Published in Oncogene on September 05, 2011
CSF1R signaling blockade stanches tumor-infiltrating myeloid cells and improves the efficacy of radiotherapy in prostate cancer. Cancer Res (2013) 2.19
Role of ABL family kinases in cancer: from leukaemia to solid tumours. Nat Rev Cancer (2013) 1.92
Arg/Abl2 promotes invasion and attenuates proliferation of breast cancer in vivo. Oncogene (2012) 1.20
Imatinib reverses doxorubicin resistance by affecting activation of STAT3-dependent NF-κB and HSP27/p38/AKT pathways and by inhibiting ABCB1. PLoS One (2013) 0.94
Ableson kinases negatively regulate invadopodia function and invasion in head and neck squamous cell carcinoma by inhibiting an HB-EGF autocrine loop. Oncogene (2012) 0.90
Activation of abl family kinases in solid tumors. Genes Cancer (2012) 0.89
The host microenvironment influences prostate cancer invasion, systemic spread, bone colonization, and osteoblastic metastasis. Front Oncol (2014) 0.87
Tumor and stromal-based contributions to head and neck squamous cell carcinoma invasion. Cancers (Basel) (2015) 0.87
Nilotinib induces autophagy in hepatocellular carcinoma through AMPK activation. J Biol Chem (2013) 0.86
Crk and ABI1: binary molecular switches that regulate abl tyrosine kinase and signaling to the cytoskeleton. Genes Cancer (2012) 0.86
Dual regulation of Myc by Abl. Oncogene (2013) 0.85
Comparison of the cancer gene targeting and biochemical selectivities of all targeted kinase inhibitors approved for clinical use. PLoS One (2014) 0.85
c-Abl and Arg induce cathepsin-mediated lysosomal degradation of the NM23-H1 metastasis suppressor in invasive cancer. Oncogene (2013) 0.82
The Emerging Role of ABL Kinases in Solid Tumors. Trends Cancer (2015) 0.81
Met acts through Abl to regulate p53 transcriptional outcomes and cell survival in the developing liver. J Hepatol (2012) 0.79
Misfolding, Aggregation, and Disordered Segments in c-Abl and p53 in Human Cancer. Front Oncol (2015) 0.79
α3β1 Integrin Suppresses Prostate Cancer Metastasis via Regulation of the Hippo Pathway. Cancer Res (2016) 0.78
Geminin overexpression promotes imatinib sensitive breast cancer: a novel treatment approach for aggressive breast cancers, including a subset of triple negative. PLoS One (2014) 0.78
Abl Kinases Regulate HGF/Met Signaling Required for Epithelial Cell Scattering, Tubulogenesis and Motility. PLoS One (2015) 0.77
Somatically mutated ABL1 is an actionable and essential NSCLC survival gene. EMBO Mol Med (2016) 0.76
c-Abl Kinase Is a Regulator of αvβ3 Integrin Mediated Melanoma A375 Cell Migration. PLoS One (2013) 0.76
Metastasis suppressor NME1 regulates melanoma cell morphology, self-adhesion and motility via induction of fibronectin expression. Exp Dermatol (2015) 0.76
ABL2 suppresses FLT3-ITD-induced cell proliferation through negative regulation of AKT signaling. Oncotarget (2017) 0.75
Overexpression of Abl2 predicts poor prognosis in hepatocellular carcinomas and is associated with cancer cell migration and invasion. Onco Targets Ther (2014) 0.75
Coordination of signalling networks and tumorigenic properties by ABL in glioblastoma cells. Oncotarget (2016) 0.75
Structure of the ABL2/ARG kinase in complex with dasatinib. Acta Crystallogr F Struct Biol Commun (2015) 0.75
Abl kinase regulation by BRAF/ERK and cooperation with Akt in melanoma. Oncogene (2017) 0.75
Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med (2010) 67.34
Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med (2010) 36.57
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med (2001) 24.51
MDA-MB-435 cells are derived from M14 melanoma cells--a loss for breast cancer, but a boon for melanoma research. Breast Cancer Res Treat (2006) 4.04
Determinants of BRAF mutations in primary melanomas. J Natl Cancer Inst (2003) 3.65
A study of tumor progression: the precursor lesions of superficial spreading and nodular melanoma. Hum Pathol (1984) 3.21
c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF. Genes Dev (1999) 3.09
The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl-Crk pathway. Nat Cell Biol (2006) 2.87
Activation of Abl tyrosine kinases promotes invasion of aggressive breast cancer cells. Cancer Res (2006) 2.69
Interstitial collagenases as markers of tumor progression. Clin Cancer Res (2000) 2.13
Targeting STAT3 affects melanoma on multiple fronts. Cancer Metastasis Rev (2005) 1.93
Aggressive breast cancer cells are dependent on activated Abl kinases for proliferation, anchorage-independent growth and survival. Oncogene (2007) 1.78
An EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion. Cancer Res (2011) 1.75
Matrix metalloproteinases: evolution, gene regulation and functional analysis in mouse models. Biochim Biophys Acta (2009) 1.73
A critical role for cortactin phosphorylation by Abl-family kinases in PDGF-induced dorsal-wave formation. Curr Biol (2007) 1.69
Lack of clinical efficacy of imatinib in metastatic melanoma. Br J Cancer (2005) 1.66
Genetic subgrouping of melanoma reveals new opportunities for targeted therapy. Cancer Res (2009) 1.57
A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-gamma1. Nat Cell Biol (2003) 1.53
Cytoplasmic signalling by the c-Abl tyrosine kinase in normal and cancer cells. Biol Cell (2008) 1.52
Signal transducer and activator of transcription 3 activation promotes invasive growth of colon carcinomas through matrix metalloproteinase induction. Neoplasia (2007) 1.49
Imatinib mesylate in cutaneous melanoma. J Invest Dermatol (2004) 1.48
Requirement of STAT3 activation for maximal collagenase-1 (MMP-1) induction by epidermal growth factor and malignant characteristics in T24 bladder cancer cells. Oncogene (2006) 1.47
Evidence for regulation of the human ABL tyrosine kinase by a cellular inhibitor. Proc Natl Acad Sci U S A (1991) 1.46
The Ets-1 and Ets-2 transcription factors activate the promoters for invasion-associated urokinase and collagenase genes in response to epidermal growth factor. Int J Cancer (1998) 1.44
A matrix metalloproteinase-1/protease activated receptor-1 signaling axis promotes melanoma invasion and metastasis. Oncogene (2009) 1.35
Treatment for metastatic malignant melanoma: old drugs and new strategies. Crit Rev Oncol Hematol (2009) 1.32
Activated c-Abl tyrosine kinase in malignant solid tumors. Oncogene (2008) 1.28
Abl kinases regulate autophagy by promoting the trafficking and function of lysosomal components. J Biol Chem (2008) 1.25
Abl kinases are required for invadopodia formation and chemokine-induced invasion. J Biol Chem (2010) 1.20
Activated Abl kinase inhibits oncogenic transforming growth factor-beta signaling and tumorigenesis in mammary tumors. FASEB J (2009) 1.20
Pharmacokinetics and cellular uptake of imatinib and its main metabolite CGP74588. Cancer Chemother Pharmacol (2003) 1.19
Oncogenic activation of c-Abl in non-small cell lung cancer cells lacking FUS1 expression: inhibition of c-Abl by the tumor suppressor gene product Fus1. Oncogene (2007) 1.15
The Role of B-RAF Mutations in Melanoma and the Induction of EMT via Dysregulation of the NF-κB/Snail/RKIP/PTEN Circuit. Genes Cancer (2010) 1.14
Anal mucosal melanoma with KIT-activating mutation and response to imatinib therapy--case report and review of the literature. Dermatology (2009) 1.12
Nilotinib. Clin Cancer Res (2008) 1.06
Abl interconnects oncogenic Met and p53 core pathways in cancer cells. Cell Death Differ (2011) 1.05
Melanoma epidemiology and public health. Dermatol Clin (2009) 0.99
B-RAF inhibitors: an evolving role in the therapy of malignant melanoma. Curr Oncol Rep (2010) 0.97
Cell density-dependent regulation of matrix metalloproteinase and TIMP expression in differently tumorigenic breast cancer cell lines. Exp Cell Res (2005) 0.97
Overexpression of the KIT/SCF in uveal melanoma does not translate into clinical efficacy of imatinib mesylate. Clin Cancer Res (2009) 0.95
Revealing the genomic heterogeneity of melanoma. Cancer Cell (2005) 0.94
The Cain and Abl of epithelial-mesenchymal transition and transforming growth factor-β in mammary epithelial cells. Cells Tissues Organs (2010) 0.94
Reciprocal regulation of Abl and receptor tyrosine kinases. Cell Signal (2009) 0.93
Quantitative cell dispersion analysis: new test to measure tumor cell aggressiveness. Int J Cancer (2001) 0.92
c-Abl and Arg tyrosine kinases regulate lysosomal degradation of the oncoprotein Galectin-3. Cell Death Differ (2010) 0.92
Improving chemotherapeutic drug penetration in melanoma by imatinib mesylate. J Dermatol Sci (2008) 0.90
Expression of tyrosine kinases in human malignancies as potential targets for kinase-specific inhibitors. Endocr Relat Cancer (2004) 0.84
Antiproliferative effect of STI571 on cultured human cutaneous melanoma-derived cell lines. Melanoma Res (2006) 0.84
Molecular pathogenesis of sporadic melanoma and melanoma-initiating cells. Arch Pathol Lab Med (2010) 0.84
Advances in treatment of chronic myelogenous leukemia--new treatment options with tyrosine kinase inhibitors. Leuk Lymphoma (2009) 0.84
Nanoneoadjuvant therapy of gastrointestinal stromal tumor (GIST). Ann Surg Oncol (2009) 0.82
A clinical and biological overview of gastrointestinal stromal tumors. Med Oncol (2005) 0.82
Expression monitoring by hybridization to high-density oligonucleotide arrays. Nat Biotechnol (1996) 72.84
Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell (2000) 10.90
Positive and negative regulation of transcription in vitro: enhancer-binding protein AP-2 is inhibited by SV40 T antigen. Cell (1987) 7.51
Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease. Proc Natl Acad Sci U S A (1988) 4.45
Lowry determination of protein in the presence of Triton X-100. Anal Biochem (1975) 3.94
Putative contributors to the secular increase in obesity: exploring the roads less traveled. Int J Obes (Lond) (2006) 3.90
Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein. Science (1995) 3.46
Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells. Arch Toxicol (2000) 3.46
Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins. J Virol (2000) 3.30
Potent neutralization of botulinum neurotoxin by recombinant oligoclonal antibody. Proc Natl Acad Sci U S A (2002) 3.16
Results of cardiopulmonary resuscitation. Failure to predict survival in two community hospitals. Arch Intern Med (1993) 3.02
Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments. Proc Natl Acad Sci U S A (2001) 2.97
Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous leukemia. Nat Med (2000) 2.78
Species identification of coagulase-negative staphylococcal isolates from blood cultures. J Clin Microbiol (1982) 2.71
The anatomic basis of parathyroid surgery. Ann Surg (1976) 2.70
A Nedd8 conjugation pathway is essential for proteolytic targeting of p27Kip1 by ubiquitination. Proc Natl Acad Sci U S A (2000) 2.69
Heat shock proteins are methylated in avian and mammalian cells. Proc Natl Acad Sci U S A (1981) 2.68
Identifying individuals with physcian diagnosed COPD in health administrative databases. COPD (2009) 2.61
Investigation, treatment and monitoring of late-onset hypogonadism in males. Aging Male (2005) 2.60
Pestivirus translation initiation occurs by internal ribosome entry. Virology (1995) 2.56
Application of a multidimensional caregiver burden inventory. Gerontologist (1989) 2.53
Inhibition of natural killer cell-mediated cytotoxicity by Kaposi's sarcoma-associated herpesvirus K5 protein. Immunity (2000) 2.53
Structural characterization of the core of the paired helical filament of Alzheimer disease. Proc Natl Acad Sci U S A (1988) 2.53
Differential clearance and host-pathogen interactions of YopE- and YopK- YopL- Yersinia pestis in BALB/c mice. Infect Immun (1989) 2.45
Crystallographic structures of the ligand-binding domains of the androgen receptor and its T877A mutant complexed with the natural agonist dihydrotestosterone. Proc Natl Acad Sci U S A (2001) 2.44
Ketamine anesthesia during the first week of life can cause long-lasting cognitive deficits in rhesus monkeys. Neurotoxicol Teratol (2011) 2.41
The role of inherited TPMT and COMT genetic variation in cisplatin-induced ototoxicity in children with cancer. Clin Pharmacol Ther (2013) 2.40
p300 and p300/cAMP-response element-binding protein-associated factor acetylate the androgen receptor at sites governing hormone-dependent transactivation. J Biol Chem (2000) 2.31
Vertebroplasty in patients with severe vertebral compression fractures: a technical report. AJNR Am J Neuroradiol (2000) 2.27
A highly divergent picornavirus in a marine mammal. J Virol (2007) 2.23
The surgical management of paraduodenal hernia. Ann Surg (1968) 2.20
Bovine interstitial retinol-binding protein (IRBP)--isolation and sequence analysis of cDNA clones, characterization and in vitro translation of mRNA. Vision Res (1986) 2.16
Bgl II RFLP recognized by a human IRBP cDNA localized to chromosome 10. Nucleic Acids Res (1987) 2.15
Importance of ICOS-B7RP-1 costimulation in acute and chronic allograft rejection. Nat Immunol (2001) 2.10
V(D)J recombination in Ku86-deficient mice: distinct effects on coding, signal, and hybrid joint formation. Immunity (1997) 2.10
Direct inoculation procedure for the rapid classification of bacteria from blood culture. J Clin Microbiol (1975) 2.09
Insuring Latinos against the costs of illness. JAMA (1993) 2.09
Oldest playable musical instruments found at Jiahu early Neolithic site in China. Nature (1999) 2.08
Thermodynamics and structure of a DNA tetraplex: a spectroscopic and calorimetric study of the tetramolecular complexes of d(TG3T) and d(TG3T2G3T). Proc Natl Acad Sci U S A (1992) 2.03
Overexpression of the hyaluronan receptor RHAMM is transforming and is also required for H-ras transformation. Cell (1995) 1.99
Long-term pharmacokinetics of transdermal testosterone gel in hypogonadal men. J Clin Endocrinol Metab (2000) 1.99
Functional differences between memory and naive CD8 T cells. Proc Natl Acad Sci U S A (1999) 1.94
Data from men in greater Seattle area reveals no downward trend in semen quality: further evidence that deterioration of semen quality is not geographically uniform. Fertil Steril (1996) 1.93
Inhibition of p38 mitogen-activated protein kinase decreases cardiomyocyte apoptosis and improves cardiac function after myocardial ischemia and reperfusion. Circulation (1999) 1.93
Odontogenic tumors. A demographic study of 759 cases in a Chinese population. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (1998) 1.93
Hepatic cytochrome P450s metabolize aristolochic acid and reduce its kidney toxicity. Kidney Int (2008) 1.86
Neuronal somatic ATP release triggers neuron-satellite glial cell communication in dorsal root ganglia. Proc Natl Acad Sci U S A (2007) 1.85
Pumilio is essential for function but not for distribution of the Drosophila abdominal determinant Nanos. Genes Dev (1992) 1.85
Anemia is associated with mortality in kidney-transplanted patients--a prospective cohort study. Am J Transplant (2007) 1.84
Variations in KCNQ1 are associated with type 2 diabetes and beta cell function in a Chinese population. Diabetologia (2009) 1.83
Somatic mutations of the MEN1 tumor suppressor gene in sporadic gastrinomas and insulinomas. Cancer Res (1997) 1.82
Role of direct interaction in BRCA1 inhibition of estrogen receptor activity. Oncogene (2001) 1.82
Androgen receptor: an overview. Crit Rev Eukaryot Gene Expr (1995) 1.81
PSA-NCAM is required for activity-induced synaptic plasticity. Neuron (1996) 1.81
Aggressive breast cancer cells are dependent on activated Abl kinases for proliferation, anchorage-independent growth and survival. Oncogene (2007) 1.78
F-box protein Skp2: a novel transcriptional target of E2F. Oncogene (2006) 1.74
Messenger RNA targeting of rice seed storage proteins to specific ER subdomains. Nature (2000) 1.72
Cyclin D1 binds the androgen receptor and regulates hormone-dependent signaling in a p300/CBP-associated factor (P/CAF)-dependent manner. Mol Endocrinol (2001) 1.71
Effects of multivitamin and mineral supplementation on adiposity, energy expenditure and lipid profiles in obese Chinese women. Int J Obes (Lond) (2010) 1.70
Stem cells of the corneal epithelium lack connexins and metabolite transfer capacity. Differentiation (1997) 1.69
Prenatal phthalate exposure and reduced masculine play in boys. Int J Androl (2009) 1.69
Molecular analysis of neurofibrillary degeneration in Alzheimer's disease. An immunohistochemical study. Am J Pathol (1990) 1.64
Natural occurrence of deoxynivalenol, 3-acetyl-deoxynivalenol, 15-acetyl-deoxynivalenol, nivalenol, 4,7-dideoxynivalenol, and zearalenone in polish wheat. Mycotoxin Res (1990) 1.64
Adenocarcinoma of renal pelvis. Arch Pathol Lab Med (1993) 1.63
Induction of phase I and phase II drug-metabolizing enzyme mRNA, protein, and activity by BHA, ethoxyquin, and oltipraz. Toxicol Appl Pharmacol (1995) 1.62
Infectivity of Cryptosporidium parvum in healthy adults with pre-existing anti-C. parvum serum immunoglobulin G. Am J Trop Med Hyg (1999) 1.60
Extracellular signal-regulated kinase plays an essential role in hypertrophic agonists, endothelin-1 and phenylephrine-induced cardiomyocyte hypertrophy. J Biol Chem (2000) 1.60
Search for supersymmetry using final states with one lepton, jets, and missing transverse momentum with the ATLAS detector in √s=7 TeV pp collisions. Phys Rev Lett (2011) 1.60
Interferon regulatory factor 5 (IRF5) gene variants are associated with multiple sclerosis in three distinct populations. J Med Genet (2008) 1.59
Disulfide bond reduction of von Willebrand factor by ADAMTS-13. J Thromb Haemost (2010) 1.59
Olfactory dysfunction in LRRK2 G2019S mutation carriers. Neurology (2011) 1.57
Effectiveness of fast-track rehabilitation vs conventional care in laparoscopic colorectal resection for elderly patients: a randomized trial. Colorectal Dis (2012) 1.55
Initiation of nucleolar assembly is independent of RNA polymerase I transcription. Mol Biol Cell (2000) 1.54
Transcatheter closure of patent ductus arteriosus with severe pulmonary arterial hypertension in adults. Heart (2006) 1.53
A clue to the basic defect in cystic fibrosis from cloning the CF antigen gene. Nature (1987) 1.53
Orientational constraints as three-dimensional structural constraints from chemical shift anisotropy: the polypeptide backbone of gramicidin A in a lipid bilayer. Protein Sci (1993) 1.53
COPD in Chinese nonsmokers. Eur Respir J (2009) 1.52
SENSITIVITY CHANGES OF ACTINOMYCES BOVIS TO PENICILLIN AND STREPTOMYCIN. J Bacteriol (1949) 1.51
Decreased glutamate receptor 2 expression and enhanced epileptogenesis in immature rat hippocampus after perinatal hypoxia-induced seizures. J Neurosci (2001) 1.51
Frequency of very low HCV viremia detected by a highly sensitive HCV-RNA assay. J Clin Virol (2007) 1.51
Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules. Arch Biochem Biophys (1998) 1.51
[The epidemiological study of HIV infection among paid blood donors in one county of China]. Zhonghua Liu Xing Bing Xue Za Zhi (2000) 1.50
Structure and dynamics of NBD1 from CFTR characterized using crystallography and hydrogen/deuterium exchange mass spectrometry. J Mol Biol (2009) 1.49
Crystal structure of Sar1-GDP at 1.7 A resolution and the role of the NH2 terminus in ER export. J Cell Biol (2001) 1.47
Single exposure to heat induces stage-specific germ cell apoptosis in rats: role of intratesticular testosterone on stage specificity. Endocrinology (1999) 1.47
Health outcomes in low-income children with current asthma in Canada. Chronic Dis Can (2009) 1.45
Direct and computed tomography thickness measurements of the human, lumbar vertebral shell and endplate. Bone (1994) 1.45
A PR1-human leukocyte antigen-A2 tetramer can be used to isolate low-frequency cytotoxic T lymphocytes from healthy donors that selectively lyse chronic myelogenous leukemia. Cancer Res (1999) 1.45
Range of motion measurements: reference values and a database for comparison studies. Haemophilia (2010) 1.45
Zinc balance in adolescent females consuming a low- or high-calcium diet. Am J Clin Nutr (1997) 1.45
Macimorelin (AEZS-130)-stimulated growth hormone (GH) test: validation of a novel oral stimulation test for the diagnosis of adult GH deficiency. J Clin Endocrinol Metab (2013) 1.45
Hypopituitarism following traumatic brain injury and aneurysmal subarachnoid hemorrhage: a preliminary report. J Neurosurg (2000) 1.44
The 68,000-dalton neurofilament-associated polypeptide is a component of nonneuronal cells and of skeletal myofibrils. Proc Natl Acad Sci U S A (1980) 1.44
Meta-analysis: incidence of endoscopic gastric and duodenal ulcers in placebo arms of randomized placebo-controlled NSAID trials. Aliment Pharmacol Ther (2009) 1.44
The incidence and persistence of the NCEP (National Cholesterol Education Program) metabolic syndrome. The French D.E.S.I.R. study. Diabetes Metab (2003) 1.44
Identical genetic changes in different histologic components of Wilms' tumors. J Natl Cancer Inst (1997) 1.44