Published in Diabetologia on July 06, 2011
Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion. PLoS Genet (2014) 1.94
Genome-wide associations between genetic and epigenetic variation influence mRNA expression and insulin secretion in human pancreatic islets. PLoS Genet (2014) 1.06
Islet autoantigens: structure, function, localization, and regulation. Cold Spring Harb Perspect Med (2012) 1.02
Co-regulation of intragenic microRNA miR-153 and its host gene Ia-2 β: identification of miR-153 target genes with functions related to IA-2β in pancreas and brain. Diabetologia (2013) 0.89
Quantitative analysis of mouse pancreatic islet architecture by serial block-face SEM. J Struct Biol (2014) 0.84
PTPRN2 and PLCβ1 promote metastatic breast cancer cell migration through PI(4,5)P2-dependent actin remodeling. EMBO J (2015) 0.82
Immunohistochemical analysis of IA-2 family of protein tyrosine phosphatases in rat gastrointestinal endocrine cells. J Histochem Cytochem (2012) 0.80
Disruption of gene expression rhythms in mice lacking secretory vesicle proteins IA-2 and IA-2β. Am J Physiol Endocrinol Metab (2012) 0.79
The dense core vesicle protein IA-2, but not IA-2β, is required for active avoidance learning. Neuroscience (2014) 0.78
Combining quantitative 2D and 3D image analysis in the serial block face SEM: application to secretory organelles of pancreatic islet cells. J Microsc (2015) 0.77
Multiple microRNAs within the 14q32 cluster target the mRNAs of major type 1 diabetes autoantigens IA-2, IA-2β, and GAD65. FASEB J (2015) 0.77
Compressed Sensing Electron Tomography for Determining Biological Structure. Sci Rep (2016) 0.77
Pathophysiologic changes in IA-2/IA-2β null mice are secondary to alterations in the secretion of hormones and neurotransmitters. Acta Diabetol (2015) 0.76
β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions. Nat Commun (2017) 0.75
Identification of Unique Antigenic Determinants in the Amino Terminus of IA-2 (ICA512) in Childhood and Adult Autoimmune Diabetes: New Biomarker Development. Diabetes Care (2017) 0.75
The minimal promoter region of the dense-core vesicle protein IA-2: transcriptional regulation by CREB. Acta Diabetol (2014) 0.75
Small cell lung cancer growth is inhibited by miR-342 through its effect of the target gene IA-2. J Transl Med (2016) 0.75
Autophagy fights disease through cellular self-digestion. Nature (2008) 33.83
Mutations in RAB27A cause Griscelli syndrome associated with haemophagocytic syndrome. Nat Genet (2000) 5.11
Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies. Diabetes (1996) 4.20
An improved method for isolation of mouse pancreatic islets. Transplantation (1985) 3.52
Autoimmune type 1 diabetes: resolved and unresolved issues. J Clin Invest (2001) 2.35
Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma. DNA Cell Biol (1994) 2.13
Releasable pools and the kinetics of exocytosis in adrenal chromaffin cells. Neuron (1994) 2.07
Fusion pore dynamics and insulin granule exocytosis in the pancreatic islet. Science (2002) 2.03
Prediction of insulin-dependent diabetes mellitus in siblings of children with diabetes. A population-based study. The Childhood Diabetes in Finland Study Group. J Clin Invest (1998) 1.91
The voltage sensitive Lc-type Ca2+ channel is functionally coupled to the exocytotic machinery. Proc Natl Acad Sci U S A (1999) 1.78
Genome-wide scan for estimated glomerular filtration rate in multi-ethnic diabetic populations: the Family Investigation of Nephropathy and Diabetes (FIND). Diabetes (2007) 1.61
The Ca2+ dynamics of isolated mouse beta-cells and islets: implications for mathematical models. Biophys J (2003) 1.59
The role of voltage-gated calcium channels in pancreatic beta-cell physiology and pathophysiology. Endocr Rev (2006) 1.59
ICA 512, an autoantigen of type I diabetes, is an intrinsic membrane protein of neurosecretory granules. EMBO J (1996) 1.59
Identification of a second transmembrane protein tyrosine phosphatase, IA-2beta, as an autoantigen in insulin-dependent diabetes mellitus: precursor of the 37-kDa tryptic fragment. Proc Natl Acad Sci U S A (1996) 1.51
Regulated autophagy controls hormone content in secretory-deficient pancreatic endocrine beta-cells. Mol Endocrinol (2007) 1.49
Targeted disruption of the protein tyrosine phosphatase-like molecule IA-2 results in alterations in glucose tolerance tests and insulin secretion. Diabetes (2002) 1.49
Targeted disruption of the IA-2beta gene causes glucose intolerance and impairs insulin secretion but does not prevent the development of diabetes in NOD mice. Diabetes (2004) 1.43
Glucose modulates [Ca2+]i oscillations in pancreatic islets via ionic and glycolytic mechanisms. Biophys J (2006) 1.35
Synergy of glucose and growth hormone signalling in islet cells through ICA512 and STAT5. Nat Cell Biol (2006) 1.31
Proteomics analysis of insulin secretory granules. Mol Cell Proteomics (2007) 1.31
Dense core vesicle proteins IA-2 and IA-2beta: metabolic alterations in double knockout mice. Diabetes (2005) 1.21
The dense core transmembrane vesicle protein IA-2 is a regulator of vesicle number and insulin secretion. Proc Natl Acad Sci U S A (2005) 1.19
Can we really predict IDDM? Diabetes (1993) 1.18
Sequential exocytosis of insulin granules is associated with redistribution of SNAP25. J Cell Biol (2004) 1.17
Regulation of insulin secretion in islets of Langerhans by Ca(2+)channels. J Membr Biol (2004) 1.13
Disruption of the transmembrane dense core vesicle proteins IA-2 and IA-2beta causes female infertility. Endocrinology (2005) 1.04
The L-type voltage-gated Ca2+ channel is the Ca2+ sensor protein of stimulus-secretion coupling in pancreatic beta cells. Biochemistry (2007) 1.03
Insulin secretion in islets from mice with a double knockout for the dense core vesicle proteins islet antigen-2 (IA-2) and IA-2beta. J Endocrinol (2008) 1.02
CAPS1 and CAPS2 regulate stability and recruitment of insulin granules in mouse pancreatic beta cells. Cell Metab (2008) 1.02
Disturbances in the secretion of neurotransmitters in IA-2/IA-2beta null mice: changes in behavior, learning and lifespan. Neuroscience (2009) 1.02
The IA-2 gene family: homologs in Caenorhabditis elegans, Drosophila and zebrafish. Diabetologia (2001) 1.01
Deletion of the secretory vesicle proteins IA-2 and IA-2beta disrupts circadian rhythms of cardiovascular and physical activity. FASEB J (2009) 0.96
The neurosecretory vesicle protein phogrin functions as a phosphatidylinositol phosphatase to regulate insulin secretion. J Biol Chem (2010) 0.93
RESP18, a homolog of the luminal domain IA-2, is found in dense core vesicles in pancreatic islet cells and is induced by high glucose. J Endocrinol (2007) 0.89
Mapping protein expression in mouse pancreatic islets by immunolabeling and electron energy loss spectrum-imaging. Microsc Res Tech (2003) 0.87
Evidence of association with type 1 diabetes in the SLC11A1 gene region. BMC Med Genet (2011) 0.86
Differential modulation of L-type calcium channel subunits by oleate. Am J Physiol Endocrinol Metab (2008) 0.85
Temperature modulates the Ca2+ current of HIT-T15 and mouse pancreatic beta-cells. Cell Calcium (1996) 0.84
Loss of the transcriptional repressor PAG-3/Gfi-1 results in enhanced neurosecretion that is dependent on the dense-core vesicle membrane protein IDA-1/IA-2. PLoS Genet (2009) 0.83
[Association of the chromosomal region 2q35 with type 1 diabetes mellitus in the Russian patients from Moscow]. Genetika (2008) 0.77
SNAP-25 inhibits L-type Ca2+ channels in feline esophagus smooth muscle cells. Biochem Biophys Res Commun (2003) 0.77
The genome sequence of Drosophila melanogaster. Science (2000) 74.32
HMG-1 as a late mediator of endotoxin lethality in mice. Science (1999) 17.72
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci U S A (1998) 12.61
FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex. Cell (1996) 12.07
Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature (2000) 11.49
Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons. Nat Neurosci (2001) 8.55
Haplotype variation and linkage disequilibrium in 313 human genes. Science (2001) 8.52
Qualitative and Quantitative Analyses of Gibberellins in Vegetative Shoots of Normal, dwarf-1, dwarf-2, dwarf-3, and dwarf-5 Seedlings of Zea mays L. Plant Physiol (1988) 8.05
Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr Rev (1999) 7.69
IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest (1999) 7.66
High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes. J Exp Med (2000) 7.38
Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling. Nature (1998) 6.49
8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G----T and A----C substitutions. J Biol Chem (1992) 6.20
RSC, an essential, abundant chromatin-remodeling complex. Cell (1996) 6.17
Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage. J Cell Biol (1994) 5.93
Identification of functional exonic splicing enhancer motifs recognized by individual SR proteins. Genes Dev (1998) 5.79
IL-17 stimulates the production and expression of proinflammatory cytokines, IL-beta and TNF-alpha, by human macrophages. J Immunol (1998) 5.79
Immune interferon in the circulation of patients with autoimmune disease. N Engl J Med (1979) 5.58
High-speed mapping of synaptic connectivity using photostimulation in Channelrhodopsin-2 transgenic mice. Proc Natl Acad Sci U S A (2007) 5.42
Complete nucleotide sequence of mouse immunoglobulin mu gene and comparison with other immunoglobulin heavy chain genes. Nucleic Acids Res (1980) 5.20
Cloning and complete nucleotide sequence of mouse immunoglobulin gamma 1 chain gene. Cell (1979) 5.04
Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction. J Exp Med (2000) 5.02
Gibberellin A(3) Is Biosynthesized from Gibberellin A(20) via Gibberellin A(5) in Shoots of Zea mays L. Plant Physiol (1990) 4.71
Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells. Proc Natl Acad Sci U S A (1990) 4.40
Effect of virus infections on the function of the immune system. Annu Rev Microbiol (1970) 4.30
The dominant non-gibberellin-responding dwarf mutant (D8) of maize accumulates native gibberellins. Proc Natl Acad Sci U S A (1988) 4.28
Modulation of osteoclast differentiation. Endocr Rev (1992) 4.27
8-oxoguanine (8-hydroxyguanine) DNA glycosylase and its substrate specificity. Proc Natl Acad Sci U S A (1991) 4.25
Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption. Neoplasia (2001) 4.22
T-cell co-stimulation through B7RP-1 and ICOS. Nature (1999) 4.20
Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents. Nucleic Acids Res (1984) 4.15
Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. Neuron (1996) 4.12
A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner. EMBO J (1994) 3.88
Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair. Carcinogenesis (1986) 3.76
Structure of the modified nucleoside Q isolated from Escherichia coli transfer ribonucleic acid. 7-(4,5-cis-Dihydroxy-1-cyclopenten-3-ylaminomethyl)-7-deazaguanosine. Biochemistry (1975) 3.73
Organization of the constant-region gene family of the mouse immunoglobulin heavy chain. Cell (1982) 3.72
Terminal differentiation of human breast cancer through PPAR gamma. Mol Cell (1998) 3.71
Rearrangement of immunoglobulin gamma 1-chain gene and mechanism for heavy-chain class switch. Proc Natl Acad Sci U S A (1980) 3.70
Amyloid fibril formation by A beta 16-22, a seven-residue fragment of the Alzheimer's beta-amyloid peptide, and structural characterization by solid state NMR. Biochemistry (2000) 3.65
Decreased virulence of recombinant vaccinia virus expression vectors is associated with a thymidine kinase-negative phenotype. Nature (1985) 3.62
Isolation of a virus from the pancreas of a child with diabetic ketoacidosis. N Engl J Med (1979) 3.62
The homeobox gene GLABRA2 is required for position-dependent cell differentiation in the root epidermis of Arabidopsis thaliana. Development (1996) 3.59
Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues. Nature (1987) 3.55
Ballistic 2-d imaging through scattering walls using an ultrafast optical kerr gate. Science (1991) 3.53
Heavy metals in agricultural soils of the Pearl River Delta, South China. Environ Pollut (2002) 3.50
Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2. J Cell Biol (1998) 3.39
Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130Cas. Nat Genet (1998) 3.38
Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6. Proc Natl Acad Sci U S A (1993) 3.29
Opiate receptor knockout mice define mu receptor roles in endogenous nociceptive responses and morphine-induced analgesia. Proc Natl Acad Sci U S A (1997) 3.26
Evidence that SH2 domains promote processive phosphorylation by protein-tyrosine kinases. Curr Biol (1995) 3.12
Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor. Mol Pharmacol (2001) 3.11
Multiple DNA fragment polymorphisms associated with immunoglobulin mu chain switch-like regions in man. Proc Natl Acad Sci U S A (1983) 3.07
Complete amino acid sequence of human plasma beta 2-glycoprotein I. Proc Natl Acad Sci U S A (1984) 3.06
The dose dependence of glucocorticoid-inducible gene expression results from changes in the number of transcriptionally active templates. EMBO J (1990) 3.04
Complete nucleotide sequence of immunoglobulin gamma2b chain gene cloned from newborn nouse DNA. Nature (1980) 2.97
CD5+ B lymphocytes, polyreactive antibodies and the human B-cell repertoire. Immunol Today (1989) 2.96
Thymus dependence of viral antigens. Nature (1975) 2.95
Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases. Mol Cell Biol (1996) 2.94
Heterogeneity in the properties of 7 S and 19S rabbit-neutralizing antibodies to herpes simplex virus. J Immunol (1968) 2.90
Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation. J Bone Miner Res (1996) 2.86
Multiple quantum solid-state NMR indicates a parallel, not antiparallel, organization of beta-sheets in Alzheimer's beta-amyloid fibrils. Proc Natl Acad Sci U S A (2000) 2.84
The bone marrow-derived stromal cell lines MC3T3-G2/PA6 and ST2 support osteoclast-like cell differentiation in cocultures with mouse spleen cells. Endocrinology (1989) 2.83
Continued expression of a poly(A)+ transcript of herpes simplex virus type 1 in trigeminal ganglia of latently infected mice. J Virol (1987) 2.78
Human lymphocytes making rheumatoid factor and antibody to ssDNA belong to Leu-1+ B-cell subset. Science (1987) 2.75
Phylogeny of the genus Pseudomonas: intrageneric structure reconstructed from the nucleotide sequences of gyrB and rpoD genes. Microbiology (2000) 2.73
Proposed procedure for the allocation of trivial names to the gibberellins. Nature (1968) 2.72
Latent ganglionic infection with herpes simplex virus types 1 and 2: viral reactivation in vivo after neurectomy. Science (1974) 2.71
Identification of Vibrio parahaemolyticus strains at the species level by PCR targeted to the toxR gene. J Clin Microbiol (1999) 2.71
Infectious virus-antibody complex in the blood of chronically infected mice. J Exp Med (1966) 2.68
Survival, integration, and differentiation of cardiomyocyte grafts: a study in normal and injured rat hearts. Circulation (1999) 2.68
U2AF65 recruits a novel human DEAD box protein required for the U2 snRNP-branchpoint interaction. Genes Dev (1997) 2.67
Periodicity of leucine and tandem repetition of a 24-amino acid segment in the primary structure of leucine-rich alpha 2-glycoprotein of human serum. Proc Natl Acad Sci U S A (1985) 2.64
Probing the human B-cell repertoire with EBV: polyreactive antibodies and CD5+ B lymphocytes. Annu Rev Immunol (1989) 2.63
Opioid modulation of taste hedonics within the ventral striatum. Physiol Behav (2002) 2.62
Molecular determinants of agonist discrimination by NMDA receptor subunits: analysis of the glutamate binding site on the NR2B subunit. Neuron (1997) 2.54
Histone octamer transfer by a chromatin-remodeling complex. Cell (1999) 2.54
Macrophage colony-stimulating factor is indispensable for both proliferation and differentiation of osteoclast progenitors. J Clin Invest (1993) 2.52
Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment. Cell Death Dis (2013) 2.52
The natriuretic peptide clearance receptor locally modulates the physiological effects of the natriuretic peptide system. Proc Natl Acad Sci U S A (1999) 2.48
Progressive glomerulosclerosis and enhanced renal accumulation of basement membrane components in mice transgenic for human immunodeficiency virus type 1 genes. Proc Natl Acad Sci U S A (1992) 2.48
Human CD4+ cells transfected with IL-16 cDNA are resistant to HIV-1 infection: inhibition of mRNA expression. Nat Med (1997) 2.47
Inhibition or enhancement of immunological injury of virus-infected cells. Proc Natl Acad Sci U S A (1971) 2.45
Proinflammatory cytokines (tumor necrosis factor and interleukin 1) stimulate release of high mobility group protein-1 by pituicytes. Surgery (1999) 2.44
Prevention of cell-to-cell spread of herpes simplex virus by leukocytes. J Exp Med (1973) 2.42
Metabolic Engineering of a Pentose Metabolism Pathway in Ethanologenic Zymomonas mobilis. Science (1995) 2.40
Activated RSC-nucleosome complex and persistently altered form of the nucleosome. Cell (1998) 2.38
An N-linked high-mannose type oligosaccharide, expressed at the major outer membrane protein of Chlamydia trachomatis, mediates attachment and infectivity of the microorganism to HeLa cells. J Clin Invest (1996) 2.35
Vaccinia virus recombinant expressing herpes simplex virus type 1 glycoprotein D prevents latent herpes in mice. Science (1985) 2.34
Benzo(a)pyrene diol epoxides as intermediates in nucleic acid binding in vitro and in vivo. Science (1976) 2.34
Solid state NMR reveals a pH-dependent antiparallel beta-sheet registry in fibrils formed by a beta-amyloid peptide. J Mol Biol (2004) 2.33
Structure of human immunoglobulin gamma genes: implications for evolution of a gene family. Cell (1982) 2.32
A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion. Mol Cell Biol (1996) 2.29
In vitro stimulation of sensitized lymphocytes by herpes simplex virus and vaccinia virus. Proc Natl Acad Sci U S A (1972) 2.29
Expression of a myelin basic protein gene in transgenic shiverer mice: correction of the dysmyelinating phenotype. Cell (1987) 2.29
Ordering of mouse immunoglobulin heavy chain genes by molecular cloning. Nature (1981) 2.28
Cellular localization and trafficking of the human ABCA1 transporter. J Biol Chem (2001) 2.26
A peripheral blood diagnostic test for acute rejection in renal transplantation. Am J Transplant (2012) 2.25
Saccadic dysmetria and adaptation after lesions of the cerebellar cortex. J Neurosci (1999) 2.24
Comparison of direct and indirect solid-phase microradioimmunoassays for the detection of viral antigens and antiviral antibody. Appl Microbiol (1973) 2.23
Immune mechanisms by which the spread of viral infections is stopped. Cell Immunol (1974) 2.23