FGF23 induces left ventricular hypertrophy.

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Published in J Clin Invest on October 10, 2011

Authors

Christian Faul1, Ansel P Amaral, Behzad Oskouei, Ming-Chang Hu, Alexis Sloan, Tamara Isakova, Orlando M Gutiérrez, Robier Aguillon-Prada, Joy Lincoln, Joshua M Hare, Peter Mundel, Azorides Morales, Julia Scialla, Michael Fischer, Elsayed Z Soliman, Jing Chen, Alan S Go, Sylvia E Rosas, Lisa Nessel, Raymond R Townsend, Harold I Feldman, Martin St John Sutton, Akinlolu Ojo, Crystal Gadegbeku, Giovana Seno Di Marco, Stefan Reuter, Dominik Kentrup, Klaus Tiemann, Marcus Brand, Joseph A Hill, Orson W Moe, Makoto Kuro-O, John W Kusek, Martin G Keane, Myles Wolf

Author Affiliations

1: Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA. cfaul@med.miami.edu

Associated clinical trials:

New Biomarkers in Heart- and Renal Failure (IM19 Register) | NCT02830464

FGF23 and Angiotensin-(1-7) in Hypophosphatemia (GAP) (GAP) | NCT03489993

Fibroblast Growth Factor 23 in Chronic Respiratory Failure (EFIC-RES) | NCT05258370

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Fibroblast growth factor receptor tyrosine kinases: molecular analysis and signal transduction. Biochim Biophys Acta (1992) 2.41

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"Stress-responsive" mitogen-activated protein kinases (c-Jun N-terminal kinases and p38 mitogen-activated protein kinases) in the myocardium. Circ Res (1998) 2.30

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Induction of the skeletal alpha-actin gene in alpha 1-adrenoceptor-mediated hypertrophy of rat cardiac myocytes. J Clin Invest (1987) 1.69

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Control of cardiac growth and function by calcineurin signaling. J Biol Chem (2003) 1.66

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The effect of a lower target blood pressure on the progression of kidney disease: long-term follow-up of the modification of diet in renal disease study. Ann Intern Med (2005) 5.45

Dialysis-requiring acute renal failure increases the risk of progressive chronic kidney disease. Kidney Int (2009) 5.28

Antithrombotic therapy for atrial fibrillation: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest (2012) 5.27

Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination Survey. Arch Intern Med (2007) 5.26

Cardiac autophagy is a maladaptive response to hemodynamic stress. J Clin Invest (2007) 5.17

Randomized trial of cardiac resynchronization in mildly symptomatic heart failure patients and in asymptomatic patients with left ventricular dysfunction and previous heart failure symptoms. J Am Coll Cardiol (2008) 5.09

A new risk scheme to predict warfarin-associated hemorrhage: The ATRIA (Anticoagulation and Risk Factors in Atrial Fibrillation) Study. J Am Coll Cardiol (2011) 5.06

Impact of creatinine calibration on performance of GFR estimating equations in a pooled individual patient database. Am J Kidney Dis (2007) 5.06

Prevalence of the metabolic syndrome and overweight among adults in China. Lancet (2005) 5.05

The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A. Nat Med (2008) 5.01

APOL1 risk variants, race, and progression of chronic kidney disease. N Engl J Med (2013) 5.00

The association between hepatitis C infection and survival after orthotopic liver transplantation. Gastroenterology (2002) 4.98

Sampling and pyrosequencing methods for characterizing bacterial communities in the human gut using 16S sequence tags. BMC Microbiol (2010) 4.97

Incidence of atrial fibrillation in whites and African-Americans: the Atherosclerosis Risk in Communities (ARIC) study. Am Heart J (2009) 4.90

Fibroblast growth factor 23 and left ventricular hypertrophy in chronic kidney disease. Circulation (2009) 4.87

Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis. Nature (2012) 4.84

Mesenchymal stem cells: biology, pathophysiology, translational findings, and therapeutic implications for cardiac disease. Circ Res (2011) 4.75

Mortality attributable to smoking in China. N Engl J Med (2009) 4.75

Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease. Kidney Int (2011) 4.74