EGFR gene amplification is related to adverse clinical outcomes in cervical squamous cell carcinoma, making the EGFR pathway a novel therapeutic target.

PubWeight™: 0.96‹?› | Rank: Top 15%

🔗 View Article (PMC 3172895)

Published in Br J Cancer on July 05, 2011

Authors

K Iida1, K Nakayama, M T Rahman, M Rahman, M Ishikawa, A Katagiri, S Yeasmin, Y Otsuki, H Kobayashi, S Nakayama, K Miyazaki

Author Affiliations

1: Department of Obstetrics and Gynecology, Shimane University School of Medicine, Enyacho 89-1, Izumo, Shimane 6938501, Japan.

Articles citing this

Oncogenic mutations in cervical cancer: genomic differences between adenocarcinomas and squamous cell carcinomas of the cervix. Cancer (2013) 1.52

Biological significance and therapeutic implication of resveratrol-inhibited Wnt, Notch and STAT3 signaling in cervical cancer cells. Genes Cancer (2014) 0.98

Up-regulated miR155 reverses the epithelial-mesenchymal transition induced by EGF and increases chemo-sensitivity to cisplatin in human Caski cervical cancer cells. PLoS One (2012) 0.90

Dihydroartemisinin induces apoptosis of cervical cancer cells via upregulation of RKIP and downregulation of bcl-2. Cancer Biol Ther (2013) 0.85

Candidate biomarkers for cervical cancer treatment: Potential for clinical practice (Review). Mol Clin Oncol (2014) 0.82

Epidermal growth factor receptor pathway mutation and expression profiles in cervical squamous cell carcinoma: therapeutic implications. J Transl Med (2015) 0.80

KRAS and MAPK1 gene amplification in type II ovarian carcinomas. Int J Mol Sci (2013) 0.79

Anti-EGFR-Conjugated Hollow Gold Nanospheres Enhance Radiocytotoxic Targeting of Cervical Cancer at Megavoltage Radiation Energies. Nanoscale Res Lett (2015) 0.79

Prognostic Impact of Epidermal Growth Factor Receptor Overexpression in Patients with Cervical Cancer: A Meta-Analysis. PLoS One (2016) 0.75

HER Family Receptors are Important Theranostic Biomarkers for Cervical Cancer: Blocking Glucose Metabolism Enhances the Therapeutic Effect of HER Inhibitors. Theranostics (2017) 0.75

Mutational analysis of the RAS/RAF/MEK/ERK signaling pathway in 260 Han Chinese patients with cervical carcinoma. Oncol Lett (2017) 0.75

Articles cited by this

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med (2004) 71.08

ERBB receptors and cancer: the complexity of targeted inhibitors. Nat Rev Cancer (2005) 16.73

The causal relation between human papillomavirus and cervical cancer. J Clin Pathol (2002) 14.73

Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst (2005) 13.00

KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab. J Clin Oncol (2008) 10.29

Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab. J Clin Oncol (2007) 9.29

United Kingdom Co-ordinating Committee on Cancer Research (UKCCCR) Guidelines for the Welfare of Animals in Experimental Neoplasia (Second Edition). Br J Cancer (1998) 4.33

Critical update and emerging trends in epidermal growth factor receptor targeting in cancer. J Clin Oncol (2005) 3.39

Sequence mutations and amplification of PIK3CA and AKT2 genes in purified ovarian serous neoplasms. Cancer Biol Ther (2006) 2.76

The rising incidence of adenocarcinoma relative to squamous cell carcinoma of the uterine cervix in the United States--a 24-year population-based study. Gynecol Oncol (2000) 2.76

Prognostic relevance of gene amplifications and coamplifications in breast cancer. Cancer Res (2004) 2.55

EGFR gene amplification in breast cancer: correlation with epidermal growth factor receptor mRNA and protein expression and HER-2 status and absence of EGFR-activating mutations. Mod Pathol (2005) 2.37

Mechanisms of genomic instability in human cancer: insights from studies with human papillomavirus oncoproteins. Int J Cancer (2004) 1.90

Oncogene amplification in solid tumors. Semin Cancer Biol (1999) 1.79

Expression of epidermal growth factor receptor and human papillomavirus E6/E7 proteins in cervical carcinoma cells. J Natl Cancer Inst (1997) 1.63

Expression of cIAP1, a target for 11q22 amplification, correlates with resistance of cervical cancers to radiotherapy. Cancer Res (2002) 1.56

Oncogene alterations in carcinomas of the uterine cervix: overexpression of the epidermal growth factor receptor is associated with poor prognosis. Clin Cancer Res (1999) 1.49

Epidermal growth factor receptor inhibitors in the treatment of non-small-cell lung cancer. J Clin Oncol (2005) 1.45

Prognostic value of 1p, 19q, 9p, 10q, and EGFR-FISH analyses in recurrent oligodendrogliomas. J Neuropathol Exp Neurol (2004) 1.39

Cervical and vulva cancer: changes in FIGO definitions of staging. Br J Obstet Gynaecol (1996) 1.26

Tumor growth inhibition with cetuximab and chemotherapy in non-small cell lung cancer xenografts expressing wild-type and mutated epidermal growth factor receptor. Clin Cancer Res (2007) 1.25

Expression of epidermal growth factor receptor in gastric carcinomas. Clin Gastroenterol Hepatol (2003) 1.20

High correlation between molecular alterations of the c-myc oncogene and carcinoma of the uterine cervix. Cancer Res (1987) 1.19

ERBB2 (HER2/neu) oncogene is frequently amplified in squamous cell carcinoma of the uterine cervix. Cancer Res (1994) 1.18

Epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) negatively affect overall survival in carcinoma of the cervix treated with radiotherapy. Int J Radiat Oncol Biol Phys (2003) 1.16

Changes in cervical cancer incidence after three decades of screening US women less than 30 years old. Obstet Gynecol (2003) 1.07

Cancer in the developing world: a call to action. BMJ (1999) 1.07

Comparison of gene expression in squamous cell carcinoma and adenocarcinoma of the uterine cervix. Gynecol Oncol (2004) 1.06

Development and clinical indications of cetuximab. Int J Biol Markers (2007) 1.05

Epidermal growth factor receptor expression status in lung cancer correlates with its mutation. Hum Pathol (2005) 1.04

Human papillomavirus type 16 E6 and E7 cooperate to increase epidermal growth factor receptor (EGFR) mRNA levels, overcoming mechanisms by which excessive EGFR signaling shortens the life span of normal human keratinocytes. Cancer Res (2001) 1.03

Gene dosage PCR and fluorescence in situ hybridization reveal low frequency of egfr amplifications despite protein overexpression in invasive breast carcinoma. Lab Invest (2004) 1.03

Expression and cisplatin sensitivity of copper-transporting P-type adenosine triphosphatase (ATP7B) in human solid carcinoma cell lines. Oncol Rep (2001) 1.02

Abnormalities in the PRAD1 (CYCLIN D1/BCL-1) oncogene are frequent in cervical and vulvar squamous cell carcinoma cell lines. Cancer (1995) 1.01

HPV16 E5 protein disrupts the c-Cbl-EGFR interaction and EGFR ubiquitination in human foreskin keratinocytes. Oncogene (2005) 1.00

Consistent absence of BRAF mutations in cervical and endometrial cancer despite KRAS mutation status. Gynecol Oncol (2005) 0.99

Overexpression of epidermal growth factor type-1 receptor (EGF-R1) in cervical cancer: implications for Cetuximab-mediated therapy in recurrent/metastatic disease. Gynecol Oncol (2007) 0.98

Evaluation of epidermal growth factor receptor (EGFR) by chromogenic in situ hybridization (CISH) and immunohistochemistry (IHC) in archival gliomas using bright-field microscopy. Diagn Mol Pathol (2004) 0.97

Absence of epidermal growth factor receptor mutations in cervical cancer. Int J Gynecol Cancer (2007) 0.96

Evaluation of the prognostic significance of cathepsin D, epidermal growth factor receptor, and c-erbB-2 in early cervical squamous cell carcinoma. An immunohistochemical study. Cancer (1996) 0.95

Clinical implications of the epidermal growth factor receptor in the squamous cell carcinoma of the uterine cervix. Gynecol Oncol (1989) 0.91

Epidermal growth factor receptor (EGFR) is not related to the prognosis of cervical cancer. Cancer Lett (1998) 0.88

Prognostic value of epidermal growth factor receptor expression in cervical carcinoma. J Clin Pathol (1993) 0.83

Abnormal expression of epidermal growth factor receptor and c-erbB2 in squamous cell carcinoma of the cervix: correlation with human papillomavirus and prognosis. Tumour Biol (2001) 0.80

Comprehensive allelotype study of ovarian tumors of low malignant potential: potential differences in pathways between tumors with and without genetic predisposition to invasive carcinoma. Int J Cancer (2001) 0.80

[Medical treatment of metastatic or recurrent cancer of the cervix]. Bull Cancer (2006) 0.77

Articles by these authors

Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12. DNA Res (2001) 15.22

High serum IgG4 concentrations in patients with sclerosing pancreatitis. N Engl J Med (2001) 12.49

Contamination of drinking-water by arsenic in Bangladesh: a public health emergency. Bull World Health Organ (2000) 9.27

Engineered GFP as a vital reporter in plants. Curr Biol (1996) 9.03

Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell (1996) 8.77

Comprehensive study on iterative algorithms of multiple sequence alignment. Comput Appl Biosci (1995) 8.39

Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ Mol Mutagen (2000) 6.24

Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice. Science (1995) 5.65

Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication. EMBO J (2000) 5.61

Progress in and deterrents to orthotopic liver transplantation, with special reference to survival, resistance to hyperacute rejection, and biliary duct reconstruction. Transplant Proc (1974) 5.53

Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation. Cell (1999) 4.98

Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti. DNA Res (2000) 4.94

Effect of ramipril vs amlodipine on renal outcomes in hypertensive nephrosclerosis: a randomized controlled trial. JAMA (2001) 4.75

Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice. Genes Dev (2000) 4.38

Arsenic poisoning of Bangladesh groundwater. Nature (1998) 4.09

Retrotransposons of rice involved in mutations induced by tissue culture. Proc Natl Acad Sci U S A (1996) 4.00

Proposal for a new clinical entity, IgG4-positive multiorgan lymphoproliferative syndrome: analysis of 64 cases of IgG4-related disorders. Ann Rheum Dis (2008) 3.77

Endothelium-dependent inhibition of platelet aggregation. Br J Pharmacol (1986) 3.66

Binocular rivalry and visual awareness in human extrastriate cortex. Neuron (1998) 3.59

The role of diffusion-weighted imaging in patients with brain tumors. AJNR Am J Neuroradiol (2001) 3.58

Attentional requirements in a 'preattentive' feature search task. Nature (1997) 3.54

Priming of pop-out: I. Role of features. Mem Cognit (1994) 3.53

Arg-X-Lys/Arg-Arg motif as a signal for precursor cleavage catalyzed by furin within the constitutive secretory pathway. J Biol Chem (1991) 3.50

An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin. EMBO J (1999) 3.42

Rearrangement of the MLL gene in acute lymphoblastic and acute myeloid leukemias with 11q23 chromosomal translocations. N Engl J Med (1993) 3.37

Quality assurance programme for drug susceptibility testing of Mycobacterium tuberculosis in the WHO/IUATLD Supranational Laboratory Network: first round of proficiency testing. Int J Tuberc Lung Dis (1997) 3.37

cDNA cloning of bovine substance-K receptor through oocyte expression system. Nature (1987) 3.31

Efficient promoter cassettes for enhanced expression of foreign genes in dicotyledonous and monocotyledonous plants. Plant Cell Physiol (1996) 3.30

Escherichia coli RecQ protein is a DNA helicase. Proc Natl Acad Sci U S A (1990) 3.27

Epidemiology and causes of death among children in a rural area of Bangladesh. Int J Epidemiol (1980) 3.16

ATP-linked calcium transport in cells and membrane vesicles of Streptococcus faecalis. J Biol Chem (1978) 3.14

Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema. Am J Hum Genet (2000) 3.06

Incidence and risk factors of vascular dementia and Alzheimer's disease in a defined elderly Japanese population: the Hisayama Study. Neurology (1995) 2.99

Role of cell surface metalloprotease MT1-MMP in epithelial cell migration over laminin-5. J Cell Biol (2000) 2.94

Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes. Science (1993) 2.93

Isolation and genetic characterization of a thymineless death-resistant mutant of Escherichia coli K12: identification of a new mutation (recQ1) that blocks the RecF recombination pathway. Mol Gen Genet (1984) 2.92

Essential role for ZAP-70 in both positive and negative selection of thymocytes. Nature (1995) 2.88

Non-invasive quantitative detection and applications of non-toxic, S65T-type green fluorescent protein in living plants. Plant J (1999) 2.88

Cloning and characterization of the asd gene of Salmonella typhimurium: use in stable maintenance of recombinant plasmids in Salmonella vaccine strains. Gene (1990) 2.80

Quality assurance programme for drug susceptibility testing of Mycobacterium tuberculosis in the WHO/IUATLD Supranational Reference Laboratory Network: five rounds of proficiency testing, 1994-1998. Int J Tuberc Lung Dis (2002) 2.79

A proton-translocating ATPase regulates pH of the bacterial cytoplasm. J Biol Chem (1985) 2.71

Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor/.NO through a radical reaction. Biochemistry (1993) 2.70

Modulation of endothelium-dependent flow-mediated dilatation of the brachial artery by sex and menstrual cycle. Circulation (1995) 2.70

Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice. Science (1993) 2.68

Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia. Proc Natl Acad Sci U S A (1994) 2.66

Prediction of variceal hemorrhage by esophageal endoscopy. Gastrointest Endosc (1981) 2.62

Expression of stromal cell-derived factor 1 and CXCR4 ligand receptor system in pancreatic cancer: a possible role for tumor progression. Clin Cancer Res (2000) 2.61

Regulation of the cytoplasmic pH in Streptococcus faecalis. J Biol Chem (1982) 2.61

Expression of bacterial chloramphenicol acetyltransferase gene in tobacco plants mediated by TMV-RNA. EMBO J (1987) 2.61

Chemical and immunological characterization of the extracellular galactomannan of Aspergillus fumigatus. Infect Immun (1994) 2.60

Three-dimensional structure of ribonuclease H from E. coli. Nature (1990) 2.58

In vitro mutagenesis of the putative replicase genes of tobacco mosaic virus. Nucleic Acids Res (1986) 2.58

Results of a nationwide study on the three-field lymph node dissection of esophageal cancer. Oncology (1991) 2.54

Serial and parallel processing of visual feature conjunctions. Nature (1986) 2.51

A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase. Nature (2001) 2.48

Mortality and survival among a cohort of drug injectors in Glasgow, 1982-1994. Addiction (1997) 2.45

Occurrence of N-nonsubstituted glucosamine residues in peptidoglycan of lysozyme-resistant cell walls from Bacillus cereus. J Biol Chem (1972) 2.45

Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia. Proc Natl Acad Sci U S A (1994) 2.44

NAK is an IkappaB kinase-activating kinase. Nature (2000) 2.44

Genetic analyses of proteolysis, hemoglobin binding, and hemagglutination of Porphyromonas gingivalis. Construction of mutants with a combination of rgpA, rgpB, kgp, and hagA. J Biol Chem (1999) 2.39

ACE inhibitors and pneumonia. Lancet (1998) 2.38

Estimation of polyamine binding to macromolecules and ATP in bovine lymphocytes and rat liver. J Biol Chem (1991) 2.36

In vitro transcription of infectious RNAs from full-length cDNAs of tobacco mosaic virus. Proc Natl Acad Sci U S A (1986) 2.35

Green-fluorescent protein as a new vital marker in plant cells. Plant J (1995) 2.28

Involvement of the IRF-1 transcription factor in antiviral responses to interferons. Science (1994) 2.28

Unique morphology of the human eye. Nature (1997) 2.27

Rapid acquisition of multicellular drug resistance after a single exposure of mammary tumor cells to antitumor alkylating agents. J Natl Cancer Inst (1994) 2.25

Twenty-four-hour recall, knowledge-attitude-practice questionnaires, and direct observations of sanitary practices: a comparative study. Bull World Health Organ (1987) 2.24

Retention of multilineage differentiation potential of mesenchymal cells during proliferation in response to FGF. Biochem Biophys Res Commun (2001) 2.24

Degradation of p27(Kip1) at the G(0)-G(1) transition mediated by a Skp2-independent ubiquitination pathway. J Biol Chem (2001) 2.23

Increased MR signal intensity due to cervical myelopathy. Analysis of 29 surgical cases. J Neurosurg (1991) 2.22

Motion perception in schizophrenia. Arch Gen Psychiatry (1999) 2.20

DNA methylation as a mechanism of transcriptional regulation in nonphotosynthetic plastids in plant cells. Proc Natl Acad Sci U S A (1988) 2.19

C-reactive protein is protective against Streptococcus pneumoniae infection in mice. J Exp Med (1981) 2.17

Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Nature (2000) 2.17

The recQ gene of Escherichia coli K12: molecular cloning and isolation of insertion mutants. Mol Gen Genet (1985) 2.16

Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Nature (2000) 2.16

Classification and evolution of EF-hand proteins. Biometals (1998) 2.11

Inhibitors of efflux pumps in Pseudomonas aeruginosa potentiate the activity of the fluoroquinolone antibacterial levofloxacin. J Med Chem (1999) 2.10

Immunohistochemical characterization of glomerular IgA deposits in IgA nephropathy. Clin Nephrol (1990) 2.09

Protein Synthesis in Bromegrass (Bromus inermis Leyss) Cultured Cells during the Induction of Frost Tolerance by Abscisic Acid or Low Temperature. Plant Physiol (1987) 2.09

The number of ribosomal RNA genes in Mycoplasma capricolum. Mol Gen Genet (1981) 2.08

Acetyl-CoA synthetase 2, a mitochondrial matrix enzyme involved in the oxidation of acetate. J Biol Chem (2001) 2.08

Pseudo-leptospires in blood culture. J Clin Pathol (1979) 2.07

Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair. Nat Med (2001) 2.04

Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1. Proc Natl Acad Sci U S A (1999) 2.04

High expression of Survivin, mapped to 17q25, is significantly associated with poor prognostic factors and promotes cell survival in human neuroblastoma. Oncogene (2000) 2.04

Streptococcal cytoplasmic pH is regulated by changes in amount and activity of a proton-translocating ATPase. J Biol Chem (1986) 2.03

Snail and SIP1 increase cancer invasion by upregulating MMP family in hepatocellular carcinoma cells. Br J Cancer (2004) 2.03

How enzymes adapt: lessons from directed evolution. Trends Biochem Sci (2001) 2.03

The relationship of arsenic levels in drinking water and the prevalence rate of skin lesions in Bangladesh. Environ Health Perspect (1999) 2.02

Copper proteins and oxygen. Correlations between structure and function of the copper oxidases. J Gen Physiol (1965) 2.02

Lysenin, a novel sphingomyelin-specific binding protein. J Biol Chem (1998) 2.02

Differential expression of bcl-2 in intestinal epithelia. Correlation with attenuation of apoptosis in colonic crypts and the incidence of colonic neoplasia. J Cell Sci (1995) 2.01