Published in Cell Cycle on September 01, 2011
Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance. Oncotarget (2012) 1.96
Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response. Oncotarget (2012) 1.85
Epithelial-mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients. EMBO Mol Med (2014) 1.51
Implications of the Hybrid Epithelial/Mesenchymal Phenotype in Metastasis. Front Oncol (2015) 1.15
Nectin like-5 overexpression correlates with the malignant phenotype in cutaneous melanoma. Oncotarget (2012) 1.02
Tumor Budding: The Name is EMT. Partial EMT. J Clin Med (2016) 1.00
Peritoneal tumor spread in serous ovarian cancer-epithelial mesenchymal status and outcome. Oncotarget (2015) 0.97
Cancer stem cells, tumor dormancy, and metastasis. Front Endocrinol (Lausanne) (2012) 0.96
Basal/HER2 breast carcinomas: integrating molecular taxonomy with cancer stem cell dynamics to predict primary resistance to trastuzumab (Herceptin). Cell Cycle (2012) 0.95
Emerging Biological Principles of Metastasis. Cell (2017) 0.94
SCCA1/SERPINB3 promotes oncogenesis and epithelial-mesenchymal transition via the unfolded protein response and IL6 signaling. Cancer Res (2014) 0.93
OVOL guides the epithelial-hybrid-mesenchymal transition. Oncotarget (2015) 0.93
The enforced expression of c-Myc in pig fibroblasts triggers mesenchymal-epithelial transition (MET) via F-actin reorganization and RhoA/Rock pathway inactivation. Cell Cycle (2013) 0.91
Implications of Mesenchymal Cells in Cancer Stem Cell Populations: Relevance to EMT. Curr Pathobiol Rep (2014) 0.90
TGFβ-dependent epithelial-to-mesenchymal transition is required to generate cardiospheres from human adult heart biopsies. Stem Cells Dev (2012) 0.89
Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity. Lab Invest (2014) 0.86
Evaluation of the mechanism of epithelial-mesenchymal transition in human ovarian cancer stem cells transfected with a WW domain-containing oxidoreductase gene. Oncol Lett (2014) 0.86
Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2. Oncotarget (2012) 0.86
Ovarian cancer stem-like cells show induced translineage-differentiation capacity and are suppressed by alkaline phosphatase inhibitor. Oncotarget (2013) 0.84
Malignant cancer and invasive placentation: A case for positive pleiotropy between endometrial and malignancy phenotypes. Evol Med Public Health (2014) 0.83
Infiltrating macrophages increase RCC epithelial mesenchymal transition (EMT) and stem cell-like populations via AKT and mTOR signaling. Oncotarget (2016) 0.82
Synergistic action of master transcription factors controls epithelial-to-mesenchymal transition. Nucleic Acids Res (2016) 0.81
Meta-Analysis of EMT Datasets Reveals Different Types of EMT. PLoS One (2016) 0.81
The importance of claudin-7 palmitoylation on membrane subdomain localization and metastasis-promoting activities. Cell Commun Signal (2015) 0.80
Akt-mediated transforming growth factor-β1-induced epithelial-mesenchymal transition in cultured human esophageal squamous cancer cells. Cancer Gene Ther (2014) 0.80
Coordination of cell proliferation and cell fate determination by CES-1 snail. PLoS Genet (2013) 0.80
SNAI1 promotes the development of HCC through the enhancement of proliferation and inhibition of apoptosis. FEBS Open Bio (2016) 0.80
Epithelial-mesenchymal transition in tissue repair and fibrosis. Cell Tissue Res (2016) 0.79
Polo-like kinase 1 induces epithelial-to-mesenchymal transition and promotes epithelial cell motility by activating CRAF/ERK signaling. Elife (2016) 0.79
SRPX2 Enhances the Epithelial-Mesenchymal Transition and Temozolomide Resistance in Glioblastoma Cells. Cell Mol Neurobiol (2015) 0.78
Mesenchymal stem cell-derived exosomes facilitate nasopharyngeal carcinoma progression. Am J Cancer Res (2016) 0.78
Chronic chemotherapeutic stress promotes evolution of stemness and WNT/beta-catenin signaling in colorectal cancer cells: implications for clinical use of WNT-signaling inhibitors. Oncotarget (2015) 0.78
A 3D in vitro model to explore the inter-conversion between epithelial and mesenchymal states during EMT and its reversion. Sci Rep (2016) 0.77
Attenuated RORC expression in the presence of EMT progression in somatotroph adenomas following treatment with somatostatin analogs is associated with poor clinical recovery. PLoS One (2013) 0.77
Ouabain promotes partial epithelial to mesenchymal transition (EMT) changes in human autosomal dominant polycystic kidney disease (ADPKD) cells. Exp Cell Res (2017) 0.76
Orai1 promotes tumor progression by enhancing cancer stemness via NFAT signaling in oral/oropharyngeal squamous cell carcinoma. Oncotarget (2016) 0.76
Putative stem cells and epithelial-mesenchymal transition revealed in sections of ovarian tumor in patients with serous ovarian carcinoma using immunohistochemistry for vimentin and pluripotency-related markers. J Ovarian Res (2017) 0.75
Interferon-induced transmembrane protein 1 (IFITM1) is required for the progression of colorectal cancer. Oncotarget (2016) 0.75
EMT and stemness: flexible processes tuned by alternative splicing in development and cancer progression. Mol Cancer (2017) 0.75
Partial epithelial-mesenchymal transition in keloid scars: regulation of keloid keratinocyte gene expression by transforming growth factor-β1. Burns Trauma (2016) 0.75
Epithelial-mesenchymal transition: potential regulator of ABC transporters in tumor progression. J Cancer (2017) 0.75
Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A (2003) 59.17
Stem cells, cancer, and cancer stem cells. Nature (2001) 50.27
A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell (2006) 48.80
The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell (2008) 46.08
Epithelial-mesenchymal transitions in development and disease. Cell (2009) 39.17
Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer (2002) 34.99
The basics of epithelial-mesenchymal transition. J Clin Invest (2009) 32.82
Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell (2004) 31.38
Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol (2006) 23.04
Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer (2007) 18.69
Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer (2008) 18.08
Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell (2008) 14.80
The epithelial-mesenchymal transition: new insights in signaling, development, and disease. J Cell Biol (2006) 11.16
Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer. Breast Cancer Res (2010) 10.90
The snail superfamily of zinc-finger transcription factors. Nat Rev Mol Cell Biol (2002) 10.59
TGF-beta and epithelial-to-mesenchymal transitions. Oncogene (2005) 10.02
Generation of breast cancer stem cells through epithelial-mesenchymal transition. PLoS One (2008) 8.97
Biomarkers for epithelial-mesenchymal transitions. J Clin Invest (2009) 8.76
Promotion of trophoblast stem cell proliferation by FGF4. Science (1998) 8.02
Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment. Proc Natl Acad Sci U S A (2001) 7.99
A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts. Cell Stem Cell (2010) 7.94
Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming. Cell Stem Cell (2010) 7.51
Dnmt3L and the establishment of maternal genomic imprints. Science (2001) 7.42
Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. EMBO J (2004) 7.32
Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation. Cell (2005) 7.30
The polycomb-group gene Ezh2 is required for early mouse development. Mol Cell Biol (2001) 7.20
Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease. J Clin Invest (2009) 6.70
Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors. Cancer Res (2007) 6.60
The SLUG zinc-finger protein represses E-cadherin in breast cancer. Cancer Res (2002) 6.47
CD44+/CD24- breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis. Breast Cancer Res (2006) 6.35
Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes. Proc Natl Acad Sci U S A (2010) 6.15
A positive role for histone acetylation in transcription factor access to nucleosomal DNA. Cell (1993) 6.13
Placental development: lessons from mouse mutants. Nat Rev Genet (2001) 6.03
Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence. Cancer Cell (2008) 5.88
Dynamic reprogramming of DNA methylation in the early mouse embryo. Dev Biol (2002) 5.86
The transcriptional repressor Snail promotes mammary tumor recurrence. Cancer Cell (2005) 5.81
Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics. Cancer Res (2009) 5.68
The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it. Dev Dyn (2005) 5.33
E-cadherin null mutant embryos fail to form a trophectoderm epithelium. Proc Natl Acad Sci U S A (1994) 5.31
A direct link between core histone acetylation and transcriptionally active chromatin. EMBO J (1988) 5.26
Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst. Development (2005) 4.89
Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. Genes Dev (2003) 4.89
Integration of TGF-beta/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition. EMBO J (2004) 4.77
Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice. Development (2002) 4.72
Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions. J Biol Chem (2003) 4.55
EMT: when epithelial cells decide to become mesenchymal-like cells. J Clin Invest (2009) 4.41
Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis. Genes Dev (2009) 4.29
Human cytotrophoblasts adopt a vascular phenotype as they differentiate. A strategy for successful endovascular invasion? J Clin Invest (1997) 3.93
Preeclampsia is associated with failure of human cytotrophoblasts to mimic a vascular adhesion phenotype. One cause of defective endovascular invasion in this syndrome? J Clin Invest (1997) 3.76
A subpopulation of CD26+ cancer stem cells with metastatic capacity in human colorectal cancer. Cell Stem Cell (2010) 3.43
SIP1/ZEB2 induces EMT by repressing genes of different epithelial cell-cell junctions. Nucleic Acids Res (2005) 3.41
Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathways. Proc Natl Acad Sci U S A (1998) 3.35
Vimentin regulates EMT induction by Slug and oncogenic H-Ras and migration by governing Axl expression in breast cancer. Oncogene (2010) 3.05
Breast tumor heterogeneity: cancer stem cells or clonal evolution? Cell Cycle (2007) 3.01
The role of the ZEB family of transcription factors in development and disease. Cell Mol Life Sci (2009) 2.95
Differential loss of E-cadherin expression in infiltrating ductal and lobular breast carcinomas. Am J Pathol (1993) 2.84
Epigenetic restriction of embryonic cell lineage fate by methylation of Elf5. Nat Cell Biol (2008) 2.77
The transcription factor snail induces tumor cell invasion through modulation of the epithelial cell differentiation program. Cancer Res (2005) 2.74
Abnormal skeletal patterning in embryos lacking a single Cbp allele: a partial similarity with Rubinstein-Taybi syndrome. Proc Natl Acad Sci U S A (1997) 2.68
Conjunction dysfunction: CBP/p300 in human disease. Trends Genet (1998) 2.64
Imprinted X inactivation maintained by a mouse Polycomb group gene. Nat Genet (2001) 2.63
Transcriptional crosstalk between TGF-β and stem cell pathways in tumor cell invasion: role of EMT promoting Smad complexes. Cell Cycle (2010) 2.61
Snail and slug play distinct roles during breast carcinoma progression. Clin Cancer Res (2006) 2.57
Epithelial-mesenchymal transition-derived cells exhibit multilineage differentiation potential similar to mesenchymal stem cells. Stem Cells (2010) 2.54
Cell lineage-specific undermethylation of mouse repetitive DNA. Nature (1984) 2.43
Changes in cytoskeletal protein composition indicative of an epithelial-mesenchymal transition in human micrometastatic and primary breast carcinoma cells. Clin Cancer Res (2005) 2.31
Cdx2 acts downstream of cell polarization to cell-autonomously promote trophectoderm fate in the early mouse embryo. Dev Biol (2007) 2.26
A specific inhibitor of TGF-beta receptor kinase, SB-431542, as a potent antitumor agent for human cancers. Neoplasia (2005) 2.16
Molecular circuits shared by placental and cancer cells, and their implications in the proliferative, invasive and migratory capacities of trophoblasts. Hum Reprod Update (2006) 2.15
Cooperation between snail and LEF-1 transcription factors is essential for TGF-beta1-induced epithelial-mesenchymal transition. Mol Biol Cell (2006) 2.06
The Polycomb group protein Eed protects the inactive X-chromosome from differentiation-induced reactivation. Nat Cell Biol (2006) 1.97
Tumour budding in colorectal carcinoma. Histopathology (2007) 1.93
Epithelial mesenchymal transition and tumor budding in aggressive colorectal cancer: tumor budding as oncotarget. Oncotarget (2010) 1.88
Epithelial-to-mesenchymal transitions and circulating tumor cells. J Mammary Gland Biol Neoplasia (2010) 1.73
MAP3K4/CBP-regulated H2B acetylation controls epithelial-mesenchymal transition in trophoblast stem cells. Cell Stem Cell (2011) 1.71
Maintenance of mouse trophoblast stem cell proliferation by TGF-beta/activin. Dev Biol (2004) 1.71
Distinct histone modifications in stem cell lines and tissue lineages from the early mouse embryo. Proc Natl Acad Sci U S A (2010) 1.64
Stem cells and lineage development in the mammalian blastocyst. Reprod Fertil Dev (2007) 1.64
Cancer cells in epithelial-to-mesenchymal transition and tumor-propagating-cancer stem cells: distinct, overlapping or same populations. Oncogene (2011) 1.56
The mouse PcG gene eed is required for Hox gene repression and extraembryonic development. Mamm Genome (2002) 1.50
Regulation of trophoblast invasion: from normal implantation to pre-eclampsia. Mol Cell Endocrinol (2002) 1.31
Slug regulates integrin expression and cell proliferation in human epidermal keratinocytes. J Biol Chem (2006) 1.30
Deregulating EMT and senescence: double impact by a single twist. Cancer Cell (2008) 1.29
The pathology of placenta accreta, a worldwide epidemic. J Clin Pathol (2008) 1.28
Ablation of MEKK4 kinase activity causes neurulation and skeletal patterning defects in the mouse embryo. Mol Cell Biol (2005) 1.21
Trophoblast stem cell maintenance by fibroblast growth factor 4 requires MEKK4 activation of Jun N-terminal kinase. Mol Cell Biol (2009) 1.19
Epigenetic landscape required for placental development. Cell Mol Life Sci (2007) 1.13
Cadherins in the human placenta--epithelial-mesenchymal transition (EMT) and placental development. Placenta (2010) 1.11
Loss of the maternal imprint in Dnmt3Lmat-/- mice leads to a differentiation defect in the extraembryonic tissue. Dev Biol (2006) 1.10
Undermethylation of structural gene sequences in extraembryonic lineages of the mouse. Dev Biol (1986) 1.07
Abnormal placentation and the syndrome of preeclampsia. Semin Nephrol (2004) 1.06
Identification and optimization of small molecules that restore E-cadherin expression and reduce invasion in colorectal carcinoma cells. ACS Chem Biol (2011) 1.06
Mechanisms of implantation in the mouse: differentiation and functional importance of trophoblast giant cell behavior. Dev Biol (2003) 1.04
Mechanisms of nitric oxide-mediated inhibition of EMT in cancer: inhibition of the metastasis-inducer Snail and induction of the metastasis-suppressor RKIP. Cell Cycle (2010) 1.04
Role of β5-integrin in epithelial-mesenchymal transition in response to TGF-β. Cell Cycle (2010) 1.03
Epithelial-mesenchymal transition and senescence: two cancer-related processes are crossing paths. Aging (Albany NY) (2010) 1.03
Genetic-epigenetic intersection in trophoblast differentiation: implications for extraembryonic tissue function. Epigenetics (2010) 0.99
Regulation of invasive growth: similar epigenetic mechanisms underpin tumour progression and implantation in human pregnancy. Clin Sci (Lond) (2009) 0.96
Trophectoderm projections: a potential means for locomotion, attachment and implantation of bovine, equine and human blastocysts. Hum Reprod (1996) 0.95
The Role of E-cadherin in the Motility and Invasion of Implantation Site Intermediate Trophoblast. Placenta (2002) 0.85
Coordination of Rho GTPase activities during cell protrusion. Nature (2009) 6.54
Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer. Cell (2012) 3.77
Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol (2002) 3.46
Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock. Nat Cell Biol (2003) 3.26
CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis. Hum Mol Genet (2005) 2.52
Analysis of orthologous gene expression between human pulmonary adenocarcinoma and a carcinogen-induced murine model. Am J Pathol (2005) 2.39
Structural and evolutionary division of phosphotyrosine binding (PTB) domains. J Mol Biol (2005) 2.19
Proteomic identification of the cerebral cavernous malformation signaling complex. J Proteome Res (2007) 1.83
Combined PI3K/mTOR and MEK inhibition provides broad antitumor activity in faithful murine cancer models. Clin Cancer Res (2012) 1.74
MAP3K4/CBP-regulated H2B acetylation controls epithelial-mesenchymal transition in trophoblast stem cells. Cell Stem Cell (2011) 1.71
The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy. J Clin Invest (2002) 1.56
Rho kinase inhibition rescues the endothelial cell cerebral cavernous malformation phenotype. J Biol Chem (2010) 1.51
Inhibitors paradoxically prime kinases. Nat Chem Biol (2009) 1.50
Sequential activation of caspases and serine proteases (serpases) during apoptosis. Cell Cycle (2002) 1.46
MEK kinase 2 and the adaptor protein Lad regulate extracellular signal-regulated kinase 5 activation by epidermal growth factor via Src. Mol Cell Biol (2003) 1.29
Inhibition of Src family kinases blocks epidermal growth factor (EGF)-induced activation of Akt, phosphorylation of c-Cbl, and ubiquitination of the EGF receptor. J Biol Chem (2002) 1.28
MEKK1 regulates calpain-dependent proteolysis of focal adhesion proteins for rear-end detachment of migrating fibroblasts. EMBO J (2003) 1.27
PB1 domain interaction of p62/sequestosome 1 and MEKK3 regulates NF-kappaB activation. J Biol Chem (2009) 1.24
The in vitro production and characterization of neutrophils from embryonic stem cells. Blood (2003) 1.23
Cerebral cavernous malformation 2 protein promotes smad ubiquitin regulatory factor 1-mediated RhoA degradation in endothelial cells. J Biol Chem (2009) 1.23
Discovery of Novel Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia. ACS Med Chem Lett (2012) 1.22
Ablation of MEKK4 kinase activity causes neurulation and skeletal patterning defects in the mouse embryo. Mol Cell Biol (2005) 1.21
Ubiquitylation of MEKK1 inhibits its phosphorylation of MKK1 and MKK4 and activation of the ERK1/2 and JNK pathways. J Biol Chem (2002) 1.20
Trophoblast stem cell maintenance by fibroblast growth factor 4 requires MEKK4 activation of Jun N-terminal kinase. Mol Cell Biol (2009) 1.19
Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex. Biochem J (2008) 1.15
Efficiently identifying genome-wide changes with next-generation sequencing data. Nucleic Acids Res (2011) 1.14
PB1 domains of MEKK2 and MEKK3 interact with the MEK5 PB1 domain for activation of the ERK5 pathway. J Biol Chem (2003) 1.13
JNK regulates the release of proapoptotic mitochondrial factors in reovirus-infected cells. J Virol (2004) 1.13
MEKK1 mediates the ubiquitination and degradation of c-Jun in response to osmotic stress. Mol Cell Biol (2006) 1.12
MEKK1 is essential for cardiac hypertrophy and dysfunction induced by Gq. Proc Natl Acad Sci U S A (2002) 1.11
MEKK2 regulates the coordinate activation of ERK5 and JNK in response to FGF-2 in fibroblasts. J Cell Physiol (2004) 1.09
Integrated activation of MAP3Ks balances cell fate in response to stress. J Cell Biochem (2007) 1.07
PB1 domain-dependent signaling complex is required for extracellular signal-regulated kinase 5 activation. Mol Cell Biol (2006) 1.07
Role of the amino-terminal domains of MEKKs in the activation of NF kappa B and MAPK pathways and in the regulation of cell proliferation and apoptosis. Cell Signal (2002) 1.05
Reovirus-induced alterations in gene expression related to cell cycle regulation. J Virol (2002) 1.03
MEKK4 stimulation of p38 and JNK activity is negatively regulated by GSK3beta. J Biol Chem (2007) 1.03
Reovirus-induced alteration in expression of apoptosis and DNA repair genes with potential roles in viral pathogenesis. J Virol (2003) 1.00
MEKK4 is an effector of the embryonic TRAF4 for JNK activation. J Biol Chem (2005) 1.00
Wiring diagrams of MAPK regulation by MEKK1, 2, and 3. Biochem Cell Biol (2004) 1.00
The dynamic nature of the kinome. Biochem J (2013) 1.00
Application of multiplexed kinase inhibitor beads to study kinome adaptations in drug-resistant leukemia. PLoS One (2013) 0.99
Laser-scanning velocimetry: a confocal microscopy method for quantitative measurement of cardiovascular performance in zebrafish embryos and larvae. BMC Biotechnol (2007) 0.98
MEKK1 regulates the AP-1 dimer repertoire via control of JunB transcription and Fra-2 protein stability. Oncogene (2005) 0.94
MicroRNA 9-3p targets β1 integrin to sensitize claudin-low breast cancer cells to MEK inhibition. Mol Cell Biol (2013) 0.94
Cerebral cavernous malformation is a vascular disease associated with activated RhoA signaling. Biol Chem (2013) 0.94
DEVDase detection in intact apoptotic cells using the cell permeant fluorogenic substrate, (z-DEVD)2-cresyl violet. Biotechniques (2003) 0.94
Loss of Arp2/3 induces an NF-κB-dependent, nonautonomous effect on chemotactic signaling. J Cell Biol (2013) 0.93
SWI/SNF chromatin-remodeling factor Smarcd3/Baf60c controls epithelial-mesenchymal transition by inducing Wnt5a signaling. Mol Cell Biol (2013) 0.93
Apoptosis stimulated by the 91-kDa caspase cleavage MEKK1 fragment requires translocation to soluble cellular compartments. J Biol Chem (2002) 0.92
Fluorochrome-labeled inhibitors of caspases: convenient in vitro and in vivo markers of apoptotic cells for cytometric analysis. Methods Mol Biol (2011) 0.91
Defining the functional domain of programmed cell death 10 through its interactions with phosphatidylinositol-3,4,5-trisphosphate. PLoS One (2010) 0.91
In vitro and in vivo apoptosis detection using membrane permeant fluorescent-labeled inhibitors of caspases. Methods Mol Biol (2008) 0.90
Kinetics of HL-60 cell entry to apoptosis during treatment with TNF-alpha or camptothecin assayed by the stathmo-apoptosis method. Cytometry (2002) 0.90
Tousled-like kinases modulate reactivation of gammaherpesviruses from latency. Cell Host Microbe (2013) 0.89
Noncanonical function of MEKK2 and MEK5 PB1 domains for coordinated extracellular signal-regulated kinase 5 and c-Jun N-terminal kinase signaling. Mol Cell Biol (2007) 0.87
Detection of caspases activation in situ by fluorochrome-labeled inhibitors of caspases (FLICA). Methods Mol Biol (2002) 0.87
UNC569, a novel small-molecule mer inhibitor with efficacy against acute lymphoblastic leukemia in vitro and in vivo. Mol Cancer Ther (2013) 0.86
MEKK1 is required for inducible urokinase-type plasminogen activator expression. J Biol Chem (2002) 0.85
An unbiased proteomic screen reveals caspase cleavage is positively and negatively regulated by substrate phosphorylation. Mol Cell Proteomics (2014) 0.84
Development and validation of a high-throughput intrinsic ATPase activity assay for the discovery of MEKK2 inhibitors. J Biomol Screen (2012) 0.84
Hyperosmotic induction of mitogen-activated protein kinase scaffolding. Methods Enzymol (2007) 0.83
Defining the expressed breast cancer kinome. Cell Res (2012) 0.82
Rac2D57N, a dominant inhibitory Rac2 mutant that inhibits p38 kinase signaling and prevents surface ruffling in bone-marrow-derived macrophages. J Cell Sci (2004) 0.82
Data-driven modeling of cellular stimulation, signaling and output response in RAW 264.7 cells. J Mol Signal (2008) 0.82
In vivo profiling endogenous interactions with knock-out in mammalian cells. Anal Chem (2009) 0.82
TRAIL and inhibitors of apoptosis are opposing determinants for NF-kappaB-dependent, genotoxin-induced apoptosis of cancer cells. Oncogene (2002) 0.81
MEF2C regulates c-Jun but not TNF-alpha gene expression in stimulated mast cells. Eur J Immunol (2003) 0.81
Homogeneous time-resolved fluorescence resonance energy transfer assay for measurement of Phox/Bem1p (PB1) domain heterodimerization. J Biomol Screen (2008) 0.80
Building a CT colonography program: necessary ingredients for reimbursement and clinical success. Radiology (2005) 0.79
Ablation of MEK kinase 1 suppresses intimal hyperplasia by impairing smooth muscle cell migration and urokinase plasminogen activator expression in a mouse blood-flow cessation model. Circulation (2005) 0.78
Col-F, a fluorescent probe for ex vivo confocal imaging of collagen and elastin in animal tissues. Cytometry A (2013) 0.78
Activation of chymotrypsin-like serine protease(s) during apoptosis detected by affinity-labeling of the enzymatic center with fluoresceinated inhibitor. Int J Oncol (2002) 0.76
Activity assays for extracellular signal-regulated kinase 5. Methods Mol Biol (2010) 0.76
MEKK1-induced apoptosis requires TRAIL death receptor activation and is inhibited by AKT/PKB through inhibition of MEKK1 cleavage. Oncogene (2002) 0.76
The role of MEKK1 in hypertrophic cardiomyopathy. Int Heart J (2010) 0.75
Bosutinib reduces the efficacy of Dasatinib in triple-negative breast cancer cell lines. Anticancer Res (2014) 0.75
The use of rabbit polyclonal antibodies to assess neoantigenicity following viral reduction of an alpha-1-proteinase inhibitor preparation. Biologicals (2006) 0.75
Optimizing 340B purchasing practices. Am J Health Syst Pharm (2012) 0.75
CP-64131, an aminobenzazepine with cytokine-like properties, stimulates human neutrophil functions through the p38-MAPK pathway. J Leukoc Biol (2004) 0.75
Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase. ChemMedChem (2017) 0.75