Published in Circ Cardiovasc Genet on August 31, 2011
Sugar-sweetened beverages and genetic risk of obesity. N Engl J Med (2012) 5.98
Fried food consumption, genetic risk, and body mass index: gene-diet interaction analysis in three US cohort studies. BMJ (2014) 2.06
Network-based multiple sclerosis pathway analysis with GWAS data from 15,000 cases and 30,000 controls. Am J Hum Genet (2013) 1.42
HYST: a hybrid set-based test for genome-wide association studies, with application to protein-protein interaction-based association analysis. Am J Hum Genet (2012) 1.41
Television watching, leisure time physical activity, and the genetic predisposition in relation to body mass index in women and men. Circulation (2012) 1.33
Novel locus including FGF21 is associated with dietary macronutrient intake. Hum Mol Genet (2013) 1.27
Association between a genetic variant related to glutamic acid metabolism and coronary heart disease in individuals with type 2 diabetes. JAMA (2013) 1.22
The emerging paradigm of network medicine in the study of human disease. Circ Res (2012) 1.12
Genetics of coronary artery disease. Circulation (2013) 1.00
MetaRanker 2.0: a web server for prioritization of genetic variation data. Nucleic Acids Res (2013) 1.00
A genome-wide association study of men with symptoms of testicular dysgenesis syndrome and its network biology interpretation. J Med Genet (2011) 0.96
Network.assisted analysis to prioritize GWAS results: principles, methods and perspectives. Hum Genet (2014) 0.94
DNA Methylation Variants at HIF3A Locus, B-Vitamin Intake, and Long-term Weight Change: Gene-Diet Interactions in Two U.S. Cohorts. Diabetes (2015) 0.93
Pathway-based genome-wide association analysis of coronary heart disease identifies biologically important gene sets. Eur J Hum Genet (2012) 0.93
Deciphering the molecular basis of human cardiovascular disease through network biology. Curr Opin Cardiol (2012) 0.85
Lack of gene-diuretic interactions on the risk of incident gout: the Nurses' Health Study and Health Professionals Follow-up Study. Ann Rheum Dis (2015) 0.83
Low birthweight and risk of type 2 diabetes: a Mendelian randomisation study. Diabetologia (2016) 0.83
Genetic predisposition to high blood pressure associates with cardiovascular complications among patients with type 2 diabetes: two independent studies. Diabetes (2012) 0.83
Genome-wide association analysis identifies TYW3/CRYZ and NDST4 loci associated with circulating resistin levels. Hum Mol Genet (2012) 0.83
Currently available versions of genome-wide association studies cannot be used to query the common haptoglobin copy number variant. J Am Coll Cardiol (2013) 0.82
Epigenetics: novel mechanism of pulmonary hypertension. Lung (2013) 0.82
Candidate disease gene prediction using Gentrepid: application to a genome-wide association study on coronary artery disease. Mol Genet Genomic Med (2013) 0.81
Using genetics to test the causal relationship of total adiposity and periodontitis: Mendelian randomization analyses in the Gene-Lifestyle Interactions and Dental Endpoints (GLIDE) Consortium. Int J Epidemiol (2015) 0.80
Genome-wide association study of selenium concentrations. Hum Mol Genet (2014) 0.79
Fetuin-A and risk of coronary heart disease: A Mendelian randomization analysis and a pooled analysis of AHSG genetic variants in 7 prospective studies. Atherosclerosis (2015) 0.78
Protein interaction networks reveal novel autism risk genes within GWAS statistical noise. PLoS One (2014) 0.78
Network-based association of hypoxia-responsive genes with cardiovascular diseases. New J Phys (2014) 0.78
A comprehensive survey of genetic variation in 20,691 subjects from four large cohorts. PLoS One (2017) 0.75
Selection in Europeans on fatty acid desaturases associated with dietary changes. Mol Biol Evol (2017) 0.75
Hope for GWAS: relevant risk genes uncovered from GWAS statistical noise. Int J Mol Sci (2014) 0.75
Genetic Susceptibility, Change in Physical Activity, and Long-term Weight Gain. Diabetes (2017) 0.75
Habitual coffee consumption and genetic predisposition to obesity: gene-diet interaction analyses in three US prospective studies. BMC Med (2017) 0.75
PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet (2007) 209.92
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 144.95
Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci U S A (2009) 54.68
Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet (2008) 25.83
Genomewide association analysis of coronary artery disease. N Engl J Med (2007) 24.38
From molecular to modular cell biology. Nature (1999) 23.51
A common allele on chromosome 9 associated with coronary heart disease. Science (2007) 20.37
A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science (2007) 18.96
Reproducibility and validity of an expanded self-administered semiquantitative food frequency questionnaire among male health professionals. Am J Epidemiol (1992) 17.17
Integrated genotype calling and association analysis of SNPs, common copy number polymorphisms and rare CNVs. Nat Genet (2008) 15.89
Development of human protein reference database as an initial platform for approaching systems biology in humans. Genome Res (2003) 14.79
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet (2011) 13.25
Discovering regulatory and signalling circuits in molecular interaction networks. Bioinformatics (2002) 12.88
Pathway-based approaches for analysis of genomewide association studies. Am J Hum Genet (2007) 12.27
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet (2009) 12.19
Network-based classification of breast cancer metastasis. Mol Syst Biol (2007) 12.18
A human phenome-interactome network of protein complexes implicated in genetic disorders. Nat Biotechnol (2007) 9.90
The Nurses' Health Study: 20-year contribution to the understanding of health among women. J Womens Health (1997) 8.00
ProbABEL package for genome-wide association analysis of imputed data. BMC Bioinformatics (2010) 6.46
Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits. PLoS Genet (2010) 5.79
Prioritizing GWAS results: A review of statistical methods and recommendations for their application. Am J Hum Genet (2010) 5.39
New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nat Genet (2009) 5.12
Pathway and network-based analysis of genome-wide association studies in multiple sclerosis. Hum Mol Genet (2009) 3.92
Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease. Am J Hum Genet (2009) 3.19
Interrogating type 2 diabetes genome-wide association data using a biological pathway-based approach. Diabetes (2009) 2.85
Using genome-wide pathway analysis to unravel the etiology of complex diseases. Genet Epidemiol (2009) 2.72
Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population. Nat Genet (2011) 2.32
dmGWAS: dense module searching for genome-wide association studies in protein-protein interaction networks. Bioinformatics (2010) 2.23
Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes. Science (2009) 1.90
Heterogeneity of the phenotypic definition of coronary artery disease and its impact on genetic association studies. Circ Cardiovasc Genet (2010) 1.62
Association of hypertension drug target genes with blood pressure and hypertension in 86,588 individuals. Hypertension (2011) 1.60
A new measure of the effective number of tests, a practical tool for comparing families of non-independent significance tests. Genet Epidemiol (2009) 1.43
Biological pathway-based genome-wide association analysis identified the vasoactive intestinal peptide (VIP) pathway important for obesity. Obesity (Silver Spring) (2010) 1.10
Meta-analysis of heterogeneous data sources for genome-scale identification of risk genes in complex phenotypes. Genet Epidemiol (2011) 1.08
Beta 1- and beta 2-adrenoceptor polymorphisms and cardiovascular diseases. Br J Pharmacol (2009) 0.99
Identification of T1D susceptibility genes within the MHC region by combining protein interaction networks and SNP genotyping data. Diabetes Obes Metab (2009) 0.86
Improved prediction of signal peptides: SignalP 3.0. J Mol Biol (2004) 48.40
A human gut microbial gene catalogue established by metagenomic sequencing. Nature (2010) 43.63
SignalP 4.0: discriminating signal peptides from transmembrane regions. Nat Methods (2011) 33.90
Enterotypes of the human gut microbiome. Nature (2011) 24.36
Locating proteins in the cell using TargetP, SignalP and related tools. Nat Protoc (2007) 19.50
Changes in diet and lifestyle and long-term weight gain in women and men. N Engl J Med (2011) 12.29
A human phenome-interactome network of protein complexes implicated in genetic disorders. Nat Biotechnol (2007) 9.90
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal (2010) 8.61
25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Arch Intern Med (2008) 8.03
Prediction of post-translational glycosylation and phosphorylation of proteins from the amino acid sequence. Proteomics (2004) 7.76
Fish intake, contaminants, and human health: evaluating the risks and the benefits. JAMA (2006) 7.73
Ancient human genome sequence of an extinct Palaeo-Eskimo. Nature (2010) 7.51
Plasma adiponectin levels and risk of myocardial infarction in men. JAMA (2004) 7.46
Prospective study of predictors of vitamin D status and cancer incidence and mortality in men. J Natl Cancer Inst (2006) 7.19
A new non-linear normalization method for reducing variability in DNA microarray experiments. Genome Biol (2002) 7.12
Diet quality and major chronic disease risk in men and women: moving toward improved dietary guidance. Am J Clin Nutr (2002) 6.96
Richness of human gut microbiome correlates with metabolic markers. Nature (2013) 6.93
Prediction of lipoprotein signal peptides in Gram-negative bacteria. Protein Sci (2003) 6.85
Comparison of abdominal adiposity and overall obesity in predicting risk of type 2 diabetes among men. Am J Clin Nutr (2005) 6.67
Cardiovascular morbidity and mortality in women diagnosed with rheumatoid arthritis. Circulation (2003) 6.62
Prediction, conservation analysis, and structural characterization of mammalian mucin-type O-glycosylation sites. Glycobiology (2004) 6.13
Sugar-sweetened beverages and genetic risk of obesity. N Engl J Med (2012) 5.98
Roles of drinking pattern and type of alcohol consumed in coronary heart disease in men. N Engl J Med (2003) 5.95
Reliable prediction of T-cell epitopes using neural networks with novel sequence representations. Protein Sci (2003) 5.94
Inflammatory markers and the risk of coronary heart disease in men and women. N Engl J Med (2004) 5.86
Alternative dietary indices both strongly predict risk of chronic disease. J Nutr (2012) 5.60
Analysis and prediction of leucine-rich nuclear export signals. Protein Eng Des Sel (2004) 5.15
Dynamic complex formation during the yeast cell cycle. Science (2005) 5.11
An Aboriginal Australian genome reveals separate human dispersals into Asia. Science (2011) 4.84
Exercise type and intensity in relation to coronary heart disease in men. JAMA (2002) 4.69
Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet (2012) 4.63
Feature-based prediction of non-classical and leaderless protein secretion. Protein Eng Des Sel (2004) 4.54
Dietary fat and meat intake in relation to risk of type 2 diabetes in men. Diabetes Care (2002) 4.48
Mining electronic health records: towards better research applications and clinical care. Nat Rev Genet (2012) 4.42
Sexual function in men older than 50 years of age: results from the health professionals follow-up study. Ann Intern Med (2003) 4.40
The metabolic syndrome and 11-year risk of incident cardiovascular disease in the atherosclerosis risk in communities study. Diabetes Care (2005) 4.38
Glycemic index, glycemic load, and dietary fiber intake and incidence of type 2 diabetes in younger and middle-aged women. Am J Clin Nutr (2004) 4.29
Sweetened beverage consumption, incident coronary heart disease, and biomarkers of risk in men. Circulation (2012) 4.24
Dietary patterns and risk for type 2 diabetes mellitus in U.S. men. Ann Intern Med (2002) 4.19
Statin drugs and risk of advanced prostate cancer. J Natl Cancer Inst (2006) 3.96
The implications of alternative splicing in the ENCODE protein complement. Proc Natl Acad Sci U S A (2007) 3.93
Non-high-density lipoprotein cholesterol and apolipoprotein B in the prediction of coronary heart disease in men. Circulation (2005) 3.85
Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials. Am J Clin Nutr (2008) 3.84
Linear motif atlas for phosphorylation-dependent signaling. Sci Signal (2008) 3.77
Improved prediction of MHC class I and class II epitopes using a novel Gibbs sampling approach. Bioinformatics (2004) 3.72
A large-scale analysis of tissue-specific pathology and gene expression of human disease genes and complexes. Proc Natl Acad Sci U S A (2008) 3.57
Recalibrating Equus evolution using the genome sequence of an early Middle Pleistocene horse. Nature (2013) 3.45
Clustering patterns of cytotoxic T-lymphocyte epitopes in human immunodeficiency virus type 1 (HIV-1) proteins reveal imprints of immune evasion on HIV-1 global variation. J Virol (2002) 3.38
Primary prevention of stroke by healthy lifestyle. Circulation (2008) 3.32
Frequency of analgesic use and risk of hypertension among men. Arch Intern Med (2007) 3.29
Co-evolution of transcriptional and post-translational cell-cycle regulation. Nature (2006) 3.28
Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes. Hum Mol Genet (2010) 3.24
History of kidney stones and the risk of coronary heart disease. JAMA (2013) 3.23
Habitual intake of flavonoid subclasses and incident hypertension in adults. Am J Clin Nutr (2010) 3.19
Non-classical protein secretion in bacteria. BMC Microbiol (2005) 3.17
Healthy lifestyle factors in the primary prevention of coronary heart disease among men: benefits among users and nonusers of lipid-lowering and antihypertensive medications. Circulation (2006) 3.10
Prediction of proprotein convertase cleavage sites. Protein Eng Des Sel (2004) 3.05
Prediction of twin-arginine signal peptides. BMC Bioinformatics (2005) 3.03
Changes in body weight and body fat distribution as risk factors for clinical diabetes in US men. Am J Epidemiol (2004) 2.90
Comparison of computational methods for the identification of cell cycle-regulated genes. Bioinformatics (2004) 2.83
Fish intake and risk of incident atrial fibrillation. Circulation (2004) 2.82
Physical activity in relation to cardiovascular disease and total mortality among men with type 2 diabetes. Circulation (2003) 2.80
Sugar-sweetened and artificially sweetened beverage consumption and risk of type 2 diabetes in men. Am J Clin Nutr (2011) 2.78
Mercury and the risk of coronary heart disease in men. N Engl J Med (2002) 2.71
Melatonin secretion and the incidence of type 2 diabetes. JAMA (2013) 2.65
Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology. EMBO J (2013) 2.58
Excess weight and the risk of incident coronary heart disease among men and women. Obesity (Silver Spring) (2009) 2.56
Body mass index and risk of suicide among men. Arch Intern Med (2007) 2.55
Habitual dietary intake of n-3 and n-6 fatty acids in relation to inflammatory markers among US men and women. Circulation (2003) 2.52
Metagenomic species profiling using universal phylogenetic marker genes. Nat Methods (2013) 2.51
A prospective study of tomato products, lycopene, and prostate cancer risk. J Natl Cancer Inst (2002) 2.49
Growth-rate regulated genes have profound impact on interpretation of transcriptome profiling in Saccharomyces cerevisiae. Genome Biol (2006) 2.43
Social ties and change in social ties in relation to subsequent total and cause-specific mortality and coronary heart disease incidence in men. Am J Epidemiol (2002) 2.41
Definition of supertypes for HLA molecules using clustering of specificity matrices. Immunogenetics (2004) 2.39
Coffee consumption and coronary heart disease in men and women: a prospective cohort study. Circulation (2006) 2.35
Pigs in sequence space: a 0.66X coverage pig genome survey based on shotgun sequencing. BMC Genomics (2005) 2.34
Alcohol consumption and risk for coronary heart disease among men with hypertension. Ann Intern Med (2007) 2.30
Drinking frequency, mediating biomarkers, and risk of myocardial infarction in women and men. Circulation (2005) 2.29
Prediction of glycosylation across the human proteome and the correlation to protein function. Pac Symp Biocomput (2002) 2.29
A nondegenerate code of deleterious variants in Mendelian loci contributes to complex disease risk. Cell (2013) 2.28
Nutritional predictors of insulin-like growth factor I and their relationships to cancer in men. Cancer Epidemiol Biomarkers Prev (2003) 2.26
Nonsteroidal antiinflammatory drugs, acetaminophen, and the risk of cardiovascular events. Circulation (2006) 2.26
A prospective study of risk factors for erectile dysfunction. J Urol (2006) 2.25
Magnesium intake and risk of type 2 diabetes in men and women. Diabetes Care (2004) 2.24
Alternative splicing in colon, bladder, and prostate cancer identified by exon array analysis. Mol Cell Proteomics (2008) 2.24
Associations between diet, lifestyle factors, and telomere length in women. Am J Clin Nutr (2010) 2.23
NESbase version 1.0: a database of nuclear export signals. Nucleic Acids Res (2003) 2.21
Periodontal disease, tooth loss, and incidence of ischemic stroke. Stroke (2003) 2.19
An integrative approach to CTL epitope prediction: a combined algorithm integrating MHC class I binding, TAP transport efficiency, and proteasomal cleavage predictions. Eur J Immunol (2005) 2.19
Using electronic patient records to discover disease correlations and stratify patient cohorts. PLoS Comput Biol (2011) 2.14
Intakes of whole grains, bran, and germ and the risk of coronary heart disease in men. Am J Clin Nutr (2004) 2.14
Interplay between different polyunsaturated fatty acids and risk of coronary heart disease in men. Circulation (2005) 2.12
Alcohol consumption and risk for coronary heart disease in men with healthy lifestyles. Arch Intern Med (2006) 2.10
A prospective study of dietary fiber intake and risk of cardiovascular disease among women. J Am Coll Cardiol (2002) 2.10
Fish consumption and risk of stroke in men. JAMA (2002) 2.08
Circulating long-chain ω-3 fatty acids and incidence of congestive heart failure in older adults: the cardiovascular health study: a cohort study. Ann Intern Med (2011) 2.06
Fried food consumption, genetic risk, and body mass index: gene-diet interaction analysis in three US cohort studies. BMJ (2014) 2.06