Published in Neural Plast on July 31, 2011
Modulation of GABAergic transmission in development and neurodevelopmental disorders: investigating physiology and pathology to gain therapeutic perspectives. Front Cell Neurosci (2014) 1.01
Finding a better drug for epilepsy: antiepileptogenesis targets. Epilepsia (2012) 0.99
Sex differences in the neurobiology of epilepsy: a preclinical perspective. Neurobiol Dis (2014) 0.91
Age-related changes in rostral basal forebrain cholinergic and GABAergic projection neurons: relationship with spatial impairment. Neurobiol Aging (2012) 0.88
Kinases SPAK and OSR1 are upregulated by estradiol and activate NKCC1 in the developing hypothalamus. J Neurosci (2012) 0.88
Glyoxalase 1 and its substrate methylglyoxal are novel regulators of seizure susceptibility. Epilepsia (2013) 0.87
Activity-dependent regulation of astrocyte GAT levels during synaptogenesis. Nat Neurosci (2014) 0.84
Early life seizures in female rats lead to anxiety-related behavior and abnormal social behavior characterized by reduced motivation to novelty and deficit in social discrimination. J Neural Transm (Vienna) (2014) 0.83
Gene expression alterations in the cerebellum and granule neurons of Cstb(-/-) mouse are associated with early synaptic changes and inflammation. PLoS One (2014) 0.82
Using sex differences in the developing brain to identify nodes of influence for seizure susceptibility and epileptogenesis. Neurobiol Dis (2014) 0.81
Enhanced synaptic connectivity in the dentate gyrus during epileptiform activity: network simulation. Comput Intell Neurosci (2013) 0.79
Ketamine alters cortical integration of GABAergic interneurons and induces long-term sex-dependent impairments in transgenic Gad67-GFP mice. Cell Death Dis (2014) 0.78
Phase shift in the 24-hour rhythm of hippocampal EEG spiking activity in a rat model of temporal lobe epilepsy. J Neurophysiol (2013) 0.77
Reduced CHRNA7 expression in C3H mice is associated with increases in hippocampal parvalbumin and glutamate decarboxylase-67 (GAD67) as well as altered levels of GABA(A) receptor subunits. Neuroscience (2014) 0.76
Feasibility of monitoring stress using skin conduction measurements during intubation of newborns. Eur J Pediatr (2015) 0.75
Excitatory neurons sculpt GABAergic neuronal connectivity in the C. elegans motor circuit. Development (2017) 0.75
Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia (2010) 18.28
Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia (2005) 9.32
Excitatory actions of gaba during development: the nature of the nurture. Nat Rev Neurosci (2002) 8.74
The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation. Nature (1999) 7.66
Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota: 1935-1984. Epilepsia (1993) 6.32
On the origin of interictal activity in human temporal lobe epilepsy in vitro. Science (2002) 5.87
NKCC1 transporter facilitates seizures in the developing brain. Nat Med (2005) 5.34
Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes. Nature (2010) 5.11
Giant synaptic potentials in immature rat CA3 hippocampal neurones. J Physiol (1989) 4.91
The distribution of thirteen GABAA receptor subunit mRNAs in the rat brain. III. Embryonic and postnatal development. J Neurosci (1992) 4.45
Mutation of ARX causes abnormal development of forebrain and testes in mice and X-linked lissencephaly with abnormal genitalia in humans. Nat Genet (2002) 4.01
Cation-chloride cotransporters and neuronal function. Neuron (2009) 3.95
Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NKCC2. Nat Genet (1996) 3.84
Sodium-potassium-chloride cotransport. Physiol Rev (2000) 3.50
Retrospective analysis of NMDA receptor antibodies in encephalitis of unknown origin. Neurology (2010) 3.40
First genetic evidence of GABA(A) receptor dysfunction in epilepsy: a mutation in the gamma2-subunit gene. Nat Genet (2001) 3.15
Excitatory GABA action is essential for morphological maturation of cortical neurons in vivo. J Neurosci (2007) 3.08
De-novo mutations of the sodium channel gene SCN1A in alleged vaccine encephalopathy: a retrospective study. Lancet Neurol (2006) 2.93
Cleft palate and decreased brain gamma-aminobutyric acid in mice lacking the 67-kDa isoform of glutamic acid decarboxylase. Proc Natl Acad Sci U S A (1997) 2.91
Perturbed chloride homeostasis and GABAergic signaling in human temporal lobe epilepsy. J Neurosci (2007) 2.79
Mechanism of activity-dependent downregulation of the neuron-specific K-Cl cotransporter KCC2. J Neurosci (2004) 2.76
Trafficking of GABA(A) receptors, loss of inhibition, and a mechanism for pharmacoresistance in status epilepticus. J Neurosci (2005) 2.75
Mutation of GABRA1 in an autosomal dominant form of juvenile myoclonic epilepsy. Nat Genet (2002) 2.72
Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition. Neuron (2001) 2.71
Two forms of the gamma-aminobutyric acid synthetic enzyme glutamate decarboxylase have distinct intraneuronal distributions and cofactor interactions. J Neurochem (1991) 2.66
Serum antibodies in epilepsy and seizure-associated disorders. Neurology (2005) 2.53
GABA itself promotes the developmental switch of neuronal GABAergic responses from excitation to inhibition. Cell (2001) 2.52
BDNF-induced TrkB activation down-regulates the K+-Cl- cotransporter KCC2 and impairs neuronal Cl- extrusion. J Cell Biol (2002) 2.40
KCC2 interacts with the dendritic cytoskeleton to promote spine development. Neuron (2007) 2.37
Truncation of the GABA(A)-receptor gamma2 subunit in a family with generalized epilepsy with febrile seizures plus. Am J Hum Genet (2001) 2.32
The spectrum of SCN1A-related infantile epileptic encephalopathies. Brain (2007) 2.30
Expression of the Na-K-2Cl cotransporter is developmentally regulated in postnatal rat brains: a possible mechanism underlying GABA's excitatory role in immature brain. J Neurobiol (1997) 2.24
Deafness and imbalance associated with inactivation of the secretory Na-K-2Cl co-transporter. Nat Genet (1999) 2.20
The cellular, molecular and ionic basis of GABA(A) receptor signalling. Prog Brain Res (2007) 2.19
Mice devoid of gamma-aminobutyrate type A receptor beta3 subunit have epilepsy, cleft palate, and hypersensitive behavior. Proc Natl Acad Sci U S A (1997) 2.16
Two developmental switches in GABAergic signalling: the K+-Cl- cotransporter KCC2 and carbonic anhydrase CAVII. J Physiol (2004) 2.11
Subunit-specific trafficking of GABA(A) receptors during status epilepticus. J Neurosci (2008) 2.09
Hyperexcitability and epilepsy associated with disruption of the mouse neuronal-specific K-Cl cotransporter gene. Hippocampus (2002) 2.06
Shunting of excitatory input to dentate gyrus granule cells by a depolarizing GABAA receptor-mediated postsynaptic conductance. J Neurophysiol (1992) 1.99
Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase. Proc Natl Acad Sci U S A (1997) 1.97
In vitro formation of a secondary epileptogenic mirror focus by interhippocampal propagation of seizures. Nat Neurosci (2003) 1.88
Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter Kcc4. Nature (2002) 1.84
Decreased seizure activity in a human neonate treated with bumetanide, an inhibitor of the Na(+)-K(+)-2Cl(-) cotransporter NKCC1. J Child Neurol (2009) 1.81
Mice lacking the 65 kDa isoform of glutamic acid decarboxylase (GAD65) maintain normal levels of GAD67 and GABA in their brains but are susceptible to seizures. Biochem Biophys Res Commun (1996) 1.79
Pathophysiological mechanisms of genetic absence epilepsy in the rat. Prog Neurobiol (1998) 1.78
Switch in the expression of rat GABAA-receptor subtypes during postnatal development: an immunohistochemical study. J Neurosci (1994) 1.76
Mutations of ARX are associated with striking pleiotropy and consistent genotype-phenotype correlation. Hum Mutat (2004) 1.76
Systematic review and meta-analysis of incidence studies of epilepsy and unprovoked seizures. Epilepsia (2002) 1.75
Impaired Cl- extrusion in layer V pyramidal neurons of chronically injured epileptogenic neocortex. J Neurophysiol (2005) 1.74
Bumetanide enhances phenobarbital efficacy in a neonatal seizure model. Ann Neurol (2008) 1.73
Expression of the KCl cotransporter KCC2 parallels neuronal maturation and the emergence of low intracellular chloride. J Comp Neurol (2004) 1.71
Anomalous levels of Cl- transporters in the hippocampal subiculum from temporal lobe epilepsy patients make GABA excitatory. Proc Natl Acad Sci U S A (2006) 1.71
Altered function of the SCN1A voltage-gated sodium channel leads to gamma-aminobutyric acid-ergic (GABAergic) interneuron abnormalities. J Biol Chem (2010) 1.70
GABRD encoding a protein for extra- or peri-synaptic GABAA receptors is a susceptibility locus for generalized epilepsies. Hum Mol Genet (2004) 1.65
Hyperglycosylation and reduced GABA currents of mutated GABRB3 polypeptide in remitting childhood absence epilepsy. Am J Hum Genet (2008) 1.64
Mutations in GABAA receptor subunits associated with genetic epilepsies. J Physiol (2010) 1.64
Sodium channel alpha1-subunit mutations in severe myoclonic epilepsy of infancy and infantile spasms. Neurology (2003) 1.61
Seizures and enhanced cortical GABAergic inhibition in two mouse models of human autosomal dominant nocturnal frontal lobe epilepsy. Proc Natl Acad Sci U S A (2006) 1.60
The United Kingdom Infantile Spasms Study (UKISS) comparing hormone treatment with vigabatrin on developmental and epilepsy outcomes to age 14 months: a multicentre randomised trial. Lancet Neurol (2005) 1.59
GABA regulates excitatory synapse formation in the neocortex via NMDA receptor activation. J Neurosci (2008) 1.58
Reduction of KCC2 expression and GABAA receptor-mediated excitation after in vivo axonal injury. J Neurosci (2002) 1.58
Infantile spasms, dystonia, and other X-linked phenotypes caused by mutations in Aristaless related homeobox gene, ARX. Brain Dev (2002) 1.56
A mutation in the GABA(A) receptor alpha(1)-subunit is associated with absence epilepsy. Ann Neurol (2006) 1.55
Special education needs of children with newly diagnosed epilepsy. Dev Med Child Neurol (2005) 1.55
BDNF regulates spontaneous correlated activity at early developmental stages by increasing synaptogenesis and expression of the K+/Cl- co-transporter KCC2. Development (2003) 1.54
Targeted loss of Arx results in a developmental epilepsy mouse model and recapitulates the human phenotype in heterozygous females. Brain (2009) 1.52
The K-Cl cotransporter KCC3 is mutant in a severe peripheral neuropathy associated with agenesis of the corpus callosum. Nat Genet (2002) 1.51
Progressive NKCC1-dependent neuronal chloride accumulation during neonatal seizures. J Neurosci (2010) 1.50
Loss of glutamate decarboxylase mRNA-containing neurons in the rat dentate gyrus following pilocarpine-induced seizures. J Neurosci (1993) 1.48
A triplet repeat expansion genetic mouse model of infantile spasms syndrome, Arx(GCG)10+7, with interneuronopathy, spasms in infancy, persistent seizures, and adult cognitive and behavioral impairment. J Neurosci (2009) 1.48
Development of cortical GABAergic circuits and its implications for neurodevelopmental disorders. Clin Genet (2007) 1.47
Enhancing GABA(A) receptor alpha 1 subunit levels in hippocampal dentate gyrus inhibits epilepsy development in an animal model of temporal lobe epilepsy. J Neurosci (2006) 1.45
The role of bicarbonate in GABAA receptor-mediated IPSPs of rat neocortical neurones. J Physiol (1993) 1.43
Loss of K-Cl co-transporter KCC3 causes deafness, neurodegeneration and reduced seizure threshold. EMBO J (2003) 1.42
A novel GABRG2 mutation associated with febrile seizures. Neurology (2006) 1.41
Neonatal status epilepticus vs recurrent neonatal seizures: clinical findings and outcome. Neurology (2007) 1.39
Maturation of kainic acid seizure-brain damage syndrome in the rat. II. Histopathological sequelae. Neuroscience (1984) 1.37
"Dormant basket cell" hypothesis revisited: relative vulnerabilities of dentate gyrus mossy cells and inhibitory interneurons after hippocampal status epilepticus in the rat. J Comp Neurol (2003) 1.36
Mutation of the Na-K-Cl co-transporter gene Slc12a2 results in deafness in mice. Hum Mol Genet (1999) 1.36
The K+-Cl cotransporter KCC2 promotes GABAergic excitation in the mature rat hippocampus. J Physiol (2010) 1.36
The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx. Proc Natl Acad Sci U S A (2000) 1.36
Expression of the GABAergic system in animal models for fragile X syndrome and fragile X associated tremor/ataxia syndrome (FXTAS). Brain Res (2008) 1.35
A new paradigm of channelopathy in epilepsy syndromes: intracellular trafficking abnormality of channel molecules. Epilepsy Res (2006) 1.33
Investigation of autism and GABA receptor subunit genes in multiple ethnic groups. Neurogenetics (2006) 1.33
Developmental changes in KCC1, KCC2, and NKCC1 mRNA expressions in the rat brain. Brain Res Dev Brain Res (2002) 1.32
The GABRG2 mutation, Q351X, associated with generalized epilepsy with febrile seizures plus, has both loss of function and dominant-negative suppression. J Neurosci (2009) 1.30
Dissociated gender-specific effects of recurrent seizures on GABA signaling in CA1 pyramidal neurons: role of GABA(A) receptors. J Neurosci (2008) 1.30
Disease-modifying effects of phenobarbital and the NKCC1 inhibitor bumetanide in the pilocarpine model of temporal lobe epilepsy. J Neurosci (2010) 1.29
Repeated neonatal handling with maternal separation permanently alters hippocampal GABAA receptors and behavioral stress responses. Proc Natl Acad Sci U S A (2003) 1.28
A novel N-terminal isoform of the neuron-specific K-Cl cotransporter KCC2. J Biol Chem (2007) 1.26
Slow endogenous activity transients and developmental expression of K+-Cl- cotransporter 2 in the immature human cortex. Eur J Neurosci (2005) 1.25
GABAB receptor coupling to G-proteins and ion channels. Adv Pharmacol (2010) 1.22
Mutations in ARX Result in Several Defects Involving GABAergic Neurons. Front Cell Neurosci (2010) 1.21
Spontaneous seizures and loss of axo-axonic and axo-somatic inhibition induced by repeated brief seizures in kindled rats. J Neurosci (2003) 1.21
Kainic acid seizures in the developing brain: status epilepticus and spontaneous recurrent seizures. Brain Res Dev Brain Res (1992) 1.21
The metabotropic GABAB receptor directly interacts with the activating transcription factor 4. J Biol Chem (2000) 1.19
Resistance of immature hippocampus to morphologic and physiologic alterations following status epilepticus or kindling. Hippocampus (2001) 1.19
Cation-chloride cotransporters and GABA-ergic innervation in the human epileptic hippocampus. Epilepsia (2007) 1.18
Sexual dimorphism and developmental regulation of substantia nigra function. Ann Neurol (2001) 1.17
Effects of status epilepticus on hippocampal GABAA receptors are age-dependent. Neuroscience (2004) 1.17
Issues related to symptomatic and disease-modifying treatments affecting cognitive and neuropsychiatric comorbidities of epilepsy. Epilepsia (2013) 2.39
A pulse rapamycin therapy for infantile spasms and associated cognitive decline. Neurobiol Dis (2011) 1.26
A model of symptomatic infantile spasms syndrome. Neurobiol Dis (2009) 1.08
Age-dependent consequences of status epilepticus: animal models. Epilepsia (2007) 0.94
Seizures in the developing brain. Epilepsia (2004) 0.92
Mechanisms of epileptogenesis in pediatric epileptic syndromes: Rasmussen encephalitis, infantile spasms, and febrile infection-related epilepsy syndrome (FIRES). Neurotherapeutics (2014) 0.92
Issues related to development of antiepileptogenic therapies. Epilepsia (2013) 0.91
Sex-dependent maturation of GABAA receptor-mediated synaptic events in rat substantia nigra reticulata. Neurosci Lett (2006) 0.90
Modeling new therapies for infantile spasms. Epilepsia (2010) 0.87
Issues for new antiepilepsy drug development. Curr Opin Neurol (2013) 0.84
CPP-115, a vigabatrin analogue, decreases spasms in the multiple-hit rat model of infantile spasms. Epilepsia (2013) 0.83
Carisbamate acutely suppresses spasms in a rat model of symptomatic infantile spasms. Epilepsia (2011) 0.82
Epilepsy and epileptic syndrome. Adv Exp Med Biol (2012) 0.81
Developmental aspects of the basal ganglia and therapeutic perspectives. Epileptic Disord (2002) 0.78
Joint AES/ILAE translational workshop to optimize preclinical epilepsy research. Epilepsia (2013) 0.78
The Perimenstrual Delta Force: A Trojan Horse for Neurosteroid Effects. Epilepsy Curr (2015) 0.76
Comment on "Infantile spasms: a U.S. consensus report". Epilepsia (2010) 0.75
Authors' response to letter by A. Mazarati. Epilepsia (2013) 0.75
Learning Through Silence: Amping up Cognition After Neonatal Hypoxic Seizures Through AMPA Receptor Inhibition. Epilepsy Curr (2012) 0.75
Stirring the pot with estrogens. Epilepsy Curr (2013) 0.75
Early life status epilepticus and stress have distinct and sex-specific effects on learning, subsequent seizure outcomes, including anticonvulsant response to phenobarbital. CNS Neurosci Ther (2014) 0.75