Published in N Engl J Med on September 26, 2011
The Leukotriene Modifier Or Corticosteroid or Corticosteroid-Salmeterol Trial | NCT00156819
Asthma genetics and personalised medicine. Lancet Respir Med (2014) 1.17
Glucocorticoid sensitivity in health and disease. Nat Rev Endocrinol (2013) 1.09
Genome-wide association analysis in asthma subjects identifies SPATS2L as a novel bronchodilator response gene. PLoS Genet (2012) 1.09
Pharmacogenomics in clinical practice and drug development. Nat Biotechnol (2012) 1.08
Relating human genetic variation to variation in drug responses. Trends Genet (2012) 1.05
Pharmacogenetics and cardiovascular disease--implications for personalized medicine. Pharmacol Rev (2013) 1.04
Implementation and utilization of genetic testing in personalized medicine. Pharmgenomics Pers Med (2014) 0.97
Lymphoblastoid cell lines in pharmacogenomics: how applicable are they to clinical outcomes? Pharmacogenomics (2013) 0.95
Vitamin D related genes in lung development and asthma pathogenesis. BMC Med Genomics (2013) 0.95
A disease module in the interactome explains disease heterogeneity, drug response and captures novel pathways and genes in asthma. Hum Mol Genet (2015) 0.93
Genome-wide association identifies the T gene as a novel asthma pharmacogenetic locus. Am J Respir Crit Care Med (2012) 0.93
Fluticasone propionate pharmacogenetics: CYP3A4*22 polymorphism and pediatric asthma control. J Pediatr (2013) 0.92
Pharmacogenetics: implications of race and ethnicity on defining genetic profiles for personalized medicine. J Allergy Clin Immunol (2014) 0.92
Inhaled corticosteroids in lung diseases. Am J Respir Crit Care Med (2013) 0.91
Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene. PLoS One (2013) 0.91
Clinical utility of asthma biomarkers: from bench to bedside. Biologics (2013) 0.90
Genome-wide association study of intraocular pressure identifies the GLCCI1/ICA1 region as a glaucoma susceptibility locus. Hum Mol Genet (2013) 0.89
Genetic polymorphisms and associated susceptibility to asthma. Int J Gen Med (2013) 0.89
Update in asthma 2011. Am J Respir Crit Care Med (2012) 0.89
Genetic mapping with multiple levels of phenotypic information reveals determinants of lymphocyte glucocorticoid sensitivity. Am J Hum Genet (2013) 0.88
Pharmacogenomics discovery and implementation in genome-wide association studies era. Wiley Interdiscip Rev Syst Biol Med (2012) 0.88
Systemic steroid exposure is associated with differential methylation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2012) 0.87
Predicting inhaled corticosteroid response in asthma with two associated SNPs. Pharmacogenomics J (2012) 0.87
Genetic predictors associated with improvement of asthma symptoms in response to inhaled corticosteroids. J Allergy Clin Immunol (2014) 0.85
CMTR1 is associated with increased asthma exacerbations in patients taking inhaled corticosteroids. Immun Inflamm Dis (2015) 0.84
A step toward personalized asthma treatment. N Engl J Med (2011) 0.84
Endoplasmic reticulum stress and the related signaling networks in severe asthma. Allergy Asthma Immunol Res (2014) 0.83
Genetics of glucocorticoids in asthma. N Engl J Med (2011) 0.82
The metabolomics of asthma control: a promising link between genetics and disease. Immun Inflamm Dis (2015) 0.81
Integrative systems biology approaches in asthma pharmacogenomics. Pharmacogenomics (2012) 0.81
Glucocorticoids and the regulation of growth hormone secretion. Nat Rev Endocrinol (2013) 0.81
Genome-wide association study of leukotriene modifier response in asthma. Pharmacogenomics J (2015) 0.80
In vitro human cell line models to predict clinical response to anticancer drugs. Pharmacogenomics (2015) 0.79
GLCCI1 rs37973 does not influence treatment response to inhaled corticosteroids in white subjects with asthma. J Allergy Clin Immunol (2013) 0.79
GLCCI1 single nucleotide polymorphisms in pediatric nephrotic syndrome. Pediatr Nephrol (2012) 0.79
Genetics of asthma susceptibility and severity. Clin Chest Med (2012) 0.78
A polymorphism affecting MYB binding within the promoter of the PDCD4 gene is associated with severe asthma in children. Hum Mutat (2013) 0.78
Glucocorticoid genes and the developmental origins of asthma susceptibility and treatment response. Am J Respir Cell Mol Biol (2015) 0.78
Effect of CYP3A5*3 on asthma control among children treated with inhaled beclomethasone. J Allergy Clin Immunol (2015) 0.78
Polymorphisms in the glucocorticoid receptor gene and in the glucocorticoid-induced transcript 1 gene are associated with disease activity and response to glucocorticoid bridging therapy in rheumatoid arthritis. Rheumatol Int (2015) 0.78
Pharmacogenomics: novel loci identification via integrating gene differential analysis and eQTL analysis. Hum Mol Genet (2014) 0.77
Genes associated with RSV lower respiratory tract infection and asthma: the application of genetic epidemiological methods to understand causality. Future Virol (2015) 0.77
Single Nucleotide Polymorphisms in Pediatric Idiopathic Nephrotic Syndrome. Int J Nephrol (2016) 0.76
LTC4 synthase polymorphism modifies efficacy of botanical seed oil combination in asthma. Springerplus (2014) 0.76
Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis. Nat Commun (2016) 0.76
Role of biomarkers in understanding and treating children with asthma: towards personalized care. Pharmgenomics Pers Med (2013) 0.76
ITGB5 and AGFG1 variants are associated with severity of airway responsiveness. BMC Med Genet (2013) 0.76
The Childhood Asthma Management Program (CAMP): Contributions to the Understanding of Therapy and the Natural History of Childhood Asthma. Curr Respir Care Rep (2012) 0.76
Asthma treatment outcome in adults is associated with rs9910408 in TBX21 gene. Sci Rep (2013) 0.76
Complex genetics of pulmonary diseases: lessons from genome-wide association studies and next-generation sequencing. Transl Res (2015) 0.76
Asthma pharmacogenetics and the development of genetic profiles for personalized medicine. Pharmgenomics Pers Med (2015) 0.75
Is personalized medicine achievable in obstetrics? Semin Perinatol (2014) 0.75
Molecular Programming of Tumor-Infiltrating CD8+ T Cells and IL15 Resistance. Cancer Immunol Res (2016) 0.75
Pharmacogenetics and the development of personalized approaches for combination therapy in asthma. Curr Allergy Asthma Rep (2013) 0.75
Pharmacodynamic genome-wide association study identifies new responsive loci for glucocorticoid intervention in asthma. Pharmacogenomics J (2015) 0.75
Differential effects of hydrocortisone, prednisone, and dexamethasone on hormonal and pharmacokinetic profiles: a pilot study in children with congenital adrenal hyperplasia. Int J Pediatr Endocrinol (2016) 0.75
Genetics of glucocorticoids in asthma. N Engl J Med (2011) 0.75
GLCCI1 rs37973: a potential genetic predictor of therapeutic response to inhaled corticosteroids in Chinese chronic obstructive pulmonary disease patients. Sci Rep (2017) 0.75
Inflammatory phenotypes underlying uncontrolled childhood asthma despite inhaled corticosteroid treatment: rationale and design of the PACMAN2 study. BMC Pediatr (2013) 0.75
Impaired anti-inflammatory action of glucocorticoid in neutrophil from patients with steroid-resistant asthma. Respir Res (2016) 0.75
Predictive Properties of the Asthma Control Test and Its Component Questions for Severe Asthma Exacerbations. J Allergy Clin Immunol Pract (2016) 0.75
Systemic Corticosteroid Responses in Children with Severe Asthma: Phenotypic and Endotypic Features. J Allergy Clin Immunol Pract (2016) 0.75
The role of glucocorticoid receptor (GR) polymorphisms in human erythropoiesis. Am J Blood Res (2014) 0.75
Pharmacogenomics in Pediatric Patients: Towards Personalized Medicine. Paediatr Drugs (2016) 0.75
Using omics approaches to understand pulmonary diseases. Respir Res (2017) 0.75
IL-10 and IL-17F Promoter Single Nucleotide Polymorphism and Asthma: A Case-Control Study in South India. Lung (2015) 0.75
Effect of genomics-related literacy on non-communicable diseases. J Hum Genet (2017) 0.75
A haplotype map of the human genome. Nature (2005) 105.70
Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet (2008) 25.83
Population genomics of human gene expression. Nat Genet (2007) 24.49
Genome-wide associations of gene expression variation in humans. PLoS Genet (2005) 17.27
A common genetic variant is associated with adult and childhood obesity. Science (2006) 14.95
The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy (2004) 13.16
Long-term effects of budesonide or nedocromil in children with asthma. The Childhood Asthma Management Program Research Group. N Engl J Med (2000) 8.32
Genomic screening and replication using the same data set in family-based association testing. Nat Genet (2005) 5.44
The Childhood Asthma Management Program (CAMP): design, rationale, and methods. Childhood Asthma Management Program Research Group. Control Clin Trials (1999) 5.11
Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial. Lancet (2004) 5.01
Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE. Am J Hum Genet (2008) 4.66
Characterization of within-subject responses to fluticasone and montelukast in childhood asthma. J Allergy Clin Immunol (2005) 4.50
Randomized comparison of strategies for reducing treatment in mild persistent asthma. N Engl J Med (2007) 4.40
Significant variability in response to inhaled corticosteroids for persistent asthma. J Allergy Clin Immunol (2002) 3.66
Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene. Am J Hum Genet (2009) 3.41
The genetic dissection of complex traits in a founder population. Am J Hum Genet (2001) 3.36
On the replication of genetic associations: timing can be everything! Am J Hum Genet (2008) 3.32
Inhaled corticosteroid reduction and elimination in patients with persistent asthma receiving salmeterol: a randomized controlled trial. JAMA (2001) 3.21
Choosing an optimal method to combine P-values. Stat Med (2009) 3.15
Heterogeneity of therapeutic responses in asthma. Br Med Bull (2000) 2.86
Long-term comparison of 3 controller regimens for mild-moderate persistent childhood asthma: the Pediatric Asthma Controller Trial. J Allergy Clin Immunol (2006) 2.79
Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment. Nat Genet (1999) 2.37
Using the noninformative families in family-based association tests: a powerful new testing strategy. Am J Hum Genet (2003) 2.18
A family-based association test for repeatedly measured quantitative traits adjusting for unknown environmental and/or polygenic effects. Stat Appl Genet Mol Biol (2004) 2.15
Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids. Hum Mol Genet (2004) 2.14
FCER2: a pharmacogenetic basis for severe exacerbations in children with asthma. J Allergy Clin Immunol (2007) 1.40
ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts. Am J Respir Crit Care Med (2008) 1.34
TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroids. Proc Natl Acad Sci U S A (2004) 1.30
Transcriptional control of steroid-regulated apoptosis in murine thymoma cells. Mol Endocrinol (1996) 1.15
The heritable nature of dexamethasone-induced ocular hypertension. Arch Ophthalmol (1966) 1.08
Heritability of daytime cortisol levels and cortisol reactivity in children. Psychoneuroendocrinology (2008) 1.06
Isolation of differentially expressed sequence tags from steroid-responsive cells using mRNA differential display. Mol Cell Endocrinol (1995) 1.04
Twin heritability study of the effect of corticosteroids on intraocular pressure. J Med Genet (1972) 1.03
Familial pattern of corticosteroids and their metabolism in adult human subjects--the Scottish Adult Twin Study. J Clin Endocrinol Metab (1999) 0.98
Apoptosis and B-cell lymphoma-2 of peripheral blood T lymphocytes and soluble fas in patients with allergic asthma. Chest (2002) 0.96
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
International network of cancer genome projects. Nature (2010) 20.35
Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27
Galaxy: a web-based genome analysis tool for experimentalists. Curr Protoc Mol Biol (2010) 17.00
A common genetic variant is associated with adult and childhood obesity. Science (2006) 14.95
Extracting principal diagnosis, co-morbidity and smoking status for asthma research: evaluation of a natural language processing system. BMC Med Inform Decis Mak (2006) 9.98
Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nat Genet (2008) 9.39
An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice. Am J Respir Crit Care Med (2009) 9.38
Azithromycin for prevention of exacerbations of COPD. N Engl J Med (2011) 8.66
SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations. Nat Genet (2008) 8.63
The Salmeterol Multicenter Asthma Research Trial: a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol. Chest (2006) 8.43
Long-term effects of budesonide or nedocromil in children with asthma. The Childhood Asthma Management Program Research Group. N Engl J Med (2000) 8.32
Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. Nat Genet (2009) 8.11
Lebrikizumab treatment in adults with asthma. N Engl J Med (2011) 8.07
Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet (2003) 7.98
Daily versus as-needed corticosteroids for mild persistent asthma. N Engl J Med (2005) 7.61
Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med (2009) 7.17
Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis. Nat Genet (2003) 7.04
Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. Nat Genet (2008) 6.75
Step-up therapy for children with uncontrolled asthma receiving inhaled corticosteroids. N Engl J Med (2010) 6.51
Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction. Nat Genet (2002) 6.46
Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children. Am J Respir Crit Care Med (2008) 6.35
Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. J Allergy Clin Immunol (2007) 6.33
Tiotropium bromide step-up therapy for adults with uncontrolled asthma. N Engl J Med (2010) 6.19
Heterozygous TGFBR2 mutations in Marfan syndrome. Nat Genet (2004) 6.15
Long-term inhaled corticosteroids in preschool children at high risk for asthma. N Engl J Med (2006) 6.10
Family-based tests for associating haplotypes with general phenotype data: application to asthma genetics. Genet Epidemiol (2004) 5.57
Genomic screening and replication using the same data set in family-based association testing. Nat Genet (2005) 5.44
Use of beclomethasone dipropionate as rescue treatment for children with mild persistent asthma (TREXA): a randomised, double-blind, placebo-controlled trial. Lancet (2011) 5.42
Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease. Hum Mol Genet (2005) 5.35
A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians. Nat Genet (2009) 5.29
Rapid DNA methylation changes after exposure to traffic particles. Am J Respir Crit Care Med (2009) 5.20
Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial. Lancet (2004) 5.01
Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion. Nat Genet (2007) 4.99
The regulatory role of Valpha14 NKT cells in innate and acquired immune response. Annu Rev Immunol (2001) 4.91
Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators. Nat Genet (2012) 4.84
SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells. Nat Cell Biol (2004) 4.72
PBAT: tools for family-based association studies. Am J Hum Genet (2004) 4.68
Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE. Am J Hum Genet (2008) 4.66
Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica. Am J Respir Crit Care Med (2009) 4.64
An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis. Nat Genet (2003) 4.61
Family-based designs in the age of large-scale gene-association studies. Nat Rev Genet (2006) 4.59
Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function. N Engl J Med (2008) 4.58
Characterization of within-subject responses to fluticasone and montelukast in childhood asthma. J Allergy Clin Immunol (2005) 4.50
A diverse group of previously unrecognized human rhinoviruses are common causes of respiratory illnesses in infants. PLoS One (2007) 4.40
Randomized comparison of strategies for reducing treatment in mild persistent asthma. N Engl J Med (2007) 4.40
Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma. J Allergy Clin Immunol (2010) 4.38
Genome-wide association study of hematological and biochemical traits in a Japanese population. Nat Genet (2010) 4.36
Family-based association between Alzheimer's disease and variants in UBQLN1. N Engl J Med (2005) 4.34
A functional polymorphism in the 5' UTR of GDF5 is associated with susceptibility to osteoarthritis. Nat Genet (2007) 4.31
Development and cross-sectional validation of the Childhood Asthma Control Test. J Allergy Clin Immunol (2007) 4.26
Worldwide severity and control of asthma in children and adults: the global asthma insights and reality surveys. J Allergy Clin Immunol (2004) 4.17
Lung-Function Trajectories Leading to Chronic Obstructive Pulmonary Disease. N Engl J Med (2015) 4.16
Instrumenting the health care enterprise for discovery research in the genomic era. Genome Res (2009) 4.13
Daily or intermittent budesonide in preschool children with recurrent wheezing. N Engl J Med (2011) 4.09
Design of a national distributed health data network. Ann Intern Med (2009) 4.09
Is vitamin D deficiency to blame for the asthma epidemic? J Allergy Clin Immunol (2007) 3.97
MMP12, lung function, and COPD in high-risk populations. N Engl J Med (2009) 3.96
HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres. Cell (2009) 3.94
Maternal intake of vitamin D during pregnancy and risk of recurrent wheeze in children at 3 y of age. Am J Clin Nutr (2007) 3.89
Seven new loci associated with age-related macular degeneration. Nat Genet (2013) 3.81
A genome-wide association study of pulmonary function measures in the Framingham Heart Study. PLoS Genet (2009) 3.78
A generalized linear mixed models approach for detecting incident clusters of disease in small areas, with an application to biological terrorism. Am J Epidemiol (2004) 3.71
Meta-analysis identifies six new susceptibility loci for atrial fibrillation. Nat Genet (2012) 3.71
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat Genet (2011) 3.68
Outcome of asthma and wheezing in the first 6 years of life: follow-up through adolescence. Am J Respir Crit Care Med (2005) 3.66
Significant variability in response to inhaled corticosteroids for persistent asthma. J Allergy Clin Immunol (2002) 3.66
Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism. Nature (2008) 3.62
Prediagnostic body-mass index, plasma C-peptide concentration, and prostate cancer-specific mortality in men with prostate cancer: a long-term survival analysis. Lancet Oncol (2008) 3.62
Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study. J Allergy Clin Immunol (2010) 3.54
A multivariate family-based association test using generalized estimating equations: FBAT-GEE. Biostatistics (2003) 3.52
Simvastatin for the prevention of exacerbations in moderate-to-severe COPD. N Engl J Med (2014) 3.51