Published in Small GTPases on May 01, 2011
The regulation of osteoclast function and bone resorption by small GTPases. Small GTPases (2011) 1.11
Regulation of lysosome biogenesis and functions in osteoclasts. Cell Cycle (2013) 0.87
Regulation of osteoclasts by membrane-derived lipid mediators. Cell Mol Life Sci (2013) 0.83
Targeted sequencing of the Paget's disease associated 14q32 locus identifies several missense coding variants in RIN3 that predispose to Paget's disease of bone. Hum Mol Genet (2015) 0.78
The Roles of Small GTPases in Osteoclast Biology. Orthop Muscular Syst (2015) 0.75
Osteoclast differentiation and activation. Nature (2003) 18.59
The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway. Cell (1992) 10.53
The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene. Nature (1990) 8.94
Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts. J Clin Invest (2000) 4.54
Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. J Pharmacol Exp Ther (2001) 3.59
Rab27a regulates the peripheral distribution of melanosomes in melanocytes. J Cell Biol (2001) 2.76
Rab27a is required for regulated secretion in cytotoxic T lymphocytes. J Cell Biol (2001) 2.74
The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs. Proc Natl Acad Sci U S A (2006) 2.73
Lysosome-related organelles: driving post-Golgi compartments into specialisation. Curr Opin Cell Biol (2007) 2.11
Biochemical and molecular mechanisms of action of bisphosphonates. Bone (2010) 1.92
Recent advances in understanding the mechanism of action of bisphosphonates. Curr Opin Pharmacol (2006) 1.80
Rab geranylgeranyl transferase alpha mutation in the gunmetal mouse reduces Rab prenylation and platelet synthesis. Proc Natl Acad Sci U S A (2000) 1.48
Megakaryocyte-osteoblast interaction revealed in mice deficient in transcription factors GATA-1 and NF-E2. J Bone Miner Res (2003) 1.39
Downregulation of small GTPase Rab7 impairs osteoclast polarization and bone resorption. J Biol Chem (2001) 1.33
Defective bone formation and anabolic response to exogenous estrogen in mice with targeted disruption of endothelial nitric oxide synthase. Endocrinology (2001) 1.32
Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans. J Clin Invest (2007) 1.29
Rho GTPases in osteoclasts: orchestrators of podosome arrangement. Eur J Cell Biol (2008) 1.25
Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically prevents Rab prenylation in osteoclasts and macrophages. J Biol Chem (2001) 1.22
Vesicular trafficking in osteoclasts. Semin Cell Dev Biol (2008) 1.19
Critical role of beta3 integrin in experimental postmenopausal osteoporosis. J Bone Miner Res (2005) 1.17
Osteoclast ruffled border has distinct subdomains for secretion and degraded matrix uptake. Traffic (2003) 1.14
Analysis of the extracellular matrix vesicle proteome in mineralizing osteoblasts. J Cell Physiol (2007) 1.14
Intracellular membrane trafficking in bone resorbing osteoclasts. Microsc Res Tech (2003) 1.13
A role for Rab27b in NF-E2-dependent pathways of platelet formation. Blood (2003) 1.11
Osteoclast formation and bone resorption are inhibited by megakaryocytes. Bone (2006) 1.10
Rab3D regulates a novel vesicular trafficking pathway that is required for osteoclastic bone resorption. Mol Cell Biol (2005) 1.08
Multiple factors contribute to inefficient prenylation of Rab27a in Rab prenylation diseases. J Biol Chem (2003) 1.07
Loss-of-function mutations in Rab escort protein 1 (REP-1) affect intracellular transport in fibroblasts and monocytes of choroideremia patients. PLoS One (2009) 0.96
Inherited thrombocytopenia caused by reduced platelet production in mice with the gunmetal pigment gene mutation. Blood (1995) 0.95
A novel method for efficient generation of transfected human osteoclasts. Calcif Tissue Int (2007) 0.94
Rab27a and Rab27b are involved in stimulation-dependent RANKL release from secretory lysosomes in osteoblastic cells. J Bone Miner Res (2011) 0.83
Cell-specific abnormal prenylation of Rab proteins in platelets and melanocytes of the gunmetal mouse. Br J Haematol (2002) 0.80
Expression of osteoprotegerin mRNA and protein in murine megakaryocytes. Exp Hematol (2003) 0.80
The gunmetal mouse reveals Rab geranylgeranyl transferase to be the major molecular target of phosphonocarboxylate analogues of bisphosphonates. Bone (2011) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat Cell Biol (2009) 5.44
NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells. Cell (2006) 5.35
Rab38 and Rab32 control post-Golgi trafficking of melanogenic enzymes. J Cell Biol (2006) 2.79
The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs. Proc Natl Acad Sci U S A (2006) 2.73
Rab GTPases, intracellular traffic and disease. Trends Mol Med (2002) 2.72
A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport. J Biol Chem (2002) 2.69
Rab27a regulates phagosomal pH and NADPH oxidase recruitment to dendritic cell phagosomes. Nat Cell Biol (2007) 2.69
Molecular mechanisms of action of bisphosphonates: current status. Clin Cancer Res (2006) 2.67
Structurally distinct membrane nanotubes between human macrophages support long-distance vesicular traffic or surfing of bacteria. J Immunol (2006) 2.65
Rab27a supports exosome-dependent and -independent mechanisms that modify the tumor microenvironment and can promote tumor progression. Cancer Res (2012) 2.55
Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy. Ann N Y Acad Sci (2007) 2.15
Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL. Nat Genet (2007) 2.04
Biochemical and molecular mechanisms of action of bisphosphonates. Bone (2010) 1.92
Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome. J Clin Invest (2002) 1.81
Recent advances in understanding the mechanism of action of bisphosphonates. Curr Opin Pharmacol (2006) 1.80
A general role for Rab27a in secretory cells. Mol Biol Cell (2003) 1.76
Osteopetrosis: genetics, treatment and new insights into osteoclast function. Nat Rev Endocrinol (2013) 1.70
Influence of bone affinity on the skeletal distribution of fluorescently labeled bisphosphonates in vivo. J Bone Miner Res (2012) 1.66
Rab27b regulates number and secretion of platelet dense granules. Proc Natl Acad Sci U S A (2007) 1.66
Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, and metastasis. J Natl Cancer Inst (2010) 1.65
Gene therapy for choroideremia: in vitro rescue mediated by recombinant adenovirus. Vision Res (2003) 1.63
The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo. Proc Natl Acad Sci U S A (2009) 1.63
Bone remodelling at a glance. J Cell Sci (2011) 1.62
Thematic review series: lipid posttranslational modifications. geranylgeranylation of Rab GTPases. J Lipid Res (2006) 1.60
The leaden gene product is required with Rab27a to recruit myosin Va to melanosomes in melanocytes. Traffic (2002) 1.59
Membrane targeting of Rab GTPases is influenced by the prenylation motif. Mol Biol Cell (2003) 1.57
2.6-Million-year-old stone tools and associated bones from OGS-6 and OGS-7, Gona, Afar, Ethiopia. J Hum Evol (2003) 1.56
Peripheral blood monocytes are responsible for gammadelta T cell activation induced by zoledronic acid through accumulation of IPP/DMAPP. Br J Haematol (2008) 1.51
Melanosome maturation defect in Rab38-deficient retinal pigment epithelium results in instability of immature melanosomes during transient melanogenesis. Mol Biol Cell (2007) 1.50
Fatty acylation and prenylation of proteins: what's hot in fat. Curr Opin Cell Biol (2005) 1.50
Statins prevent bisphosphonate-induced gamma,delta-T-cell proliferation and activation in vitro. J Bone Miner Res (2003) 1.46
Thousands of rab GTPases for the cell biologist. PLoS Comput Biol (2011) 1.44
Human osteoclast-poor osteopetrosis with hypogammaglobulinemia due to TNFRSF11A (RANK) mutations. Am J Hum Genet (2008) 1.41
Cutmarked bones from Pliocene archaeological sites at Gona, Afar, Ethiopia: implications for the function of the world's oldest stone tools. J Hum Evol (2005) 1.40
Fluorescent risedronate analogues reveal bisphosphonate uptake by bone marrow monocytes and localization around osteocytes in vivo. J Bone Miner Res (2010) 1.39
Further insight into mechanism of action of clodronate: inhibition of mitochondrial ADP/ATP translocase by a nonhydrolyzable, adenine-containing metabolite. Mol Pharmacol (2002) 1.38
Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase. J Med Chem (2008) 1.37
Cytosolic entry of bisphosphonate drugs requires acidification of vesicles after fluid-phase endocytosis. Mol Pharmacol (2006) 1.37
Melanosomes at a glance. J Cell Sci (2008) 1.36
Rab27a and Rab27b regulate neutrophil azurophilic granule exocytosis and NADPH oxidase activity by independent mechanisms. Traffic (2009) 1.35
The role of Rab27a in the regulation of melanosome distribution within retinal pigment epithelial cells. Mol Biol Cell (2004) 1.30
Independent degeneration of photoreceptors and retinal pigment epithelium in conditional knockout mouse models of choroideremia. J Clin Invest (2006) 1.29
Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans. J Clin Invest (2007) 1.29
The ternary Rab27a-Myrip-Myosin VIIa complex regulates melanosome motility in the retinal pigment epithelium. Traffic (2007) 1.27
Multiple regions contribute to membrane targeting of Rab GTPases. J Cell Sci (2004) 1.26
Visualizing mineral binding and uptake of bisphosphonate by osteoclasts and non-resorbing cells. Bone (2008) 1.25
Mechanisms of osteopontin and CD44 as metastatic principles in prostate cancer cells. Mol Cancer (2007) 1.24
Retinal pigment epithelium defects accelerate photoreceptor degeneration in cell type-specific knockout mouse models of choroideremia. Invest Ophthalmol Vis Sci (2010) 1.23
Technological variation in the earliest Oldowan from Gona, Afar, Ethiopia. J Hum Evol (2010) 1.22
Rab27b regulates mast cell granule dynamics and secretion. Traffic (2007) 1.22
Fluorescently labeled risedronate and related analogues: "magic linker" synthesis. Bioconjug Chem (2008) 1.22
Landscape-scale variation in hominin tool use: Evidence from the Developed Oldowan. J Hum Evol (2008) 1.21
A role for L-alpha-lysophosphatidylinositol and GPR55 in the modulation of migration, orientation and polarization of human breast cancer cells. Br J Pharmacol (2010) 1.21
The ability of statins to inhibit bone resorption is directly related to their inhibitory effect on HMG-CoA reductase activity. J Bone Miner Res (2003) 1.20
Rab GTPases containing a CAAX motif are processed post-geranylgeranylation by proteolysis and methylation. J Biol Chem (2006) 1.20
Weibel-Palade bodies recruit Rab27 by a content-driven, maturation-dependent mechanism that is independent of cell type. J Cell Sci (2003) 1.19
The bisphosphonate zoledronic acid has antimyeloma activity in vivo by inhibition of protein prenylation. Int J Cancer (2010) 1.18
A coiled-coil domain of melanophilin is essential for Myosin Va recruitment and melanosome transport in melanocytes. Mol Biol Cell (2006) 1.18
Osteoclast heterogeneity: lessons from osteopetrosis and inflammatory conditions. Biochim Biophys Acta (2009) 1.15
Inhibition of protein prenylation by bisphosphonates causes sustained activation of Rac, Cdc42, and Rho GTPases. J Bone Miner Res (2006) 1.14
The regulation of osteoclast function and bone resorption by small GTPases. Small GTPases (2011) 1.11
A role for Rab27b in NF-E2-dependent pathways of platelet formation. Blood (2003) 1.11
Rab27a and MyRIP regulate the amount and multimeric state of VWF released from endothelial cells. Blood (2009) 1.11
The skeleton: a multi-functional complex organ: the role of key signalling pathways in osteoclast differentiation and in bone resorption. J Endocrinol (2011) 1.11
Alkylamines cause Vgamma9Vdelta2 T-cell activation and proliferation by inhibiting the mevalonate pathway. Blood (2005) 1.10
The melanosome as a model to study organelle motility in mammals. Pigment Cell Res (2004) 1.09
Functional expression of Rab escort protein 1 following AAV2-mediated gene delivery in the retina of choroideremia mice and human cells ex vivo. J Mol Med (Berl) (2013) 1.09
Rab27b is up-regulated in human Griscelli syndrome type II melanocytes and linked to the actin cytoskeleton via exon F-Myosin Va transcripts. Pigment Cell Res (2004) 1.08
Rab3GEP is the non-redundant guanine nucleotide exchange factor for Rab27a in melanocytes. J Biol Chem (2008) 1.07
Multiple factors contribute to inefficient prenylation of Rab27a in Rab prenylation diseases. J Biol Chem (2003) 1.07
Rab27a and MyoVa are the primary Mlph interactors regulating melanosome transport in melanocytes. J Cell Sci (2007) 1.04
Novel functions for Rab GTPases in multiple aspects of tumour progression. Biochem Soc Trans (2012) 1.04
The matricellular protein CYR61 inhibits osteoclastogenesis by a mechanism independent of alphavbeta3 and alphavbeta5. Endocrinology (2007) 1.03
Armus is a Rac1 effector that inactivates Rab7 and regulates E-cadherin degradation. Curr Biol (2010) 1.03
Regulation of bone mass and bone turnover by neuronal nitric oxide synthase. Endocrinology (2004) 1.03
Autophagy: a new player in skeletal maintenance? J Bone Miner Res (2012) 1.01
Early Pliocene hominids from Gona, Ethiopia. Nature (2005) 1.01
Antagonistic effects of different classes of bisphosphonates in osteoclasts and macrophages in vitro. J Bone Miner Res (2003) 1.00