Published in Curr Opin Rheumatol on September 01, 2011
Study to Prevent Cartilage Damage Following Acute Knee Injury. | NCT00332254
Catabolic Marker Levels After Platelet Poor Plasma (PPP) Lavage (PPP) | NCT03120988
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Catabolic cytokines disrupt the circadian clock and the expression of clock-controlled genes in cartilage via an NFкB-dependent pathway. Osteoarthritis Cartilage (2015) 0.82
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Potentially effective natural drugs in treatment for the most common rheumatic disorder: osteoarthritis. Rheumatol Int (2014) 0.77
SOCS1 suppresses IL-1β-induced C/EBPβ expression via transcriptional regulation in human chondrocytes. Exp Mol Med (2016) 0.77
Damage-Associated Molecular Patterns Generated in Osteoarthritis Directly Excite Murine Nociceptive Neurons Through Toll-like Receptor 4. Arthritis Rheumatol (2015) 0.77
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Muscle cell-derived factors inhibit inflammatory stimuli-induced damage in hMSC-derived chondrocytes. Osteoarthritis Cartilage (2013) 0.76
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Increased DNA Methylation and Reduced Expression of Transcription Factors in Human Osteoarthritis Cartilage. Arthritis Rheumatol (2016) 0.76
Schisandrae Fructus ethanol extract ameliorates inflammatory responses and articular cartilage damage in monosodium iodoacetate-induced osteoarthritis in rats. EXCLI J (2017) 0.75
Novel measure of articular instability based on contact stress confirms that the anterior cruciate ligament is a critical stabilizer of the lateral compartment. J Orthop Res (2015) 0.75
Changes in synovial fluid biomarkers and clinical efficacy of intra-articular injections of hyaluronic acid for patients with knee osteoarthritis. J Exp Orthop (2014) 0.75
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Molecular mechanisms underlying osteoarthritis development: Notch and NF-κB. Arthritis Res Ther (2017) 0.75
miR-146a facilitates osteoarthritis by regulating cartilage homeostasis via targeting Camk2d and Ppp3r2. Cell Death Dis (2017) 0.75
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Profiling the secretion of soluble mediators by end stage osteoarthritis synovial tissue explants reveals a reduced responsiveness to an inflammatory trigger. PLoS One (2013) 0.75
Wnt7a Inhibits IL-1β Induced Catabolic Gene Expression and Prevents Articular Cartilage Damage in Experimental Osteoarthritis. Sci Rep (2017) 0.75
Reduced tissue osmolarity increases TRPV4 expression and pro-inflammatory cytokines in intervertebral disc cells. Eur Cell Mater (2016) 0.75
Vitamin C Protects Chondrocytes against Monosodium Iodoacetate-Induced Osteoarthritis by Multiple Pathways. Int J Mol Sci (2016) 0.75
JNK activation is essential for activation of MEK/ERK signaling in IL-1β-induced COX-2 expression in synovial fibroblasts. Sci Rep (2017) 0.75
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Does statin use have a disease modifying effect in symptomatic knee osteoarthritis? Study protocol for a randomised controlled trial. Trials (2015) 0.75
Analgesic and anti-Inflammatory effect of UP3005, a botanical composition Containing two standardized extracts of Uncaria gambir and Morus alba. Pharmacognosy Res (2015) 0.75
Enhanced expression of the central survival of motor neuron (SMN) protein during the pathogenesis of osteoarthritis. J Cell Mol Med (2013) 0.75
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Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction. Nat Med (2010) 3.55
The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis. Nat Rev Rheumatol (2010) 3.14
MicroRNA-140 plays dual roles in both cartilage development and homeostasis. Genes Dev (2010) 2.70
Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis. Arthritis Rheum (2010) 2.43
Plasma and synovial fluid microRNAs as potential biomarkers of rheumatoid arthritis and osteoarthritis. Arthritis Res Ther (2010) 2.25
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Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis. Nat Med (2009) 2.08
NF-kappaB signaling: multiple angles to target OA. Curr Drug Targets (2010) 1.89
High abundance synovial fluid proteome: distinct profiles in health and osteoarthritis. Arthritis Res Ther (2007) 1.88
Imaging of synovitis in osteoarthritis: current status and outlook. Semin Arthritis Rheum (2011) 1.86
New developments in osteoarthritis. Posttraumatic osteoarthritis: pathogenesis and pharmacological treatment options. Arthritis Res Ther (2010) 1.84
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MicroRNA-27b regulates the expression of matrix metalloproteinase 13 in human osteoarthritis chondrocytes. Arthritis Rheum (2010) 1.78
Synovial inflammation in patients undergoing arthroscopic meniscectomy: molecular characterization and relationship to symptoms. Arthritis Rheum (2011) 1.74
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Sumoylation and nuclear translocation of S100A4 regulate IL-1beta-mediated production of matrix metalloproteinase-13. J Biol Chem (2010) 1.64
The infrapatellar fat pad should be considered as an active osteoarthritic joint tissue: a narrative review. Osteoarthritis Cartilage (2010) 1.61
Changes in serum and synovial fluid biomarkers after acute injury (NCT00332254). Arthritis Res Ther (2010) 1.61
The role of mitochondria in osteoarthritis. Nat Rev Rheumatol (2011) 1.59
Osteoarthritis year 2010 in review: pathomechanisms. Osteoarthritis Cartilage (2011) 1.58
Regulation of autophagy in human and murine cartilage: hypoxia-inducible factor 2 suppresses chondrocyte autophagy. Arthritis Rheum (2009) 1.56
Rotenone prevents impact-induced chondrocyte death. J Orthop Res (2010) 1.56
The role of the cartilage matrix in osteoarthritis. Nat Rev Rheumatol (2010) 1.54
Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice. Arthritis Res Ther (2010) 1.48
Why is osteoarthritis an age-related disease? Best Pract Res Clin Rheumatol (2010) 1.40
Type II collagen expression is regulated by tissue-specific miR-675 in human articular chondrocytes. J Biol Chem (2010) 1.39
Attenuation of osteoarthritis progression by reduction of discoidin domain receptor 2 in mice. Arthritis Rheum (2010) 1.39
MicroRNA-146a is linked to pain-related pathophysiology of osteoarthritis. Gene (2011) 1.38
Mitochondrial DNA damage is involved in apoptosis caused by pro-inflammatory cytokines in human OA chondrocytes. Osteoarthritis Cartilage (2009) 1.28
Mechanical impact induces cartilage degradation via mitogen activated protein kinases. Osteoarthritis Cartilage (2010) 1.25
Expanding the adipokine network in cartilage: identification and regulation of novel factors in human and murine chondrocytes. Ann Rheum Dis (2011) 1.25
High mobility group box 1 potentiates the pro-inflammatory effects of interleukin-1β in osteoarthritic synoviocytes. Arthritis Res Ther (2010) 1.24
Role of HTRA1, a serine protease, in the progression of articular cartilage degeneration. Histol Histopathol (2010) 1.24
Adiponectin is a potential catabolic mediator in osteoarthritis cartilage. Arthritis Res Ther (2010) 1.24
Regulation of complement by cartilage oligomeric matrix protein allows for a novel molecular diagnostic principle in rheumatoid arthritis. Arthritis Rheum (2010) 1.23
Accelerated development of aging-associated and instability-induced osteoarthritis in osteopontin-deficient mice. Arthritis Rheum (2009) 1.20
Advanced glycation end products induce the expression of interleukin-6 and interleukin-8 by receptor for advanced glycation end product-mediated activation of mitogen-activated protein kinases and nuclear factor-κB in human osteoarthritis chondrocytes. Rheumatology (Oxford) (2010) 1.19
New molecular targets for the treatment of osteoarthritis. Biochem Pharmacol (2010) 1.15
The epigenetic effect of glucosamine and a nuclear factor-kappa B (NF-kB) inhibitor on primary human chondrocytes--implications for osteoarthritis. Biochem Biophys Res Commun (2011) 1.15
Mechanical load inhibits IL-1 induced matrix degradation in articular cartilage. Osteoarthritis Cartilage (2009) 1.13
Expression and activity profiling of selected cysteine cathepsins and matrix metalloproteinases in synovial fluids from patients with rheumatoid arthritis and osteoarthritis. Biol Chem (2010) 1.13
Molecular size hyaluronan differently modulates toll-like receptor-4 in LPS-induced inflammation in mouse chondrocytes. Biochimie (2009) 1.12
Regulation of the human ADAMTS-4 promoter by transcription factors and cytokines. Biochem Biophys Res Commun (2006) 1.11
Regulation of mechanical stress-induced MMP-13 and ADAMTS-5 expression by RUNX-2 transcriptional factor in SW1353 chondrocyte-like cells. Osteoarthritis Cartilage (2010) 1.11
MicroRNA-221 regulates chondrogenic differentiation through promoting proteosomal degradation of slug by targeting Mdm2. J Biol Chem (2010) 1.09
Is cartilage matrix breakdown an appropriate therapeutic target in osteoarthritis--insights from studies of aggrecan and collagen proteolysis? Curr Drug Targets (2010) 1.09
S100A8 and S100A9 in experimental osteoarthritis. Arthritis Res Ther (2010) 1.08
Stigmasterol: a phytosterol with potential anti-osteoarthritic properties. Osteoarthritis Cartilage (2009) 1.06
Resistin induces expression of proinflammatory cytokines and chemokines in human articular chondrocytes via transcription and messenger RNA stabilization. Arthritis Rheum (2010) 1.04
Suppressors of cytokine signalling (SOCS) are reduced in osteoarthritis. Biochem Biophys Res Commun (2011) 1.03
Characterization of the human ADAMTS-5 (aggrecanase-2) gene promoter. Mol Biol Rep (2007) 1.03
No association between markers of inflammation and osteoarthritis of the hands and knees. J Rheumatol (2011) 0.99
Chondroprotective effects and mechanisms of resveratrol in advanced glycation end products-stimulated chondrocytes. Arthritis Res Ther (2010) 0.98
High mobility group box-1 (HMGB-1) in osteoarthritic cartilage. Clin Exp Rheumatol (2010) 0.95
MicroRNA-140 and the silencing of osteoarthritis. Genes Dev (2010) 0.93
Proteomic analysis by two-dimensional electrophoresis to identify the normal human chondrocyte proteome stimulated by tumor necrosis factor alpha and interleukin-1beta. Arthritis Rheum (2010) 0.93
PGE2 inhibits MMP expression by suppressing MKK4-JNK MAP kinase-c-JUN pathway via EP4 in human articular chondrocytes. J Cell Biochem (2010) 0.91
Cytokine-induced increases in ADAMTS-4 messenger RNA expression do not lead to increased aggrecanase activity in ADAMTS-5-deficient mice. Arthritis Rheum (2010) 0.91
Regulation of chondrocyte gene expression by osteogenic protein-1. Arthritis Res Ther (2011) 0.90
p38gamma mitogen-activated protein kinase suppresses chondrocyte production of MMP-13 in response to catabolic stimulation. Osteoarthritis Cartilage (2010) 0.89
Effect of nitric oxide on mitochondrial activity of human synovial cells. BMC Musculoskelet Disord (2011) 0.88
Toll-like receptor 4 signalling is specifically TGF-beta-activated kinase 1 independent in synovial fibroblasts. Rheumatology (Oxford) (2011) 0.87
Intensification and stimulation therapy for human immunodeficiency virus type 1 reservoirs in infected persons receiving virally suppressive highly active antiretroviral therapy. J Infect Dis (2002) 1.91
NF-kappaB signaling: multiple angles to target OA. Curr Drug Targets (2010) 1.89
Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis. Eur Cell Mater (2011) 1.84
Differential expression of GADD45beta in normal and osteoarthritic cartilage: potential role in homeostasis of articular chondrocytes. Arthritis Rheum (2008) 1.33
Regulated transcription of human matrix metalloproteinase 13 (MMP13) and interleukin-1β (IL1B) genes in chondrocytes depends on methylation of specific proximal promoter CpG sites. J Biol Chem (2013) 1.22
A cis-regulatory site downregulates PTHLH in translocation t(8;12)(q13;p11.2) and leads to Brachydactyly Type E. Hum Mol Genet (2009) 1.13
ESE-1 is a potent repressor of type II collagen gene (COL2A1) transcription in human chondrocytes. J Cell Physiol (2008) 1.06
GADD45beta enhances Col10a1 transcription via the MTK1/MKK3/6/p38 axis and activation of C/EBPbeta-TAD4 in terminally differentiating chondrocytes. J Biol Chem (2010) 1.02
Rhabdovirus-based vectors with human immunodeficiency virus type 1 (HIV-1) envelopes display HIV-1-like tropism and target human dendritic cells. J Virol (2002) 1.01
Residual HIV-1 disease in seminal cells of HIV-1-infected men on suppressive HAART: latency without on-going cellular infections. AIDS (2002) 0.94
Association of reduced type IX collagen gene expression in human osteoarthritic chondrocytes with epigenetic silencing by DNA hypermethylation. Arthritis Rheumatol (2014) 0.93
Anti-inflammatory activity of an ethanolic Caesalpinia sappan extract in human chondrocytes and macrophages. J Ethnopharmacol (2011) 0.92
Dual regulation of metalloproteinase expression in chondrocytes by Wnt-1-inducible signaling pathway protein 3/CCN6. Arthritis Rheum (2012) 0.89
ADAM17 controls endochondral ossification by regulating terminal differentiation of chondrocytes. Mol Cell Biol (2013) 0.87
Genotypic alteration of HAART-persistent HIV-1 reservoirs in vivo. Virology (2003) 0.86
Caesalpinia sappan extract inhibits IL1β-mediated overexpression of matrix metalloproteinases in human chondrocytes. Genes Nutr (2011) 0.84
Use of interleukin 15 to enhance interferon-gamma production by antigen-specific stimulated lymphocytes from rhesus macaques. J Immunol Methods (2003) 0.81
Mouse models of osteoarthritis: surgical model of posttraumatic osteoarthritis induced by destabilization of the medial meniscus. Methods Mol Biol (2015) 0.79
Independence of granzyme B secretion and interferon- gamma production during acute simian immunodeficiency virus infection. J Infect Dis (2006) 0.78
IKKα/CHUK regulates extracellular matrix remodeling independent of its kinase activity to facilitate articular chondrocyte differentiation. PLoS One (2013) 0.78
Lack of ADAM10 in endothelial cells affects osteoclasts at the chondro-osseus junction. J Orthop Res (2013) 0.76
Induction of a Soluble Anti-HIV-1 factor (s) with IFN-γ, IL-10, and β-Chemokine Modulating Activity by an Influenza-Bacterial Polyantigenic Mixture. Am J Infect Dis (2007) 0.75