted anticancer drugs. Expert Opin Investig Drugs (2010) 1.79

Autophagy is a therapeutic target in anticancer drug resistance. Biochim Biophys Acta (2010) 1.77

Histone deacetylase inhibition reduces myocardial ischemia-reperfusion injury in mice. FASEB J (2008) 1.76

Clinical outcome and phenotypic expression in LAMP2 cardiomyopathy. JAMA (2009) 1.75

Lysosomal alterations in hypoxic and reoxygenated hearts. I. Ultrastructural and cytochemical changes. Am J Pathol (1980) 1.75

Inhibition of autophagy in the heart induces age-related cardiomyopathy. Autophagy (2010) 1.70

ROS-mediated mechanisms of autophagy stimulation and their relevance in cancer therapy. Autophagy (2010) 1.68

AMPK-mediated autophagy inhibits apoptosis in cisplatin-treated tumour cells. J Cell Mol Med (2009) 1.67

Autophagy in the heart and liver during normal aging and calorie restriction. Rejuvenation Res (2007) 1.66

Cardioprotection by adaptation to ischaemia augments autophagy in association with BAG-1 protein. J Cell Mol Med (2008) 1.54

Autophagy induced by valproic acid is associated with oxidative stress in glioma cell lines. Neuro Oncol (2009) 1.51

Autophagy mediates pharmacological lifespan extension by spermidine and resveratrol. Aging (Albany NY) (2009) 1.48

Autophagy potentiates the anti-cancer effects of the histone deacetylase inhibitors in hepatocellular carcinoma. Autophagy (2010) 1.47

Beneficial effects of Mammalian target of rapamycin inhibition on left ventricular remodeling after myocardial infarction. J Am Coll Cardiol (2009) 1.46

Mitochondria regulate autophagy by conserved signalling pathways. EMBO J (2011) 1.45

Inhibition of histone deacetylases triggers pharmacologic preconditioning effects against myocardial ischemic injury. Cardiovasc Res (2007) 1.44

Autophagy induced by ischemic preconditioning is essential for cardioprotection. J Cardiovasc Transl Res (2010) 1.43

Inositol and IP3 levels regulate autophagy: biology and therapeutic speculations. Autophagy (2006) 1.42

BCL-2 family inhibitors enhance histone deacetylase inhibitor and sorafenib lethality via autophagy and overcome blockade of the extrinsic pathway to facilitate killing. Mol Pharmacol (2009) 1.38

Echocardiographic assessment of age-associated changes in systolic and diastolic function of the female F344 rat heart. J Appl Physiol (1985) (2003) 1.26

Molecular and cellular basis of lysosomal transmembrane protein dysfunction. Biochim Biophys Acta (2008) 1.24

Role of AMP-activated protein kinase in autophagy and proteasome function. Biochem Biophys Res Commun (2008) 1.22

Impact of long-term caloric restriction on cardiac senescence: caloric restriction ameliorates cardiac diastolic dysfunction associated with aging. J Mol Cell Cardiol (2010) 1.22

Altered distribution of lysosomal cathepsin D in ischemic myocardium. J Clin Invest (1977) 1.21

Autophagy and protein kinase C are required for cardioprotection by sulfaphenazole. Am J Physiol Heart Circ Physiol (2009) 1.18

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis. Proc Natl Acad Sci U S A (2008) 9.86

Transient regenerative potential of the neonatal mouse heart. Science (2011) 9.02

The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell (2008) 7.26

FGF23 induces left ventricular hypertrophy. J Clin Invest (2011) 7.22

Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy. Cell (2002) 7.10

Heart repair by reprogramming non-myocytes with cardiac transcription factors. Nature (2012) 6.65

Cardiac autophagy is a maladaptive response to hemodynamic stress. J Clin Invest (2007) 5.17

Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis. Nature (2012) 4.84

Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility. Genes Dev (2007) 4.50

Hypertrophy of the heart: a new therapeutic target? Circulation (2004) 4.45

Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development. Mol Cell Biol (2004) 4.24

Fibrosis--a common pathway to organ injury and failure. N Engl J Med (2015) 3.94

Mitochondrial deficiency and cardiac sudden death in mice lacking the MEF2A transcription factor. Nat Med (2002) 3.31

Activated glycogen synthase-3 beta suppresses cardiac hypertrophy in vivo. Proc Natl Acad Sci U S A (2002) 3.27

Reprogramming of human fibroblasts toward a cardiac fate. Proc Natl Acad Sci U S A (2013) 3.14

Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice. J Clin Invest (2010) 3.04

Histone deacetylase (HDAC) inhibitors attenuate cardiac hypertrophy by suppressing autophagy. Proc Natl Acad Sci U S A (2011) 2.80

TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling. J Clin Invest (2006) 2.74

Suppression of class I and II histone deacetylases blunts pressure-overload cardiac hypertrophy. Circulation (2006) 2.70

The delta isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload. Proc Natl Acad Sci U S A (2009) 2.66

Foxo transcription factors blunt cardiac hypertrophy by inhibiting calcineurin signaling. Circulation (2006) 2.55

Pathogenesis of myocardial ischemia-reperfusion injury and rationale for therapy. Am J Cardiol (2010) 2.52

The IKK complex contributes to the induction of autophagy. EMBO J (2009) 2.41

The transcriptional coactivator CAMTA2 stimulates cardiac growth by opposing class II histone deacetylases. Cell (2006) 2.26

The MEF2D transcription factor mediates stress-dependent cardiac remodeling in mice. J Clin Invest (2008) 2.24

A dynamic notch injury response activates epicardium and contributes to fibrosis repair. Circ Res (2010) 2.23

Requirement of protein kinase D1 for pathological cardiac remodeling. Proc Natl Acad Sci U S A (2008) 2.12

Mice lacking calsarcin-1 are sensitized to calcineurin signaling and show accelerated cardiomyopathy in response to pathological biomechanical stress. Nat Med (2004) 2.11

Serum uric acid correlates with extracellular superoxide dismutase activity in patients with chronic heart failure. Eur J Heart Fail (2008) 2.09

FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases. Proc Natl Acad Sci U S A (2007) 2.08

Histone deacetylase inhibition blunts ischemia/reperfusion injury by inducing cardiomyocyte autophagy. Circulation (2014) 2.07

Autophagy is an adaptive response in desmin-related cardiomyopathy. Proc Natl Acad Sci U S A (2008) 2.07

Abnormal coronary function in mice deficient in alpha1H T-type Ca2+ channels. Science (2003) 2.05

Angiotensin-(1-9) reverses experimental hypertension and cardiovascular damage by inhibition of the angiotensin converting enzyme/Ang II axis. J Hypertens (2014) 2.04

Intracellular protein aggregation is a proximal trigger of cardiomyocyte autophagy. Circulation (2008) 1.95

Macrophages are required for neonatal heart regeneration. J Clin Invest (2014) 1.93

Impaired autophagosome clearance contributes to cardiomyocyte death in ischemia/reperfusion injury. Circulation (2012) 1.91

MicroRNA-214 protects the mouse heart from ischemic injury by controlling Ca²⁺ overload and cell death. J Clin Invest (2012) 1.90

Autophagy in load-induced heart disease. Circ Res (2008) 1.89

Eplerenone blocks nongenomic effects of aldosterone on the Na+/H+ exchanger, intracellular Ca2+ levels, and vasoconstriction in mesenteric resistance vessels. Endocrinology (2004) 1.65

Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress. J Cell Sci (2011) 1.65

Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in mice. J Clin Invest (2012) 1.63

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Modulation of adverse cardiac remodeling by STARS, a mediator of MEF2 signaling and SRF activity. J Clin Invest (2007) 1.50

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C/EBP transcription factors mediate epicardial activation during heart development and injury. Science (2012) 1.48

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Calcineurin is necessary for the maintenance but not embryonic development of slow muscle fibers. Mol Cell Biol (2005) 1.47

Rho kinase inhibition activates the homologous angiotensin-converting enzyme-angiotensin-(1-9) axis in experimental hypertension. J Hypertens (2011) 1.46

Physical and functional interaction between calcineurin and the cardiac L-type Ca2+ channel. Circ Res (2009) 1.42

Enhanced autophagy ameliorates cardiac proteinopathy. J Clin Invest (2013) 1.41

Cardiovascular side effects of cancer therapies: a position statement from the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail (2011) 1.40

Senescence, apoptosis or autophagy? When a damaged cell must decide its path--a mini-review. Gerontology (2008) 1.40

Differential activation of stress-response signaling in load-induced cardiac hypertrophy and failure. Physiol Genomics (2005) 1.39

Cardiac myosin light chain kinase is necessary for myosin regulatory light chain phosphorylation and cardiac performance in vivo. J Biol Chem (2010) 1.37

Diabetic Cardiomyopathy: Mechanisms and Therapeutic Targets. Drug Discov Today Dis Mech (2010) 1.28

The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism. J Clin Invest (2012) 1.23

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STIM1-dependent store-operated Ca²⁺ entry is required for pathological cardiac hypertrophy. J Mol Cell Cardiol (2011) 1.18

Ca2+/calmodulin-dependent protein kinase II-dependent remodeling of Ca2+ current in pressure overload heart failure. J Biol Chem (2008) 1.16

Autophagy in hypertensive heart disease. J Biol Chem (2010) 1.15

Mitochondrial control of cell death induced by hyperosmotic stress. Apoptosis (2007) 1.15

Inhibition of autophagy by TAB2 and TAB3. EMBO J (2011) 1.15

Glucose deprivation causes oxidative stress and stimulates aggresome formation and autophagy in cultured cardiac myocytes. Biochim Biophys Acta (2010) 1.14

Autophagy in cardiovascular biology. J Clin Invest (2015) 1.14

The histone trimethyllysine demethylase JMJD2A promotes cardiac hypertrophy in response to hypertrophic stimuli in mice. J Clin Invest (2011) 1.13

FoxO, autophagy, and cardiac remodeling. J Cardiovasc Transl Res (2010) 1.11

Attenuation of endoplasmic reticulum stress using the chemical chaperone 4-phenylbutyric acid prevents cardiac fibrosis induced by isoproterenol. Exp Mol Pathol (2011) 1.10

Myocyte autophagy in heart disease: friend or foe? Autophagy (2007) 1.09

Testosterone induces cardiomyocyte hypertrophy through mammalian target of rapamycin complex 1 pathway. J Endocrinol (2009) 1.08

Local control of nuclear calcium signaling in cardiac myocytes by perinuclear microdomains of sarcolemmal insulin-like growth factor 1 receptors. Circ Res (2012) 1.06

Endoplasmic reticulum: ER stress regulates mitochondrial bioenergetics. Int J Biochem Cell Biol (2011) 1.06

Beta(2)-adrenergic receptor regulates cardiac fibroblast autophagy and collagen degradation. Biochim Biophys Acta (2010) 1.06

Adipose tissue biology and cardiomyopathy: translational implications. Circ Res (2012) 1.05

Electrophysiological remodeling in heart failure. J Mol Cell Cardiol (2010) 1.05

Tuning flux: autophagy as a target of heart disease therapy. Curr Opin Cardiol (2011) 1.05

Histone deacetylase inhibition in the treatment of heart disease. Expert Opin Drug Saf (2008) 1.04

Doxycycline attenuates isoproterenol- and transverse aortic banding-induced cardiac hypertrophy in mice. J Pharmacol Exp Ther (2007) 1.04