miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades.

PubWeight™: 5.83‹?› | Rank: Top 1%

🔗 View Article (PMC 3245920)

Published in Nucleic Acids Res on September 12, 2011


Marc R Friedländer1, Sebastian D Mackowiak, Na Li, Wei Chen, Nikolaus Rajewsky

Author Affiliations

1: Laboratory for Systems Biology of Gene Regulatory Elements, Berlin Institute for Medical Systems Biology at Max-Delbrück-Center for Molecular Medicine, Berlin-Buch 13125, Germany.

Articles citing this

(truncated to the top 100)

Circular RNAs are a large class of animal RNAs with regulatory potency. Nature (2013) 8.54

The draft genomes of soft-shell turtle and green sea turtle yield insights into the development and evolution of the turtle-specific body plan. Nat Genet (2013) 4.40

Evolution of microRNA diversity and regulation in animals. Nat Rev Genet (2011) 2.92

Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs. Proc Natl Acad Sci U S A (2015) 2.72

Characterization of human plasma-derived exosomal RNAs by deep sequencing. BMC Genomics (2013) 2.27

Exosomal miR-1290 and miR-375 as prognostic markers in castration-resistant prostate cancer. Eur Urol (2014) 2.05

A blood based 12-miRNA signature of Alzheimer disease patients. Genome Biol (2013) 1.99

Identification of extracellular miRNA in human cerebrospinal fluid by next-generation sequencing. RNA (2013) 1.56

bacterial infection drives the expression dynamics of microRNAs and their isomiRs. PLoS Genet (2015) 1.50

Chromosomal-Level Assembly of the Asian Seabass Genome Using Long Sequence Reads and Multi-layered Scaffolding. PLoS Genet (2016) 1.49

Exosomes secreted by nematode parasites transfer small RNAs to mammalian cells and modulate innate immunity. Nat Commun (2014) 1.49

NSun2-mediated cytosine-5 methylation of vault noncoding RNA determines its processing into regulatory small RNAs. Cell Rep (2013) 1.48

Analysis of Biobanked Serum from a Mycobacterium avium subsp paratuberculosis Bovine Infection Model Confirms the Remarkable Stability of Circulating miRNA Profiles and Defines a Bovine Serum miRNA Repertoire. PLoS One (2015) 1.43

Genomic innovations, transcriptional plasticity and gene loss underlying the evolution and divergence of two highly polyphagous and invasive Helicoverpa pest species. BMC Biol (2017) 1.39

miRNA Repertoires of Demosponges Stylissa carteri and Xestospongia testudinaria. PLoS One (2016) 1.38

miRDeep*: an integrated application tool for miRNA identification from RNA sequencing data. Nucleic Acids Res (2012) 1.37

Identifying miRNAs, targets and functions. Brief Bioinform (2012) 1.35

Lessons from miR-143/145: the importance of cell-type localization of miRNAs. Nucleic Acids Res (2014) 1.34

ShortStack: comprehensive annotation and quantification of small RNA genes. RNA (2013) 1.31

miREvo: an integrative microRNA evolutionary analysis platform for next-generation sequencing experiments. BMC Bioinformatics (2012) 1.27

The miRNA profile of human pancreatic islets and beta-cells and relationship to type 2 diabetes pathogenesis. PLoS One (2013) 1.25

Evidence for the biogenesis of more than 1,000 novel human microRNAs. Genome Biol (2014) 1.23

MiRGator v3.0: a microRNA portal for deep sequencing, expression profiling and mRNA targeting. Nucleic Acids Res (2012) 1.21

CAP-miRSeq: a comprehensive analysis pipeline for microRNA sequencing data. BMC Genomics (2014) 1.15

Deep sequencing of small RNAs identifies canonical and non-canonical miRNA and endogenous siRNAs in mammalian somatic tissues. Nucleic Acids Res (2013) 1.12

Differential expression of miR-145 in children with Kawasaki disease. PLoS One (2013) 1.12

Off-target effect of doublecortin family shRNA on neuronal migration associated with endogenous microRNA dysregulation. Neuron (2014) 1.10

Insights into the evolution of longevity from the bowhead whale genome. Cell Rep (2015) 1.09

Transcriptome microRNA profiling of bovine mammary epithelial cells challenged with Escherichia coli or Staphylococcus aureus bacteria reveals pathogen directed microRNA expression profiles. BMC Genomics (2014) 1.09

Genome of the house fly, Musca domestica L., a global vector of diseases with adaptations to a septic environment. Genome Biol (2014) 1.08

"A draft Musa balbisiana genome sequence for molecular genetics in polyploid, inter- and intra-specific Musa hybrids". BMC Genomics (2013) 1.07

Profiles of extracellular miRNA in cerebrospinal fluid and serum from patients with Alzheimer's and Parkinson's diseases correlate with disease status and features of pathology. PLoS One (2014) 1.07

A highly expressed miR-101 isomiR is a functional silencing small RNA. BMC Genomics (2013) 1.05

Parasite-derived microRNAs in host serum as novel biomarkers of helminth infection. PLoS Negl Trop Dis (2014) 1.04

YM500: a small RNA sequencing (smRNA-seq) database for microRNA research. Nucleic Acids Res (2012) 1.04

Bioinformatic analysis of barcoded cDNA libraries for small RNA profiling by next-generation sequencing. Methods (2012) 1.04

Diversity of miRNAs, siRNAs, and piRNAs across 25 Drosophila cell lines. Genome Res (2014) 1.03

Recent advances in candidate-gene and whole-genome approaches to the discovery of anthelmintic resistance markers and the description of drug/receptor interactions. Int J Parasitol Drugs Drug Resist (2014) 1.02

sRNAtoolbox: an integrated collection of small RNA research tools. Nucleic Acids Res (2015) 1.02

Bioinformatic tools for microRNA dissection. Nucleic Acids Res (2015) 1.02

Computational analysis of noncoding RNAs. Wiley Interdiscip Rev RNA (2012) 1.01

mirTools 2.0 for non-coding RNA discovery, profiling, and functional annotation based on high-throughput sequencing. RNA Biol (2013) 1.01

Characterization of the mammalian miRNA turnover landscape. Nucleic Acids Res (2015) 1.00

iMir: an integrated pipeline for high-throughput analysis of small non-coding RNA data obtained by smallRNA-Seq. BMC Bioinformatics (2013) 0.99

Comprehensive miRNA sequence analysis reveals survival differences in diffuse large B-cell lymphoma patients. Genome Biol (2015) 0.99

Comparison of hepatocellular carcinoma miRNA expression profiling as evaluated by next generation sequencing and microarray. PLoS One (2014) 0.97

Dependence of intracellular and exosomal microRNAs on viral E6/E7 oncogene expression in HPV-positive tumor cells. PLoS Pathog (2015) 0.97

Computational Approaches for the Analysis of ncRNA through Deep Sequencing Techniques. Front Bioeng Biotechnol (2015) 0.96

Substantial loss of conserved and gain of novel MicroRNA families in flatworms. Mol Biol Evol (2013) 0.96

Analysis options for high-throughput sequencing in miRNA expression profiling. BMC Res Notes (2014) 0.96

Genome and transcriptome of the porcine whipworm Trichuris suis. Nat Genet (2014) 0.96

Cnidarian microRNAs frequently regulate targets by cleavage. Genome Res (2014) 0.96

MicroRNAs and essential components of the microRNA processing machinery are not encoded in the genome of the ctenophore Mnemiopsis leidyi. BMC Genomics (2012) 0.96

A computational approach for identifying microRNA-target interactions using high-throughput CLIP and PAR-CLIP sequencing. BMC Genomics (2013) 0.96

Genome-wide profiling of the microRNA-mRNA regulatory network in skeletal muscle with aging. Aging (Albany NY) (2014) 0.96

Small RNA profiling and characterization of piRNA clusters in the adult testes of the common marmoset, a model primate. RNA (2014) 0.96

Select microRNAs are essential for early development in the sea urchin. Dev Biol (2011) 0.95

Deep sequencing reveals unique small RNA repertoire that is regulated during head regeneration in Hydra magnipapillata. Nucleic Acids Res (2012) 0.94

Potential regulatory role of microRNAs in the development of bovine gastrointestinal tract during early life. PLoS One (2014) 0.94

Computational prediction of the localization of microRNAs within their pre-miRNA. Nucleic Acids Res (2013) 0.94

Computational Prediction of miRNA Genes from Small RNA Sequencing Data. Front Bioeng Biotechnol (2015) 0.94

High-throughput sequencing reveals extraordinary fluidity of miRNA, piRNA, and siRNA pathways in nematodes. Genome Res (2013) 0.93

Discovery and characterization of miRNA genes in Atlantic salmon (Salmo salar) by use of a deep sequencing approach. BMC Genomics (2013) 0.92

Transcriptome-wide analysis of microRNA expression in the malaria mosquito Anopheles gambiae. BMC Genomics (2014) 0.92

Structured RNAs and synteny regions in the pig genome. BMC Genomics (2014) 0.92

Small RNA deep sequencing identifies microRNAs and other small noncoding RNAs from human herpesvirus 6B. J Virol (2011) 0.92

Identification of differentially expressed non-coding RNAs in embryonic stem cell neural differentiation. Nucleic Acids Res (2012) 0.92

Detecting miRNAs in deep-sequencing data: a software performance comparison and evaluation. Brief Bioinform (2012) 0.92

Prioritizing and selecting likely novel miRNAs from NGS data. Nucleic Acids Res (2015) 0.91

Extracellular Onchocerca-derived small RNAs in host nodules and blood. Parasit Vectors (2015) 0.91

RNA expression profiling of human iPSC-derived cardiomyocytes in a cardiac hypertrophy model. PLoS One (2014) 0.91

Integrating microRNA and mRNA expression profiling in Symbiodinium microadriaticum, a dinoflagellate symbiont of reef-building corals. BMC Genomics (2013) 0.91

Deep sequencing identifies circulating mouse miRNAs that are functionally implicated in manifestations of aging and responsive to calorie restriction. Aging (Albany NY) (2013) 0.90

eRNA: a graphic user interface-based tool optimized for large data analysis from high-throughput RNA sequencing. BMC Genomics (2014) 0.90

Evidence for small RNAs homologous to effector-encoding genes and transposable elements in the oomycete Phytophthora infestans. PLoS One (2012) 0.89

Competition between virus-derived and endogenous small RNAs regulates gene expression in Caenorhabditis elegans. Genome Res (2013) 0.88

CoRAL: predicting non-coding RNAs from small RNA-sequencing data. Nucleic Acids Res (2013) 0.88

A cross comparison of technologies for the detection of microRNAs in clinical FFPE samples of hepatoblastoma patients. Sci Rep (2015) 0.88

miRPlant: an integrated tool for identification of plant miRNA from RNA sequencing data. BMC Bioinformatics (2014) 0.88

Annotation of primate miRNAs by high throughput sequencing of small RNA libraries. BMC Genomics (2012) 0.88

Characterization of human pseudogene-derived non-coding RNAs for functional potential. PLoS One (2014) 0.87

Expansion of ruminant-specific microRNAs shapes target gene expression divergence between ruminant and non-ruminant species. BMC Genomics (2013) 0.87

YM500v2: a small RNA sequencing (smRNA-seq) database for human cancer miRNome research. Nucleic Acids Res (2014) 0.87

ADAR1 is required for differentiation and neural induction by regulating microRNA processing in a catalytically independent manner. Cell Res (2015) 0.87

Expression profiling of exosomal miRNAs derived from human esophageal cancer cells by Solexa high-throughput sequencing. Int J Mol Sci (2014) 0.87

Genome-wide, integrative analysis implicates microRNA dysregulation in autism spectrum disorder. Nat Neurosci (2016) 0.86

MicroRNA expression profiles of bovine milk exosomes in response to Staphylococcus aureus infection. BMC Genomics (2015) 0.86

The expression pattern of microRNAs in granulosa cells of subordinate and dominant follicles during the early luteal phase of the bovine estrous cycle. PLoS One (2014) 0.86

High-throughput sequencing of microRNA transcriptome and expression assay in the sturgeon, Acipenser schrenckii. PLoS One (2014) 0.86

Developmental regulation of ecdysone receptor (EcR) and EcR-controlled gene expression during pharate-adult development of honeybees (Apis mellifera). Front Genet (2014) 0.86

Discovery of novel microRNAs in rat kidney using next generation sequencing and microarray validation. PLoS One (2012) 0.86

Automatically clustering large-scale miRNA sequences: methods and experiments. BMC Genomics (2012) 0.86

High-throughput sequencing reveals altered expression of hepatic microRNAs in nonalcoholic fatty liver disease-related fibrosis. Transl Res (2015) 0.85

microRNA profiling in the zoonotic parasite Echinococcus canadensis using a high-throughput approach. Parasit Vectors (2015) 0.85

Optimization of miRNA-seq data preprocessing. Brief Bioinform (2015) 0.85

The impact of age, biogenesis, and genomic clustering on Drosophila microRNA evolution. RNA (2013) 0.85

Specific microRNAs regulate heat stress responses in Caenorhabditis elegans. Sci Rep (2015) 0.85

Comparison of Analysis Tools for miRNA High Throughput Sequencing Using Nerve Crush as a Model. Front Genet (2013) 0.85

cPAS-based sequencing on the BGISEQ-500 to explore small non-coding RNAs. Clin Epigenetics (2016) 0.85

Next-generation sequencing of small RNAs from inner ear sensory epithelium identifies microRNAs and defines regulatory pathways. BMC Genomics (2014) 0.84

Articles cited by this

Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics (2009) 190.94

Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res (2002) 76.95

Combinatorial microRNA target predictions. Nat Genet (2005) 50.48

Identification of novel genes coding for small expressed RNAs. Science (2001) 44.44

An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science (2001) 44.16

miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res (2006) 39.25

Most mammalian mRNAs are conserved targets of microRNAs. Genome Res (2008) 37.16

An extensive class of small RNAs in Caenorhabditis elegans. Science (2001) 34.17

Database resources of the National Center for Biotechnology Information. Nucleic Acids Res (2007) 22.53

Vienna RNA secondary structure server. Nucleic Acids Res (2003) 19.69

Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP. Cell (2010) 17.87

microRNA functions. Annu Rev Cell Dev Biol (2007) 15.74

Large-scale sequencing reveals 21U-RNAs and additional microRNAs and endogenous siRNAs in C. elegans. Cell (2006) 15.12

HITS-CLIP yields genome-wide insights into brain alternative RNA processing. Nature (2008) 14.17

The NIH Roadmap Epigenomics Mapping Consortium. Nat Biotechnol (2010) 13.99

Phylogenetic shadowing and computational identification of human microRNA genes. Cell (2005) 13.24

Small non-coding RNAs in animal development. Nat Rev Mol Cell Biol (2008) 12.35

Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol (2009) 11.50

Widespread shortening of 3'UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells. Cell (2009) 10.50

Discovering microRNAs from deep sequencing data using miRDeep. Nat Biotechnol (2008) 10.17

Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAs. Genome Res (2007) 9.61

The evolution of gene regulation by transcription factors and microRNAs. Nat Rev Genet (2007) 7.92

Mammalian microRNAs: experimental evaluation of novel and previously annotated genes. Genes Dev (2010) 7.14

Early origins and evolution of microRNAs and Piwi-interacting RNAs in animals. Nature (2008) 6.81

A human snoRNA with microRNA-like functions. Mol Cell (2008) 5.84

Evidence that microRNA precursors, unlike other non-coding RNAs, have lower folding free energies than random sequences. Bioinformatics (2004) 4.95

tRNAdb 2009: compilation of tRNA sequences and tRNA genes. Nucleic Acids Res (2008) 4.88

Mechanisms of miRNA-mediated post-transcriptional regulation in animal cells. Curr Opin Cell Biol (2009) 4.56

Identification of miRNomes in human liver and hepatocellular carcinoma reveals miR-199a/b-3p as therapeutic target for hepatocellular carcinoma. Cancer Cell (2011) 4.54

Expanding the microRNA targeting code: functional sites with centered pairing. Mol Cell (2010) 4.20

Aligning short sequencing reads with Bowtie. Curr Protoc Bioinformatics (2010) 4.07

Mammalian microRNAs derived from genomic repeats. Trends Genet (2005) 3.60

Posttranscriptional crossregulation between Drosha and DGCR8. Cell (2009) 3.54

Regulation of microRNA expression and abundance during lymphopoiesis. Immunity (2010) 3.29

miRanalyzer: a microRNA detection and analysis tool for next-generation sequencing experiments. Nucleic Acids Res (2009) 2.90

Dynamic expression of small non-coding RNAs, including novel microRNAs and piRNAs/21U-RNAs, during Caenorhabditis elegans development. Genome Biol (2009) 2.81

A family of human microRNA genes from miniature inverted-repeat transposable elements. PLoS One (2007) 2.63

MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain. Genome Res (2010) 2.44

Functionally distinct regulatory RNAs generated by bidirectional transcription and processing of microRNA loci. Genes Dev (2008) 2.35

miRanalyzer: an update on the detection and analysis of microRNAs in high-throughput sequencing experiments. Nucleic Acids Res (2011) 2.25

miRTRAP, a computational method for the systematic identification of miRNAs from high throughput sequencing data. Genome Biol (2010) 2.18

Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. Blood (2010) 2.15

Deep sequencing of human nuclear and cytoplasmic small RNAs reveals an unexpectedly complex subcellular distribution of miRNAs and tRNA 3' trailers. PLoS One (2010) 2.12

Characterization of the Melanoma miRNAome by Deep Sequencing. PLoS One (2010) 2.08

Human miRNA precursors with box H/ACA snoRNA features. PLoS Comput Biol (2009) 2.06

A distinct class of small RNAs arises from pre-miRNA-proximal regions in a simple chordate. Nat Struct Mol Biol (2009) 1.90

Analysis of microRNA transcriptome by deep sequencing of small RNA libraries of peripheral blood. BMC Genomics (2010) 1.84

Large-scale sorting of C. elegans embryos reveals the dynamics of small RNA expression. Nat Methods (2009) 1.82

Nuclear-localized tiny RNAs are associated with transcription initiation and splice sites in metazoans. Nat Struct Mol Biol (2010) 1.69

Post-transcriptional control of DGCR8 expression by the Microprocessor. RNA (2009) 1.67

MIReNA: finding microRNAs with high accuracy and no learning at genome scale and from deep sequencing data. Bioinformatics (2010) 1.53

High-resolution profiling and discovery of planarian small RNAs. Proc Natl Acad Sci U S A (2009) 1.53

The non-coding RNA of the multidrug resistance-linked vault particle encodes multiple regulatory small RNAs. Nat Cell Biol (2009) 1.48

Genome-wide identification of micro-ribonucleic acids associated with human endometrial receptivity in natural and stimulated cycles by deep sequencing. Fertil Steril (2011) 1.05

Articles by these authors

Combinatorial microRNA target predictions. Nat Genet (2005) 50.48

A draft sequence of the rice genome (Oryza sativa L. ssp. indica). Science (2002) 42.78

Silencing of microRNAs in vivo with 'antagomirs'. Nature (2005) 32.56

Widespread changes in protein synthesis induced by microRNAs. Nature (2008) 31.44

A genome-wide association study of global gene expression. Nat Genet (2007) 22.98

Global quantification of mammalian gene expression control. Nature (2011) 22.36

A pancreatic islet-specific microRNA regulates insulin secretion. Nature (2004) 15.02

Regulation of the germinal center response by microRNA-155. Science (2007) 12.25

High-quality binary protein interaction map of the yeast interactome network. Science (2008) 10.65

Prevalence of chronic kidney disease in China: a cross-sectional survey. Lancet (2012) 10.53

Discovering microRNAs from deep sequencing data using miRDeep. Nat Biotechnol (2008) 10.17

A genome-wide map of conserved microRNA targets in C. elegans. Curr Biol (2006) 10.14

Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project. Science (2010) 9.78

A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat Genet (2007) 9.47

MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb. Cell (2007) 9.33

Circular RNAs are a large class of animal RNAs with regulatory potency. Nature (2013) 8.54

The evolution of gene regulation by transcription factors and microRNAs. Nat Rev Genet (2007) 7.92

The Genomes of Oryza sativa: a history of duplications. PLoS Biol (2005) 7.67

Pooled analysis of fluorouracil-based adjuvant therapy for stage II and III colon cancer: who benefits and by how much? J Clin Oncol (2004) 7.36

Childhood adiposity, adult adiposity, and cardiovascular risk factors. N Engl J Med (2011) 7.16

Cell-type-specific signatures of microRNAs on target mRNA expression. Proc Natl Acad Sci U S A (2006) 7.11

Cubic AgPb(m)SbTe(2+m): bulk thermoelectric materials with high figure of merit. Science (2004) 7.07

Evidence for substantial fine-scale variation in recombination rates across the human genome. Nat Genet (2004) 6.99

microRNA target predictions across seven Drosophila species and comparison to mammalian targets. PLoS Comput Biol (2005) 6.77

Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev (2007) 6.71

Altered histone acetylation is associated with age-dependent memory impairment in mice. Science (2010) 6.38

A human snoRNA with microRNA-like functions. Mol Cell (2008) 5.84

Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage. Cell (2008) 5.53

A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer. Nat Genet (2002) 5.38

The oyster genome reveals stress adaptation and complexity of shell formation. Nature (2012) 5.30

Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophrenia. Hum Mol Genet (2007) 5.28

Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins. Arthritis Rheum (2005) 5.18

MicroRNA profiling of the murine hematopoietic system. Genome Biol (2005) 4.94

Childhood cardiovascular risk factors and carotid vascular changes in adulthood: the Bogalusa Heart Study. JAMA (2003) 4.88

Deep sequencing reveals 50 novel genes for recessive cognitive disorders. Nature (2011) 4.85

Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA. Dev Cell (2005) 4.83

Sequence and analysis of rice chromosome 4. Nature (2002) 4.39

Natural selection on human microRNA binding sites inferred from SNP data. Nat Genet (2006) 4.34

Ligand configurational entropy and protein binding. Proc Natl Acad Sci U S A (2007) 4.33

Survival of resting mature B lymphocytes depends on BCR signaling via the Igalpha/beta heterodimer. Cell (2004) 4.31

Transmit and receive transmission line arrays for 7 Tesla parallel imaging. Magn Reson Med (2005) 4.25

Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase. Science (2011) 4.16

Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR. Mol Cell (2011) 4.15

Decay rates of human mRNAs: correlation with functional characteristics and sequence attributes. Genome Res (2003) 4.07

Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres. Nature (2012) 4.00

HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo. EMBO J (2003) 3.96

Estimating accuracy of RNA-Seq and microarrays with proteomics. BMC Genomics (2009) 3.87

Seven new loci associated with age-related macular degeneration. Nat Genet (2013) 3.81

A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus. Nat Genet (2008) 3.71

Intradiscal injection therapy for degenerative chronic discogenic low back pain with end plate Modic changes. Spine J (2010) 3.55

Array CGH identifies reciprocal 16p13.1 duplications and deletions that predispose to autism and/or mental retardation. Hum Mutat (2007) 3.52

A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration. Proc Natl Acad Sci U S A (2007) 3.50

Transcriptional control in the segmentation gene network of Drosophila. PLoS Biol (2004) 3.47

Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice. J Clin Invest (2009) 3.45

Comparing the DNA hypermethylome with gene mutations in human colorectal cancer. PLoS Genet (2007) 3.39

The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI/SNF complex. Nat Genet (2013) 3.39

Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet (2010) 3.37

The landscape of C. elegans 3'UTRs. Science (2010) 3.32

E2-2 protein and Fuchs's corneal dystrophy. N Engl J Med (2010) 3.31

Gene expression in skin and lymphoblastoid cells: Refined statistical method reveals extensive overlap in cis-eQTL signals. Am J Hum Genet (2010) 3.28

Rise in insulin resistance is associated with escalated telomere attrition. Circulation (2005) 3.27

Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase. Proc Natl Acad Sci U S A (2007) 3.27

Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells. Cell (2012) 3.26

Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease. Nat Genet (2010) 3.24

Leukocyte telomeres are longer in African Americans than in whites: the National Heart, Lung, and Blood Institute Family Heart Study and the Bogalusa Heart Study. Aging Cell (2008) 3.24

Beta-arrestin-mediated localization of smoothened to the primary cilium. Science (2008) 3.10

Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4+CD25+ regulatory T cells. J Immunol (2004) 3.10

Type 5 adenylyl cyclase disruption increases longevity and protects against stress. Cell (2007) 2.96

Leukocyte telomere dynamics: longitudinal findings among young adults in the Bogalusa Heart Study. Am J Epidemiol (2008) 2.86

Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally. Mol Cell Biol (2008) 2.85

Racial diversity of actionable mutations in non-small cell lung cancer. J Thorac Oncol (2015) 2.80

Preperitoneal single-port transvesical enucleation of the prostate (STEP) for large-volume BPH: one-year follow-up of Qmax, IPSS, and QoL. Urology (2012) 2.78

Atrial Fibrillation Is an Independent Predictor of Mortality in Critically Ill Patients. Crit Care Med (2015) 2.77

Single-incision transaxillary robotic thyroidectomy: challenges and limitations in a North American population. Otolaryngol Head Neck Surg (2012) 2.76

Mapping translocation breakpoints by next-generation sequencing. Genome Res (2008) 2.73

Prognostic and predictive value of a microRNA signature in stage II colon cancer: a microRNA expression analysis. Lancet Oncol (2013) 2.67

A maximum entropy model applied to spatial and temporal correlations from cortical networks in vitro. J Neurosci (2008) 2.65

Long noncoding RNA MALAT1 regulates endothelial cell function and vessel growth. Circ Res (2014) 2.60

Analysis of wave behavior in lossy dielectric samples at high field. Magn Reson Med (2002) 2.59

Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation. Circulation (2012) 2.58

Anesthesiologist board certification and patient outcomes. Anesthesiology (2002) 2.57

Molecular dissection of formation of senescence-associated heterochromatin foci. Mol Cell Biol (2007) 2.56

Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor. Proc Natl Acad Sci U S A (2005) 2.53

The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes. Nat Immunol (2010) 2.53

Identification of small ORFs in vertebrates using ribosome footprinting and evolutionary conservation. EMBO J (2014) 2.47

Dissecting the genetic complexity of the association between human leukocyte antigens and rheumatoid arthritis. Am J Hum Genet (2002) 2.47

Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology. Proc Natl Acad Sci U S A (2010) 2.47

A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy. Cell (2008) 2.47

Childhood uric acid predicts adult blood pressure: the Bogalusa Heart Study. Hypertension (2004) 2.46

The efficacy and safety of milnacipran for treatment of fibromyalgia. a randomized, double-blind, placebo-controlled trial. J Rheumatol (2009) 2.46

MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain. Genome Res (2010) 2.44