Published in Viruses on May 01, 2011
An unusual topological structure of the HIV-1 Rev response element. Cell (2013) 1.26
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Progress and outlook in structural biology of large viral RNAs. Virus Res (2014) 0.79
A structurally plastic ribonucleoprotein complex mediates post-transcriptional gene regulation in HIV-1. Wiley Interdiscip Rev RNA (2016) 0.76
Computational modeling suggests dimerization of equine infectious anemia virus Rev is required for RNA binding. Retrovirology (2014) 0.75
CRM1 is an export receptor for leucine-rich nuclear export signals. Cell (1997) 18.60
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HTLV-III expression and production involve complex regulation at the levels of splicing and translation of viral RNA. Cell (1986) 12.74
A second post-transcriptional trans-activator gene required for HTLV-III replication. Nature (1986) 10.76
CRM1 is responsible for intracellular transport mediated by the nuclear export signal. Nature (1997) 10.49
The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs. Cell (1995) 9.98
Identification of a signal for rapid export of proteins from the nucleus. Cell (1995) 9.92
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Regulation by HIV Rev depends upon recognition of splice sites. Cell (1989) 7.13
Evidence for a role of CRM1 in signal-mediated nuclear protein export. Science (1997) 6.60
HIV-1 structural gene expression requires binding of the Rev trans-activator to its RNA target sequence. Cell (1990) 5.82
Regulation of human immunodeficiency virus env expression by the rev gene product. J Virol (1989) 5.79
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Sequence-specific RNA binding by the HIV-1 Rev protein. Nature (1989) 5.36
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Specific binding of HIV-1 recombinant Rev protein to the Rev-responsive element in vitro. Nature (1989) 4.96
The HIV-1 Rev protein. Annu Rev Microbiol (1998) 4.78
HIV-1 regulator of virion expression (Rev) protein binds to an RNA stem-loop structure located within the Rev response element region. Cell (1990) 4.50
A small element from the Mason-Pfizer monkey virus genome makes human immunodeficiency virus type 1 expression and replication Rev-independent. Proc Natl Acad Sci U S A (1994) 4.43
HIV-1 Rev regulation involves recognition of non-Watson-Crick base pairs in viral RNA. Cell (1991) 4.43
The importin-beta family member Crm1p bridges the interaction between Rev and the nuclear pore complex during nuclear export. Curr Biol (1997) 4.35
Alternative splicing of human immunodeficiency virus type 1 mRNA modulates viral protein expression, replication, and infectivity. J Virol (1993) 3.90
Post-transcriptional regulator (rex) of HTLV-1 initiates expression of viral structural proteins but suppresses expression of regulatory proteins. EMBO J (1988) 3.45
Alpha helix-RNA major groove recognition in an HIV-1 rev peptide-RRE RNA complex. Science (1996) 3.39
The HIV-1 Rev trans-activator shuttles between the nucleus and the cytoplasm. Genes Dev (1994) 3.34
Structural analysis of the interaction between the human immunodeficiency virus Rev protein and the Rev response element. Proc Natl Acad Sci U S A (1991) 3.06
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Two cis-acting elements responsible for posttranscriptional trans-regulation of gene expression of human T-cell leukemia virus type I. Proc Natl Acad Sci U S A (1988) 2.25
Human immunodeficiency virus type 1 regulator of virion expression, rev, forms nucleoprotein filaments after binding to a purine-rich "bubble" located within the rev-responsive region of viral mRNAs. Proc Natl Acad Sci U S A (1991) 2.19
A structured retroviral RNA element that mediates nucleocytoplasmic export of intron-containing RNA. Mol Cell Biol (1997) 2.07
Characterization of HIV-1 REV protein: binding stoichiometry and minimal RNA substrate. Nucleic Acids Res (1991) 1.96
Human immunodeficiency virus rev protein recognizes a target sequence in rev-responsive element RNA within the context of RNA secondary structure. J Virol (1990) 1.94
An intron with a constitutive transport element is retained in a Tap messenger RNA. Nature (2006) 1.65
Identification of the activation domain of equine infectious anemia virus rev. J Virol (1993) 1.57
Structural basis for cooperative RNA binding and export complex assembly by HIV Rev. Nat Struct Mol Biol (2010) 1.57
Implications of the HIV-1 Rev dimer structure at 3.2 A resolution for multimeric binding to the Rev response element. Proc Natl Acad Sci U S A (2010) 1.51
Trans-activating rev protein of the human immunodeficiency virus 1 interacts directly and specifically with its target RNA. Proc Natl Acad Sci U S A (1990) 1.49
Binding of an HIV Rev peptide to Rev responsive element RNA induces formation of purine-purine base pairs. Biochemistry (1994) 1.47
Structural model for the cooperative assembly of HIV-1 Rev multimers on the RRE as deduced from analysis of assembly-defective mutants. Mol Cell (2001) 1.46
Costabilization of peptide and RNA structure in an HIV Rev peptide-RRE complex. Biochemistry (1994) 1.44
HIV-1 Rev expressed in recombinant Escherichia coli: purification, polymerization, and conformational properties. Biochemistry (1991) 1.38
Regulation of retroviral RNA export. Semin Cell Dev Biol (1997) 1.37
A solution to limited genomic capacity: using adaptable binding surfaces to assemble the functional HIV Rev oligomer on RNA. Mol Cell (2008) 1.37
HIV-1 Rev protein assembles on viral RNA one molecule at a time. Proc Natl Acad Sci U S A (2009) 1.36
Mouse mammary tumor virus encodes a self-regulatory RNA export protein and is a complex retrovirus. J Virol (2005) 1.36
A structural model for the HIV-1 Rev-RRE complex deduced from altered-specificity rev variants isolated by a rapid genetic strategy. Cell (1996) 1.25
Sequence requirements for Rev multimerization in vivo. Virology (1994) 1.18
HIV Rev response element (RRE) directs assembly of the Rev homooligomer into discrete asymmetric complexes. Proc Natl Acad Sci U S A (2010) 1.17
Overcoming the solubility limit with solubility-enhancement tags: successful applications in biomolecular NMR studies. J Biomol NMR (2010) 1.15
Equine infectious anemia virus trans-regulatory protein Rev controls viral mRNA stability, accumulation, and alternative splicing. J Virol (1994) 1.15
Solution oligomerization of the rev protein of HIV-1: implications for function. Biochemistry (1993) 1.06
The signal peptide of a simple retrovirus envelope functions as a posttranscriptional regulator of viral gene expression. J Virol (2009) 1.04
Tap and Dbp5, but not Gag, are involved in DR-mediated nuclear export of unspliced Rous sarcoma virus RNA. Virology (2007) 1.01
A dynamic in vivo view of the HIV-I Rev-RRE interaction. J Mol Biol (1997) 0.99
Foamy virus nuclear RNA export is distinct from that of other retroviruses. J Virol (2010) 0.98
Jaagsiekte sheep retrovirus encodes a regulatory factor, Rej, required for synthesis of Gag protein. J Virol (2009) 0.96
Identification and mutational analysis of a Rej response element in Jaagsiekte sheep retrovirus RNA. J Virol (2009) 0.92
An intron with a constitutive transport element is retained in a Tap messenger RNA. Nature (2006) 1.65
Tap and NXT promote translation of unspliced mRNA. Genes Dev (2003) 1.48
Sam68 enhances the cytoplasmic utilization of intron-containing RNA and is functionally regulated by the nuclear kinase Sik/BRK. Mol Cell Biol (2003) 1.46
The shuttling SR protein 9G8 plays a role in translation of unspliced mRNA containing a constitutive transport element. J Biol Chem (2007) 1.32
Probing the HIV-1 genomic RNA trafficking pathway and dimerization by genetic recombination and single virion analyses. PLoS Pathog (2009) 1.30
Resistance to RevM10 inhibition reflects a conformational switch in the HIV-1 Rev response element. Proc Natl Acad Sci U S A (2008) 1.22
The Wilms' tumor 1 (WT1) gene (+KTS isoform) functions with a CTE to enhance translation from an unspliced RNA with a retained intron. Genes Dev (2006) 1.11
Chondrocyte transplantation into articular cartilage defects with use of calcium alginate: the fate of the cells. J Bone Joint Surg Am (2003) 1.00
The Tpr protein regulates export of mRNAs with retained introns that traffic through the Nxf1 pathway. RNA (2011) 0.97
The envelope gene is a cytopathic determinant of CCR5 tropic HIV-1. Virology (2006) 0.92
Trafficking through the Rev/RRE pathway is essential for efficient inhibition of human immunodeficiency virus type 1 by an antisense RNA derived from the envelope gene. J Virol (2008) 0.86
Heterocyclic compounds that inhibit Rev-RRE function and human immunodeficiency virus type 1 replication. Antimicrob Agents Chemother (2008) 0.85
Mutations in tap uncouple RNA export activity from translocation through the nuclear pore complex. Mol Biol Cell (2005) 0.84
Limited nucleotide changes in the Rev response element (RRE) during HIV-1 infection alter overall Rev-RRE activity and Rev multimerization. J Virol (2013) 0.84
Single-nucleotide changes in the HIV Rev-response element mediate resistance to compounds that inhibit Rev function. J Virol (2011) 0.83
Tracing transduced cells in osteochondral defects. J Pediatr Orthop (2003) 0.78
Molecular epidemiology of HIV in two highly endemic areas of northeastern South Africa. Arch Virol (2011) 0.78
Xenotropic MLV envelope proteins induce tumor cells to secrete factors that promote the formation of immature blood vessels. Retrovirology (2013) 0.76
Nef does not contribute to replication differences between R5 pre-AIDS and AIDS HIV-1 clones from patient ACH142. Retrovirology (2008) 0.75
Genotype testing and antiretroviral resistance profiles from HIV-1 patients experiencing therapeutic failure in northeast Brazil. Braz J Infect Dis (2007) 0.75