Live attenuated malaria vaccine designed to protect through hepatic CD8⁺ T cell immunity.

PubWeight™: 4.72‹?› | Rank: Top 1%

🔗 View Article (PMID 21903775)

Published in Science on September 08, 2011


J E Epstein1, K Tewari, K E Lyke, B K L Sim, P F Billingsley, M B Laurens, A Gunasekera, S Chakravarty, E R James, M Sedegah, A Richman, S Velmurugan, S Reyes, M Li, K Tucker, A Ahumada, A J Ruben, T Li, R Stafford, A G Eappen, C Tamminga, J W Bennett, C F Ockenhouse, J R Murphy, J Komisar, N Thomas, M Loyevsky, A Birkett, C V Plowe, C Loucq, R Edelman, T L Richie, R A Seder, S L Hoffman

Author Affiliations

1: U.S. Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, MD 20910, USA.

Associated clinical trials:

Clinical Trial of the PfSPZ Vaccine | NCT01001650

Study of Controlled Human Malaria Infections to Evaluate Protection After Intravenous or Intramuscular Administration of PfSPZ Vaccine in Malaria-Naive Adults | NCT02015091

Study of Safety and Effectiveness of Intravenous Immunization With PfSPZ Vaccine in Healthy African Adults | NCT01988636

PfSPZ Vaccine: Dose Optimization With Heterologous Challenge in Healthy Malaria-Naïve Adults | NCT02601716

Articles citing this

(truncated to the top 100)

Malaria medicines: a glass half full? Nat Rev Drug Discov (2015) 2.53

A microscale human liver platform that supports the hepatic stages of Plasmodium falciparum and vivax. Cell Host Microbe (2013) 1.95

Protective CD8+ T-cell immunity to human malaria induced by chimpanzee adenovirus-MVA immunisation. Nat Commun (2013) 1.95

A review of malaria vaccine clinical projects based on the WHO rainbow table. Malar J (2012) 1.87

Controlled human malaria infections by intradermal injection of cryopreserved Plasmodium falciparum sporozoites. Am J Trop Med Hyg (2012) 1.62

DNA prime/Adenovirus boost malaria vaccine encoding P. falciparum CSP and AMA1 induces sterile protection associated with cell-mediated immunity. PLoS One (2013) 1.47

Immune mechanisms in malaria: new insights in vaccine development. Nat Med (2013) 1.40

Malaria immunity in man and mosquito: insights into unsolved mysteries of a deadly infectious disease. Annu Rev Immunol (2014) 1.38

Optimising Controlled Human Malaria Infection Studies Using Cryopreserved P. falciparum Parasites Administered by Needle and Syringe. PLoS One (2013) 1.33

Controlled human malaria infection of Tanzanians by intradermal injection of aseptic, purified, cryopreserved Plasmodium falciparum sporozoites. Am J Trop Med Hyg (2014) 1.32

Current trends of immunization in Nigeria: prospect and challenges. Trop Med Health (2014) 1.26

Vaccines for malaria: how close are we? Annu Rev Med (2011) 1.20

Looking under the skin: the first steps in malarial infection and immunity. Nat Rev Microbiol (2013) 1.20

Total and putative surface proteomics of malaria parasite salivary gland sporozoites. Mol Cell Proteomics (2013) 1.19

IFNγ/IL-10 co-producing cells dominate the CD4 response to malaria in highly exposed children. PLoS Pathog (2014) 1.17

Cytotoxic markers associate with protection against malaria in human volunteers immunized with Plasmodium falciparum sporozoites. J Infect Dis (2014) 1.16

Protective CD8+ T lymphocytes in primates immunized with malaria sporozoites. PLoS One (2012) 1.16

Experimentally induced blood-stage Plasmodium vivax infection in healthy volunteers. J Infect Dis (2013) 1.15

Evaluation of the efficacy of ChAd63-MVA vectored vaccines expressing circumsporozoite protein and ME-TRAP against controlled human malaria infection in malaria-naive individuals. J Infect Dis (2014) 1.09

GlaxoSmithKline malaria vaccine phase 3 trial heralded. Nat Biotechnol (2011) 1.09

Protection against malaria at 1 year and immune correlates following PfSPZ vaccination. Nat Med (2016) 1.06

Sterile immunity to malaria after DNA prime/adenovirus boost immunization is associated with effector memory CD8+T cells targeting AMA1 class I epitopes. PLoS One (2014) 1.04

Long term protection after immunization with P. berghei sporozoites correlates with sustained IFNγ responses of hepatic CD8+ memory T cells. PLoS One (2012) 1.04

A rapid and scalable density gradient purification method for Plasmodium sporozoites. Malar J (2012) 1.01

Idiopathic acute myocarditis during treatment for controlled human malaria infection: a case report. Malar J (2014) 1.00

Discovering naturally processed antigenic determinants that confer protective T cell immunity. J Clin Invest (2013) 0.99

Direct venous inoculation of Plasmodium falciparum sporozoites for controlled human malaria infection: a dose-finding trial in two centres. Malar J (2015) 0.99

Model for in vivo assessment of humoral protection against malaria sporozoite challenge by passive transfer of monoclonal antibodies and immune serum. Infect Immun (2013) 0.99

In vivo characterization of the physicochemical properties of polymer-linked TLR agonists that enhance vaccine immunogenicity. Nat Biotechnol (2015) 0.98

DNA repair mechanisms and their biological roles in the malaria parasite Plasmodium falciparum. Microbiol Mol Biol Rev (2014) 0.96

Translating the immunogenicity of prime-boost immunization with ChAd63 and MVA ME-TRAP from malaria naive to malaria-endemic populations. Mol Ther (2014) 0.96

The March Toward Malaria Vaccines. Am J Prev Med (2015) 0.96

Progress with Plasmodium falciparum sporozoite (PfSPZ)-based malaria vaccines. Vaccine (2015) 0.95

Successful human infection with P. falciparum using three aseptic Anopheles stephensi mosquitoes: a new model for controlled human malaria infection. PLoS One (2013) 0.95

The march toward malaria vaccines. Vaccine (2015) 0.95

Clinical trial in healthy malaria-naïve adults to evaluate the safety, tolerability, immunogenicity and efficacy of MuStDO5, a five-gene, sporozoite/hepatic stage Plasmodium falciparum DNA vaccine combined with escalating dose human GM-CSF DNA. Hum Vaccin Immunother (2012) 0.95

Lymph-node resident CD8α+ dendritic cells capture antigens from migratory malaria sporozoites and induce CD8+ T cell responses. PLoS Pathog (2015) 0.94

Inducing humoral and cellular responses to multiple sporozoite and liver-stage malaria antigens using exogenous plasmid DNA. Infect Immun (2013) 0.94

A phase 1b randomized, controlled, double-blinded dosage-escalation trial to evaluate the safety, reactogenicity and immunogenicity of an adenovirus type 35 based circumsporozoite malaria vaccine in Burkinabe healthy adults 18 to 45 years of age. PLoS One (2013) 0.93

Mechanisms of protective immune responses induced by the Plasmodium falciparum circumsporozoite protein-based, self-assembling protein nanoparticle vaccine. Malar J (2013) 0.93

Mosquito transmission of the rodent malaria parasite Plasmodium chabaudi. Malar J (2012) 0.92

External quality assurance of malaria nucleic acid testing for clinical trials and eradication surveillance. PLoS One (2014) 0.92

Safety, Immunogenicity, and Protective Efficacy of Intradermal Immunization with Aseptic, Purified, Cryopreserved Plasmodium falciparum Sporozoites in Volunteers Under Chloroquine Prophylaxis: A Randomized Controlled Trial. Am J Trop Med Hyg (2015) 0.91

Killing the hypnozoite--drug discovery approaches to prevent relapse in Plasmodium vivax. Pathog Glob Health (2015) 0.90

Malaria induces anemia through CD8+ T cell-dependent parasite clearance and erythrocyte removal in the spleen. MBio (2015) 0.90

Mechanisms of stage-transcending protection following immunization of mice with late liver stage-arresting genetically attenuated malaria parasites. PLoS Pathog (2015) 0.90

CD8+ T cells from a novel T cell receptor transgenic mouse induce liver-stage immunity that can be boosted by blood-stage infection in rodent malaria. PLoS Pathog (2014) 0.89

CD8 T-cell-mediated protection against liver-stage malaria: lessons from a mouse model. Front Microbiol (2014) 0.89

A genetically attenuated malaria vaccine candidate based on P. falciparum b9/slarp gene-deficient sporozoites. Elife (2014) 0.89

Malaria and the liver: immunological hide-and-seek or subversion of immunity from within? Front Microbiol (2015) 0.88

Cross-species malaria immunity induced by chemically attenuated parasites. J Clin Invest (2013) 0.88

Taking a bite out of malaria: controlled human malaria infection by needle and syringe. Am J Trop Med Hyg (2013) 0.88

A glycolipid adjuvant, 7DW8-5, enhances CD8+ T cell responses induced by an adenovirus-vectored malaria vaccine in non-human primates. PLoS One (2013) 0.87

Development of cultured Plasmodium falciparum blood-stage malaria cell banks for early phase in vivo clinical trial assessment of anti-malaria drugs and vaccines. Malar J (2015) 0.87

CSP--a model for in vivo presentation of Plasmodium berghei sporozoite antigens by hepatocytes. PLoS One (2012) 0.87

Controlled human malaria infection by intramuscular and direct venous inoculation of cryopreserved Plasmodium falciparum sporozoites in malaria-naïve volunteers: effect of injection volume and dose on infectivity rates. Malar J (2015) 0.87

Protection against Plasmodium falciparum malaria by PfSPZ Vaccine. JCI Insight (2017) 0.86

Immunogenicity of a prime-boost vaccine containing the circumsporozoite proteins of Plasmodium vivax in rodents. Infect Immun (2013) 0.86

Linking Murine and Human Plasmodium falciparum Challenge Models in a Translational Path for Antimalarial Drug Development. Antimicrob Agents Chemother (2016) 0.85

Skin-draining lymph node priming is sufficient to induce sterile immunity against pre-erythrocytic malaria. EMBO Mol Med (2012) 0.85

Plasmodium cellular effector mechanisms and the hepatic microenvironment. Front Microbiol (2015) 0.84

The design and statistical power of treatment re-infection studies of the association between pre-erythrocytic immunity and infection with Plasmodium falciparum. Malar J (2013) 0.84

Murine infection models for vaccine development: the malaria example. Hum Vaccin Immunother (2012) 0.84

IFNγ Responses to Pre-erythrocytic and Blood-stage Malaria Antigens Exhibit Differential Associations With Past Exposure and Subsequent Protection. J Infect Dis (2014) 0.83

Malaria vaccine research and development: the role of the WHO MALVAC committee. Malar J (2013) 0.83

Circumsporozoite protein-specific K(d)-restricted CD8+ T cells mediate protective antimalaria immunity in sporozoite-immunized MHC-I-K(d) transgenic mice. Mediators Inflamm (2014) 0.83

A Meta-Analysis of Experimental Studies of Attenuated Schistosoma mansoni Vaccines in the Mouse Model. Front Immunol (2015) 0.83

Coadministration of polyinosinic:polycytidylic acid and immunostimulatory complexes modifies antigen processing in dendritic cell subsets and enhances HIV gag-specific T cell immunity. J Immunol (2013) 0.82

Radiation-induced cellular and molecular alterations in asexual intraerythrocytic Plasmodium falciparum. J Infect Dis (2012) 0.82

Optimizing Intradermal Administration of Cryopreserved Plasmodium falciparum Sporozoites in Controlled Human Malaria Infection. Am J Trop Med Hyg (2015) 0.82

Discovery of Novel Plasmodium falciparum Pre-Erythrocytic Antigens for Vaccine Development. PLoS One (2015) 0.82

Robust, reproducible, industrialized, standard membrane feeding assay for assessing the transmission blocking activity of vaccines and drugs against Plasmodium falciparum. Malar J (2015) 0.82

A nonintegrative lentiviral vector-based vaccine provides long-term sterile protection against malaria. PLoS One (2012) 0.81

Tissue signatures influence the activation of intrahepatic CD8(+) T cells against malaria sporozoites. Front Microbiol (2014) 0.81

Multidrug ATP-binding cassette transporters are essential for hepatic development of Plasmodium sporozoites. Cell Microbiol (2015) 0.81

The case for a rational genome-based vaccine against malaria. Front Microbiol (2015) 0.81

Correlates of protective immunity following whole sporozoite vaccination against malaria. Immunol Res (2014) 0.81

Immunology. Another shot at a malaria vaccine. Science (2011) 0.80

Immune-tolerant elastin-like polypeptides (iTEPs) and their application as CTL vaccine carriers. J Drug Target (2015) 0.80

Plasmodium falciparum synthetic LbL microparticle vaccine elicits protective neutralizing antibody and parasite-specific cellular immune responses. Vaccine (2013) 0.80

APC licensing and CD4+T cell help in liver-stage malaria. Front Microbiol (2014) 0.80

In vivo CD8+ T cell dynamics in the liver of Plasmodium yoelii immunized and infected mice. PLoS One (2013) 0.80

Large screen approaches to identify novel malaria vaccine candidates. Vaccine (2015) 0.80

Attenuated PfSPZ Vaccine induces strain-transcending T cells and durable protection against heterologous controlled human malaria infection. Proc Natl Acad Sci U S A (2017) 0.79

Genetic Adjuvantation of Recombinant MVA with CD40L Potentiates CD8 T Cell Mediated Immunity. Front Immunol (2013) 0.79

Laser mimicking mosquito bites for skin delivery of malaria sporozoite vaccines. J Control Release (2015) 0.79

Does the arthropod microbiota impact the establishment of vector-borne diseases in mammalian hosts? PLoS Pathog (2015) 0.79

The Jeremiah Metzger lecture: new additions to the toolbox for global malaria eradication. Trans Am Clin Climatol Assoc (2014) 0.78

Protective immunity to liver-stage malaria. Clin Transl Immunology (2016) 0.78

IMPIPS: the immune protection-inducing protein structure concept in the search for steric-electron and topochemical principles for complete fully-protective chemically synthesised vaccine development. PLoS One (2015) 0.78

Plasmodium berghei sporozoites acquire virulence and immunogenicity during mosquito hemocoel transit. Infect Immun (2013) 0.78

Application of radiation technology in vaccines development. Clin Exp Vaccine Res (2015) 0.78

Immunization of mice with live-attenuated late liver stage-arresting Plasmodium yoelii parasites generates protective antibody responses to preerythrocytic stages of malaria. Infect Immun (2014) 0.78

Comparative cost models of a liquid nitrogen vapor phase (LNVP) cold chain-distributed cryopreserved malaria vaccine vs. a conventional vaccine. Vaccine (2012) 0.78

Human CD8+ T cells mediate protective immunity induced by a human malaria vaccine in human immune system mice. Vaccine (2016) 0.78

Systems analysis of protective immune responses to RTS,S malaria vaccination in humans. Proc Natl Acad Sci U S A (2017) 0.77

Colocalization of a CD1d-Binding Glycolipid with a Radiation-Attenuated Sporozoite Vaccine in Lymph Node-Resident Dendritic Cells for a Robust Adjuvant Effect. J Immunol (2015) 0.77

CD40 is required for protective immunity against liver stage Plasmodium infection. J Immunol (2015) 0.77

Discovery of novel cross-protective Rickettsia prowazekii T-cell antigens using a combined reverse vaccinology and in vivo screening approach. Vaccine (2014) 0.77

The ability to inoculate purified malaria sporozoites will accelerate vaccine and drug discovery. Am J Trop Med Hyg (2014) 0.77

Articles by these authors

Isolation of putative progenitor endothelial cells for angiogenesis. Science (1997) 30.27

Spirochetes isolated from the blood of two patients with Lyme disease. N Engl J Med (1983) 11.15

The clinical significance of positive blood cultures: a comprehensive analysis of 500 episodes of bacteremia and fungemia in adults. I. Laboratory and epidemiologic observations. Rev Infect Dis (1983) 10.03

A molecular marker for chloroquine-resistant falciparum malaria. N Engl J Med (2001) 9.18

Association between bacterial vaginosis and preterm delivery of a low-birth-weight infant. The Vaginal Infections and Prematurity Study Group. N Engl J Med (1995) 8.89

Lymphocyte responses and cytokines. Cell (1994) 8.35

FcR gamma chain deletion results in pleiotrophic effector cell defects. Cell (1994) 7.66

Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities. J Biol Chem (2001) 7.03

Human gene mutation database-a biomedical information and research resource. Hum Mutat (2000) 6.87

Effects of a polypill (Polycap) on risk factors in middle-aged individuals without cardiovascular disease (TIPS): a phase II, double-blind, randomised trial. Lancet (2009) 6.83

Matching using estimated propensity scores: relating theory to practice. Biometrics (1996) 6.73

Trichomonas vaginalis associated with low birth weight and preterm delivery. The Vaginal Infections and Prematurity Study Group. Sex Transm Dis (1997) 6.64

Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization. Proc Natl Acad Sci U S A (2000) 6.59

Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors. Science (2000) 6.44

Retinal degeneration in the rd mouse is caused by a defect in the beta subunit of rod cGMP-phosphodiesterase. Nature (1990) 6.29

Cyclin D1 provides a link between development and oncogenesis in the retina and breast. Cell (1995) 6.08

Diagnosis of malaria by detection of Plasmodium falciparum HRP-2 antigen with a rapid dipstick antigen-capture assay. Lancet (1994) 6.01

Enteropathogenic Escherichia coli of classic serotypes associated with infant diarrhea: epidemiology and pathogenesis. Epidemiol Rev (1984) 5.98

KSHV antibodies among Americans, Italians and Ugandans with and without Kaposi's sarcoma. Nat Med (1996) 5.96

Influenza A virus NS1 protein prevents activation of NF-kappaB and induction of alpha/beta interferon. J Virol (2000) 5.44

Cre-mediated gene deletion in the mammary gland. Nucleic Acids Res (1997) 4.89

American College of Rheumatology classification criteria for Sjögren's syndrome: a data-driven, expert consensus approach in the Sjögren's International Collaborative Clinical Alliance cohort. Arthritis Care Res (Hoboken) (2012) 4.82

CD8+ T cells (cytotoxic/suppressors) are required for protection in mice immunized with malaria sporozoites. Proc Natl Acad Sci U S A (1988) 4.67

Chloroquine-resistant malaria. J Infect Dis (2001) 4.58

A 1.5 million-base pair inversion polymorphism in families with Williams-Beuren syndrome. Nat Genet (2001) 4.58

The clinical significance of positive blood cultures: a comprehensive analysis of 500 episodes of bacteremia and fungemia in adults. II. Clinical observations, with special reference to factors influencing prognosis. Rev Infect Dis (1983) 4.52

DNA vaccines: immunology, application, and optimization*. Annu Rev Immunol (2000) 4.51

Dicistronic targeting constructs: reporters and modifiers of mammalian gene expression. Proc Natl Acad Sci U S A (1994) 4.44

Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt, June 2013. Euro Surveill (2013) 4.37

Neurotoxicity induces cleavage of p35 to p25 by calpain. Nature (2000) 4.31

The effects of frequent nocturnal home hemodialysis: the Frequent Hemodialysis Network Nocturnal Trial. Kidney Int (2011) 4.27

Summary of an international workshop on typhoid fever. Rev Infect Dis (1986) 4.21

Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease. Nat Med (2000) 4.18

Analysis of deletions in DNA from patients with Becker and Duchenne muscular dystrophy. Nature (1986) 4.13

Aromatic hydrogen bond in sequence-specific protein DNA recognition. Nat Struct Biol (1996) 3.91

X-linked anhidrotic (hypohidrotic) ectodermal dysplasia is caused by mutation in a novel transmembrane protein. Nat Genet (1996) 3.90

15-deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway. Proc Natl Acad Sci U S A (2000) 3.89

Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: what next? Trends Parasitol (2001) 3.84

Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Science (1998) 3.83

Resistance studies with daptomycin. Antimicrob Agents Chemother (2001) 3.63

Diagnosis of resistance to chloroquine by Plasmodium vivax: timing of recurrence and whole blood chloroquine levels. Am J Trop Med Hyg (1997) 3.61

Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors. Neuron (1998) 3.59

Isolation and partial characterization of a corynebacteriophage beta, tox operator constitutive-like mutant lysogen of Corynebacterium diphtheriae. J Virol (1976) 3.55

Safety and immunogenicity in man of a synthetic peptide malaria vaccine against Plasmodium falciparum sporozoites. Nature (1987) 3.51

Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine. Science (1998) 3.46

Activation events during thymic selection. J Exp Med (1992) 3.43

Retinopathy and attenuated circadian entrainment in Crx-deficient mice. Nat Genet (1999) 3.42

Relations of vitamin B-12, vitamin B-6, folate, and homocysteine to cognitive performance in the Normative Aging Study. Am J Clin Nutr (1996) 3.42

Molecular cloning and DNA sequence analysis of a diphtheria tox iron-dependent regulatory element (dtxR) from Corynebacterium diphtheriae. Proc Natl Acad Sci U S A (1990) 3.42

Assembly of the mitochondrial membrane system: sequences of yeast mitochondrial valine and an unusual threonine tRNA gene. Cell (1979) 3.39

Socioeconomic and behavioral factors leading to acquired bacterial resistance to antibiotics in developing countries. Emerg Infect Dis (1999) 3.38

Mechanism of NO-induced oxidation of myoglobin and hemoglobin. Biochemistry (1996) 3.36

A simplified model for predicting malaria entomologic inoculation rates based on entomologic and parasitologic parameters relevant to control. Am J Trop Med Hyg (2000) 3.33

Resistance to chloroquine by Plasmodium vivax in Irian Jaya, Indonesia. Am J Trop Med Hyg (1991) 3.31

Efficacy and safety of abatacept or infliximab vs placebo in ATTEST: a phase III, multi-centre, randomised, double-blind, placebo-controlled study in patients with rheumatoid arthritis and an inadequate response to methotrexate. Ann Rheum Dis (2007) 3.31

Plasmodium falciparum cross-resistance between trimethoprim and pyrimethamine. Lancet (2001) 3.30

Crystal structure and functional analysis of the HERG potassium channel N terminus: a eukaryotic PAS domain. Cell (1998) 3.22

Codon recognition rules in yeast mitochondria. Proc Natl Acad Sci U S A (1980) 3.11

Molecular immune responses of the mosquito Anopheles gambiae to bacteria and malaria parasites. Proc Natl Acad Sci U S A (1997) 3.07

High-dose intravenous immune globulin for stiff-person syndrome. N Engl J Med (2001) 3.04

Safety, infectivity, immunogenicity, and in vivo stability of two attenuated auxotrophic mutant strains of Salmonella typhi, 541Ty and 543Ty, as live oral vaccines in humans. J Clin Invest (1987) 3.03

Oral immunisation against typhoid fever in Indonesia with Ty21a vaccine. Lancet (1991) 3.01

Middle East Respiratory Syndrome (MERS) coronavirus seroprevalence in domestic livestock in Saudi Arabia, 2010 to 2013. Euro Surveill (2013) 2.99

Perturbation of CD4+ and CD8+ T-cell repertoires during progression to AIDS and regulation of the CD4+ repertoire during antiviral therapy. Nat Med (1998) 2.99

Safety and efficacy of a recombinant DNA Plasmodium falciparum sporozoite vaccine. Lancet (1987) 2.98

Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease. Nature (1999) 2.97

The complexity of protective immunity against liver-stage malaria. J Immunol (2000) 2.92

Isolation of enterotoxin structural gene deletion mutations in Vibrio cholerae induced by two mutagenic vibriophages. Proc Natl Acad Sci U S A (1982) 2.92

Evidence for in vivo but not in vitro expression of a Borrelia burgdorferi outer surface protein F (OspF) homologue. Mol Microbiol (1995) 2.92

Serum levels of the proinflammatory cytokines interleukin-1 beta (IL-1beta), IL-6, IL-8, IL-10, tumor necrosis factor alpha, and IL-12(p70) in Malian children with severe Plasmodium falciparum malaria and matched uncomplicated malaria or healthy controls. Infect Immun (2004) 2.84

Association between 5-HT2A gene promoter polymorphism and anorexia nervosa. Lancet (1997) 2.83

Alcohol drinking and all cancer mortality: a meta-analysis. Ann Oncol (2012) 2.83

Vaccination with DNA encoding the immunodominant LACK parasite antigen confers protective immunity to mice infected with Leishmania major. J Exp Med (1997) 2.81

Structure of the CAP-DNA complex at 2.5 angstroms resolution: a complete picture of the protein-DNA interface. J Mol Biol (1996) 2.80

Role in cell permeability of an essential two-component system in Staphylococcus aureus. J Bacteriol (1999) 2.73

From the National Institute of Allergy and Infectious Diseases. Summary of a workshop on enteropathogenic Escherichia coli. J Infect Dis (1983) 2.71

Identification of the paromomycin-resistance mutation in the 15 S rRNA gene of yeast mitochondria. J Biol Chem (1982) 2.70

Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. Oncogene (2007) 2.68

Nucleotide sequence and expression of the diphtheria tox228 gene in Escherichia coli. Science (1983) 2.65

Caveolin-3 null mice show a loss of caveolae, changes in the microdomain distribution of the dystrophin-glycoprotein complex, and t-tubule abnormalities. J Biol Chem (2001) 2.62

Synthesis of diphtheria tox-gene products in Escherichia coli extracts. Proc Natl Acad Sci U S A (1974) 2.62

A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders. Mol Psychiatry (1996) 2.60

Protection against malaria by immunization with plasmid DNA encoding circumsporozoite protein. Proc Natl Acad Sci U S A (1994) 2.58

Cloning of the Aspergillus parasiticus apa-2 gene associated with the regulation of aflatoxin biosynthesis. Appl Environ Microbiol (1993) 2.57

Linkage disequilibrium fine mapping and haplotype association analysis of the tau gene in progressive supranuclear palsy and corticobasal degeneration. J Med Genet (2005) 2.56

Clinical manifestations of Plasmodium falciparum malaria experimentally induced by mosquito challenge. J Infect Dis (1997) 2.55

Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. Nat Genet (2001) 2.55

Rescue of cyclin D1 deficiency by knockin cyclin E. Cell (1999) 2.54

Efficacy of recombinant circumsporozoite protein vaccine regimens against experimental Plasmodium falciparum malaria. J Infect Dis (2001) 2.54

Interpreting hospital mortality data. The role of clinical risk adjustment. JAMA (1989) 2.53

Limb-salvage treatment versus amputation for osteosarcoma of the distal end of the femur. J Bone Joint Surg Am (1986) 2.49

Measurement of genetic structure within populations using Moran's spatial autocorrelation statistics. Proc Natl Acad Sci U S A (1996) 2.48

More and more is less and less the myth of massive psychiatric need. Br J Psychiatry (1985) 2.47

Studies on the molecular epidemiology of diphtheria. Lancet (1983) 2.45

Safety of live oral Salmonella typhi vaccine strains with deletions in htrA and aroC aroD and immune response in humans. Infect Immun (1997) 2.44

Ketamine anesthesia during the first week of life can cause long-lasting cognitive deficits in rhesus monkeys. Neurotoxicol Teratol (2011) 2.41

Null RPGRIP1 alleles in patients with Leber congenital amaurosis. Am J Hum Genet (2001) 2.40

The potential impact of integrated malaria transmission control on entomologic inoculation rate in highly endemic areas. Am J Trop Med Hyg (2000) 2.40