Published in Nat Rev Immunol on October 14, 2011
Macrophage biology in development, homeostasis and disease. Nature (2013) 8.28
Macrophage activation and polarization: nomenclature and experimental guidelines. Immunity (2014) 7.26
Mechanisms of fibrosis: therapeutic translation for fibrotic disease. Nat Med (2012) 6.15
Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes. Immunity (2013) 5.47
The M1 and M2 paradigm of macrophage activation: time for reassessment. F1000Prime Rep (2014) 4.97
Transcriptome-based network analysis reveals a spectrum model of human macrophage activation. Immunity (2014) 3.94
The cellular and molecular origin of tumor-associated macrophages. Science (2014) 3.89
Functional polarization of tumour-associated macrophages by tumour-derived lactic acid. Nature (2014) 3.31
Metabolic pathways in immune cell activation and quiescence. Immunity (2013) 3.09
NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation. J Clin Invest (2015) 2.93
Tissue-specific signals control reversible program of localization and functional polarization of macrophages. Cell (2014) 2.61
Evolving therapies for liver fibrosis. J Clin Invest (2013) 2.59
Interleukin-4- and interleukin-13-mediated alternatively activated macrophages: roles in homeostasis and disease. Annu Rev Immunol (2013) 2.47
The roles of TGFβ in the tumour microenvironment. Nat Rev Cancer (2013) 2.35
Re(de)fining the dendritic cell lineage. Nat Immunol (2012) 2.17
Macrophages Facilitate Electrical Conduction in the Heart. Cell (2017) 2.10
M1 and M2 macrophages: the chicken and the egg of immunity. J Innate Immun (2014) 2.06
The role of macrophage phenotype in vascularization of tissue engineering scaffolds. Biomaterials (2014) 2.04
From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation. Front Immunol (2014) 2.03
A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages. Nat Cell Biol (2014) 2.01
Allergic host defences. Nature (2012) 1.99
Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization. Proc Natl Acad Sci U S A (2012) 1.97
Mechanisms and metabolic implications of regional differences among fat depots. Cell Metab (2013) 1.94
Hepatitis B virus infection and immunopathogenesis in a humanized mouse model: induction of human-specific liver fibrosis and M2-like macrophages. PLoS Pathog (2014) 1.88
Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation. Nat Med (2014) 1.87
Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion. Nat Immunol (2014) 1.86
Regulatory immune cells in transplantation. Nat Rev Immunol (2012) 1.82
Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine. Biomaterials (2012) 1.81
M2 Macrophage Polarization Mediates Anti-inflammatory Effects of Endothelial Nitric Oxide Signaling. Diabetes (2015) 1.77
Cutaneous Na+ storage strengthens the antimicrobial barrier function of the skin and boosts macrophage-driven host defense. Cell Metab (2015) 1.74
Tumor-associated macrophages as major players in the tumor microenvironment. Cancers (Basel) (2014) 1.74
IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1. J Exp Med (2013) 1.73
SOCS3 deficiency promotes M1 macrophage polarization and inflammation. J Immunol (2012) 1.71
Opsonic phagocytosis of Plasmodium falciparum merozoites: mechanism in human immunity and a correlate of protection against malaria. BMC Med (2014) 1.71
Cellular mechanisms of tissue fibrosis. 1. Common and organ-specific mechanisms associated with tissue fibrosis. Am J Physiol Cell Physiol (2012) 1.70
Chitinase dependent control of protozoan cyst burden in the brain. PLoS Pathog (2012) 1.68
Macrophage phenotypes during tissue repair. J Leukoc Biol (2013) 1.67
Alternatively activated macrophages promote pancreatic fibrosis in chronic pancreatitis. Nat Commun (2015) 1.64
Efficient derivation of microglia-like cells from human pluripotent stem cells. Nat Med (2016) 1.64
Type 2 cytokines: mechanisms and therapeutic strategies. Nat Rev Immunol (2015) 1.57
The TSC-mTOR pathway regulates macrophage polarization. Nat Commun (2013) 1.57
In vitro generation of monocyte-derived macrophages under serum-free conditions improves their tumor promoting functions. PLoS One (2012) 1.57
Vagus nerve stimulation mediates protection from kidney ischemia-reperfusion injury through α7nAChR+ splenocytes. J Clin Invest (2016) 1.56
Macrophage heterogeneity in tissues: phenotypic diversity and functions. Immunol Rev (2014) 1.55
Effect of helminth-induced immunity on infections with microbial pathogens. Nat Immunol (2013) 1.55
Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report. Am J Respir Crit Care Med (2014) 1.54
Tumor-associated macrophages: functional diversity, clinical significance, and open questions. Semin Immunopathol (2013) 1.54
IL-34 mediates acute kidney injury and worsens subsequent chronic kidney disease. J Clin Invest (2015) 1.51
Macrophage polarization in inflammatory diseases. Int J Biol Sci (2014) 1.51
Epigenetic regulation of macrophage polarization and function. Trends Immunol (2012) 1.50
Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation. Nat Immunol (2016) 1.50
Tumor-associated macrophages predict inferior outcomes in classic Hodgkin lymphoma: a correlative study from the E2496 Intergroup trial. Blood (2012) 1.49
Restraint of inflammatory signaling by interdependent strata of negative regulatory pathways. Nat Immunol (2012) 1.49
MicroRNAs in immune response and macrophage polarization. Arterioscler Thromb Vasc Biol (2013) 1.48
Sequential Immune Responses: The Weapons of Immunity. J Innate Immun (2015) 1.47
Corpse Engulfment Generates a Molecular Memory that Primes the Macrophage Inflammatory Response. Cell (2016) 1.47
Diverse macrophage populations mediate acute lung inflammation and resolution. Am J Physiol Lung Cell Mol Physiol (2014) 1.45
Divergent effects of Tlr9 deletion in experimental late venous thrombosis resolution and vein wall injury. Thromb Haemost (2015) 1.43
High-resolution transcriptome of human macrophages. PLoS One (2012) 1.42
Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers. J Hematol Oncol (2013) 1.42
Macrophages and their relevance in Human Immunodeficiency Virus Type I infection. Retrovirology (2012) 1.41
Extracellular poly(ADP-ribose) is a pro-inflammatory signal for macrophages. Chem Biol (2015) 1.41
Alternatively Activated (M2) Macrophage Phenotype Is Inducible by Endothelin-1 in Cultured Human Macrophages. PLoS One (2016) 1.41
Cyclooxygenase-2 and Prostaglandin E2 Signaling through Prostaglandin Receptor EP-2 Favor the Development of Myocarditis during Acute Trypanosoma cruzi Infection. PLoS Negl Trop Dis (2015) 1.40
Redox control of inflammation in macrophages. Antioxid Redox Signal (2013) 1.39
Metabotropic glutamate receptor 5 may be involved in macrophage plasticity. Biol Res (2017) 1.39
Cardiosphere-Derived Cells Facilitate Heart Repair by Modulating M1/M2 Macrophage Polarization and Neutrophil Recruitment. PLoS One (2016) 1.39
An update on the biology of sphingosine 1-phosphate receptors. J Lipid Res (2014) 1.37
Identification of an adipogenic niche for adipose tissue remodeling and restoration. Cell Metab (2013) 1.36
The effects of airway microbiome on corticosteroid responsiveness in asthma. Am J Respir Crit Care Med (2013) 1.36
Depletion of alveolar macrophages during influenza infection facilitates bacterial superinfections. J Immunol (2013) 1.34
Eosinophils secrete IL-4 to facilitate liver regeneration. Proc Natl Acad Sci U S A (2013) 1.33
Lipocalin 2 deactivates macrophages and worsens pneumococcal pneumonia outcomes. J Clin Invest (2013) 1.32
The adventitia: essential regulator of vascular wall structure and function. Annu Rev Physiol (2012) 1.31
Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages. Cell (2014) 1.30
Flow Cytometric Analysis of Myeloid Cells in Human Blood, Bronchoalveolar Lavage, and Lung Tissues. Am J Respir Cell Mol Biol (2016) 1.28
The role of macrophage polarization in infectious and inflammatory diseases. Mol Cells (2014) 1.28
Nilotinib reduces muscle fibrosis in chronic muscle injury by promoting TNF-mediated apoptosis of fibro/adipogenic progenitors. Nat Med (2015) 1.28
Particle disease: biologic mechanisms of periprosthetic osteolysis in total hip arthroplasty. Innate Immun (2012) 1.24
Macrophages in Tissue Repair, Regeneration, and Fibrosis. Immunity (2016) 1.22
Inducible microRNA-223 down-regulation promotes TLR-triggered IL-6 and IL-1β production in macrophages by targeting STAT3. PLoS One (2012) 1.20
Metabolism via Arginase or Nitric Oxide Synthase: Two Competing Arginine Pathways in Macrophages. Front Immunol (2014) 1.15
Functional diversity of microglia - how heterogeneous are they to begin with? Front Cell Neurosci (2013) 1.14
Microglial M1/M2 polarization and metabolic states. Br J Pharmacol (2015) 1.14
TLR9 signaling in the tumor microenvironment initiates cancer recurrence after radiotherapy. Cancer Res (2013) 1.14
IFN-γ-induced iNOS expression in mouse regulatory macrophages prolongs allograft survival in fully immunocompetent recipients. Mol Ther (2012) 1.14
Innate immune programing by endotoxin and its pathological consequences. Front Immunol (2015) 1.13
Acute injury in the peripheral nervous system triggers an alternative macrophage response. J Neuroinflammation (2012) 1.12
Myeloid cells in tumor inflammation. Vasc Cell (2012) 1.12
Regulation of macrophage function by adenosine. Arterioscler Thromb Vasc Biol (2012) 1.11
Patrolling monocytes control tumor metastasis to the lung. Science (2015) 1.10
Synthetic Nanoparticles for Vaccines and Immunotherapy. Chem Rev (2015) 1.10
Immune-based antitumor effects of BRAF inhibitors rely on signaling by CD40L and IFNγ. Cancer Res (2014) 1.10
Macrophages are critical effectors of antibody therapies for cancer. MAbs (2015) 1.09
IL-1R1 is required for dendritic cell-mediated T cell reactivation within the CNS during West Nile virus encephalitis. J Exp Med (2013) 1.09
The ischemic environment drives microglia and macrophage function. Front Neurol (2015) 1.09
Altered macrophage phenotype transition impairs skeletal muscle regeneration. Am J Pathol (2014) 1.08
Monocyte trafficking to the brain with stress and inflammation: a novel axis of immune-to-brain communication that influences mood and behavior. Front Neurosci (2015) 1.08
Infiltration of diametrically polarized macrophages predicts overall survival of patients with gastric cancer after surgical resection. Gastric Cancer (2014) 1.07
Kruppel-like transcription factor 6 regulates inflammatory macrophage polarization. J Biol Chem (2014) 1.07
Hallmarks of cancer: the next generation. Cell (2011) 140.01
Alternative activation of macrophages. Nat Rev Immunol (2003) 27.53
Exploring the full spectrum of macrophage activation. Nat Rev Immunol (2008) 26.08
Monocyte and macrophage heterogeneity. Nat Rev Immunol (2005) 24.36
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med (2004) 22.96
Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest (2007) 20.19
Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J Exp Med (2003) 14.60
Cellular and molecular mechanisms of fibrosis. J Pathol (2008) 14.01
The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature (1998) 13.58
Development of monocytes, macrophages, and dendritic cells. Science (2010) 12.86
Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci U S A (1986) 12.14
Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature (2007) 11.59
Macrophage activation and polarization. Front Biosci (2008) 11.17
Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity (2011) 11.15
Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2. Nat Immunol (2006) 11.06
IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells. J Immunol (1991) 11.04
Identification of splenic reservoir monocytes and their deployment to inflammatory sites. Science (2009) 10.47
Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nat Immunol (2010) 9.59
The regulation of IL-10 production by immune cells. Nat Rev Immunol (2010) 9.18
Sterile inflammation: sensing and reacting to damage. Nat Rev Immunol (2010) 8.87
Tumor-associated macrophages and survival in classic Hodgkin's lymphoma. N Engl J Med (2010) 8.74
CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis. Nature (2011) 8.62
Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. J Clin Invest (2005) 8.58
CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell (2009) 8.54
Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation. Science (2011) 8.53
Identification of scavenger receptor SR-BI as a high density lipoprotein receptor. Science (1996) 8.29
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat Med (2011) 8.00
Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis. J Exp Med (2007) 7.87
Nonresolving inflammation. Cell (2010) 7.74
Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses. Nat Immunol (2007) 7.64
TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection. Immunity (2003) 7.33
Monocyte-mediated defense against microbial pathogens. Annu Rev Immunol (2008) 7.21
RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation. Nat Immunol (2011) 6.96
Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science (2011) 6.83
Fibrotic disease and the T(H)1/T(H)2 paradigm. Nat Rev Immunol (2004) 6.75
Intestinal homeostasis and its breakdown in inflammatory bowel disease. Nature (2011) 6.43
Interferons at age 50: past, current and future impact on biomedicine. Nat Rev Drug Discov (2007) 6.33
Altered macrophage differentiation and immune dysfunction in tumor development. J Clin Invest (2007) 6.31
The myofibroblast in wound healing and fibrocontractive diseases. J Pathol (2003) 6.16
Phagocytosis of immune complexes by macrophages. Different roles of the macrophage receptor sites for complement (C3) and for immunoglobulin (IgG). J Exp Med (1972) 6.13
Activation of beta-catenin in dendritic cells regulates immunity versus tolerance in the intestine. Science (2010) 6.04
Origin of the lamina propria dendritic cell network. Immunity (2009) 5.95
Chitin induces accumulation in tissue of innate immune cells associated with allergy. Nature (2007) 5.82
De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent. Cancer Cell (2005) 5.79
CD36: a class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism. J Clin Invest (2001) 5.72
A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection. Nature (1997) 5.55
MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis. J Exp Med (2007) 5.48
Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors. Immunity (2010) 5.43
Intestinal lamina propria dendritic cell subsets have different origin and functions. Immunity (2009) 5.43
The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF. Nat Immunol (2011) 5.41
Macrophages sequentially change their functional phenotype in response to changes in microenvironmental influences. J Immunol (2005) 5.20
IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses. Nat Immunol (2011) 5.11
Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells. Nature (2007) 4.88
A significant part of macrophage-derived growth factor consists of at least two forms of PDGF. Cell (1985) 4.81
Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis. Nat Immunol (2009) 4.76
NKT cell-mediated repression of tumor immunosurveillance by IL-13 and the IL-4R-STAT6 pathway. Nat Immunol (2000) 4.75
Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1). J Exp Med (2001) 4.71
Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease. Nat Med (2008) 4.70
Macrophage-mediated inflammation in metabolic disease. Nat Rev Immunol (2011) 4.68
Transforming growth factor beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis. Proc Natl Acad Sci U S A (1991) 4.61
Macrophage diversity in renal injury and repair. J Clin Invest (2008) 4.41
Down-regulation of the macrophage lineage through interaction with OX2 (CD200). Science (2000) 4.41
"Re-educating" tumor-associated macrophages by targeting NF-kappaB. J Exp Med (2008) 4.38
In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma. J Exp Med (2005) 4.34
Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E. Proc Natl Acad Sci U S A (1995) 4.31
Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens. Nat Immunol (2008) 4.31
Unravelling mononuclear phagocyte heterogeneity. Nat Rev Immunol (2010) 4.25
MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α-PU.1 pathway. Nat Med (2010) 4.24
Macrophages: master regulators of inflammation and fibrosis. Semin Liver Dis (2010) 4.24
IFN-gamma potentiates atherosclerosis in ApoE knock-out mice. J Clin Invest (1997) 4.18
Memory T(H)2 cells induce alternatively activated macrophages to mediate protection against nematode parasites. Nat Med (2006) 4.16
Arginase-1-expressing macrophages suppress Th2 cytokine-driven inflammation and fibrosis. PLoS Pathog (2009) 4.12
Functional plasticity of macrophages: reversible adaptation to changing microenvironments. J Leukoc Biol (2004) 4.05
Bone marrow mesenchymal stem and progenitor cells induce monocyte emigration in response to circulating toll-like receptor ligands. Immunity (2011) 3.88
Macrophages and angiogenesis. J Leukoc Biol (1994) 3.85
FcRgamma activation regulates inflammation-associated squamous carcinogenesis. Cancer Cell (2010) 3.80
B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma. J Exp Med (2006) 3.75
Transient expression of IL-1beta induces acute lung injury and chronic repair leading to pulmonary fibrosis. J Clin Invest (2001) 3.72
Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus. Nature (2010) 3.71
TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection. Proc Natl Acad Sci U S A (2009) 3.70
An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice. J Clin Invest (2011) 3.69
Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice. PLoS Med (2009) 3.68
Alternative macrophage activation and metabolism. Annu Rev Pathol (2011) 3.59
Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease. J Exp Med (2009) 3.58
IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion. Genes Dev (2010) 3.56
Monocytes in atherosclerosis: subsets and functions. Nat Rev Cardiol (2010) 3.53
Bleomycin and IL-1beta-mediated pulmonary fibrosis is IL-17A dependent. J Exp Med (2010) 3.44
Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis. Nat Med (2009) 3.43
IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation. J Immunol (2009) 3.41
CD36 modulates migration of mouse and human macrophages in response to oxidized LDL and may contribute to macrophage trapping in the arterial intima. J Clin Invest (2008) 3.29
Regulatory T cells reinforce intestinal homeostasis. Immunity (2009) 3.27
Cutting edge: Stat6-dependent substrate depletion regulates nitric oxide production. J Immunol (2001) 3.25
Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation. Nature (2009) 3.21
The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C- monocytes. Nat Immunol (2011) 3.19
Obstacles and opportunities for understanding macrophage polarization. J Leukoc Biol (2011) 3.16
Retracted Foxp3-positive macrophages display immunosuppressive properties and promote tumor growth. J Exp Med (2011) 3.15
Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes. Comparison with IL-4 and modulation by IFN-gamma or IL-10. J Immunol (1993) 3.14
Krüppel-like factor 4 regulates macrophage polarization. J Clin Invest (2011) 3.08
Unique CD14 intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-gamma axis. J Clin Invest (2008) 3.00
High-Throughput GoMiner, an 'industrial-strength' integrative gene ontology tool for interpretation of multiple-microarray experiments, with application to studies of Common Variable Immune Deficiency (CVID). BMC Bioinformatics (2005) 14.02
Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection. J Exp Med (2007) 4.47
Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens. Nat Immunol (2008) 4.31
Arginase-1-expressing macrophages suppress Th2 cytokine-driven inflammation and fibrosis. PLoS Pathog (2009) 4.12
Bleomycin and IL-1beta-mediated pulmonary fibrosis is IL-17A dependent. J Exp Med (2010) 3.44
The IL-21 receptor augments Th2 effector function and alternative macrophage activation. J Clin Invest (2006) 3.33
Obstacles and opportunities for understanding macrophage polarization. J Leukoc Biol (2011) 3.16
Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils. Nat Immunol (2011) 2.92
Immunopathology of schistosomiasis. Immunol Cell Biol (2006) 2.74
Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response. J Exp Med (2003) 2.71
A crucial role for the vitamin D receptor in experimental inflammatory bowel diseases. Mol Endocrinol (2003) 2.69
An essential role for TH2-type responses in limiting acute tissue damage during experimental helminth infection. Nat Med (2012) 2.60
The pathogenesis of schistosomiasis is controlled by cooperating IL-10-producing innate effector and regulatory T cells. J Immunol (2004) 2.50
Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor alpha1 chain. Nat Immunol (2007) 2.50
Global gene expression profiles during acute pathogen-induced pulmonary inflammation reveal divergent roles for Th1 and Th2 responses in tissue repair. J Immunol (2003) 2.48
IL-13 activates a mechanism of tissue fibrosis that is completely TGF-beta independent. J Immunol (2004) 2.47
Regulation of pathogenesis and immunity in helminth infections. J Exp Med (2009) 2.39
Evolution of Th2 immunity: a rapid repair response to tissue destructive pathogens. PLoS Pathog (2011) 2.25
Host responses in tissue repair and fibrosis. Annu Rev Pathol (2012) 2.10
Th2 cytokine-induced alterations in intestinal smooth muscle function depend on alternatively activated macrophages. Gastroenterology (2008) 2.09
Retnla (relmalpha/fizz1) suppresses helminth-induced Th2-type immunity. PLoS Pathog (2009) 2.07
Type 2 immunity and wound healing: evolutionary refinement of adaptive immunity by helminths. Nat Rev Immunol (2013) 1.96
Muc5ac: a critical component mediating the rejection of enteric nematodes. J Exp Med (2011) 1.88
Immunoglobulin class switch recombination is impaired in Atm-deficient mice. J Exp Med (2004) 1.87
T(H)-17: a giant step from T(H)1 and T(H)2. Nat Immunol (2005) 1.86
IL-13 receptor alpha 2 down-modulates granulomatous inflammation and prolongs host survival in schistosomiasis. Proc Natl Acad Sci U S A (2003) 1.80
Resistance of C57BL/6 mice to amoebiasis is mediated by nonhemopoietic cells but requires hemopoietic IL-10 production. J Immunol (2006) 1.77
Interleukin-5 (IL-5) augments the progression of liver fibrosis by regulating IL-13 activity. Infect Immun (2006) 1.76
NK cell-derived IFN-gamma differentially regulates innate resistance and neutrophil response in T cell-deficient hosts infected with Mycobacterium tuberculosis. J Immunol (2006) 1.76
The adaptor protein CIKS/Act1 is essential for IL-25-mediated allergic airway inflammation. J Immunol (2009) 1.76
Granulomas in schistosome and mycobacterial infections: a model of local immune responses. Trends Immunol (2003) 1.75
Transforming growth factor-β signaling promotes pulmonary hypertension caused by Schistosoma mansoni. Circulation (2013) 1.68
Chitinase dependent control of protozoan cyst burden in the brain. PLoS Pathog (2012) 1.68
Cytokine-mediated host responses during schistosome infections; walking the fine line between immunological control and immunopathology. Adv Parasitol (2002) 1.61
Suppression of murine allergic airway disease by IL-2:anti-IL-2 monoclonal antibody-induced regulatory T cells. J Immunol (2008) 1.58
IL-10 is critical for host resistance and survival during gastrointestinal helminth infection. J Immunol (2002) 1.58
Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report. Am J Respir Crit Care Med (2014) 1.54
Redundant and pathogenic roles for IL-22 in mycobacterial, protozoan, and helminth infections. J Immunol (2010) 1.53
IL-13Ralpha2 and IL-10 coordinately suppress airway inflammation, airway-hyperreactivity, and fibrosis in mice. J Clin Invest (2007) 1.47
Fibrosis is regulated by Th2 and Th17 responses and by dynamic interactions between fibroblasts and macrophages. Am J Physiol Gastrointest Liver Physiol (2011) 1.44
Schistosoma mansoni infection in eosinophil lineage-ablated mice. Blood (2006) 1.42
Critical role of IL-25 in nematode infection-induced alterations in intestinal function. J Immunol (2010) 1.40
Opposing roles for IL-13 and IL-13 receptor alpha 2 in health and disease. Immunol Rev (2004) 1.37
Structure of the catalytic domain of human polo-like kinase 1. Biochemistry (2007) 1.37
Matrix metalloproteinase 12-deficiency augments extracellular matrix degrading metalloproteinases and attenuates IL-13-dependent fibrosis. J Immunol (2010) 1.35
Schistosomiasis-induced experimental pulmonary hypertension: role of interleukin-13 signaling. Am J Pathol (2010) 1.33
Macrophage activation governs schistosomiasis-induced inflammation and fibrosis. Eur J Immunol (2011) 1.31
Endogenous pro- and anti-inflammatory cytokines differentially regulate an in vivo humoral response to Streptococcus pneumoniae. Infect Immun (2002) 1.30
Functional importance of regional differences in localized gene expression of receptors for IL-13 in murine gut. J Immunol (2006) 1.26
Regulation of macrophage arginase expression and tumor growth by the Ron receptor tyrosine kinase. J Immunol (2011) 1.26
Alternatively activated dendritic cells regulate CD4+ T-cell polarization in vitro and in vivo. Proc Natl Acad Sci U S A (2012) 1.24
T cell-specific deletion of the inositol phosphatase SHIP reveals its role in regulating Th1/Th2 and cytotoxic responses. Proc Natl Acad Sci U S A (2007) 1.23
Colitis and intestinal inflammation in IL10-/- mice results from IL-13Rα2-mediated attenuation of IL-13 activity. Gastroenterology (2010) 1.22
Cationic amino acid transporter-2 regulates immunity by modulating arginase activity. PLoS Pathog (2008) 1.19
IL-10 and TGF-beta control the establishment of persistent and transmissible infections produced by Leishmania tropica in C57BL/6 mice. J Immunol (2008) 1.16
Exploiting worm and allergy models to understand Th2 cytokine biology. Curr Opin Allergy Clin Immunol (2005) 1.14
Inhibition of T helper 2-type responses, IgE production and eosinophilia by synthetic lipopeptides. Eur J Immunol (2003) 1.14
IL-13 receptor alpha2 regulates the immune and functional response to Nippostrongylus brasiliensis infection. J Immunol (2009) 1.13
Regulation of helminth-induced Th2 responses by thymic stromal lymphopoietin. J Immunol (2009) 1.11
miR-182 and miR-10a are key regulators of Treg specialisation and stability during Schistosome and Leishmania-associated inflammation. PLoS Pathog (2013) 1.11
Strain-dependent genomic factors affect allergen-induced airway hyperresponsiveness in mice. Am J Respir Cell Mol Biol (2011) 1.11
Immunopathogenic mechanisms in schistosomiasis: what can be learnt from human studies? Trends Parasitol (2005) 1.09
Macrophages as IL-25/IL-33-responsive cells play an important role in the induction of type 2 immunity. PLoS One (2013) 1.09
Cytokine mediated tissue fibrosis. Biochim Biophys Acta (2012) 1.06
Fibrosis under arrest. Nat Med (2010) 1.05
Accelerated and progressive and lethal liver fibrosis in mice that lack interleukin (IL)-10, IL-12p40, and IL-13Rα2. Gastroenterology (2011) 1.05
IL-10 blocks the development of resistance to re-infection with Schistosoma mansoni. PLoS Pathog (2011) 1.03
Role of arginase 1 from myeloid cells in th2-dominated lung inflammation. PLoS One (2013) 1.02
Gene microarray analysis reveals interleukin-5-dependent transcriptional targets in mouse bone marrow. Blood (2003) 0.97
Basophils trump dendritic cells as APCs for T(H)2 responses. Nat Immunol (2009) 0.96
Blood fluke exploitation of non-cognate CD4+ T cell help to facilitate parasite development. PLoS Pathog (2010) 0.95
An efferocytosis-induced, IL-4-dependent macrophage-iNKT cell circuit suppresses sterile inflammation and is defective in murine CGD. Blood (2013) 0.92
RGS16 attenuates pulmonary Th2/Th17 inflammatory responses. J Immunol (2012) 0.89
Conventional NK cells can produce IL-22 and promote host defense in Klebsiella pneumoniae pneumonia. J Immunol (2014) 0.89
IL-33-induced alterations in murine intestinal function and cytokine responses are MyD88, STAT6, and IL-13 dependent. Am J Physiol Gastrointest Liver Physiol (2012) 0.87
Plasminogen activator inhibitor-2 (PAI-2) in eosinophilic leukocytes. J Leukoc Biol (2004) 0.84
Interleukin-5 does not influence differential transcription of transmembrane and soluble isoforms of IL-5R alpha in vivo. Eur J Haematol (2006) 0.83
A Trypanosoma brucei kinesin heavy chain promotes parasite growth by triggering host arginase activity. PLoS Pathog (2013) 0.82
Schistosoma mansoni arginase shares functional similarities with human orthologs but depends upon disulphide bridges for enzymatic activity. Int J Parasitol (2008) 0.82
Chronic graft-versus-host disease: how can we release Prometheus? Biol Blood Marrow Transplant (2008) 0.81
Myeloid-cell differentiation redefined in cancer. Nat Immunol (2013) 0.78
Shedding LIGHT on severe asthma. Nat Med (2011) 0.77
Mapping mouse IL-13 binding regions using structure modeling, molecular docking, and high-density peptide microarray analysis. Proteins (2011) 0.77
Enhanced interleukin-12 and CD40 ligand activities but reduced Staphylococcus aureus Cowan 1-induced responses suggest a generalized and progressively impaired type 1 cytokine pattern for human schistosomiasis. Infect Immun (2002) 0.76
Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): a tale of two waters. Bioorg Med Chem Lett (2012) 0.75