Published in Trends Biochem Sci on July 07, 2011
Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system. Nat Cell Biol (2012) 3.90
A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress. Cell (2012) 3.27
The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks. Nat Struct Mol Biol (2011) 2.23
Cleaning up: ER-associated degradation to the rescue. Cell (2012) 2.08
Eukaryotic stress granules are cleared by autophagy and Cdc48/VCP function. Cell (2013) 1.88
Protein quality control in the ER: balancing the ubiquitin checkbook. Trends Cell Biol (2011) 1.68
Ubiquitin and proteasomes in transcription. Annu Rev Biochem (2012) 1.67
Inhibitors of the AAA+ chaperone p97. Molecules (2015) 1.61
Cdc48-associated complex bound to 60S particles is required for the clearance of aberrant translation products. Proc Natl Acad Sci U S A (2013) 1.42
The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis. J Cell Sci (2014) 1.32
Identification of the Cdc48•20S proteasome as an ancient AAA+ proteolytic machine. Science (2012) 1.22
Role of Cdc48/p97 as a SUMO-targeted segregase curbing Rad51-Rad52 interaction. Nat Cell Biol (2013) 1.20
Proteasomes and protein conjugation across domains of life. Nat Rev Microbiol (2011) 1.12
Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains. J Mol Biol (2014) 1.11
The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution. Front Mol Neurosci (2014) 1.10
Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions. J Biol Chem (2012) 1.09
Yeast sterol regulatory element-binding protein (SREBP) cleavage requires Cdc48 and Dsc5, a ubiquitin regulatory X domain-containing subunit of the Golgi Dsc E3 ligase. J Biol Chem (2011) 1.07
Ribosome-associated protein quality control. Nat Struct Mol Biol (2016) 1.00
A pro-cathepsin L mutant is a luminal substrate for endoplasmic-reticulum-associated degradation in C. elegans. PLoS One (2012) 0.97
Translating DRiPs: MHC class I immunosurveillance of pathogens and tumors. J Leukoc Biol (2014) 0.97
How early studies on secreted and membrane protein quality control gave rise to the ER associated degradation (ERAD) pathway: the early history of ERAD. Biochim Biophys Acta (2013) 0.96
Transcriptome sequencing (RNA-seq) analysis of the effects of metal nanoparticle exposure on the transcriptome of Chlamydomonas reinhardtii. Appl Environ Microbiol (2013) 0.95
Pathological stress granules in Alzheimer's disease. Brain Res (2014) 0.94
Role of p97/VCP (Cdc48) in genome stability. Front Genet (2013) 0.94
Three old and one new: protein import into red algal-derived plastids surrounded by four membranes. Protoplasma (2013) 0.93
Ubiquitination of the N-terminal region of caveolin-1 regulates endosomal sorting by the VCP/p97 AAA-ATPase. J Biol Chem (2013) 0.93
Novel VCP modulators mitigate major pathologies of rd10, a mouse model of retinitis pigmentosa. Sci Rep (2014) 0.92
Chromera velia, endosymbioses and the rhodoplex hypothesis--plastid evolution in cryptophytes, alveolates, stramenopiles, and haptophytes (CASH lineages). Genome Biol Evol (2014) 0.91
Physiological response of Pichia pastoris GS115 to methanol-induced high level production of the Hepatitis B surface antigen: catabolic adaptation, stress responses, and autophagic processes. Microb Cell Fact (2012) 0.91
The general definition of the p97/valosin-containing protein (VCP)-interacting motif (VIM) delineates a new family of p97 cofactors. J Biol Chem (2011) 0.90
Control of Tobacco mosaic virus movement protein fate by CELL-DIVISION-CYCLE protein48. Plant Physiol (2012) 0.90
Expanding proteostasis by membrane trafficking networks. Cold Spring Harb Perspect Biol (2013) 0.89
p97 complexes as signal integration hubs. BMC Biol (2012) 0.89
The ubiquitin regulatory X (UBX) domain-containing protein TUG regulates the p97 ATPase and resides at the endoplasmic reticulum-golgi intermediate compartment. J Biol Chem (2011) 0.87
A conserved protein with AN1 zinc finger and ubiquitin-like domains modulates Cdc48 (p97) function in the ubiquitin-proteasome pathway. J Biol Chem (2013) 0.86
Subunit architecture of the Golgi Dsc E3 ligase required for sterol regulatory element-binding protein (SREBP) cleavage in fission yeast. J Biol Chem (2013) 0.86
Functional chromatography reveals three natural products that target the same protein with distinct mechanisms of action. Chembiochem (2014) 0.85
Origin and Functional Evolution of the Cdc48/p97/VCP AAA+ Protein Unfolding and Remodeling Machine. J Mol Biol (2015) 0.84
What makes the engine hum: Rad6, a cell cycle supercharger. Cell Cycle (2012) 0.84
Doa1 targets ubiquitinated substrates for mitochondria-associated degradation. J Cell Biol (2016) 0.84
Mmi1, the yeast homologue of mammalian TCTP, associates with stress granules in heat-shocked cells and modulates proteasome activity. PLoS One (2013) 0.84
VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy. EMBO J (2016) 0.83
Methylation of the PTPRO gene in human hepatocellular carcinoma and identification of VCP as its substrate. J Cell Biochem (2013) 0.83
Cuz1/Ynl155w, a zinc-dependent ubiquitin-binding protein, protects cells from metalloid-induced proteotoxicity. J Biol Chem (2013) 0.83
The Cdc48 protein and its cofactor Vms1 are involved in Cdc13 protein degradation. J Biol Chem (2012) 0.82
Cell biology of the endoplasmic reticulum and the Golgi apparatus through proteomics. Cold Spring Harb Perspect Biol (2013) 0.82
Establishment of an in vitro transport assay that reveals mechanistic differences in cytosolic events controlling cholera toxin and T-cell receptor α retro-translocation. PLoS One (2013) 0.82
Mak5 and Ebp2 act together on early pre-60S particles and their reduced functionality bypasses the requirement for the essential pre-60S factor Nsa1. PLoS One (2013) 0.81
Concerted action of the ubiquitin-fusion degradation protein 1 (Ufd1) and Sumo-targeted ubiquitin ligases (STUbLs) in the DNA-damage response. PLoS One (2013) 0.81
Ring of Change: CDC48/p97 Drives Protein Dynamics at Chromatin. Front Genet (2016) 0.81
The p97-Ufd1-Npl4 ATPase complex ensures robustness of the G2/M checkpoint by facilitating CDC25A degradation. Cell Cycle (2014) 0.81
Perturbations to the ubiquitin conjugate proteome in yeast δubx mutants identify Ubx2 as a regulator of membrane lipid composition. Mol Cell Proteomics (2013) 0.81
Degradation of the deubiquitinating enzyme USP33 is mediated by p97 and the ubiquitin ligase HERC2. J Biol Chem (2014) 0.80
Proteomics reveals plastid- and periplastid-targeted proteins in the chlorarachniophyte alga Bigelowiella natans. Genome Biol Evol (2012) 0.80
The protein translocation systems in plants - composition and variability on the example of Solanum lycopersicum. BMC Genomics (2013) 0.80
Quality control of a cytoplasmic protein complex: chaperone motors and the ubiquitin-proteasome system govern the fate of orphan fatty acid synthase subunit Fas2 of yeast. J Biol Chem (2015) 0.80
The life cycle of the 26S proteasome: from birth, through regulation and function, and onto its death. Cell Res (2016) 0.80
Human ASPL/TUG interacts with p97 and complements the proteasome mislocalization of a yeast ubx4 mutant, but not the ER-associated degradation defect. BMC Cell Biol (2014) 0.79
Valosin-containing Protein (VCP)/p97 Segregase Mediates Proteolytic Processing of Cockayne Syndrome Group B (CSB) in Damaged Chromatin. J Biol Chem (2016) 0.79
Protein quality control in the nucleus. Biomolecules (2014) 0.79
Archaeal proteasomes and sampylation. Subcell Biochem (2013) 0.79
CDC48 function during TMV infection: regulation of virus movement and replication by degradation? Plant Signal Behav (2012) 0.79
The Interplay of Cofactor Interactions and Post-translational Modifications in the Regulation of the AAA+ ATPase p97. Front Mol Biosci (2017) 0.79
New Regulators of Clathrin-Mediated Endocytosis Identified in Saccharomyces cerevisiae by Systematic Quantitative Fluorescence Microscopy. Genetics (2015) 0.78
NEDD8 ultimate buster-1 long (NUB1L) protein promotes transfer of NEDD8 to proteasome for degradation through the P97UFD1/NPL4 complex. J Biol Chem (2013) 0.78
The N-terminal Region of the Ubiquitin Regulatory X (UBX) Domain-containing Protein 1 (UBXD1) Modulates Interdomain Communication within the Valosin-containing Protein p97. J Biol Chem (2015) 0.78
Oxaspirol B with p97 Inhibitory Activity and Other Oxaspirols from Lecythophora sp. FL1375 and FL1031, Endolichenic Fungi Inhabiting Parmotrema tinctorum and Cladonia evansii. J Nat Prod (2016) 0.77
A Golgi rhomboid protease Rbd2 recruits Cdc48 to cleave yeast SREBP. EMBO J (2016) 0.77
KUS121, a VCP modulator, attenuates ischemic retinal cell death via suppressing endoplasmic reticulum stress. Sci Rep (2017) 0.77
Single base substitution in OsCDC48 is responsible for premature senescence and death phenotype in rice. J Integr Plant Biol (2015) 0.77
The budding yeast Cdc48(Shp1) complex promotes cell cycle progression by positive regulation of protein phosphatase 1 (Glc7). PLoS One (2013) 0.77
Dexamethasone-induced selenoprotein S degradation is required for adipogenesis. J Lipid Res (2013) 0.76
Structure and Function of p97 and Pex1/6 Type II AAA+ Complexes. Front Mol Biosci (2017) 0.76
The chaperone BAG6 captures dislocated glycoproteins in the cytosol. PLoS One (2014) 0.75
Nucleotide Excision Repair: Finely Tuned Molecular Orchestra of Early Pre-incision Events. Photochem Photobiol (2016) 0.75
FBG1 Is the Final Arbitrator of A1AT-Z Degradation. PLoS One (2015) 0.75
Regulation of Sterol Biosynthesis in the Human Fungal Pathogen Aspergillus fumigatus: Opportunities for Therapeutic Development. Front Microbiol (2017) 0.75
Single site suppressors of a fission yeast temperature-sensitive mutant in cdc48 identified by whole genome sequencing. PLoS One (2015) 0.75
Valosin-containing protein is a key mediator between autophagic cell death and apoptosis in adult hippocampal neural stem cells following insulin withdrawal. Mol Brain (2016) 0.75
VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break Repair. Mol Cell (2016) 0.75
UV-induced proteolysis of RNA polymerase II is mediated by VCP/p97 segregase and timely orchestration by Cockayne syndrome B protein. Oncotarget (2016) 0.75
The Cdc48-Vms1 complex maintains 26S proteasome architecture. Biochem J (2014) 0.75
Deviation of the typical AAA substrate-threading pore prevents fatal protein degradation in yeast Cdc48. Sci Rep (2017) 0.75
Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48. Nat Cell Biol (2002) 4.06
For whom the bell tolls: protein quality control of the endoplasmic reticulum and the ubiquitin-proteasome connection. EMBO J (2003) 2.82
Membrane-bound Ubx2 recruits Cdc48 to ubiquitin ligases and their substrates to ensure efficient ER-associated protein degradation. Nat Cell Biol (2005) 2.06
A genomic screen identifies Dsk2p and Rad23p as essential components of ER-associated degradation. EMBO Rep (2004) 2.02
Use of modular substrates demonstrates mechanistic diversity and reveals differences in chaperone requirement of ERAD. J Biol Chem (2003) 1.99
Ubiquitin receptors and ERAD: a network of pathways to the proteasome. Semin Cell Dev Biol (2007) 1.88
The cytoplasmic Hsp70 chaperone machinery subjects misfolded and endoplasmic reticulum import-incompetent proteins to degradation via the ubiquitin-proteasome system. Mol Biol Cell (2006) 1.61
Degradation of misfolded protein in the cytoplasm is mediated by the ubiquitin ligase Ubr1. FEBS Lett (2008) 1.61
Imbalances in p97 co-factor interactions in human proteinopathy. EMBO Rep (2010) 1.55
The proteasome: a proteolytic nanomachine of cell regulation and waste disposal. Biochim Biophys Acta (2004) 1.54
ER-golgi traffic is a prerequisite for efficient ER degradation. Mol Biol Cell (2002) 1.42
Shp1 and Ubx2 are adaptors of Cdc48 involved in ubiquitin-dependent protein degradation. EMBO Rep (2004) 1.40
A genome-wide screen identifies Yos9p as essential for ER-associated degradation of glycoproteins. FEBS Lett (2004) 1.40
Catabolite degradation of fructose-1,6-bisphosphatase in the yeast Saccharomyces cerevisiae: a genome-wide screen identifies eight novel GID genes and indicates the existence of two degradation pathways. Mol Biol Cell (2003) 1.37
Protein quality control and elimination of protein waste: the role of the ubiquitin-proteasome system. Biochim Biophys Acta (2013) 1.28
Importance of carbohydrate positioning in the recognition of mutated CPY for ER-associated degradation. J Cell Sci (2005) 1.27
Cystic fibrosis transmembrane conductance regulator degradation depends on the lectins Htm1p/EDEM and the Cdc48 protein complex in yeast. Mol Biol Cell (2004) 1.25
The yeast GID complex, a novel ubiquitin ligase (E3) involved in the regulation of carbohydrate metabolism. Mol Biol Cell (2008) 1.15
Hierarchical binding of cofactors to the AAA ATPase p97. Structure (2011) 1.14
Endoplasmic reticulum-associated protein degradation--one model fits all? Biochim Biophys Acta (2004) 1.10
The PUB domain functions as a p97 binding module in human peptide N-glycanase. J Biol Chem (2006) 1.08
Sec61p is part of the endoplasmic reticulum-associated degradation machinery. EMBO J (2009) 1.07
Suppression of LUBAC-mediated linear ubiquitination by a specific interaction between LUBAC and the deubiquitinases CYLD and OTULIN. Genes Cells (2014) 1.06
Der1p, a protein required for degradation of malfolded soluble proteins of the endoplasmic reticulum: topology and Der1-like proteins. FEMS Yeast Res (2004) 1.05
Cellular functions of Ufd2 and Ufd3 in proteasomal protein degradation depend on Cdc48 binding. Mol Cell Biol (2011) 1.02
Ubiquitin ligase Hul5 is required for fragment-specific substrate degradation in endoplasmic reticulum-associated degradation. J Biol Chem (2008) 1.01
UBXD1 binds p97 through two independent binding sites. Biochem Biophys Res Commun (2009) 0.99
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell. Biochim Biophys Acta (2010) 0.99
Exploring the topology of the Gid complex, the E3 ubiquitin ligase involved in catabolite-induced degradation of gluconeogenic enzymes. J Biol Chem (2012) 0.99
DER7, encoding alpha-glucosidase I is essential for degradation of malfolded glycoproteins of the endoplasmic reticulum. FEMS Yeast Res (2004) 0.96
Ubx4 modulates cdc48 activity and influences degradation of misfolded proteins of the endoplasmic reticulum. J Biol Chem (2009) 0.93
The general definition of the p97/valosin-containing protein (VCP)-interacting motif (VIM) delineates a new family of p97 cofactors. J Biol Chem (2011) 0.90
VHL mutations linked to type 2C von Hippel-Lindau disease cause extensive structural perturbations in pVHL. J Biol Chem (2009) 0.88
Gid9, a second RING finger protein contributes to the ubiquitin ligase activity of the Gid complex required for catabolite degradation. FEBS Lett (2011) 0.87
Sit4 phosphatase is functionally linked to the ubiquitin-proteasome system. Genetics (2003) 0.87
Previously unknown role for the ubiquitin ligase Ubr1 in endoplasmic reticulum-associated protein degradation. Proc Natl Acad Sci U S A (2013) 0.83
Waste disposal in plants: where and how? Trends Plant Sci (2003) 0.83
Yos9, a control protein for misfolded glycosylated and non-glycosylated proteins in ERAD. FEBS Lett (2011) 0.82
The ubiquitin-proteasome-system. Biochim Biophys Acta (2013) 0.81
The Cdc48-Ufd1-Npl4 complex is central in ubiquitin-proteasome triggered catabolite degradation of fructose-1,6-bisphosphatase. Biochem Biophys Res Commun (2010) 0.81
Dfm1 forms distinct complexes with Cdc48 and the ER ubiquitin ligases and is required for ERAD. Traffic (2010) 0.81
Mutants of the deubiquitinating enzyme Ubp14 decipher pathway diversity of ubiquitin-proteasome linked protein degradation. Biochem Biophys Res Commun (2006) 0.80
Yeast genomics in the elucidation of endoplasmic reticulum (ER) quality control and associated protein degradation (ERQD). Methods Enzymol (2005) 0.79
Endoplasmic reticulum-associated protein quality control and degradation: genome-wide screen for ERAD components. Methods Mol Biol (2005) 0.78
The Hsp70 chaperone Ssa1 is essential for catabolite induced degradation of the gluconeogenic enzyme fructose-1,6-bisphosphatase. Biochem Biophys Res Commun (2010) 0.78
A yeast two-hybrid system reconstituting substrate recognition of the von Hippel-Lindau tumor suppressor protein. Nucleic Acids Res (2007) 0.78
Use of CPY and its derivatives to study protein quality control in various cell compartments. Methods Mol Biol (2012) 0.77
The budding yeast Cdc48(Shp1) complex promotes cell cycle progression by positive regulation of protein phosphatase 1 (Glc7). PLoS One (2013) 0.77
Ubiquitylation in the ERAD Pathway. Subcell Biochem (2010) 0.77
Endoplasmic reticulum-associated protein quality control and degradation: screen for ERAD mutants after ethylmethane sulfonate mutagenesis. Methods Mol Biol (2005) 0.76
Death gives birth to life: the essential role of the ubiquitin-proteasome system in biology. Biochim Biophys Acta (2004) 0.76
The yeast kinetochore protein Slk19 is required to prevent aberrant chromosome segregation in meiosis and mitosis. Genes Cells (2002) 0.76
Mnl2, a novel component of the ER associated protein degradation pathway. Biochem Biophys Res Commun (2011) 0.75